Search Results - (Author, Cooperation:M. E. Hahn)
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1Latest Papers from Table of Contents or Articles in PressC. T. Amemiya ; J. Alfoldi ; A. P. Lee ; S. Fan ; H. Philippe ; I. Maccallum ; I. Braasch ; T. Manousaki ; I. Schneider ; N. Rohner ; C. Organ ; D. Chalopin ; J. J. Smith ; M. Robinson ; R. A. Dorrington ; M. Gerdol ; B. Aken ; M. A. Biscotti ; M. Barucca ; D. Baurain ; A. M. Berlin ; G. L. Blatch ; F. Buonocore ; T. Burmester ; M. S. Campbell ; A. Canapa ; J. P. Cannon ; A. Christoffels ; G. De Moro ; A. L. Edkins ; L. Fan ; A. M. Fausto ; N. Feiner ; M. Forconi ; J. Gamieldien ; S. Gnerre ; A. Gnirke ; J. V. Goldstone ; W. Haerty ; M. E. Hahn ; U. Hesse ; S. Hoffmann ; J. Johnson ; S. I. Karchner ; S. Kuraku ; M. Lara ; J. Z. Levin ; G. W. Litman ; E. Mauceli ; T. Miyake ; M. G. Mueller ; D. R. Nelson ; A. Nitsche ; E. Olmo ; T. Ota ; A. Pallavicini ; S. Panji ; B. Picone ; C. P. Ponting ; S. J. Prohaska ; D. Przybylski ; N. R. Saha ; V. Ravi ; F. J. Ribeiro ; T. Sauka-Spengler ; G. Scapigliati ; S. M. Searle ; T. Sharpe ; O. Simakov ; P. F. Stadler ; J. J. Stegeman ; K. Sumiyama ; D. Tabbaa ; H. Tafer ; J. Turner-Maier ; P. van Heusden ; S. White ; L. Williams ; M. Yandell ; H. Brinkmann ; J. N. Volff ; C. J. Tabin ; N. Shubin ; M. Schartl ; D. B. Jaffe ; J. H. Postlethwait ; B. Venkatesh ; F. Di Palma ; E. S. Lander ; A. Meyer ; K. Lindblad-Toh
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-04-20Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Animals, Genetically Modified ; *Biological Evolution ; Chick Embryo ; Conserved Sequence/genetics ; Enhancer Elements, Genetic/genetics ; Evolution, Molecular ; Extremities/anatomy & histology/growth & development ; Fishes/anatomy & histology/*classification/*genetics/physiology ; Genes, Homeobox/genetics ; Genome/*genetics ; Genomics ; Immunoglobulin M/genetics ; Mice ; Molecular Sequence Annotation ; Molecular Sequence Data ; Phylogeny ; Sequence Alignment ; Sequence Analysis, DNA ; Vertebrates/anatomy & histology/genetics/physiologyPublished by: -
2Latest Papers from Table of Contents or Articles in PressI. Wirgin ; N. K. Roy ; M. Loftus ; R. C. Chambers ; D. G. Franks ; M. E. Hahn
American Association for the Advancement of Science (AAAS)
Published 2011Staff ViewPublication Date: 2011-02-19Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Cell Line, Tumor ; DNA, Mitochondrial/genetics ; Drug Resistance ; Evolution, Molecular ; Gadiformes/*genetics/*metabolism ; Gene Expression ; Gene Frequency ; Genes, Reporter ; Haplotypes ; Ligands ; Mice ; Molecular Sequence Data ; New York ; Polychlorinated Biphenyls/metabolism/*toxicity ; Polymorphism, Genetic ; Polymorphism, Single Nucleotide ; Receptors, Aryl Hydrocarbon/chemistry/*genetics/*metabolism ; Rivers ; Selection, Genetic ; Sequence Deletion ; Tetrachlorodibenzodioxin/metabolism/*toxicity ; Water Pollutants, Chemical/metabolism/*toxicityPublished by: -
3Articles: DFG German National LicensesStaff View
ISSN: 1432-0703Source: Springer Online Journal Archives 1860-2000Topics: Energy, Environment Protection, Nuclear Power EngineeringMedicineNotes: Abstract. The present study describes the use of a fish hepatoma cell line (PLHC-1) in monitoring the biological effects of sediments collected from recipient waters of the oil shale industry. Sampling sites were located in River Purtse and River Kohtla in northeast Estonia. The effects of pure oil shale on the PLHC-1 cells were also studied. The cells were exposed to n-hexane–extracted samples in 48-well plates for 24 h, and 7-ethoxyresorufin O-deethylase (EROD) activity, total protein, and porphyrin content were measured in the exposed cells. Polycyclic aromatic hydrocarbon (PAH) contents in the samples were measured by high-performance liquid chromatography (HPLC). All the sediment and oil shale samples induced CYP1A activity and led to porphyrin accumulation in the cells. The most potent inducers were the sediments collected near the oil shale processing plants (site Lüganuse in River Purtse and Kohtla in River Kohtla), as well as those at the most downstream site in River Purtse (Purtse). These samples possessed high total PAH contents, ranging from 4,270 to nearly 150,000 μg/kg dry sediment. The presence of other lipophilic organic contaminants in the samples was not determined in this study. Both EROD activity and porphyrin content exhibited biphasic induction curves, and the ED50 1 values for EROD activity were lower than the ED50s for porphyrin content. 2,3,7,8-Tetrachlorodibenzo-p-dioxin induction equivalents (TCDD-EQs) calculated from EROD induction potencies correlated well with total PAHs (r 2 = 0.827 and p = 0.003 for log-transformed data) and also with individual PAHs. TCDD-EQs for porphyrin content did not correlate significantly with total PAHs (log-log r2 = 0.785, p = 0.116). The biological potency and PAH contamination of the samples showed the same rank order, except at Lüganuse, where sediment extracts induced CYP1A and porphyrins more than could have been expected based on PAH contents. Bioassay-derived induction EQs (normalized to dibenz(a,h)anthracene) were 20- to 3,200-fold greater than EQs calculated from the concentrations of five PAHs, suggesting important contributions from other compounds or nonadditive effects. The PLHC-1 cells proved to be a sensitive bioanalytical tool for sediments contaminated with PAH-type pollutants in the oil shale processing area. We suggest further use of this bioassay in screening and monitoring waters with similar background of pollution as in northeast Estonia.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 1573-3297Keywords: biometrical analysis ; cerebellar foliation ; diallel cross ; genetic analysis ; inbred mice ; incomplete penetranceSource: Springer Online Journal Archives 1860-2000Topics: BiologyPsychologyNotes: Abstract Four inbred strains of mice, DBA/2J, C57BL/10J, BALB/cJ, and SJL/J, were mated in a diallel cross. The cerebella of the F1 generation were examined for the presence (Type I) or absence (Type II) of an intraculminate fissure between vermian lobule IV and vermian lobule V (the ventral and dorsal lobules of the culmen). One strain (DBA/2J) consistently expressed the Type I pattern. Another strain (SJL/J) expressed predominantly the Type II pattern. The other two strains (C57BL/10J and BALB/cJ) and many of the hybrids exhibited variability in their expression of the foliation patterns. The results were analyzed using biometrical genetic procedures and showed significant additive and dominance genetic effects and a maternal effect. Correlations of these cerebellar anatomical variants with the development of behavior are discussed.Type of Medium: Electronic ResourceURL: