Search Results - (Author, Cooperation:M. G. Lewis)
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1Latest Papers from Table of Contents or Articles in PressD. H. Barouch ; G. Alter ; T. Broge ; C. Linde ; M. E. Ackerman ; E. P. Brown ; E. N. Borducchi ; K. M. Smith ; J. P. Nkolola ; J. Liu ; J. Shields ; L. Parenteau ; J. B. Whitney ; P. Abbink ; D. M. Ng'ang'a ; M. S. Seaman ; C. L. Lavine ; J. R. Perry ; W. Li ; A. D. Colantonio ; M. G. Lewis ; B. Chen ; H. Wenschuh ; U. Reimer ; M. Piatak ; J. D. Lifson ; S. A. Handley ; H. W. Virgin ; M. Koutsoukos ; C. Lorin ; G. Voss ; M. Weijtens ; M. G. Pau ; H. Schuitemaker
American Association for the Advancement of Science (AAAS)
Published 2015Staff ViewPublication Date: 2015-07-04Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: AIDS Vaccines/*immunology ; Adenovirus Vaccines/*immunology ; Adoptive Transfer ; Animals ; Antibodies, Neutralizing/immunology ; Female ; Gene Products, env/*immunology ; Gene Products, gag/immunology ; Gene Products, pol/immunology ; Genetic Vectors/immunology ; HIV-1/*immunology ; Histocompatibility Antigens Class I/genetics/immunology ; Immunization, Secondary ; Macaca mulatta ; Male ; SAIDS Vaccines/*immunology ; Simian Acquired Immunodeficiency Syndrome/*prevention & control ; Simian Immunodeficiency Virus/immunologyPublished by: -
2Latest Papers from Table of Contents or Articles in PressJ. B. Whitney ; A. L. Hill ; S. Sanisetty ; P. Penaloza-MacMaster ; J. Liu ; M. Shetty ; L. Parenteau ; C. Cabral ; J. Shields ; S. Blackmore ; J. Y. Smith ; A. L. Brinkman ; L. E. Peter ; S. I. Mathew ; K. M. Smith ; E. N. Borducchi ; D. I. Rosenbloom ; M. G. Lewis ; J. Hattersley ; B. Li ; J. Hesselgesser ; R. Geleziunas ; M. L. Robb ; J. H. Kim ; N. L. Michael ; D. H. Barouch
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-07-22Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Anti-Retroviral Agents/administration & dosage/pharmacology/therapeutic use ; Carrier State/drug therapy/virology ; DNA, Viral/analysis/biosynthesis/blood ; Disease Models, Animal ; Female ; Kinetics ; Macaca mulatta/immunology/*virology ; Male ; Proviruses/genetics ; RNA, Viral/blood ; Rectum/virology ; Simian Acquired Immunodeficiency Syndrome/drug therapy/immunology/*virology ; Simian Immunodeficiency Virus/drug effects/*growth & ; development/immunology/physiology ; Time Factors ; Treatment Failure ; *Viral Load/drug effects ; Viremia/drug therapy/*virology ; Virus Replication/drug effectsPublished by: -
3Latest Papers from Table of Contents or Articles in PressD. H. Barouch ; J. B. Whitney ; B. Moldt ; F. Klein ; T. Y. Oliveira ; J. Liu ; K. E. Stephenson ; H. W. Chang ; K. Shekhar ; S. Gupta ; J. P. Nkolola ; M. S. Seaman ; K. M. Smith ; E. N. Borducchi ; C. Cabral ; J. Y. Smith ; S. Blackmore ; S. Sanisetty ; J. R. Perry ; M. Beck ; M. G. Lewis ; W. Rinaldi ; A. K. Chakraborty ; P. Poignard ; M. C. Nussenzweig ; D. R. Burton
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-11-01Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Antibodies, Monoclonal/*therapeutic use ; Antibodies, Neutralizing/*therapeutic use ; DNA, Viral/blood ; HIV Antibodies/immunology ; HIV-1/*immunology ; Macaca mulatta ; Simian Acquired Immunodeficiency Syndrome/*therapy ; Simian Immunodeficiency Virus/*physiology ; T-Lymphocytes/immunology ; Viremia/therapyPublished by: -
4Latest Papers from Table of Contents or Articles in PressJ. A. Harker ; G. M. Lewis ; L. Mack ; E. I. Zuniga
American Association for the Advancement of Science (AAAS)
Published 2011Staff ViewPublication Date: 2011-10-01Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Antibodies, Viral/blood/immunology ; Antibody Affinity ; Arenaviridae Infections/*immunology/virology ; B-Lymphocytes/immunology ; Chronic Disease ; Cytokines/blood ; DNA-Binding Proteins/metabolism ; Germinal Center/immunology ; Interleukin-6/blood/*immunology/*metabolism ; Lymphocytic choriomeningitis virus/*immunology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Receptors, Interleukin-6/genetics/metabolism ; Signal Transduction ; T-Lymphocytes, Helper-Inducer/*immunologyPublished by: -
5Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2018-06-05Publisher: Rockefeller University PressPrint ISSN: 0022-1007Electronic ISSN: 1540-9538Topics: MedicineKeywords: Innate Immunity and Inflammation, Infectious Disease and Host DefensePublished by: -
6Articles: DFG German National LicensesStaff View
ISSN: 1471-0528Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: A case of a large teratomatous ovarian cyst in parts of which arrhenoblastic tissue occurred and caused virilization is reported.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesLEWIS, M. G. ; PHILLIPS, T. M. ; NOBLE, P. B. ; HARTMANN, D. P.
Oxford, UK : Blackwell Publishing Ltd
Published 1979Staff ViewISSN: 1600-0560Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: The interaction between immune system and growing tumor can be expressed differently at different stages of the disease. This presentation covers three facets of these reactions in melanoma patients. A. The Primary Tumor. Time-lapse cinematography, with an analysis of lymphocyte movement demonstrated positive and negative chemotaxis against tumor tissues which correlated with their histological presence or absence within the primary tumor. B. The Regional Lymph Nodes. Histological examination of regional lymph nodes showed an increase in germinal center activity and B cell number, with a decrease in sinus histiocytosis and monocyte count as the tumor progressively invaded the node. This correlated with the elution studies, wherein the anti-membrane antibody decreased and the anti-cytoplasmic antibody increased during the same period of progression. C. Humoral Immunity and Metastasis. Clinical metastasis heralded the decrease of anti-membrane antibodies with a rise in anti-immunoglobulins, especially anti-idotypic antibodies and immune complexes containing tumor-directed antibody and either antigen or anti-immunoglobulin. This triad of anti-immunoglobulin, immune complexes and anergy as seen in other diseases with persistent antigenic stimulation, results in abnormal regulation and derangement.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 1365-2133Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: SUMMARY. The frequency and regional distribution of pigmented naevi has been studied in Ugandan Africans. An average of 11 naevi was present in each adult.The association between the distribution of naevi and that of malignant melanoma is discussed and evidence is presented that pigmented skin is able to prevent the malignant transformation of naevi and the spread of already established malignant melanoma.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesJERRY, L. M. ; ROWDEN, G. ; CANO, P. O. ; PHILLIPS, T. M. ; DEUTSCH, G. F. ; CAPEK, A. ; HARTMANN, D. ; LEWIS, M. G.
Oxford, UK : Blackwell Publishing Ltd
Published 1976Staff ViewISSN: 1365-3083Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Circulating immune complexes were detected in 62 individuals with malignant melanoma by precipitation with isolated human C1q and polyclonal rheumatoid factors. In 56 patients the C1q deviation assay showed low to moderate levels of complexes, with increased amounts with advancing stage of disease. Both heavy (〉19S) and intermediate (7S to 19S) varieties were present, and complexes containing tumor antigen-antibody or antibody- anti-antibody were identified. Complexes were found in the kidneys of one patient with malignancy and the nephrotic syndrome and in two further patients with melanoma in whom there were DO clinical manifestations of nephrosis. Serial determinations in 51 patients showed slow cyclic variations in the levels of complexes and fluctuations in response to therapy. The coexistence of anti-antibodies, immune complex disease, and anergy in melanoma patients may indicate a deranged immune regulation consequent to chronic antigenic stimulation by the tumor.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesROWDEN, G. ; PHILLIPS, T. M. ; LEWIS, M. G. ; WILKINSON, R. D.
Oxford, UK : Blackwell Publishing Ltd
Published 1979Staff ViewISSN: 1600-0560Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Langerhans cells of the epidermis are “special” macrophages, as indicated by their expression of Fc and C, receptors and la antigen. Functionally, they can replace macrophages in presentation of antigens to T cells and in the MLR. Ultrastructural and immunologic studies were carried out on epidermal samples of mycosis fungoides. As in contact allergy, apposition of lymphocytes to Langerhans cells was noted. Destruction of Langerhans cells appeared to act as the focus for the development of Pautrier microabscesses. This destruction was accompanied by ingress of histocytic cells, probably related to the stem cell population for Langerhans cells. The target cell role of Langerhans cells appears to be similar in contact allergy and mycosis fungoides.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 1365-2133Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: An antiserum against human B-lymphoblastoid cell membrane alloantigens (Ia-like antigens) was used to study the presence of such antigens on dendritic cells in human epidermis. Only Langerhans cells and the majority (85%) of so-called indeterminate cells were positively stained, as shown by ummuno-electron microscopy. Fifteen percent of the indeterminate cells were negative and were considered to be immature melanocytes. A relationship exists between the indeterminate cell and the Langerhans cell. A proposal is made concerning emigration of Langerhans cells in response to haptenic stimulation, and the immigration of indeterminate cells to restore the status quo.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] The la antigens are surface glycoproteins associated with particular groups of immunologically active cells5"7. Although they have been detected in small quantities on T cells they seem to be associated (primarily with B cells8'9. Recent studies have, however, shown them to also be expressed on ...Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 1749-6632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Natural Sciences in GeneralType of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesLEWIS, M. G. ; PHILLIPS, T. M. ; COOK, K. B. ; BLAKE, J.
[s.l.] : Nature Publishing Group
Published 1971Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] The first two suggestions have been largely refuted by recent work, in which patients with disseminated malignant melanoma, having no detectable antibody, responded to auto-immunization with their own tumour cells, and produced antibody in their sera14. The third possibility is considered unlikely ...Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 1432-8798Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary Receptor-mediated activation is accompanied by phospholipid metabolism and by calcium fluctuation resulting in a chemiluminescence (CL) response in the neutrophil. This pathway involves activation of protein kinase C (PKC) and the NADPH oxidase. Artificial stimulants such as phorbol esters, specifically 12-O-tetradecanylphorbol-13-acetate (TPA), circumvent the receptor-mediated pathway and activate PKC resulting in a measurable CL response. Neutrophils from feline leukemia virus (FeLV) exposed cats were tested for their ability to generate a TPA-induced CL response. As compared to the non-FeLV-exposed specific-pathogen-free (SPF) control cat neutrophil CL responses, both viremic and nonviremic FeLV-exposed cats showed significant decreases in their CL responsiveness. Neither ultraviolet light-inactivated FeLV (UV-FeLV) nor protein components (FeLV-p15E and FeLV-p27) caused a significant decrease in the CL responses of the SPF cat neutrophils. The suppressed TPA-induced CL response from FeLV-infected cats may involve an intracellular mechanism not affected in vitro by exposure of the neutrophil to the virus or viral components.Type of Medium: Electronic ResourceURL: