Search Results - (Author, Cooperation:M. Ferguson)
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1Latest Papers from Table of Contents or Articles in PressSoares, M. L., Edwards, C. A., Dearden, F. L., Ferron, S. R., Curran, S., Corish, J. A., Rancourt, R. C., Allen, S. E., Charalambous, M., Ferguson-Smith, M. A., Rens, W., Adams, D. J., Ferguson-Smith, A. C.
Cold Spring Harbor Laboratory Press
Published 2018Staff ViewPublication Date: 2018-03-06Publisher: Cold Spring Harbor Laboratory PressElectronic ISSN: 1549-5469Topics: BiologyMedicinePublished by: -
2Latest Papers from Table of Contents or Articles in PressEvan C. Ewers; Sarah K. Anisowicz; Tomas M. Ferguson; Scott E. Seronello; Jason C. Barnhill; Michael B. Lustik; Willie Agee IIIMichael A. Washington; Md A. Nahid; Mark W. Burnett; Ladaporn Bodhidatta; Apichai Srijan; Supaporn Rukasiri; Patcharawalai Wassanarungroj; Sirigade Ruekit; Panida Nobthai; Brett E. Swierczewski; Woradee Lurchachaiwong; Oralak Serichantalergs; Viseth Ngauy
Nature Publishing Group (NPG)
Published 2018Staff ViewPublication Date: 2018-08-07Publisher: Nature Publishing Group (NPG)Electronic ISSN: 2045-2322Topics: Natural Sciences in GeneralPublished by: -
3Latest Papers from Table of Contents or Articles in PressP. Nouvellet ; T. Garske ; H. L. Mills ; G. Nedjati-Gilani ; W. Hinsley ; I. M. Blake ; M. D. Van Kerkhove ; A. Cori ; I. Dorigatti ; T. Jombart ; S. Riley ; C. Fraser ; C. A. Donnelly ; N. M. Ferguson
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-12-04Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Africa, Western/epidemiology ; *Diagnostic Tests, Routine ; *Hemorrhagic Fever, Ebola/diagnosis/epidemiology/prevention & ; control/transmission ; Humans ; Time Factors ; TriagePublished by: -
4Latest Papers from Table of Contents or Articles in PressS. Yokoyama ; S. L. Woods ; G. M. Boyle ; L. G. Aoude ; S. MacGregor ; V. Zismann ; M. Gartside ; A. E. Cust ; R. Haq ; M. Harland ; J. C. Taylor ; D. L. Duffy ; K. Holohan ; K. Dutton-Regester ; J. M. Palmer ; V. Bonazzi ; M. S. Stark ; J. Symmons ; M. H. Law ; C. Schmidt ; C. Lanagan ; L. O'Connor ; E. A. Holland ; H. Schmid ; J. A. Maskiell ; J. Jetann ; M. Ferguson ; M. A. Jenkins ; R. F. Kefford ; G. G. Giles ; B. K. Armstrong ; J. F. Aitken ; J. L. Hopper ; D. C. Whiteman ; P. D. Pharoah ; D. F. Easton ; A. M. Dunning ; J. A. Newton-Bishop ; G. W. Montgomery ; N. G. Martin ; G. J. Mann ; D. T. Bishop ; H. Tsao ; J. M. Trent ; D. E. Fisher ; N. K. Hayward ; K. M. Brown
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-11-15Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adult ; Aged ; Aged, 80 and over ; Female ; Gene Expression Regulation, Neoplastic ; *Genetic Predisposition to Disease ; Humans ; Male ; Melanoma/*genetics ; Microphthalmia-Associated Transcription Factor/*genetics ; Middle Aged ; *Mutation ; Sumoylation/genetics ; Young AdultPublished by: -
5Latest Papers from Table of Contents or Articles in PressAndrew D. Nguyen, Thi A. Nguyen, Jiasheng Zhang, Swathi Devireddy, Ping Zhou, Anna M. Karydas, Xialian Xu, Bruce L. Miller, Frank Rigo, Shawn M. Ferguson, Eric J. Huang, Tobias C. Walther, Robert V. Farese Jr.
National Academy of Sciences
Published 2018Staff ViewPublication Date: 2018-03-21Publisher: National Academy of SciencesPrint ISSN: 0027-8424Electronic ISSN: 1091-6490Topics: BiologyMedicineNatural Sciences in GeneralPublished by: -
6Latest Papers from Table of Contents or Articles in PressR. A. Ibata ; G. F. Lewis ; A. R. Conn ; M. J. Irwin ; A. W. McConnachie ; S. C. Chapman ; M. L. Collins ; M. Fardal ; A. M. Ferguson ; N. G. Ibata ; A. D. Mackey ; N. F. Martin ; J. Navarro ; R. M. Rich ; D. Valls-Gabaud ; L. M. Widrow
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-01-04Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsPublished by: -
7Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2015-10-10Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Humans ; Neoplasms/*metabolism ; Oncogene Proteins/*metabolism ; Phosphatidylinositol 3-Kinases/*metabolism ; rab GTP-Binding Proteins/*metabolismPublished by: -
8Latest Papers from Table of Contents or Articles in PressM. G. Baud ; E. Lin-Shiao ; T. Cardote ; C. Tallant ; A. Pschibul ; K. H. Chan ; M. Zengerle ; J. R. Garcia ; T. T. Kwan ; F. M. Ferguson ; A. Ciulli
American Association for the Advancement of Science (AAAS)
Published 2014Staff ViewPublication Date: 2014-10-18Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Amino Acid Sequence ; Azepines/chemistry/pharmacology ; Cell Line, Tumor ; Chromatin/chemistry ; Crystallography, X-Ray ; Humans ; Leucine/genetics ; Models, Molecular ; Molecular Probes/*chemistry ; Mutation ; Nuclear Proteins/antagonists & inhibitors/*chemistry/genetics ; Protein Engineering/*methods ; Protein Structure, Tertiary ; Transcription Factors/antagonists & inhibitors/*chemistry/genetics ; Triazoles/chemistry/pharmacologyPublished by: -
9Latest Papers from Table of Contents or Articles in PressM. D. Van Kerkhove ; S. Riley ; M. Lipsitch ; Y. Guan ; A. S. Monto ; R. G. Webster ; M. Zambon ; A. Nicoll ; J. S. Peiris ; N. M. Ferguson
American Association for the Advancement of Science (AAAS)
Published 2012Staff ViewPublication Date: 2012-06-23Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Antibodies, Viral/*blood ; Humans ; Influenza A Virus, H5N1 Subtype/*immunology ; Influenza, Human/*epidemiology/*virologyPublished by: -
10Latest Papers from Table of Contents or Articles in PressDimitri A. Christakis, Julian S. Benedikt Ramirez, Susan M. Ferguson, Shilpa Ravinder, Jan-Marino Ramirez
National Academy of Sciences
Published 2018Staff ViewPublication Date: 2018-10-04Publisher: National Academy of SciencesPrint ISSN: 0027-8424Electronic ISSN: 1091-6490Topics: BiologyMedicineNatural Sciences in GeneralKeywords: Sackler Colloquium on Digital Media and Developing MindsPublished by: -
11Articles: DFG German National LicensesFerguson, M. L. ; Miller, B. N. ; Thompson, M. A.
Woodbury, NY : American Institute of Physics (AIP)
Published 1999Staff ViewISSN: 1089-7682Source: AIP Digital ArchiveTopics: PhysicsNotes: Gravitational billiards provide a simple method for the illustration of the dynamics of Hamiltonian systems. Here we examine a new billiard system with two parameters, which exhibits, in two limiting cases, the behaviors of two previously studied one-parameter systems, namely the wedge and parabolic billiard. The billiard consists of a point mass moving in two dimensions under the influence of a constant gravitational field with a hyperbolic lower boundary. An iterative mapping between successive collisions with the lower boundary is derived analytically. The behavior of the system during transformation from the wedge to the parabola is investigated for a few specific cases. It is surprising that the nature of the transformation depends strongly on the parameter values. © 1999 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesLin, M.P. ; Marti, G.P. ; Dieb, R. ; Wang, J. ; Ferguson, M. ; Qaiser, R. ; Bonde, P. ; Duncan, M.D. ; Harmon, J.W.
Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.
Published 2005Staff ViewISSN: 1524-475XSource: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Introduction: Using peptide growth factors to improve upon natural wound healing provides promise, but topical application of growth factors has found limited clinical success. Gene therapy has been limited by low transfection efficiency. We are investigating the use of electroporation (EP)in vivo to enhance transfection efficiency and improve wound healing with DNA expression vectors for growth factors.Methods: To assess plasmid transfection and wound healing, gWIZ luciferase vector and PCDNA3.1/KGF expression vector were used, respectively. Cutaneous wounds were produced via 8 mm-punch biopsy in Sprague Dawley rats. Healing was impaired by cecal ligation induced sepsis. We used NIH image analysis software and histologic assessment to assess wound closure.Results: Plasmid Transfection: EP effectively increased expression of gWIZ luciferase vector 53-fold compared to vector without EP (p 〈 0.001). We demonstrated that transfection was localized to skin when transfected skin was reflected to reveal underlying muscle. We found that EP-assisted transfection lasted for 30 days, which is appropriate for treatment of wound healing.Wound Healing: Using PCDNA3.1/KGF expression vector and EP wounds were 60% smaller on day 12 versus vector without EP (p 〈 0.009). We assessed quality of healing with a histologic scoring system grading quality of epithelial coverage, organization of scar and resolution of inflammation. KGF vector + EP score of 3.0 +/− 0.3 was better than that of 1.8 +/− 0.3 for treatment with vector alone (p 〈 0.05).Conclusions: These results demonstrate the capacity of electroporation-facilitated transfection with DNA plasmid expression vector for growth factor to improve wound healing.Acknowledgments: Funding from USAMRMC PRMRP DAMDI7-03-1-0029 and Maryland State Firefighters FundType of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesFerguson, M. ; Marti, G.P. ; Nasir, I. ; Broor, A. ; Wang, J. ; Duncan, M.D. ; Harmon, J.W.
Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.
Published 2005Staff ViewISSN: 1524-475XSource: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Introduction: Diabetes is known to impair wound healing. We assessed the effect of aging on this impairment and further explored the possibility of repairing age-dependant impairment by replenishing levels of the growth factor KGF-1 using our system of electroporation enhanced gene therapy.Methods: Female BKS.Cg-m+/+Leprdb/J mice (diabetic) were obtained from the Jackson Laboratory (Bar Harbor, ME). Mice at time of study were 7, 27, and 84 weeks, respectively. Two wounds were created using a 5 mm punch biopsy. Plasmid DNA encoding KGF-1 was injected at 40 μg / wound. Electroporation was carried out with six square wave pulses, at 1800 volts for 100 μs; with aninterval of 125 ms. Wounds were assessed planometrically over a 14-day period.Results: We found that wound healing is severely impaired in older, but not young diabetic mice (7-week-old mice displayed a threefold smaller wound area than 84-week-old mice on day 9). Glucose levels were similar in old and young groups ruling out differences in intensity of the metabolic derangement to explain this disparity (old: 334 +/− 41 mg/dl vs. young: 290 +/− 33 mg/dl). Treatment with KGF-1 gene therapy increased wound closure in aged mice 5.9-fold as compared to untreated aged mice 5 days after wounding (treated: 3724 +/− 631 vs. untreated: 632 +/− 517, P = 0.002). Aged KGF-1 gene therapy-treated mice closed wounds 10-fold faster than treated young mice 5 days after wounding (old: 3724: +/− 631 vs. young 358 +/− 871, P = 0.004).Conclusions: We conclude that progressive damage to the tissues capability to heal occurs in individuals with diabetes. Treatment with KGF-1 gene therapy is more effective in aged mice than young mice. With an increasing geriatric diabetic population, gene therapy to replenish growth factors may be worth exploring.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesMort, J. ; Machonkin, M. ; Ziolo, R. ; Huffman, D. R. ; Ferguson, M. I.
Woodbury, NY : American Institute of Physics (AIP)
Published 1992Staff ViewISSN: 1077-3118Source: AIP Digital ArchiveTopics: PhysicsNotes: We report the temperature dependence from 330 to 230 K of the photoconductivity measured in sublimed films of buckminsterfullerene, specifically, C60/70, up to 3 μm thick. In contrast to the temperature dependence of the dark conductivity, where reversible structure, associated with the onset of a phase transition to orientational ordering below 250 K, is observed, the photoconductivity shows an essentially monotonic decrease to lower temperatures. This provides additional evidence that the thermal generation rate increases as the C60/70 becomes orientationally ordered. It also suggests that the increased order below the transition temperature does not lead to significantly increased carrier mobilities.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStubhan, F. ; Ferguson, M. ; Füsser, H.-J. ; Behm, R. J.
Woodbury, NY : American Institute of Physics (AIP)
Published 1995Staff ViewISSN: 1077-3118Source: AIP Digital ArchiveTopics: PhysicsNotes: Heteroepitaxial nucleation of diamond on mirror-polished Si(001) substrates was achieved in a conventional hot filament reactor. The key to this achievement was the development of a bias-enhanced nucleation process step analogous to the procedure for heteroepitaxial nucleation in microwave plasma chemical vapor deposition. The nucleation and subsequent growth of diamond were characterized by means of scanning electron microscopy, scanning tunneling microscopy, and Raman spectroscopy. Well-developed diamond (001) crystal faces are observed even for very thin (∼0.3 μm) diamond films. High-resolution scanning electron microscopy investigations of the early stage of growth revealed oriented crystallites on the substrate surface with a nucleation density of 109 cm−2. © 1995 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesBayat, A. ; Walter, J. ; Lamb, H. ; Marino, M. ; Ferguson, M. W. J. ; Ollier, W. E. R.
Oxford, UK : Blackwell Science Ltd
Published 2005Staff ViewISSN: 1744-313XSource: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyMedicineNotes: In this study, we investigated the presence of mutations within the mitochondrial genome in 40 Caucasian subjects using an enhanced multiplex denaturing high-performance liquid chromatography (DHPLC) approach. The enhanced DHPLC approach has increased sensitivity and throughput, and reduced analysis time per individual sample compared to conventional methods. This technique involved amplifying the mitochondrial genome in 18 fragments ranging in size from 300 to 2000 bp using a novel proofreading polymerase (OptimaseTM, Transgenomic Inc., Omaha, NE) with a low misincorporation rate. Fourteen of these fragments underwent subsequent restriction digestion using a combination of five restriction enzymes to enable multiplex DHPLC analysis; the remaining four underwent conventional DHPLC. Using this complete mitochondrial genome-screening approach, we confirmed a number of previously reported mutations and additionally identified a large number of novel mutations using an enhanced DHPLC technique.Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesFERGUSON, M. ; COCHRAN, G. V. B. ; CARDI, M. ; TRACHTMAN, L.
Oxford, UK : Blackwell Publishing Ltd
Published 1986Staff ViewISSN: 1749-6632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Natural Sciences in GeneralType of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesBarlow, S. E. ; Van Doren, J. M. ; DePuy, C. H. ; Bierbaum, V. M. ; Dotan, I. ; Ferguson, E. E. ; Adams, N. G. ; Smith, D. ; Rowe, B. R. ; Marquette, J. B. ; Dupeyrat, G. ; Durup-Ferguson, M.
College Park, Md. : American Institute of Physics (AIP)
Published 1986Staff ViewISSN: 1089-7690Source: AIP Digital ArchiveTopics: PhysicsChemistry and PharmacologyNotes: In the gas phase O+2 reacts with methane at 300 K to produce a hydrogen atom and the CH3O+2 ion. The structure of this ion has recently been determined to be H2COOH+, methylene hydroperoxide ion. The reaction rate coefficients and product distributions have now been measured at 300 K for the CHnD4−n isotopes. The reaction shows both inter- and intramolecular isotope effects, e.g., CH2D2 reacts more slowly than methane and more rapidly than CD4, but loses hydrogen or deuterium with equal probability. The ion readily transfers HO+ to alkenes, CS2, and many other neutral molecules. The reaction with CS2 has been used to investigate the isotopic distribution within mixed isotope product ions. In addition, the reaction rate coefficients for both CH4 and CD4 have been measured as functions of temperature between 20 and 500 K; in both cases a clear minimum is observed in the reaction rate coefficient near room temperature. A mechanism for the reaction is proposed which allows us to model the temperature dependence of the reaction rate coefficient over the entire range for which there are data.Type of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesFederer, W. ; Dobler, W. ; Howorka, F. ; Lindinger, W. ; Durup-Ferguson, M. ; Ferguson, E. E.
College Park, Md. : American Institute of Physics (AIP)
Published 1985Staff ViewISSN: 1089-7690Source: AIP Digital ArchiveTopics: PhysicsChemistry and PharmacologyNotes: Vibrational quenching rate constants have been measured for NO+(v) ions in collision with 17 neutral molecules. The dependence of the quenching rate constants on collision energy have been determined from near thermal energy up to ∼ 1 eV in some of these cases. The experimental results can be satisfactorily interpreted using a model of complex formation followed by vibrational predissociation with a rate constant of the order of 109–1010 s−1.Type of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesSWEATMAN, M. C. ; TASKER, R. ; WARNER, J. O. ; FERGUSON, M. M. ; MITCHELL, D. N.
Oxford, UK : Blackwell Publishing Ltd
Published 1986Staff ViewISSN: 1365-2222Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: We report the case of an 8·5-year-old girl with oro-facial granulomatosis associated with clinical atopy, in whom relapse of her granulomatous disorder was shown to be related to exposure to specific food additives, viz. carmoisine, sunset yellow and monosodium glutamate. Treatment with a restricted diet resulted in considerable regression in the facial swelling which has been maintained for 6 months. A brief account of the histological features, both under light and electron microscopy, is given, together with a description of the use of nuclear magnetic resonance scanning in the assessment of this disease. The patient had no evidence to support a diagnosis of sarcoidosis or Crohn's disease.Type of Medium: Electronic ResourceURL: