ILSE | Search Results - (Author, Cooperation:M. D. Taylor)

1

Epigenomic alterations define lethal CIMP-positive ependymomas of infancy

S. C. Mack ; H. Witt ; R. M. Piro ; L. Gu ; S. Zuyderduyn ; A. M. Stutz ; X. Wang ; M. Gallo ; L. Garzia ; K. Zayne ; X. Zhang ; V. Ramaswamy ; N. Jager ; D. T. Jones ; M. Sill ; T. J. Pugh ; M. Ryzhova ; K. M. Wani ; D. J. Shih ; R. Head ; M. Remke ; S. D. Bailey ; T. Zichner ; C. C. Faria ; M. Barszczyk ; S. Stark ; H. Seker-Cin ; S. Hutter ; P. Johann ; S. Bender ; V. Hovestadt ; T. Tzaridis ; A. M. Dubuc ; P. A. Northcott ; J. Peacock ; K. C. Bertrand ; S. Agnihotri ; F. M. Cavalli ; I. Clarke ; K. Nethery-Brokx ; C. L. Creasy ; S. K. Verma ; J. Koster ; X. Wu ; Y. Yao ; T. Milde ; P. Sin-Chan ; J. Zuccaro ; L. Lau ; S. Pereira ; P. Castelo-Branco ; M. Hirst ; M. A. Marra ; S. S. Roberts ; D. Fults ; L. Massimi ; Y. J. Cho ; T. Van Meter ; W. Grajkowska ; B. Lach ; A. E. Kulozik ; A. von Deimling ; O. Witt ; S. W. Scherer ; X. Fan ; K. M. Muraszko ; M. Kool ; S. L. Pomeroy ; N. Gupta ; J. Phillips ; A. Huang ; U. Tabori ; C. Hawkins ; D. Malkin ; P. N. Kongkham ; W. A. Weiss ; N. Jabado ; J. T. Rutka ; E. Bouffet ; J. O. Korbel ; M. Lupien ; K. D. Aldape ; G. D. Bader ; R. Eils ; P. Lichter ; P. B. Dirks ; S. M. Pfister ; A. Korshunov ; M. D. Taylor
Nature Publishing Group (NPG)
Published 2014

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Publication Date:	2014-02-21
Publisher:	Nature Publishing Group (NPG)
Print ISSN:	0028-0836
Electronic ISSN:	1476-4687
Topics:	Biology Chemistry and Pharmacology Medicine Natural Sciences in General Physics
Keywords:	Animals ; Brain Neoplasms/drug therapy/genetics ; CpG Islands/genetics ; DNA Methylation/drug effects ; Embryonic Stem Cells/metabolism ; Ependymoma/drug therapy/genetics ; Epigenesis, Genetic/*genetics ; Epigenomics ; Female ; Gene Expression Regulation, Neoplastic ; Gene Silencing/drug effects ; Histones/drug effects/metabolism ; Humans ; Infant ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Mutation/genetics ; Phenotype ; Polycomb Repressive Complex 2/metabolism ; Prognosis ; Rhombencephalon/pathology ; Xenograft Model Antitumor Assays
Published by:	http://www.nature.com/

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2

Clonal selection drives genetic divergence of metastatic medulloblastoma

X. Wu ; P. A. Northcott ; A. Dubuc ; A. J. Dupuy ; D. J. Shih ; H. Witt ; S. Croul ; E. Bouffet ; D. W. Fults ; C. G. Eberhart ; L. Garzia ; T. Van Meter ; D. Zagzag ; N. Jabado ; J. Schwartzentruber ; J. Majewski ; T. E. Scheetz ; S. M. Pfister ; A. Korshunov ; X. N. Li ; S. W. Scherer ; Y. J. Cho ; K. Akagi ; T. J. MacDonald ; J. Koster ; M. G. McCabe ; A. L. Sarver ; V. P. Collins ; W. A. Weiss ; D. A. Largaespada ; L. S. Collier ; M. D. Taylor
Nature Publishing Group (NPG)
Published 2012

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Publication Date:	2012-02-22
Publisher:	Nature Publishing Group (NPG)
Print ISSN:	0028-0836
Electronic ISSN:	1476-4687
Topics:	Biology Chemistry and Pharmacology Medicine Natural Sciences in General Physics
Keywords:	Animals ; Clonal Evolution/genetics ; CpG Islands/genetics ; DNA Methylation ; DNA Transposable Elements/genetics ; Disease Models, Animal ; Genes, p53/genetics ; Germ-Line Mutation/genetics ; Humans ; Li-Fraumeni Syndrome/complications/genetics ; Medulloblastoma/complications/genetics/pathology ; Mice ; Mutagenesis, Insertional ; Neoplasm Metastasis/genetics/*pathology ; Survival Rate
Published by:	http://www.nature.com/

Latest Papers from Table of Contents or Articles in Press

3

Subgroup-specific structural variation across 1,000 medulloblastoma genomes

P. A. Northcott ; D. J. Shih ; J. Peacock ; L. Garzia ; A. S. Morrissy ; T. Zichner ; A. M. Stutz ; A. Korshunov ; J. Reimand ; S. E. Schumacher ; R. Beroukhim ; D. W. Ellison ; C. R. Marshall ; A. C. Lionel ; S. Mack ; A. Dubuc ; Y. Yao ; V. Ramaswamy ; B. Luu ; A. Rolider ; F. M. Cavalli ; X. Wang ; M. Remke ; X. Wu ; R. Y. Chiu ; A. Chu ; E. Chuah ; R. D. Corbett ; G. R. Hoad ; S. D. Jackman ; Y. Li ; A. Lo ; K. L. Mungall ; K. M. Nip ; J. Q. Qian ; A. G. Raymond ; N. T. Thiessen ; R. J. Varhol ; I. Birol ; R. A. Moore ; A. J. Mungall ; R. Holt ; D. Kawauchi ; M. F. Roussel ; M. Kool ; D. T. Jones ; H. Witt ; L. A. Fernandez ; A. M. Kenney ; R. J. Wechsler-Reya ; P. Dirks ; T. Aviv ; W. A. Grajkowska ; M. Perek-Polnik ; C. C. Haberler ; O. Delattre ; S. S. Reynaud ; F. F. Doz ; S. S. Pernet-Fattet ; B. K. Cho ; S. K. Kim ; K. C. Wang ; W. Scheurlen ; C. G. Eberhart ; M. Fevre-Montange ; A. Jouvet ; I. F. Pollack ; X. Fan ; K. M. Muraszko ; G. Y. Gillespie ; C. Di Rocco ; L. Massimi ; E. M. Michiels ; N. K. Kloosterhof ; P. J. French ; J. M. Kros ; J. M. Olson ; R. G. Ellenbogen ; K. Zitterbart ; L. Kren ; R. C. Thompson ; M. K. Cooper ; B. Lach ; R. E. McLendon ; D. D. Bigner ; A. Fontebasso ; S. Albrecht ; N. Jabado ; J. C. Lindsey ; S. Bailey ; N. Gupta ; W. A. Weiss ; L. Bognar ; A. Klekner ; T. E. Van Meter ; T. Kumabe ; T. Tominaga ; S. K. Elbabaa ; J. R. Leonard ; J. B. Rubin ; L. M. Liau ; E. G. Van Meir ; M. Fouladi ; H. Nakamura ; G. Cinalli ; M. Garami ; P. Hauser ; A. G. Saad ; A. Iolascon ; S. Jung ; C. G. Carlotti ; R. Vibhakar ; Y. S. Ra ; S. Robinson ; M. Zollo ; C. C. Faria ; J. A. Chan ; M. L. Levy ; P. H. Sorensen ; M. Meyerson ; S. L. Pomeroy ; Y. J. Cho ; G. D. Bader ; U. Tabori ; C. E. Hawkins ; E. Bouffet ; S. W. Scherer ; J. T. Rutka ; D. Malkin ; S. C. Clifford ; S. J. Jones ; J. O. Korbel ; S. M. Pfister ; M. A. Marra ; M. D. Taylor
Nature Publishing Group (NPG)
Published 2012

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Publication Date:	2012-07-27
Publisher:	Nature Publishing Group (NPG)
Print ISSN:	0028-0836
Electronic ISSN:	1476-4687
Topics:	Biology Chemistry and Pharmacology Medicine Natural Sciences in General Physics
Keywords:	Carrier Proteins/genetics ; Cerebellar Neoplasms/classification/genetics/metabolism ; Child ; DNA Copy Number Variations/genetics ; Gene Duplication/genetics ; Genes, myc/genetics ; Genome, Human/genetics ; Genomic Structural Variation/genetics ; Genomics ; Hedgehog Proteins/metabolism ; Humans ; Medulloblastoma/classification/genetics/metabolism ; NF-kappa B/metabolism ; Nerve Tissue Proteins/genetics ; Oncogene Proteins, Fusion/genetics ; Proteins/genetics ; RNA, Long Noncoding ; Signal Transduction ; Transforming Growth Factor beta/metabolism ; Translocation, Genetic/genetics
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4

Dissecting the genomic complexity underlying medulloblastoma

D. T. Jones ; N. Jager ; M. Kool ; T. Zichner ; B. Hutter ; M. Sultan ; Y. J. Cho ; T. J. Pugh ; V. Hovestadt ; A. M. Stutz ; T. Rausch ; H. J. Warnatz ; M. Ryzhova ; S. Bender ; D. Sturm ; S. Pleier ; H. Cin ; E. Pfaff ; L. Sieber ; A. Wittmann ; M. Remke ; H. Witt ; S. Hutter ; T. Tzaridis ; J. Weischenfeldt ; B. Raeder ; M. Avci ; V. Amstislavskiy ; M. Zapatka ; U. D. Weber ; Q. Wang ; B. Lasitschka ; C. C. Bartholomae ; M. Schmidt ; C. von Kalle ; V. Ast ; C. Lawerenz ; J. Eils ; R. Kabbe ; V. Benes ; P. van Sluis ; J. Koster ; R. Volckmann ; D. Shih ; M. J. Betts ; R. B. Russell ; S. Coco ; G. P. Tonini ; U. Schuller ; V. Hans ; N. Graf ; Y. J. Kim ; C. Monoranu ; W. Roggendorf ; A. Unterberg ; C. Herold-Mende ; T. Milde ; A. E. Kulozik ; A. von Deimling ; O. Witt ; E. Maass ; J. Rossler ; M. Ebinger ; M. U. Schuhmann ; M. C. Fruhwald ; M. Hasselblatt ; N. Jabado ; S. Rutkowski ; A. O. von Bueren ; D. Williamson ; S. C. Clifford ; M. G. McCabe ; V. P. Collins ; S. Wolf ; S. Wiemann ; H. Lehrach ; B. Brors ; W. Scheurlen ; J. Felsberg ; G. Reifenberger ; P. A. Northcott ; M. D. Taylor ; M. Meyerson ; S. L. Pomeroy ; M. L. Yaspo ; J. O. Korbel ; A. Korshunov ; R. Eils ; S. M. Pfister ; P. Lichter
Nature Publishing Group (NPG)
Published 2012

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Publication Date:	2012-07-27
Publisher:	Nature Publishing Group (NPG)
Print ISSN:	0028-0836
Electronic ISSN:	1476-4687
Topics:	Biology Chemistry and Pharmacology Medicine Natural Sciences in General Physics
Keywords:	Aging/genetics ; Amino Acid Sequence ; Cell Transformation, Neoplastic ; Cerebellar Neoplasms/classification/diagnosis/genetics/pathology ; Child ; Chromatin/metabolism ; Chromosomes, Human/genetics ; DEAD-box RNA Helicases/genetics ; DNA Helicases/genetics ; DNA-Binding Proteins/genetics ; Genome, Human/genetics ; Genomics ; Hedgehog Proteins/metabolism ; High-Throughput Nucleotide Sequencing ; Histone Demethylases/genetics ; Humans ; Medulloblastoma/classification/diagnosis/*genetics/pathology ; Methylation ; Mutation/genetics ; Mutation Rate ; Neoplasm Proteins/genetics ; Nuclear Proteins/genetics ; Oncogene Proteins, Fusion/genetics ; Phosphoprotein Phosphatases/genetics ; Polyploidy ; Receptors, Cell Surface/genetics ; Sequence Analysis, RNA ; Signal Transduction ; T-Box Domain Proteins/genetics ; Transcription Factors/genetics ; Wnt Proteins/metabolism ; beta Catenin/genetics
Published by:	http://www.nature.com/

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5

The genetic landscape of the childhood cancer medulloblastoma

D. W. Parsons ; M. Li ; X. Zhang ; S. Jones ; R. J. Leary ; J. C. Lin ; S. M. Boca ; H. Carter ; J. Samayoa ; C. Bettegowda ; G. L. Gallia ; G. I. Jallo ; Z. A. Binder ; Y. Nikolsky ; J. Hartigan ; D. R. Smith ; D. S. Gerhard ; D. W. Fults ; S. VandenBerg ; M. S. Berger ; S. K. Marie ; S. M. Shinjo ; C. Clara ; P. C. Phillips ; J. E. Minturn ; J. A. Biegel ; A. R. Judkins ; A. C. Resnick ; P. B. Storm ; T. Curran ; Y. He ; B. A. Rasheed ; H. S. Friedman ; S. T. Keir ; R. McLendon ; P. A. Northcott ; M. D. Taylor ; P. C. Burger ; G. J. Riggins ; R. Karchin ; G. Parmigiani ; D. D. Bigner ; H. Yan ; N. Papadopoulos ; B. Vogelstein ; K. W. Kinzler ; V. E. Velculescu
American Association for the Advancement of Science (AAAS)
Published 2010

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Publication Date:	2010-12-18
Publisher:	American Association for the Advancement of Science (AAAS)
Print ISSN:	0036-8075
Electronic ISSN:	1095-9203
Topics:	Biology Chemistry and Pharmacology Computer Science Medicine Natural Sciences in General Physics
Keywords:	Adult ; Cerebellar Neoplasms/genetics/metabolism ; Child ; DNA Copy Number Variations ; DNA-Binding Proteins/genetics/metabolism ; Genes, Neoplasm ; Genes, Tumor Suppressor ; Histone-Lysine N-Methyltransferase/genetics/metabolism ; Histones/metabolism ; Humans ; Medulloblastoma/genetics/metabolism ; Methylation ; MicroRNAs/genetics ; Mutation ; Neoplasm Proteins/genetics/metabolism ; Oligonucleotide Array Sequence Analysis ; Point Mutation ; Sequence Analysis, DNA ; Signal Transduction
Published by:	http://www.aaas.org/

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6

Decoding the regulatory landscape of medulloblastoma using DNA methylation sequencing

V. Hovestadt ; D. T. Jones ; S. Picelli ; W. Wang ; M. Kool ; P. A. Northcott ; M. Sultan ; K. Stachurski ; M. Ryzhova ; H. J. Warnatz ; M. Ralser ; S. Brun ; J. Bunt ; N. Jager ; K. Kleinheinz ; S. Erkek ; U. D. Weber ; C. C. Bartholomae ; C. von Kalle ; C. Lawerenz ; J. Eils ; J. Koster ; R. Versteeg ; T. Milde ; O. Witt ; S. Schmidt ; S. Wolf ; T. Pietsch ; S. Rutkowski ; W. Scheurlen ; M. D. Taylor ; B. Brors ; J. Felsberg ; G. Reifenberger ; A. Borkhardt ; H. Lehrach ; R. J. Wechsler-Reya ; R. Eils ; M. L. Yaspo ; P. Landgraf ; A. Korshunov ; M. Zapatka ; B. Radlwimmer ; S. M. Pfister ; P. Lichter
Nature Publishing Group (NPG)
Published 2014

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Publication Date:	2014-05-23
Publisher:	Nature Publishing Group (NPG)
Print ISSN:	0028-0836
Electronic ISSN:	1476-4687
Topics:	Biology Chemistry and Pharmacology Medicine Natural Sciences in General Physics
Keywords:	Animals ; Binding Sites ; Cell Line, Tumor ; Chromatin/genetics/metabolism ; Chromatin Immunoprecipitation ; DNA Methylation/genetics ; Female ; Gene Expression Regulation, Neoplastic ; Gene Silencing ; Genome/genetics ; Histones/metabolism ; Humans ; Medulloblastoma/genetics/pathology ; Mice ; Promoter Regions, Genetic/genetics ; RNA-Binding Proteins/genetics ; Sequence Analysis, DNA/*methods ; Transcription Factors/metabolism ; Transcription, Genetic
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Latest Papers from Table of Contents or Articles in Press

7

Divergent clonal selection dominates medulloblastoma at recurrence

A. S. Morrissy ; L. Garzia ; D. J. Shih ; S. Zuyderduyn ; X. Huang ; P. Skowron ; M. Remke ; F. M. Cavalli ; V. Ramaswamy ; P. E. Lindsay ; S. Jelveh ; L. K. Donovan ; X. Wang ; B. Luu ; K. Zayne ; Y. Li ; C. Mayoh ; N. Thiessen ; E. Mercier ; K. L. Mungall ; Y. Ma ; K. Tse ; T. Zeng ; K. Shumansky ; A. J. Roth ; S. Shah ; H. Farooq ; N. Kijima ; B. L. Holgado ; J. J. Lee ; S. Matan-Lithwick ; J. Liu ; S. C. Mack ; A. Manno ; K. A. Michealraj ; C. Nor ; J. Peacock ; L. Qin ; J. Reimand ; A. Rolider ; Y. Y. Thompson ; X. Wu ; T. Pugh ; A. Ally ; M. Bilenky ; Y. S. Butterfield ; R. Carlsen ; Y. Cheng ; E. Chuah ; R. D. Corbett ; N. Dhalla ; A. He ; D. Lee ; H. I. Li ; W. Long ; M. Mayo ; P. Plettner ; J. Q. Qian ; J. E. Schein ; A. Tam ; T. Wong ; I. Birol ; Y. Zhao ; C. C. Faria ; J. Pimentel ; S. Nunes ; T. Shalaby ; M. Grotzer ; I. F. Pollack ; R. L. Hamilton ; X. N. Li ; A. E. Bendel ; D. W. Fults ; A. W. Walter ; T. Kumabe ; T. Tominaga ; V. P. Collins ; Y. J. Cho ; C. Hoffman ; D. Lyden ; J. H. Wisoff ; J. H. Garvin, Jr. ; D. S. Stearns ; L. Massimi ; U. Schuller ; J. Sterba ; K. Zitterbart ; S. Puget ; O. Ayrault ; S. E. Dunn ; D. P. Tirapelli ; C. G. Carlotti ; H. Wheeler ; A. R. Hallahan ; W. Ingram ; T. J. MacDonald ; J. J. Olson ; E. G. Van Meir ; J. Y. Lee ; K. C. Wang ; S. K. Kim ; B. K. Cho ; T. Pietsch ; G. Fleischhack ; S. Tippelt ; Y. S. Ra ; S. Bailey ; J. C. Lindsey ; S. C. Clifford ; C. G. Eberhart ; M. K. Cooper ; R. J. Packer ; M. Massimino ; M. L. Garre ; U. Bartels ; U. Tabori ; C. E. Hawkins ; P. Dirks ; E. Bouffet ; J. T. Rutka ; R. J. Wechsler-Reya ; W. A. Weiss ; L. S. Collier ; A. J. Dupuy ; A. Korshunov ; D. T. Jones ; M. Kool ; P. A. Northcott ; S. M. Pfister ; D. A. Largaespada ; A. J. Mungall ; R. A. Moore ; N. Jabado ; G. D. Bader ; S. J. Jones ; D. Malkin ; M. A. Marra ; M. D. Taylor
Nature Publishing Group (NPG)
Published 2016

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Publication Date:	2016-01-14
Publisher:	Nature Publishing Group (NPG)
Print ISSN:	0028-0836
Electronic ISSN:	1476-4687
Topics:	Biology Chemistry and Pharmacology Medicine Natural Sciences in General Physics
Published by:	http://www.nature.com/

Latest Papers from Table of Contents or Articles in Press

8

Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma

P. A. Northcott ; C. Lee ; T. Zichner ; A. M. Stutz ; S. Erkek ; D. Kawauchi ; D. J. Shih ; V. Hovestadt ; M. Zapatka ; D. Sturm ; D. T. Jones ; M. Kool ; M. Remke ; F. M. Cavalli ; S. Zuyderduyn ; G. D. Bader ; S. VandenBerg ; L. A. Esparza ; M. Ryzhova ; W. Wang ; A. Wittmann ; S. Stark ; L. Sieber ; H. Seker-Cin ; L. Linke ; F. Kratochwil ; N. Jager ; I. Buchhalter ; C. D. Imbusch ; G. Zipprich ; B. Raeder ; S. Schmidt ; N. Diessl ; S. Wolf ; S. Wiemann ; B. Brors ; C. Lawerenz ; J. Eils ; H. J. Warnatz ; T. Risch ; M. L. Yaspo ; U. D. Weber ; C. C. Bartholomae ; C. von Kalle ; E. Turanyi ; P. Hauser ; E. Sanden ; A. Darabi ; P. Siesjo ; J. Sterba ; K. Zitterbart ; D. Sumerauer ; P. van Sluis ; R. Versteeg ; R. Volckmann ; J. Koster ; M. U. Schuhmann ; M. Ebinger ; H. L. Grimes ; G. W. Robinson ; A. Gajjar ; M. Mynarek ; K. von Hoff ; S. Rutkowski ; T. Pietsch ; W. Scheurlen ; J. Felsberg ; G. Reifenberger ; A. E. Kulozik ; A. von Deimling ; O. Witt ; R. Eils ; R. J. Gilbertson ; A. Korshunov ; M. D. Taylor ; P. Lichter ; J. O. Korbel ; R. J. Wechsler-Reya ; S. M. Pfister
Nature Publishing Group (NPG)
Published 2014

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Publication Date:	2014-07-22
Publisher:	Nature Publishing Group (NPG)
Print ISSN:	0028-0836
Electronic ISSN:	1476-4687
Topics:	Biology Chemistry and Pharmacology Medicine Natural Sciences in General Physics
Keywords:	Animals ; Child ; Chromosomes, Human, Pair 9/genetics ; DNA-Binding Proteins/genetics/metabolism ; Enhancer Elements, Genetic/genetics ; Genomic Structural Variation/genetics ; Humans ; Medulloblastoma/classification/genetics/pathology ; Mice ; Oncogenes/genetics ; Proto-Oncogene Proteins/genetics/metabolism ; Repressor Proteins/genetics/metabolism ; Transcription Factors/genetics/metabolism
Published by:	http://www.nature.com/

Latest Papers from Table of Contents or Articles in Press

9

Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations

T. J. Pugh ; S. D. Weeraratne ; T. C. Archer ; D. A. Pomeranz Krummel ; D. Auclair ; J. Bochicchio ; M. O. Carneiro ; S. L. Carter ; K. Cibulskis ; R. L. Erlich ; H. Greulich ; M. S. Lawrence ; N. J. Lennon ; A. McKenna ; J. Meldrim ; A. H. Ramos ; M. G. Ross ; C. Russ ; E. Shefler ; A. Sivachenko ; B. Sogoloff ; P. Stojanov ; P. Tamayo ; J. P. Mesirov ; V. Amani ; N. Teider ; S. Sengupta ; J. P. Francois ; P. A. Northcott ; M. D. Taylor ; F. Yu ; G. R. Crabtree ; A. G. Kautzman ; S. B. Gabriel ; G. Getz ; N. Jager ; D. T. Jones ; P. Lichter ; S. M. Pfister ; T. M. Roberts ; M. Meyerson ; S. L. Pomeroy ; Y. J. Cho
Nature Publishing Group (NPG)
Published 2012

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Publication Date:	2012-07-24
Publisher:	Nature Publishing Group (NPG)
Print ISSN:	0028-0836
Electronic ISSN:	1476-4687
Topics:	Biology Chemistry and Pharmacology Medicine Natural Sciences in General Physics
Keywords:	Cerebellar Neoplasms/classification/genetics ; Child ; DEAD-box RNA Helicases/chemistry/genetics/metabolism ; DNA Helicases/chemistry/genetics ; DNA-Binding Proteins/genetics ; Exome/genetics ; Genome, Human/genetics ; Hedgehog Proteins/metabolism ; Histone-Lysine N-Methyltransferase/genetics/metabolism ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; LIM Domain Proteins/genetics ; Medulloblastoma/classification/genetics ; Models, Molecular ; Mutation/*genetics ; Neoplasm Proteins/genetics ; Nuclear Proteins/chemistry/genetics ; Promoter Regions, Genetic/genetics ; Protein Structure, Tertiary/genetics ; Proto-Oncogene Proteins/genetics ; Receptors, Cell Surface/genetics ; Repressor Proteins/genetics ; Signal Transduction ; TCF Transcription Factors/metabolism ; Transcription Factors/chemistry/genetics ; Tumor Suppressor Protein p53/genetics ; Wnt Proteins/metabolism ; beta Catenin/genetics/metabolism
Published by:	http://www.nature.com/

Latest Papers from Table of Contents or Articles in Press

10

Multiplexed protein-DNA cross-linking: Scrunching in transcription start site selection

J. T. Winkelman ; I. O. Vvedenskaya ; Y. Zhang ; J. G. Bird ; D. M. Taylor ; R. L. Gourse ; R. H. Ebright ; B. E. Nickels
American Association for the Advancement of Science (AAAS)
Published 2016

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Publication Date:	2016-03-05
Publisher:	American Association for the Advancement of Science (AAAS)
Print ISSN:	0036-8075
Electronic ISSN:	1095-9203
Topics:	Biology Chemistry and Pharmacology Computer Science Medicine Natural Sciences in General Physics
Published by:	http://www.aaas.org/

Latest Papers from Table of Contents or Articles in Press

11

A Novel Method for Rapid Molecular Subgrouping of Medulloblastoma

Gomez, S., Garrido-Garcia, A., Garcia-Gerique, L., Lemos, I., Sunol, M., de Torres, C., Kulis, M., Perez-Jaume, S., Carcaboso, A. M., Luu, B., Kieran, M. W., Jabado, N., Kozlenkov, A., Dracheva, S., Ramaswamy, V., Hovestadt, V., Johann, P., Jones, D. T. W., Pfister, S. M., Morales La Madrid, A., Cruz, O., Taylor, M. D., Martin-Subero, J.-I., Mora, J., Lavarino, C.
The American Association for Cancer Research (AACR)
Published 2018

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Publication Date:	2018-03-16
Publisher:	The American Association for Cancer Research (AACR)
Print ISSN:	1078-0432
Electronic ISSN:	1557-3265
Topics:	Medicine
Published by:	http://www.aacr.org/

Latest Papers from Table of Contents or Articles in Press

12

Preferential flow in a well drained and a poorly drained soil under different overhead irrigation regimes

McLeod, M. ; Schipper, L. A. ; Taylor, M. D.

Oxford, UK : Blackwell Publishing Ltd
Published 1998

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ISSN:	1475-2743
Source:	Blackwell Publishing Journal Backfiles 1879-2005
Topics:	Geosciences Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
Notes:	Abstract. There is environmental concern about the increasing land application of dairy shed effluent in New Zealand. To minimize groundwater contamination by applied nutrients and pathogens it is desirable to avoid preferential flow through topsoils. Our objective was to determine an irrigation rate that retained applied effluent in the topsoil of two commonly irrigated New Zealand soils. In a field experiment, well drained Horotiu soils and poorly drained Te Kowhai soils were irrigated with a pyranine dye/KBr tracer solution at four rates (5, 10, 15, 20 mm/h) using a drip-type rainfall simulator. Twenty minutes after irrigation ceased the soil was excavated horizontally at 25 or 50 mm intervals, and photographed under UV light until no further fluorescence was vishle. Each layer was also analysed for bromide content, without subsampling. The wetting pattern was uneven in both soils as leachate moved preferentially through worm channels and structural cracks. Preferential flow was greatest in the Te Kowhai soil and increased at faster application rates. Dye fluorescence was curvilinearly related to bromide concentration. At both study sites, maintaining the irrigation rate at 〈inlineGraphic alt="leqslant R: less-than-or-eq, slant" extraInfo="nonStandardEntity" href="urn:x-wiley:02660032:SUM96:les" location="les.gif"/〉 10 mm/h minimized leachate movement into the subsoil. Pulsed irrigation at faster rates was not retained in the topsoil.
Type of Medium:	Electronic Resource
URL:	http://dx.doi.org/10.1111/j.1475-2743.1998.tb00622.x

Articles: DFG German National Licenses

13

Nanoprobe-induced electrostatic lateral quantization in near-surface resonant-tunneling heterostructures

Taylor, M. D. ; Wetsel, G. C. ; McBride, S. E. ; Brown, R. C. ; Frensley, W. R. ; Seabaugh, A. C. ; Kao, Y.-C. ; Beam, E. A.

Woodbury, NY : American Institute of Physics (AIP)
Published 1995

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ISSN:	1077-3118
Source:	AIP Digital Archive
Topics:	Physics
Notes:	We report experimental and theoretical evidence for electrostatic lateral confinement induced by a nanoprobe. The lateral confinement is manifest as oscillations of the differential conductance of a near-surface resonant-tunneling heterostructure in air at room temperature. © 1995 American Institute of Physics.
Type of Medium:	Electronic Resource
URL:	http://dx.doi.org/10.1063/1.113807

Articles: DFG German National Licenses

14

Doping of covalently bound fullerene monolayers: Ag clusters on C60/Si(111)

Taylor, M. D. R. ; Moriarty, P. ; Cotier, B. N. ; Butcher, M. J. ; Beton, P. H.

Woodbury, NY : American Institute of Physics (AIP)
Published 2000

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ISSN:	1077-3118
Source:	AIP Digital Archive
Topics:	Physics
Notes:	The deposition of silver on a C60 monolayer chemisorbed on Si(111) leads to the formation of nanoscale clusters which, as determined from valence band photoemission measurements, donate minimal charge to the adsorbed fullerene molecules. The low doping level of the C60 monolayer leads to a slow rate of Ag cluster neutralization following the emission of a photoelectron, resulting in a significant shift of the cluster Fermi level and valence band features to higher binding energy. © 2000 American Institute of Physics.
Type of Medium:	Electronic Resource
URL:	http://dx.doi.org/10.1063/1.1289797

Articles: DFG German National Licenses

15

Responsible estuarine finfish stock enhancement: an Australian perspective

Taylor, M. D. ; Palmer, P. J. ; Fielder, D. S. ; Suthers, I. M.

Oxford, UK; Malden, USA : Blackwell Science Ltd
Published 2005

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ISSN:	1095-8649
Source:	Blackwell Publishing Journal Backfiles 1879-2005
Topics:	Biology
Notes:	The responsible approach to marine stock enhancement is a set of principles aimed at maximising the success and benefits of artificially re-stocking depleted fisheries. The benefits of such an approach are evident in the 400% increase in survival of stocked striped mullet in Hawaii through refinement of release techniques, however financially or temporally constrained stocking programs in Australia have not adhered to all principles. A pragmatic approach to address these principles is proposed, using international examples and Australian marine finfish pilot stockings of barramundi, mulloway, sand whiting, dusky flathead and black bream. Biological ranking of candidate species by estuarine residency, a low natural-mortality to growth ratio, a large L∞ and comparison by recreational value and available rearing technologies, show that mulloway, barramundi and sea mullet are ideal species for stocking in Australia. Australian intermittently closed opening landlocked lagoons and recreational fishing havens, especially near cities, provide experimental opportunities to apply this approach and stock suitable species through small-scale pilot experiments. This would allow evaluation of production and carrying capacity, and density dependent processes with respect to optimal stocking strategies unconfounded by emigration and commercial fishing practices. Twenty per cent of Australians fish each year, and harvest approximately 27 000 t of finfish. Stocking recreationally important species in Australia should give a greater financial benefit, which is spread across a larger cross-section of the community, compared to stocking to enhance commercial fisheries. The pragmatic application of the responsible approach, and stocking of fast growing estuarine residents into recreational fishing havens would enhance the benefit from marine stocking.
Type of Medium:	Electronic Resource
URL:	http://dx.doi.org/10.1111/j.0022-1112.2005.00809.x

Articles: DFG German National Licenses

16

Batch marking of otoliths and fin spines to assess the stock enhancement of Argyrosomus japonicus

Taylor, M. D. ; Fielder, D. S. ; Suthers, I. M.

Oxford, UK; Malden, USA : Blackwell Science Ltd
Published 2005

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ISSN:	1095-8649
Source:	Blackwell Publishing Journal Backfiles 1879-2005
Topics:	Biology
Notes:	Juvenile mulloway Argyrosomus japonicus(54·6 ± 4·6 mm total length, mean ± s.e.) were immersed in a range of oxytetracycline (OTC) solutions ranging between 0–600 mg l−1 in salinities of 5 (diluted sea water) and 35 (undiluted sea water), and alizarin complexone (ALC) solutions ranging between 0–60 mg l−1 in undiluted sea water, for 6, 12 and 24 h. Optimal marking conditions were 600 mg l−1 OTC for 24 h in a salinity of 5, and 30 mg l−1 ALC for 12 h respectively. Mark quality (MQ) was assessed using a score of 0–3 in both otoliths and anal fin spines, with a score 〉2 found to be acceptable for adequate mark identification. Acceptable marks were not produced using OTC in undiluted sea water. Immersion in OTC or ALC, or reduced salinity had no effect on survival relative to controls. Transverse sections of vertebrae from the ALC and OTC treatments with the highest otolith mark quality showed no discrete marks. Optimal marking techniques were used to produce double marks with a 3 day interval between marking, and marking techniques were applied to 130 000 juvenile mulloway in batch mode with minimal mortality. A numerical model of the chemical behaviour of OTC in sea water describes the decline of available OTC in increasing salinity, so that a species’ salinity tolerance and successful marking can be optimized.
Type of Medium:	Electronic Resource
URL:	http://dx.doi.org/10.1111/j.0022-1112.2005.00678.x

Articles: DFG German National Licenses

17

Addition of metronidazole to omeprazole/amoxycillin dual therapy increases the rate of Helicobacter pylori eradication: a double-blind, randomized trial

BELL, G. D. ; BATE, C. M. ; AXON, A. T. R. ; TILDESLEY, G. ; KERR, G. D. ; GREEN, J. R. B. ; EMMAS, C. E. ; TAYLOR, M. D.

Oxford, UK : Blackwell Publishing Ltd
Published 1995

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ISSN:	1365-2036
Source:	Blackwell Publishing Journal Backfiles 1879-2005
Topics:	Medicine
Notes:	Aims: To compare the efficacy, safety and tolerability of an omeprazole/amoxycillin (OA) dual therapy Helicobacter pylori eradication regimen with an omeprazole/amoxycillin/metronidazole (OAM) triple therapy regimen. Methods: In this double-blind trial, conducted in 19 hospitals, 119 patients with symptomatic duodenal ulcer disease were randomized to receive either 14 days treatment with omeprazole 40 mg daily, amoxycillin 500 mg t.d.s. and placebo followed by a further 14 days’treatment with omeprazole 20 mg daily (n= 59) or 14 days treatment with omeprazole 40 mg daily, amoxycillin 500 mg t.d.s., and metronidazole 400 mg t.d.s., followed by a further 14 days’treatment with omeprazole 20 mg daily (n= 60). H. pylori status was assessed by 13C-urea breath test at entry and at 4 weeks post-treatment. Results: H. pylori infection was eradicated in 46% of the OA treated patients and in 92% of the OAM treated patients, a mean difference of 46% (P 〈 0.0001, 95% CI for the difference: + 30 to + 62). In only one patient was the duodenal ulcer not endoscopically healed after 4 weeks of treatment (OA 100%; OAM 98% healed). There were no significant differences in speed of symptom relief or improvement in symptoms between the two groups. Both regimens were well tolerated, with 96% of patients completing the course, and only one patient withdrawing due to an adverse event. The only side-effect with a significantly higher incidence in the OAM group was diarrhoea, which occurred in 36% of patients compared to 16% of patients in the OA group (P 〈 0.05). Conclusions: A regimen consisting of omeprazole 40 mg daily, amoxycillin 500 mg t.d.s. and metronidazole 400 mg t.d.s. for 14 days gives an appreciably higher H. pylori eradication rate than omeprazole and amoxycillin alone, with acceptable tolerability.
Type of Medium:	Electronic Resource
URL:	http://dx.doi.org/10.1111/j.1365-2036.1995.tb00414.x

Articles: DFG German National Licenses

18

Symptomatic and endoscopic duodenal ulcer relapse rates 12 months following Helicobacter pylori eradication treatment with omeprazole and amoxycillin with or without metronidazole

BELL, G. D. ; BATE, C. M. ; AXON, A. T. R. ; TILDESLEY, G. ; MARTIN, J. L. ; TAYLOR, M. D. ; RICHARDSON, P. D. I.

Oxford BSL : Blackwell Science
Published 1996

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ISSN:	1365-2036
Source:	Blackwell Publishing Journal Backfiles 1879-2005
Topics:	Medicine
Notes:	Aim: To determine the effect of Helicobacter pylori eradication with omeprazole and amoxycillin, with or without metronidazole, on the 12-month course of duodenal ulcer disease. Methods: In a randomized, double-blind study, conducted in 19 hospitals, 105 H. pylori positive duodenal ulcer patients were healed and symptom-free following either omeprazole dual therapy (omeprazole 40 mg o.m.+amoxycillin 500 mg t.d.s., OA, eradication rate 46%, n=52) or omeprazole triple therapy (omeprazole 40 mg o.m.+amoxycillin 500 mg t.d.s.+metronidazole 400 mg t.d.s., OAM, eradication rate 92%, n=53) for 2 weeks, followed by 2 weeks of omeprazole 20 mg o.m. and a 12-month untreated follow-up period, after which time all patients were endoscoped. Endoscopic and symptomatic relapse rates, and effect on H. pylori status measured using 13C-urea breath test, were determined. Results: During the 12-month untreated follow-up period, the life-table endoscopic relapse rates were 12% (95% CI: 2–22%) and 2% (95% CI: 0–6%) for OA and OAM patients, respectively. By 12 months, life-table symptomatic relapse rates were 22% (95% CI: 13–37%) and 19% (95% CI: 8–30%) for OA and OAM, respectively. In the 12 months untreated follow-up period, 2/69 (3%, 95% CI: 0–7%) patients rendered H. pylori negative had an endoscopic relapse at the end of the 12-month follow-up period, compared with 5/31 (16%, 95% CI: 3–29%) patients remaining H. pylori positive (P=0.03 between H. pylori positive and negative groups). Twelve of 69 (17%, 95% CI: 8–26%) patients rendered H. pylori negative relapsed symptomatically, compared with 9/31 (29%, 95% CI: 13–45%) patients remaining H. pylori positive (P= N.S. between groups). There was a significant improvement in epigastric pain (P=0.0001), nausea and vomiting (P〈0.05) between entry to the study and 1, 6 and 12 months post-treatment for both treatment groups. Conclusions: OAM eradicates H. pylori in significantly more patients than OA, but successful H. pylori eradication with either OAM or OA predisposes to low endoscopic and symptomatic relapse rates for duodenal ulcer patients when followed up for 12 months.
Type of Medium:	Electronic Resource
URL:	http://dx.doi.org/10.1046/j.1365-2036.1996.36178000.x

Articles: DFG German National Licenses

19

Reflux symptom relief with omeprazole in patients without unequivocal oesophagitis

BATE, C. M. ; GRIFFIN, S. M. ; KEELING, P. W. N. ; AXON, A. T. R. ; DRONFIELD, M. W. ; CHAPMAN, R. W. G. ; O'DONOGHUE, D. ; CALAM, J. ; CROWE, J. ; MOUNTFORD, R. A. ; WATTS, D. A. ; TAYLOR, M. D. ; RICHARDSON, P. D. I.

Oxford BSL : Blackwell Science
Published 1996

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ISSN:	1365-2036
Source:	Blackwell Publishing Journal Backfiles 1879-2005
Topics:	Medicine
Notes:	Background: As many as 50% of patients with reflux symptoms have no endoscopic evidence of oesophagitis. This multicentre study was designed to assess symptom relief after omeprazole 20 mg once daily in patients with symptoms typical of gastro-oesophageal reflux disease but without endoscopic evidence of oesophagitis. Methods: Patients (n=209) were randomized in a double-blind study to receive either omeprazole 20 mg once daily (n=98) or placebo (n=111) for 4 weeks. Symptoms were assessed at clinic visits and using daily diary cards, with patient-completed questionnaires providing additional data on symptoms and on psychological disturbance. Results: On completion, symptom relief favoured omeprazole: 57% of patients on omeprazole were free of heartburn (vs. 19% on placebo), 75% were free of regurgitation (47%) and 43% were completely asymptomatic (14%), each with P〈0.0001. Fewer patients in the omeprazole group required alginate/antacid relief medication (P〈0.05). Symptom relief (time to first heartburn-free day) was more rapid with omeprazole (2 vs. 5 days on placebo; P〈0.01). A greater reduction in anxiety occurred in the omeprazole group (P〈0.05). Conclusion: Omeprazole 20 mg once daily is effective in providing relief of the symptoms typical of gastro-oesophageal reflux disease in patients with essentially normal oesophageal mucosa.
Type of Medium:	Electronic Resource
URL:	http://dx.doi.org/10.1046/j.1365-2036.1996.44186000.x

Articles: DFG German National Licenses

20

Omeprazole is more effective than cimetidine for the relief of all grades of gastro-oesophageal reflux disease-associated heartburn, irrespective of the presence or absence of endo...

BATE, C. M. ; GREEN, J. R. B. ; AXON, A. T. R. ; MURRAY, F. E. ; TILDESLEY, G. ; EMMAS, C. E. ; TAYLOR, M. D.

Oxford, UK : Blackwell Science Ltd
Published 1997

Staff View

ISSN:	1365-2036
Source:	Blackwell Publishing Journal Backfiles 1879-2005
Topics:	Medicine
Notes:	Background: Previous studies have demonstrated greater efficacy for omeprazole compared with cimetidine in patients with endoscopically verified oesophagitis, but excluded the substantial group of gastro-oesophageal reflux disease (GERD) patients with reflux symptoms but without endoscopic abnormality. This prospective, randomized, double-blind study compared omeprazole and cimetidine in the treatment of GERD-associated heartburn both in patients with symptomatic non-ulcerative oesophagitis and in those with heartburn but without oesophagitis. Methods: A total of 221 patients with heartburn and oesophageal mucosa grade 0 (normal, n = 51), 1 (no macroscopic erosions, n = 52), 2 (isolated erosions, n = 97) or 3 (confluent erosions, n = 21) were randomized to receive double-blind either omeprazole 20 mg daily or cimetidine 400 mg q.d.s. for a period of 4 weeks. Those still symptomatic after 4 weeks of treatment received omeprazole 20 mg daily for a further 4 weeks. Results: There was no correlation between severity of heartburn and endoscopic grade at entry (correlation coefficient = 0.196). After 4 weeks of treatment, the proportion of patients in whom heartburn was controlled (no more than mild symptoms on no more than 1 day in the previous 7) on omeprazole (66%; 74/112) was more than double that on cimetidine (31%; 34/109) (P 〈 0.0001). There was no significant difference between the relief of heartburn in the 47% of patients without unequivocal oesophagitis (endoscopic grade 0 or 1) and in the 53% of patients with erosive oesophagitis (grade 2 or 3) (P = 0.31). Only treatment with omeprazole (P 〈 0.0001) and lower severity of heartburn at entry (P 〈 0.01) were significant in predicting heartburn relief. Amongst those patients requiring an additional 4 weeks of treatment with omeprazole, 67% (54/81) reported that their heartburn was controlled after 8 weeks of treatment. Conclusion: We conclude that omeprazole is superior to cimetidine for the relief of all grades of heartburn in GERD, whether or not the patient has unequivocal endoscopic oesophagitis.
Type of Medium:	Electronic Resource
URL:	http://dx.doi.org/10.1046/j.1365-2036.1997.00198.x

Articles: DFG German National Licenses

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