Search Results - (Author, Cooperation:M. E. Hill)

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  1. 1
    S. M. Krimigis ; R. B. Decker ; E. C. Roelof ; M. E. Hill ; T. P. Armstrong ; G. Gloeckler ; D. C. Hamilton ; L. J. Lanzerotti
    American Association for the Advancement of Science (AAAS)
    Published 2013
    Staff View
    Publication Date:
    2013-07-03
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  2. 2
    S. A. Stern ; F. Bagenal ; K. Ennico ; G. R. Gladstone ; W. M. Grundy ; W. B. McKinnon ; J. M. Moore ; C. B. Olkin ; J. R. Spencer ; H. A. Weaver ; L. A. Young ; T. Andert ; J. Andrews ; M. Banks ; B. Bauer ; J. Bauman ; O. S. Barnouin ; P. Bedini ; K. Beisser ; R. A. Beyer ; S. Bhaskaran ; R. P. Binzel ; E. Birath ; M. Bird ; D. J. Bogan ; A. Bowman ; V. J. Bray ; M. Brozovic ; C. Bryan ; M. R. Buckley ; M. W. Buie ; B. J. Buratti ; S. S. Bushman ; A. Calloway ; B. Carcich ; A. F. Cheng ; S. Conard ; C. A. Conrad ; J. C. Cook ; D. P. Cruikshank ; O. S. Custodio ; C. M. Dalle Ore ; C. Deboy ; Z. J. Dischner ; P. Dumont ; A. M. Earle ; H. A. Elliott ; J. Ercol ; C. M. Ernst ; T. Finley ; S. H. Flanigan ; G. Fountain ; M. J. Freeze ; T. Greathouse ; J. L. Green ; Y. Guo ; M. Hahn ; D. P. Hamilton ; S. A. Hamilton ; J. Hanley ; A. Harch ; H. M. Hart ; C. B. Hersman ; A. Hill ; M. E. Hill ; D. P. Hinson ; M. E. Holdridge ; M. Horanyi ; A. D. Howard ; C. J. Howett ; C. Jackman ; R. A. Jacobson ; D. E. Jennings ; J. A. Kammer ; H. K. Kang ; D. E. Kaufmann ; P. Kollmann ; S. M. Krimigis ; D. Kusnierkiewicz ; T. R. Lauer ; J. E. Lee ; K. L. Lindstrom ; I. R. Linscott ; C. M. Lisse ; A. W. Lunsford ; V. A. Mallder ; N. Martin ; D. J. McComas ; R. L. McNutt, Jr. ; D. Mehoke ; T. Mehoke ; E. D. Melin ; M. Mutchler ; D. Nelson ; F. Nimmo ; J. I. Nunez ; A. Ocampo ; W. M. Owen ; M. Paetzold ; B. Page ; A. H. Parker ; J. W. Parker ; F. Pelletier ; J. Peterson ; N. Pinkine ; M. Piquette ; S. B. Porter ; S. Protopapa ; J. Redfern ; H. J. Reitsema ; D. C. Reuter ; J. H. Roberts ; S. J. Robbins ; G. Rogers ; D. Rose ; K. Runyon ; K. D. Retherford ; M. G. Ryschkewitsch ; P. Schenk ; E. Schindhelm ; B. Sepan ; M. R. Showalter ; K. N. Singer ; M. Soluri ; D. Stanbridge ; A. J. Steffl ; D. F. Strobel ; T. Stryk ; M. E. Summers ; J. R. Szalay ; M. Tapley ; A. Taylor ; H. Taylor ; H. B. Throop ; C. C. Tsang ; G. L. Tyler ; O. M. Umurhan ; A. J. Verbiscer ; M. H. Versteeg ; M. Vincent ; R. Webbert ; S. Weidner ; G. E. Weigle, 2nd ; O. L. White ; K. Whittenburg ; B. G. Williams ; K. Williams ; S. Williams ; W. W. Woods ; A. M. Zangari ; E. Zirnstein
    American Association for the Advancement of Science (AAAS)
    Published 2015
    Staff View
    Publication Date:
    2015-10-17
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Staff View
    Publication Date:
    2016-03-19
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  4. 4
    S. M. Krimigis ; E. C. Roelof ; R. B. Decker ; M. E. Hill
    Nature Publishing Group (NPG)
    Published 2011
    Staff View
    Publication Date:
    2011-06-17
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  5. 5
    R. B. Decker ; S. M. Krimigis ; E. C. Roelof ; M. E. Hill
    Nature Publishing Group (NPG)
    Published 2012
    Staff View
    Publication Date:
    2012-09-08
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  6. 6
    Staff View
    Publication Date:
    2018-10-05
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Geosciences
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Geochemistry, Geophysics, Online Only, Planetary Science
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  7. 7
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] The outer limit of the Solar System is often considered to be at the distance from the Sun where the solar wind changes from supersonic to subsonic flow. Theory predicts that a termination shock marks this boundary, with locations ranging from a few to over 100 au ...
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  8. 8
    Staff View
    ISSN:
    1569-8041
    Keywords:
    biochemotherapy ; cytokines ; GM-CSF ; melanoma
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract Background:Ineffective tumour antigen processing is recognisedas an important cause of failure of immunotherapy in melanoma. GM-CSF mayaugment the cytotoxic lymphocyte response by activating antigen-presentingcells. This study evaluates a schedule combining GM-CSF with biochemotherapy. Patients and methods:Nineteen patients with advanced malignantmelanoma received cisplatin (25 mg/m2 days 1–3), dacarbazine(220 mg/m2 days 1–3), interleukin-2 (9 MIU/m2/24h)and interferon-α2b (5 MIU/m2) both days 6–10 and days17–21, and tamoxifen 40 mg/day continuously. Subcutaneous GM-CSF wasgiven in escalating doses to three cohorts: 1) 450 µg/m2 days4–5 and 15–16; 2) as 1) plus 225 µg/m2 days6–10 and 17–21; 3) 450 µg/m2 days 4–10 and15–21. Each cycle was 28 days. Results:Constitutional side effects were the majornon-haematological toxicity and lymphopaenia the main haematological toxicity.Six patients responded (32%, 95% confidence interval:13%–57%), two patients had complete remission. There wasan apparent trend for increasing responses with increasing GM-CSF dose; zeroof six responses in cohort 1, two of seven in cohort 2 and three of six incohort 3 (P = 0.016). Median overall survival was 6.2 months.Increasing GM-CSF doses significantly increased serum concentrations ofneopterin and TNF-α. Conclusions:The combination of GM-CSF with biochemotherapy isfeasible and there appears to be a dose-response relationship with GM-CSF interms of host immunological response, and possibly clinical efficacy.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  9. 9
    Staff View
    ISSN:
    1569-8041
    Keywords:
    chemotherapy ; head and neck cancer ; symptom control
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract Background: The role of chemotherapy in patients with recurrent squamouscell carcinomas of the head and neck (SCCHN) is unclear. The aim of this studywas to assess the ability of combination chemotherapy to control symptoms inthis setting. Patients and methods: Using a prospectively accrued database all patientsreferred for chemotherapy with symptomatic relapse following surgery wereidentified. Objective response was recorded using standard criteria andmaximum symptom response was assessed retrospectively from case notes usinga published scoring scale. Results: A total of 57 (median age 56, range 37–85) patients werestudied who had received mainly cisplatin/5-fluorouracil combinations.Thirty-seven had previously received radiotherapy. Fifty-two patients hadevaluable disease; 18 (35%) had objective responses (14 PRs and 4 CRs).There were a total of 103 symptoms recorded with eight different individualsymptoms. Forty-four (43%) symptoms improved on treatment, 52(50%) were unchanged and 7 (7%) worsened. The number of pateintswith improvement in the most frequently recorded symptoms were as follows:pain 11/28 (39%), swelling 12/23 (52%) and dysphagia 6/18(33%). Sixty-seven percent of patients with objective response also hadan improvement in their symptoms but a significant proportion (33%) ofnon-responders had a symptomatic response. Lack of objective response was notcorrelated with worsening symptoms. Grade 3/4 toxicity was uncommon(6%–17%) and there were no toxic deaths. A majority ofpatients (82%) experienced either no change or an improvement inperformance status. Conclusion: These results demonstrate that chemotherapy improves many ofthe symptoms associated with recurrent SCCHN, without deterioration inperformance status. Symptomatic improvement is more likely if there isevidence of significant tumour shrinkage, but even non-responding patients canbenefit.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses