Search Results - (Author, Cooperation:M. Fruttiger)
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1Latest Papers from Table of Contents or Articles in PressK. Wilhelm ; K. Happel ; G. Eelen ; S. Schoors ; M. F. Oellerich ; R. Lim ; B. Zimmermann ; I. M. Aspalter ; C. A. Franco ; T. Boettger ; T. Braun ; M. Fruttiger ; K. Rajewsky ; C. Keller ; J. C. Bruning ; H. Gerhardt ; P. Carmeliet ; M. Potente
Nature Publishing Group (NPG)
Published 2016Staff ViewPublication Date: 2016-01-07Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Cell Proliferation ; Cell Respiration ; Endothelium, Vascular/cytology/*growth & development/*metabolism ; Female ; Forkhead Transcription Factors/deficiency/genetics/*metabolism ; Glycolysis ; Human Umbilical Vein Endothelial Cells/cytology/metabolism ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Proto-Oncogene Proteins c-myc/deficiency/genetics/metabolism ; Signal TransductionPublished by: -
2Articles: DFG German National LicensesFruttiger, M. ; Montag, D. ; Schachner, M. ; Martini, R.
Oxford, UK : Blackwell Publishing Ltd
Published 1995Staff ViewISSN: 1460-9568Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: It has recently been shown that mice deficient in the gene for myelin-associated glycoprotein develop normal myelin sheaths in the peripheral nervous system. Here we report that in mutant mice older than 8 months the maintenance of axon-myelin units is disturbed, resulting in both axon and myelin degeneration. Morphological features include those typically seen in human peripheral neuropathies, where demyelination-induced Schwann cell proliferation and remyelination lead to the formation of so-called onion bulbs. Expression of tenascin-C, a molecule indicative of peripheral nerve degeneration, was up-regulated by axon-deprived Schwann cells and regenerating axons were occasionally seen. Myelin-associated glycoprotein thus appears to play a crucial role in the long-term maintenance of the integrity of both myelin and axons.Type of Medium: Electronic ResourceURL: