Search Results - (Author, Cooperation:M. Coltorti)
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1M. Gallego Llorente ; E. R. Jones ; A. Eriksson ; V. Siska ; K. W. Arthur ; J. W. Arthur ; M. C. Curtis ; J. T. Stock ; M. Coltorti ; P. Pieruccini ; S. Stretton ; F. Brock ; T. Higham ; Y. Park ; M. Hofreiter ; D. G. Bradley ; J. Bhak ; R. Pinhasi ; A. Manica
American Association for the Advancement of Science (AAAS)
Published 2015Staff ViewPublication Date: 2015-10-10Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: African Continental Ancestry Group/*genetics ; Asia ; Biological Evolution ; Ethiopia ; Europe ; Genetic Variation ; *Genome, Human ; *Human Migration ; Humans ; MalePublished by: -
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ISSN: 0009-8981Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: MedicineType of Medium: Electronic ResourceURL: -
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ISSN: 0009-8981Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: MedicineType of Medium: Electronic ResourceURL: -
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ISSN: 0009-8981Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: MedicineType of Medium: Electronic ResourceURL: -
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ISSN: 0003-9861Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
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ISSN: 1420-9071Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Riassunto Nell'epatite virale umana acuta l'attività fosfoglicomutasica del siero è notevolemente aumentata rispetto ai valori normali. L'aggiunta di omogenato bollito di fegato di topo produce ulteriore notevole incremento dell'attività fosfoglicomutasica del siero di soggetti affetti da epatite epidemica; non influenza tale attività nel siero di soggetti normali.Type of Medium: Electronic ResourceURL: -
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ISSN: 1420-9071Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Riassunto Sono state studiate le variazioni di alcuni enzimi microsomiali del fegato di topi trattati con fenobarbital in varie fasi della epatite da MHV-3. È stato osservato che anche in fasi di avanzata citonecrosi epatica il trattamento con fenobarbital determina netti incrementi del citocromo P-450, della NADPH ossidasi e della anilina idrossilasi microsomiali. Nelle stesse condizioni invece la glucosio-6-fosfatasi mostra un decremento sia nei topi controllo che negli infetti.Type of Medium: Electronic ResourceURL: -
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ISSN: 1438-1168Source: Springer Online Journal Archives 1860-2000Topics: GeosciencesDescription / Table of Contents: Zusammenfassung Auf der Grundlage von Gesteins- und Mineralchemie der paläozoischen Vulkanite der Karnischen Alpen können zwei magmatische Hauptgruppen unterschieden werden: die Hoch-Ti Vulkanite (HTV) und die Nieder-Ti Vulkanite (LTV). Der Prozess der Spilitisation vermochte die ursprünglichen magmatischen Charakteristika nicht zu überdecken. Die zwei Gruppen sind durch sehr verschiedene Spurenelementgehalte charakterisiert und können nicht durch einen Differentiationsprozeß verknüpft werden. Die HTV erfordern eine angereicherte „mantle source”, während die Geochemie der LTV deutlich auf Kontamination hinweist. Beide magmatische Gruppen sind aus einer „rifting” Episode hervorgegangen. Die Kontamination der LTV-Gruppe durch Assimilation von Krustengesteinen zeigt, daß das „rifting” sich in einer kontinentalen Umgebung entwickelte.Notes: Summary On the basis of whole-rock and mineral chemistry two main magmatic groups can be established for the Paleozoic Volcanism of the Carnian Alps. High-Ti Volcanics (HTV) and Low-Ti Volcanics (LTV). Spilitization processes have not masked the primary magmatic character. The two groups are characterized by very different trace element patterns and cannot be correlated by a fractionation process. The HTV require an enriched mantle source whereas the geochemistry of the LTV indicates strong crustal contamination. Both magmatic groups are consistent with a major rifting episode. The contamination via assimilation of crustal rocks of the LTV group implies that rifting developed in a continental area.Type of Medium: Electronic ResourceURL: -
9Coltorti, M. ; Cremaschi, M. ; Delitala, M. C. ; Esu, D. ; Fornaseri, M. ; McPherron, A. ; Nicoletti, M. ; Otterloo, R. van ; Peretto, C. ; Sala, B. ; Schmidt, V. ; Sevink, J.
[s.l.] : Nature Publishing Group
Published 1982Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Fig. 1 Isernia La Pineta. Portion of archaeological horizon, sector I. The archaeological levels are contained in fluvial and fluviolacustrine sediments pertaining to the principal fill of the Isernia Basin (Fig. 3)3. A lacustrine facies, evident at the base of this unit, ends in the north-east of ...Type of Medium: Electronic ResourceURL: -
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ISSN: 1420-9071Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Summary In experimental hepatitis from MHV-3 Craig strain, the enolase activity of plasma increases significatively from 48th h of the infection, reaching the highest values at 72–96th h. The same activity in the liver decreases only after 72th h, while in the precocious stages of the infection it is unmodified. The physiopathological significance of the enzymatic modification in the plasma is related to the liver necrosis (enzymo-plasmatic syndrome of virus hepatitis).Type of Medium: Electronic ResourceURL: -
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ISSN: 1432-8798Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary In intracerebrally with EMC virus infected mice the adenylpyrophosphatase activity increases early starting from the 10th hour after infection both in cerebral and myocardial tissues and reaches the highest value at the 18th hour. From this time it remains at the same level in the cerebral, but drops in the myocardial tissue where at the 30th hour the enzymatic activity, even being still increased of + 17%, is no longer statistically significant. On the other hand it has been shown that the rhodanese activity in cerebral and hepatic tissues is already at the 10th hour p. i. 29% respectively 33% lower than the normal values found in these tissues. The significance of these metabolic modifications is discussed in relation to the viral multiplication and cellular damage through the different stages of the disease.Type of Medium: Electronic ResourceURL: -
12Coltorti, M. ; Romano, M. ; Persico, M. ; Morisco, Filomena ; Tuccillo, Concetta ; Caporaso, Nicola
Springer
Published 1995Staff ViewISSN: 1439-0973Source: Springer Online Journal Archives 1860-2000Topics: MedicineDescription / Table of Contents: Zusammenfassung Bei asymptomatischen, anti-HCV positiven Personen mit andauernd normalen oder leicht (das heißt ≤1,5 fach über der oberen Normgrenze) liegenden Serum ALT-Spiegeln wurden die HCV-RNA im Serum, Leberhistologie und das RIBA-II-Muster untersucht. Bei 22 asymptomatischen, anti-HCV positiven Personen (11 Männern und 11 Frauen im mittleren Alter von 40; Bereich 21–70 Jahren) wurde eine Leberbiopsie durchgeführt und HCV-RNA im Serum bestimmt. Der Nachweis von anti-HCV wurde mit ELISA-2 und RIBA-II-Tests geführt. Die HCV-RNA im Serum wurde mittels PCR bestimmt. Unsere Untersuchungen zeigten, 1.) daß 9/22 asymptomatischen, anti-HCV-positiven Personen histologische Zeichen einer chronischen Lebererkrankung mit fortbestehender HCV-Infektion hatten. 2.) Vier Personen hatten keine histologischen Zeichen einer chronischen Hepatitis und normale Serum-ALT-Spiegel trotz Nachweises von HCV-RNA im Serum. 3.) Die ALT-Spiegel im Serum unterschieden HCV-RNA positive Personen mit chronischer Hepatitis nicht von denjenigen ohne chronische Hepatitis. 4.) Bei anti-HCV positiven Personen mit normalen ALT-Spiegeln ist ein positiver RIBA-II Test nicht immer mit einer HCV-Virämie oder einer chronischen Hepatitis assoziiert. Bei unklarem RIBA-II-Muster bestanden häufig unspezifische Leberveränderungen oder ein normaler histologischer Befund. „Wirklich“ gesunde Träger von HCV (das heißt, Personen mit normalem Serum ALT-Spiegel, ohne histologische Zeichen einer chronischen Hepatitis trotz HCV Virämie) können folglich vorkommen.Notes: Summary This study was designed to evaluate serum HCV-RNA, liver histology, and RIBA-II pattern in asymptomatic anti-HCV positive subjects with persistently normal or slightly (i.e. ≤1.5 times the upper limit of the normal range) elevated serum ALT levels. To this purpose, 22 asymptomatic anti-HCV positive subjects (11 men and 11 women, median age 40, range 21–70 years) underwent liver biopsy and determination of serum HCV-RNA. Positivity for anti-HCV was determined by ELISA-2 and by RIBA-II. Serum HCV-RNA was determined by PCR. Our data show that: 1) 9/22 symptom-free, anti-HCV positive subjects had histological features of chronic liver disease associated with ongoing HCV infection; 2) four subjects had no histological signs of chronic hepatitis and normal serum ALT levels despite positivity for serum HCV-RNA; 3) serum ALT levels did not discriminate HCV-RNA positive subjects with from those without chronic hepatitis; 4) in anti-HCV positive subjects with normal serum ALT levels, a positive RIBA-II pattern was not always predictive of HCV viraemia or chronic hepatitis while an indeterminate RIBA-II pattern was frequently associated with nonspecific liver changes or normal histology. In conclusion, based on these findings, “true” healthy carriers of HCV (i.e. subjects with normal serum ALT levels and no histological features of chronic hepatitis despite HCV viraemia) may exist.Type of Medium: Electronic ResourceURL: -
13Coltorti, M. ; Caporaso, Nicola ; Morisco, Filomena ; Suozzo, Rosalba ; Romano, M. ; D'Antonio, M.
Springer
Published 1994Staff ViewISSN: 1439-0973Source: Springer Online Journal Archives 1860-2000Topics: MedicineDescription / Table of Contents: Zusammenfassung Die Bedeutung der Familie als Faktor für die Ausbreitung der HCV-Infektion wird immer noch kontrovers diskutiert. In der vorliegenden Studie wurde versucht, die Prävalenz anti-HCV-positiver Fälle unter den häuslichen Kontaktpersonen von Patienten mit HCV-assoziierter chronischer Hepatitis zu bestimmen. Nahezu alle Kontaktpersonen von 113 Personen mit anti-HCV-positiver Hepatitis (100/113 Ehegatten, 260/290 Kinder) wurden untersucht. Für die Bestimmung von anti-HCV wurde ELISA-II mit Bestätigung durch RIBA II eingesetzt. 27% der Ehegatten und 1,9% der Kinder erwiesen sich als anti-HCV-positiv. Bei den Gatten korrelierte die Prävalenz der anti-HCV-Positivität mit der Dauer der Ehe. Bei 17/32 (53,1%) der anti-HCV-positiven Personen wurde eine chronische Hepatitis aufgedeckt. Diese Studie gibt Hinweise auf eine vorwiegend horizontale Übertragung der HCV-Infektion zwischen Ehegatten und eine positive Korrelation zwischen Übertragung und Dauer der Ehe.Notes: Summary It is still controversial whether the familial environment plays a role in the diffusion of HCV infection. The aim of this study was to evaluate the prevalence of anti-HCV positivity in the household contacts of patients with HCV-related chronic hepatitis. Nearly all the household contacts of 113 subjects with anti-HCV+ chronic hepatitis (100/113 spouses and 260/290 children) were investigated. Anti-HCV was determined by means of ELISA II and was confirmed by RIBA II. Anti-HCV positivity was found in 27% of the spouses and in 1.9% of the children. Prevalence of anti-HCV positivity in spouses correlated positively with the duration of the marital status. Seventeen/32 (53.1%) of anti-HCV-positive subjects were found to have chronic hepatitis. This study indicates that intrafamilial diffusion of HCV infection is mostly accounted for by horizontal, in particular spouse to spouse, transmission and that spouse to spouse transmission of HCV infection correlates positively with the duration of marital status.Type of Medium: Electronic ResourceURL: -
14Coltorti, M. ; Caporaso, N. ; Persico, M. ; Sio, I ; Marmo, R. ; Morisco, F. ; Tuccillo, C. ; Romano, Marco
Springer
Published 1994Staff ViewISSN: 1573-2568Source: Springer Online Journal Archives 1860-2000Topics: MedicineType of Medium: Electronic ResourceURL: