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  1. 1
    A. G. Hinch ; A. Tandon ; N. Patterson ; Y. Song ; N. Rohland ; C. D. Palmer ; G. K. Chen ; K. Wang ; S. G. Buxbaum ; E. L. Akylbekova ; M. C. Aldrich ; C. B. Ambrosone ; C. Amos ; E. V. Bandera ; S. I. Berndt ; L. Bernstein ; W. J. Blot ; C. H. Bock ; E. Boerwinkle ; Q. Cai ; N. Caporaso ; G. Casey ; L. A. Cupples ; S. L. Deming ; W. R. Diver ; J. Divers ; M. Fornage ; E. M. Gillanders ; J. Glessner ; C. C. Harris ; J. J. Hu ; S. A. Ingles ; W. Isaacs ; E. M. John ; W. H. Kao ; B. Keating ; R. A. Kittles ; L. N. Kolonel ; E. Larkin ; L. Le Marchand ; L. H. McNeill ; R. C. Millikan ; A. Murphy ; S. Musani ; C. Neslund-Dudas ; S. Nyante ; G. J. Papanicolaou ; M. F. Press ; B. M. Psaty ; A. P. Reiner ; S. S. Rich ; J. L. Rodriguez-Gil ; J. I. Rotter ; B. A. Rybicki ; A. G. Schwartz ; L. B. Signorello ; M. Spitz ; S. S. Strom ; M. J. Thun ; M. A. Tucker ; Z. Wang ; J. K. Wiencke ; J. S. Witte ; M. Wrensch ; X. Wu ; Y. Yamamura ; K. A. Zanetti ; W. Zheng ; R. G. Ziegler ; X. Zhu ; S. Redline ; J. N. Hirschhorn ; B. E. Henderson ; H. A. Taylor, Jr. ; A. L. Price ; H. Hakonarson ; S. J. Chanock ; C. A. Haiman ; J. G. Wilson ; D. Reich ; S. R. Myers
    Nature Publishing Group (NPG)
    Published 2011
    Staff View
    Publication Date:
    2011-07-22
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Africa, Western/ethnology ; African Americans/*genetics ; Alleles ; Amino Acid Motifs ; Base Sequence ; Chromosome Mapping ; Crossing Over, Genetic/*genetics ; Europe/ethnology ; European Continental Ancestry Group/genetics ; Evolution, Molecular ; Female ; Gene Frequency ; Genetics, Population ; Genome, Human/*genetics ; Genomics ; Haplotypes/genetics ; Histone-Lysine N-Methyltransferase/chemistry/genetics/metabolism ; Humans ; Male ; Molecular Sequence Data ; Pedigree ; Polymorphism, Single Nucleotide/genetics ; Probability
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Press, M. F.
    Springer
    Published 1985
    Staff View
    ISSN:
    1432-0533
    Keywords:
    Lead encephalopathy ; Developing blood-brain barrier ; Endothelial sprouts
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary The ultrastructure and microcirculatory permeability changes of lead encephalopathy were studied in an animal model using horseradish peroxidase as an intravascular tracer. The fine structure of capillary sprouts in the developing cerebellar microcirculation of lead-poisoned rats were described. Immature vessels, characterized by the presence of endothelial sprouts, were found to have focal areas of endothelial injury with degenerating endothelial cells. These disruptions of the microcirculatory endothelium had tracer extending from the vessel lumen to the surrounding neuropil. The degenerating endothelial cells were found as early as 24–28 h after the first administration of lead acetate by gastric lavage (2–3-day-old rats). The early injury to endothelial cells of immature vessels in the developing microcirculation is suggested as an important component of the vascular permeability changes which characterize lead encephalopathy. Older animals (5–10 days old) had microaneurysmal vascular dilatations which had a complex internal structure formed by endothelial cells. These microaneurysmally dilated vessels may represent an endothelial response to preceding endothelial injury of immature vessels.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00688128

    Articles: DFG German National Licenses