Search Results - (Author, Cooperation:M. Carrington)
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1Ramsuran, V., Naranbhai, V., Horowitz, A., Qi, Y., Martin, M. P., Yuki, Y., Gao, X., Walker-Sperling, V., Del Prete, G. Q., Schneider, D. K., Lifson, J. D., Fellay, J., Deeks, S. G., Martin, J. N., Goedert, J. J., Wolinsky, S. M., Michael, N. L., Kirk, G. D., Buchbinder, S., Haas, D., Ndungu, T., Goulder, P., Parham, P., Walker, B. D., Carlson, J. M., Carrington, M.
American Association for the Advancement of Science (AAAS)
Published 2018Staff ViewPublication Date: 2018-01-05Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyGeosciencesComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Genetics, ImmunologyPublished by: -
2L. Abi-Rached ; M. J. Jobin ; S. Kulkarni ; A. McWhinnie ; K. Dalva ; L. Gragert ; F. Babrzadeh ; B. Gharizadeh ; M. Luo ; F. A. Plummer ; J. Kimani ; M. Carrington ; D. Middleton ; R. Rajalingam ; M. Beksac ; S. G. Marsh ; M. Maiers ; L. A. Guethlein ; S. Tavoularis ; A. M. Little ; R. E. Green ; P. J. Norman ; P. Parham
American Association for the Advancement of Science (AAAS)
Published 2011Staff ViewPublication Date: 2011-08-27Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Adaptation, Biological ; African Continental Ancestry Group/genetics ; Alleles ; Animals ; Asian Continental Ancestry Group/genetics ; Continental Population Groups/*genetics ; European Continental Ancestry Group/genetics ; Evolution, Molecular ; *Genes, MHC Class I ; Genetic Variation ; HLA-A Antigens/*genetics/immunology/metabolism ; HLA-B Antigens/*genetics/immunology/metabolism ; HLA-C Antigens/*genetics/immunology ; Haplotypes ; Hominidae/*genetics/*immunology ; Humans ; *Hybridization, Genetic ; Killer Cells, Natural/immunology ; Ligands ; Linkage Disequilibrium ; Molecular Sequence Data ; Oceanic Ancestry Group/genetics ; Receptors, KIR/immunology/metabolism ; Selection, GeneticPublished by: -
3P. Ruibal ; L. Oestereich ; A. Ludtke ; B. Becker-Ziaja ; D. M. Wozniak ; R. Kerber ; M. Korva ; M. Cabeza-Cabrerizo ; J. A. Bore ; F. R. Koundouno ; S. Duraffour ; R. Weller ; A. Thorenz ; E. Cimini ; D. Viola ; C. Agrati ; J. Repits ; B. Afrough ; L. A. Cowley ; D. Ngabo ; J. Hinzmann ; M. Mertens ; I. Vitoriano ; C. H. Logue ; J. P. Boettcher ; E. Pallasch ; A. Sachse ; A. Bah ; K. Nitzsche ; E. Kuisma ; J. Michel ; T. Holm ; E. G. Zekeng ; I. Garcia-Dorival ; R. Wolfel ; K. Stoecker ; E. Fleischmann ; T. Strecker ; A. Di Caro ; T. Avsic-Zupanc ; A. Kurth ; S. Meschi ; S. Mely ; E. Newman ; A. Bocquin ; Z. Kis ; A. Kelterbaum ; P. Molkenthin ; F. Carletti ; J. Portmann ; S. Wolff ; C. Castilletti ; G. Schudt ; A. Fizet ; L. J. Ottowell ; E. Herker ; T. Jacobs ; B. Kretschmer ; E. Severi ; N. Ouedraogo ; M. Lago ; A. Negredo ; L. Franco ; P. Anda ; S. Schmiedel ; B. Kreuels ; D. Wichmann ; M. M. Addo ; A. W. Lohse ; H. De Clerck ; C. Nanclares ; S. Jonckheere ; M. Van Herp ; A. Sprecher ; G. Xiaojiang ; M. Carrington ; O. Miranda ; C. M. Castro ; M. Gabriel ; P. Drury ; P. Formenty ; B. Diallo ; L. Koivogui ; N. Magassouba ; M. W. Carroll ; S. Gunther ; C. Munoz-Fontela
Nature Publishing Group (NPG)
Published 2016Staff ViewPublication Date: 2016-05-07Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: CTLA-4 Antigen/metabolism ; Ebolavirus/*immunology ; Female ; Flow Cytometry ; Guinea/epidemiology ; Hemorrhagic Fever, Ebola/*immunology/mortality/*physiopathology ; Humans ; Inflammation Mediators/immunology ; Longitudinal Studies ; Lymphocyte Activation ; Male ; Patient Discharge ; Programmed Cell Death 1 Receptor/metabolism ; Survivors ; T-Lymphocytes/*immunology/metabolism ; Viral LoadPublished by: -
4S. Kulkarni ; R. Savan ; Y. Qi ; X. Gao ; Y. Yuki ; S. E. Bass ; M. P. Martin ; P. Hunt ; S. G. Deeks ; A. Telenti ; F. Pereyra ; D. Goldstein ; S. Wolinsky ; B. Walker ; H. A. Young ; M. Carrington
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-04-19Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: 3' Untranslated Regions/genetics ; Alleles ; Base Sequence ; Cell Line ; *Gene Expression Regulation/genetics/immunology ; Genes, Reporter/genetics ; HIV/*immunology ; HIV Infections/*genetics/*immunology/therapy ; HLA-C Antigens/*genetics ; Humans ; MicroRNAs/*genetics ; Polymorphism, Single Nucleotide/genetics ; Viral LoadPublished by: -
5Staff View
Publication Date: 2013-09-14Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: *Gene Expression Regulation ; HIV/*immunology ; HIV Infections/*genetics/*immunology ; HLA-C Antigens/*genetics ; Humans ; T-Lymphocytes, Cytotoxic/*immunologyPublished by: -
6R. Apps ; Y. Qi ; J. M. Carlson ; H. Chen ; X. Gao ; R. Thomas ; Y. Yuki ; G. Q. Del Prete ; P. Goulder ; Z. L. Brumme ; C. J. Brumme ; M. John ; S. Mallal ; G. Nelson ; R. Bosch ; D. Heckerman ; J. L. Stein ; K. A. Soderberg ; M. A. Moody ; T. N. Denny ; X. Zeng ; J. Fang ; A. Moffett ; J. D. Lifson ; J. J. Goedert ; S. Buchbinder ; G. D. Kirk ; J. Fellay ; P. McLaren ; S. G. Deeks ; F. Pereyra ; B. Walker ; N. L. Michael ; A. Weintrob ; S. Wolinsky ; W. Liao ; M. Carrington
American Association for the Advancement of Science (AAAS)
Published 2013Staff ViewPublication Date: 2013-04-06Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: African Americans/genetics ; Alleles ; Amino Acid Sequence ; Anti-Retroviral Agents/therapeutic use ; Crohn Disease/genetics/immunology ; *Gene Expression Regulation ; HIV/genetics/*immunology ; HIV Infections/drug therapy/*genetics/*immunology ; HLA-C Antigens/*genetics ; Humans ; Immunodominant Epitopes/genetics ; Molecular Sequence Data ; Mutation ; Peptide Fragments/immunology ; Polymorphism, Single Nucleotide ; T-Lymphocytes, Cytotoxic/*immunology ; Viral Load/geneticsPublished by: -
7G. Alter ; D. Heckerman ; A. Schneidewind ; L. Fadda ; C. M. Kadie ; J. M. Carlson ; C. Oniangue-Ndza ; M. Martin ; B. Li ; S. I. Khakoo ; M. Carrington ; T. M. Allen ; M. Altfeld
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-08-05Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adaptation, Physiological/genetics/*immunology ; Antibodies, Neutralizing/immunology ; CD4-Positive T-Lymphocytes/immunology/virology ; Decision Trees ; *Evolution, Molecular ; Genotype ; HIV Infections/*immunology/*virology ; HIV-1/genetics/*immunology/physiology ; Host-Pathogen Interactions/immunology ; Human Immunodeficiency Virus Proteins/genetics/immunology/metabolism ; Humans ; Immune Evasion/*immunology ; Killer Cells, Natural/*immunology ; Polymorphism, Genetic ; Receptors, KIR/deficiency/genetics/immunology/metabolism ; Receptors, KIR2DL2/chemistry/deficiency/genetics/immunology ; Viral Regulatory and Accessory Proteins/genetics/immunology/metabolism ; Virus Replication ; env Gene Products, Human Immunodeficiency Virus/genetics/immunology/metabolismPublished by: -
8Chikata, T., Tran, G. V., Murakoshi, H., Akahoshi, T., Qi, Y., Naranbhai, V., Kuse, N., Tamura, Y., Koyanagi, M., Sakai, S., Nguyen, D. H., Nguyen, D. T., Nguyen, H. T., Nguyen, T. V., Oka, S., Martin, M. P., Carrington, M., Sakai, K., Nguyen, K. V., Takiguchi, M.
The American Society for Microbiology (ASM)
Published 2018Staff ViewPublication Date: 2018-02-14Publisher: The American Society for Microbiology (ASM)Print ISSN: 0022-538XElectronic ISSN: 1098-5514Topics: MedicinePublished by: -
9Staff View
Publication Date: 2018-01-31Publisher: The American Society for Microbiology (ASM)Print ISSN: 0022-538XElectronic ISSN: 1098-5514Topics: MedicinePublished by: -
10Kaslow, R.A. ; Carrington, M. ; Apple, R. ; Park, L. ; Muñoz, A. ; Saah, A.J. ; Goedert, J.J. ; Winkler, C. ; O'Brien, S.J. ; Rinaldo, C. ; Detels, R. ; Blattner, W. ; Phair, J. ; Erlich, H. ; Mann, D.L.
[s.l.] : Nature Publishing Group
Published 1996Staff ViewISSN: 1546-170XSource: Nature Archives 1869 - 2009Topics: BiologyMedicineNotes: [Auszug] Major histocompatibility complex (MHC) genes (HLA in humans) regulate the immune response to foreign antigens. Molecular and serologic techniques were used to identify products of HLA class I, class II and transporter (TAP) genes (also part of the MHC) in homosexual seroconverters to human ...Type of Medium: Electronic ResourceURL: -
11Staff View
ISSN: 0022-2836Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
12Katzer, F. ; Carrington, M. ; Knight, P. ; Williamson, S. ; Tait, A. ; Morrison, I.W. ; Hall, R.
Amsterdam : ElsevierStaff ViewISSN: 0166-6851Keywords: Antigen ; Polymorphism ; Sporozoite ; Theileria ; Vaccine ; [abr] RFLP; restriction fragment length polymorphismSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
13Staff View
ISSN: 0309-1651Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
14Staff View
ISSN: 1432-1211Keywords: Key words Antigen presentation ; Autoimmune disease ; Evolution ; MHC ; Self peptidesSource: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Abstract Comparison of peptides eluted from human class I and class II major histocompatibility complex (MHC) molecules and the proteins from which they are derived (source proteins) revealed that class I MHC bind peptides derived from proteins that are highly conserved, hydrophilic, and universally expressed, while the peptides themselves are hydrophobic and even more conserved than their source proteins. In contrast, source proteins for class II-bound peptides were not significantly more conserved than a random sample of proteins. Class II-bound peptides were generally more conserved than their source proteins but were significantly less conserved than class I-bound peptides. The characteristics of class I-bound peptides can probably be explained by the selectivity of processing and transport of peptides for binding by class I, while the relative lack of selectivity of peptide binding for class II may explain the high incidence of autoimmune diseases associated with alleles of these molecules.Type of Medium: Electronic ResourceURL: -
15Staff View
ISSN: 0166-6851Keywords: Gene family ; Stage specific transcription ; Theileria parva ; [abr] ECF; East Coast Fever ; [abr] ORF; open reading frame ; [abr] RFLP; restriction fragment length polymorphism ; [abr] SDS; sodium dodecyl sulphate ; [abr] SSC; saline sodium citrateSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
16Staff View
ISSN: 0166-6851Keywords: Glutamine-rich protein ; Proline rich protein ; Repeated sequence ; Schizont ; Theileria parva ; [abr] GST; glutathione S-transferase ; [abr] IFA; Indirect immunofluorescence assay ; [abr] PAGE; polyacrylamide gel electrophoresis ; [abr] SSC; standard saline citrateSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
17Martin, Maureen P. ; Harding, Anita ; Chadwwick, Robert ; Kronick, Mel ; Cullen, Michael ; Lin, Ling ; Mignot, Emmanuel ; Carrington, M.
Springer
Published 1998Staff ViewISSN: 1432-1211Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
18Bream, J. H. ; Carrington, M. ; O'Toole, S. ; Dean, M. ; Gerrard, B. ; Shin, H. D. ; Kosack, D. ; Modi, W. ; Young, H. A. ; Smith, M. W.
Springer
Published 2000Staff ViewISSN: 1432-1211Keywords: Key words Interferon gamma ; Polymorphism ; Promoter ; AIOS ; 3′UTRSource: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Abstract Interferon gamma (IFN-gamma) is a multifunctional cytokine that is essential in the development of Th1 cells and in cellular responses to a variety of intracellular pathogens including human immunodeficiency virus (HIV-1). We screened genomic DNA samples from a predominately Caucasian male population of HIV-infected and healthy donors for polymorphisms in the human IFNG gene from –777 to +5608 by single-stranded conformational polymorphism. Surprisingly, the proximal promoter (–777 to transcription start) is invariant as no polymorphisms were found in over 100 samples tested. However, further screening revealed polymorphisms in other regions of the gene including a single base insertion in a poly-T tract in the first intron, three single base pair substitutions in the third intron, and another single base pair substitution in the 3′ untranslated region (UTR). Electrophoretic mobility shift assay was used to investigate whether these variants have altered DNA-binding abilities, since intronic enhancer elements have been reported for the IFNG gene. Oligonucleotides constructed for two third intron variants showed no difference in DNA-binding abilities as compared with wild-type sequences. However, the 3′UTR variant showed the formation of unique DNA-binding complexes to radiolabeled oligonucleotide probes as compared with the wild-type sequence. The influence of a CA-repeat microsatellite on AIDS disease progression in HIV-1 seroconverters was tested by a Cox proportional hazards model. There is no evidence of an association between alleles and infection with HIV-1 or progression to AIDS. We report an invariant proximal human IFNG promoter and the existence of multiple intronic variants and a potentially functional 3′UTR polymorphism.Type of Medium: Electronic ResourceURL: -
19Martin, Maureen P. ; Harding, Anita ; Chadwick, Robert ; Kronick, Mel ; Cullen, Michael ; Lin, Ling ; Mignot, Emmanuel ; Carrington, M.
Springer
Published 1997Staff ViewISSN: 1432-1211Keywords: Key words HLA ; Microsatellite loci ; Microsatellite typing ; Human ; MHCSource: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Abstract The human genome contains a large number of interspersed microsatellite repeats which exhibit a high degree of polymorphism and are inherited in a Mendelian fashion, making them extremely useful genetic markers. Several microsatellites have been described in the HLA region, but allele nomenclature, a set of broadly distributed controls, and typing methods have not been standardized, which has resulted in discrepant microsatellite data between laboratories. In this report we present a detailed protocol for genotyping microsatellites using a semi-automated fluorescence-based method. Twelve microsatellites within or near the major histocompatibility complex (MHC) were typed in the 10th International Histocompatibility Workshop homozygous typing cell lines (HTCs) and alleles were designated based on size. All loci were sequenced in two HTCs providing some information on the level of complexity of the repeat sequence. A comparison of allele size obtained by genotyping versus that obtained by direct sequencing showed minor discrepancies in some cases, but these were not unexpected given the technical differences in the methodologies. Fluorescence-based typing of microsatellites in the MHC described herein is highly efficient, accurate, and reproducible, and will allow comparison of results between laboratories.Type of Medium: Electronic ResourceURL: -
20Tinge, Jenny P. -Y. ; Carrington, M. N. ; Salter, R. D. ; DeMars, R. ; Cresswell, P.
Springer
Published 1985Staff ViewISSN: 1432-1211Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Abstract We examined the possibility that one mechanism for controlling HLA-DR-α gene expression involves the alteration of chromatin structure. Chromatin structure was analyzed by measuring the susceptibility of DR α genes in intact nuclei to nuclease treatment. We first examined a somatic cell hybrid of a T-lymphoblastoid cell line (LCL) and a B-LCL, since the DR αgene, which is inactive in the T-LCL parent, is expressed in the hybrid, thus providing a system to study DR αgene induction. The hybrid line 174 × CEM.T1 contains and expresses solely the DR αgene from the T-LCL parent, since the DR αgene from the B-LCL parent, 174, is deleted. Using cytoplasmic dot blot analysis and RNA-DNA Northern hybridization, we detected DR α-specific transcripts in the hybrid, but not in the parental lines, indicating activation of the DR αgene in the hybrid. The transcribed DR αgene from the hybrid was compared with the untranscribed gene from the T-LCL parental line, and an association between DR αgene expression and increased sensitivity to DNase I was observed. A switch in the chromatin structure of the DR αgene from a closed to an open configuration apparently occurred in this hybrid. Such a change is associated with DR αgene expression. Comparison of a DR-positive B-LCL and an isogenic DR-negative T-LCL also showed that the chromatin of the former is more sensitive to DNase I digestion. There were no restriction enzyme fragment length differences between the DR αgenes from 174 × CEM.T1 and CEMR, indicating that the process of somatic cell hybridization did not result in DNA rearrangement or translocation.Type of Medium: Electronic ResourceURL: