Search Results - (Author, Cooperation:M. Doherty)
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1Latest Papers from Table of Contents or Articles in PressC. H. Park ; S. Y. Lee ; D. S. Hwang ; D. W. Shin ; D. H. Cho ; K. H. Lee ; T. W. Kim ; M. Lee ; D. S. Kim ; C. M. Doherty ; A. W. Thornton ; A. J. Hill ; M. D. Guiver ; Y. M. Lee
Nature Publishing Group (NPG)
Published 2016Staff ViewPublication Date: 2016-04-29Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Biomimetic Materials/chemistry ; Biomimetics ; Cactaceae/metabolism ; Desiccation ; Dialysis ; Electrochemistry ; Humidity ; Hydrophobic and Hydrophilic Interactions ; *Membranes, Artificial ; *Nanotechnology ; Plant Stomata/metabolism ; Polymers/*chemistry ; Protons ; Surface Properties ; Temperature ; Water/*analysisPublished by: -
2Latest Papers from Table of Contents or Articles in PressA. Phillips ; A. Shroufi ; L. Vojnov ; J. Cohn ; T. Roberts ; T. Ellman ; K. Bonner ; C. Rousseau ; G. Garnett ; V. Cambiano ; F. Nakagawa ; D. Ford ; L. Bansi-Matharu ; A. Miners ; J. D. Lundgren ; J. W. Eaton ; R. Parkes-Ratanshi ; Z. Katz ; D. Maman ; N. Ford ; M. Vitoria ; M. Doherty ; D. Dowdy ; B. Nichols ; M. Murtagh ; M. Wareham ; K. M. Palamountain ; C. Chakanyuka Musanhu ; W. Stevens ; D. Katzenstein ; A. Ciaranello ; R. Barnabas ; R. S. Braithwaite ; E. Bendavid ; K. J. Nathoo ; D. van de Vijver ; D. P. Wilson ; C. Holmes ; A. Bershteyn ; S. Walker ; E. Raizes ; I. Jani ; L. J. Nelson ; R. Peeling ; F. Terris-Prestholt ; J. Murungu ; T. Mutasa-Apollo ; T. B. Hallett ; P. Revill
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-12-04Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adolescent ; Adult ; Africa ; Aged ; Anti-HIV Agents/economics/pharmacology/therapeutic use ; Cost-Benefit Analysis ; HIV Infections/diagnosis/*drug therapy/economics/*virology ; Humans ; Middle Aged ; Precision Medicine/economics/*methods ; *Viral Load/drug effects ; Young AdultPublished by: -
3Articles: DFG German National LicensesNon-invasive ventilation in the treatment of ventilatory failure following corrective spinal surgeryDoherty, M. J. ; Millner, P. A. ; Latham, M. ; Dickson, R. A. ; Elliott, M. W.
Oxford, UK : Blackwell Science Ltd
Published 2001Staff ViewISSN: 1365-2044Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Non-invasive positive pressure ventilation has previously been used successfully to treat both acute and chronic ventilatory failure secondary to a number of conditions, including scoliosis. We report two patients in whom it was used, on three separate occasions, to treat acute ventilatory failure following corrective spinal surgery. Non-invasive positive pressure ventilation may be useful postoperatively in high-risk patients undergoing major spinal surgery in an attempt to prevent intubation and its attendant complications.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 1600-0838Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineSports ScienceNotes: The purpose of this study was to use the meta-analytic approach to examine the effects of caffeine ingestion on ratings of perceived exertion (RPE). Twenty-one studies with 109 effect sizes (ESs) met the inclusion criteria. Coding incorporated RPE scores obtained both during constant load exercise (n=89) and upon termination of exhausting exercise (n=20). In addition, when reported, the exercise performance ES was also computed (n=16). In comparison to placebo, caffeine reduced RPE during exercise by 5.6% (95% CI (confidence interval), −4.5% to −6.7%), with an equivalent RPE ES of −0.47 (95% CI, −0.35 to −0.59). These values were significantly greater (P〈0.05) than RPE obtained at the end of exercise (RPE % change, 0.01%; 95% CI, −1.9 to 2.0%; RPE ES, 0.00, 95% CI, −0.17 to 0.17). In addition, caffeine improved exercise performance by 11.2% (95% CI; 4.6–17.8%). Regression analysis revealed that RPE obtained during exercise could account for ∼29% of the variance in the improvement in exercise performance. The results demonstrate that caffeine reduces RPE during exercise and this may partly explain the subsequent ergogenic effects of caffeine on performance.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 1094-348XSource: Blackwell Publishing Journal Backfiles 1879-2005Topics: English, American StudiesType of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesRussell-Jones, R. ; Healy, C. ; Calonje, E. ; Doherty, M. ; Acland, K.
Oxford, UK : Blackwell Science Ltd
Published 2002Staff ViewISSN: 1365-2133Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] The temperature-sensitive Escherichia coli mutant, N4316, is one of this class. At 36 C, in vivo, N4316 suppresses the termination codons UAA and UGA, but not UAG (ref. 3). At 30 C the mutant does not suppress3. This observation implied a temperature-dependent lesion in termination, and a moderate ...Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesSong, W. ; Huss, R. S. ; Malone, M. F. ; Doherty, M. F.
[s.l.] : Macmillan Magazines Ltd.
Published 1997Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Mixtures are azeotropic if they can be distilled (or condensed) without a change of composition. The existence of azeotropes in multicomponent mixtures in the absence of chemical reactions is well understood phenomenologically, and theoretically,. Azeotropes place a fundamental limit on the ...Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 0007-0955Topics: LawURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 0378-4347Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 0272-7358Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PsychologyType of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1437-160XKeywords: Crystals ; Inflammation ; Urate ; Pyrophosphate ; HydroxyapatiteSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary The inflammatory response to intradermal injections of urate, pyrophosphate and hydroxyapatite crystals in human forearm skin is described. Patients with rheumatoid arthritis responded normally to urate crystals, and patients with osteoarthritis or pyrophosphate arthropathy responded normally to hydroxyapatite and pyrophosphate crystals respectively. These results suggest that variation in host response to crystals cannot explain the different patterns of crystal-induced disease seen in man. The model, however, is recommended as a safe, simple ethical and reproducible test of inflammation in human subjects.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 0040-5639Topics: Theology and Religious StudiesNotes: BOOK REVIEWSURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 0040-5639Topics: Theology and Religious StudiesNotes: BOOK REVIEWSURL: -
15Articles: DFG German National LicensesKing, D. J. ; Blomqvist, M. ; Cooper, S. J. ; Doherty, M. M. ; Mitchell, M. J. ; Montgomery, R. C.
Springer
Published 1992Staff ViewISSN: 1432-2072Keywords: Remoxipride ; Neuroleptics ; Placebo controlled trial ; Chronic schizophrenia ; Relapse rates ; Relapse preventionSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Sixty-two DSM III chronic schizophrenic inpatients were selected for a double-blind, placebo controlled, multi-centre, relapse prevention study of remoxipride, a selective dopamine (D2)-receptor antagonist. After a 1 month placebo washout, 23 patients had relapsed and were withdrawn. Of the remaining patients 19 were randomised to remoxipride (150–300 mg daily) and 20 to placebo. Their median age was 58 years, 26 were male, and the median duration of illness was 33 years. After 24 weeks a further total of 8 remoxipride and 17 placebo patients had been withdrawn. Excluding three patients withdrawn for reasons other than relapse, the comparative relapse rates were 37% and 75%, respectively (P=0.015). Efficacy analyses using clinical global impression (P=0.04) and change in BPRS scores (P=0.016) were in favour of remoxipride. Extrapyramidal symptoms were minimal in both groups. Treatment emergent adverse events were similar in the two groups. Remoxipride is therefore of potential value as a safe drug which is both effective and well tolerated in the long term management of chronic schizophrenic patients.Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 0001-1541Keywords: Chemistry ; Chemical EngineeringSource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyProcess Engineering, Biotechnology, Nutrition TechnologyNotes: The product compositions in single-feed distillation columns can be specified only in certain regions of the composition space, which depend only on the pressure, feed, and vapor-liquid equilibrium for the mixture. In nonideal mixtures, even without azeotropes, the regions may allow unusual product distributions. For example, the distillate in a “direct split” is composed primarily of the lightest component. Intuition and experience with relatively ideal mixtures suggest that the next most plentiful component is the intermediate boiler. In nonideal mixtures, however, with or without azeotropes, the next most plentiful component may be the highestboiling species with only trace amounts of the intermediate boiler. For azeotropic mixtures, distillation boundaries may give rise to additional restrictions on the product compositions. We describe how simple distillation boundaries deform into continuous distillation boundaries and, in a limited number of cases, how the simple distillation boundaries can be crossed in continuous columns for certain ranges of the design variables. Unfortunately, such designs may be quite sensitive to model uncertainties or to disturbances in the parameters.Additional Material: 24 Ill.Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 0001-1541Keywords: Chemistry ; Chemical EngineeringSource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyProcess Engineering, Biotechnology, Nutrition TechnologyNotes: A method for the design of distillation systems for nonideal multicomponent mixtures is described, offering an alternative to extensive performance simulations. The basis is an analysis of the pinches or “fixed points” in the model equations and the results are widely applicable because approximations such as constant volatilities and ideal solutions are unnecessary. Tangent pinches are represented naturally as turning points in the diagram of pinch composition vs. reflux ratio, giving a basis for designs that alleviate the effects of tangent pinches in certain nonideal mixtures. An efficient computational approach for design is demonstrated in examples for homogeneous liquid mixtures, containing as many as four components, with and without azeotropic behavior. The results are in excellent agreement with detailed performance simulations.Additional Material: 25 Ill.Type of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 0001-1541Keywords: Chemistry ; Chemical EngineeringSource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyProcess Engineering, Biotechnology, Nutrition TechnologyNotes: An order-of-magnitude analysis that evaluates the significant economic trade-offs for the process design optimization problem allows rapid screening of flowsheet alternatives. The optimization problem is simplified by eliminating all but the most important design variables and by including only the dominant cost functions for each trade-off. Quantitative parameters are defined which allow a straightforward selection of these elements and identify the incentive for optimization. A new optimization criterion helps to prevent the rigor of the optimization analysis from exceeding the accuracy of the design and economic models used.Additional Material: 5 Ill.Type of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesSteppan, D. D. ; Doherty, M. F. ; Malone, M. F.
New York, NY [u.a.] : Wiley-Blackwell
Published 1990Staff ViewISSN: 0021-8995Keywords: Chemistry ; Polymer and Materials ScienceSource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyMechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsPhysicsNotes: An unsteady reaction-diffusion model has been developed to represent the polymerization of a nylon 6,6 prepolymer in a stationary film. A realistic kinetic and equilibrium description is incorporated by the use of apparent rate and equilibrium constants that are composition dependent. The model is suitable for evaluating the effect(s) of changes in throughput (film thickness), temperature, and catalyst activity on the performance of an idealized film reactor. The model is characterized by a single dimensionless parameter, the Thiele modulus. The composition-dependent kinetic constants are important for accurate prediction of molecular weight evolution in the film. Below a threshold value of the Thiele modulus, molecular weight generation is reaction-controlled, while above another threshold value it is diffusion-controlled.Additional Material: 12 Ill.Type of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesSteppan, D. D. ; Doherty, M. F. ; Malone, M. F.
New York, NY [u.a.] : Wiley-Blackwell
Published 1991Staff ViewISSN: 0021-8995Keywords: Chemistry ; Polymer and Materials ScienceSource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyMechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsPhysicsNotes: A simplified reaction scheme for nylon 6,6 degradation that is consistent with all the published data is described. The degradation model has been incorporated into a flowing film polymerizer model with a distribution of residence times in order to predict molecular weight, amount of undegraded (amine and carboxyl) and degraded chain ends, and the extent of crosslinking. The outlet average molecular weight and water concentration come to steady state in about one mean residence time after a change in polymerizer operating conditions, whereas the degradation products continue to change slowly even after four residence times. Also, it is possible to choose the operating conditions of the polymerizer so the same molecular weight is produced at two different temperatures but with very different amounts of degradation products giving rise to products of significantly different quality.Additional Material: 13 Ill.Type of Medium: Electronic ResourceURL: