Search Results - (Author, Cooperation:M. Carrington)

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  1. 1
    Staff View
    Publication Date:
    2018-01-05
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Geosciences
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Genetics, Immunology
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Staff View
    Publication Date:
    2011-08-27
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Adaptation, Biological ; African Continental Ancestry Group/genetics ; Alleles ; Animals ; Asian Continental Ancestry Group/genetics ; Continental Population Groups/*genetics ; European Continental Ancestry Group/genetics ; Evolution, Molecular ; *Genes, MHC Class I ; Genetic Variation ; HLA-A Antigens/*genetics/immunology/metabolism ; HLA-B Antigens/*genetics/immunology/metabolism ; HLA-C Antigens/*genetics/immunology ; Haplotypes ; Hominidae/*genetics/*immunology ; Humans ; *Hybridization, Genetic ; Killer Cells, Natural/immunology ; Ligands ; Linkage Disequilibrium ; Molecular Sequence Data ; Oceanic Ancestry Group/genetics ; Receptors, KIR/immunology/metabolism ; Selection, Genetic
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    P. Ruibal ; L. Oestereich ; A. Ludtke ; B. Becker-Ziaja ; D. M. Wozniak ; R. Kerber ; M. Korva ; M. Cabeza-Cabrerizo ; J. A. Bore ; F. R. Koundouno ; S. Duraffour ; R. Weller ; A. Thorenz ; E. Cimini ; D. Viola ; C. Agrati ; J. Repits ; B. Afrough ; L. A. Cowley ; D. Ngabo ; J. Hinzmann ; M. Mertens ; I. Vitoriano ; C. H. Logue ; J. P. Boettcher ; E. Pallasch ; A. Sachse ; A. Bah ; K. Nitzsche ; E. Kuisma ; J. Michel ; T. Holm ; E. G. Zekeng ; I. Garcia-Dorival ; R. Wolfel ; K. Stoecker ; E. Fleischmann ; T. Strecker ; A. Di Caro ; T. Avsic-Zupanc ; A. Kurth ; S. Meschi ; S. Mely ; E. Newman ; A. Bocquin ; Z. Kis ; A. Kelterbaum ; P. Molkenthin ; F. Carletti ; J. Portmann ; S. Wolff ; C. Castilletti ; G. Schudt ; A. Fizet ; L. J. Ottowell ; E. Herker ; T. Jacobs ; B. Kretschmer ; E. Severi ; N. Ouedraogo ; M. Lago ; A. Negredo ; L. Franco ; P. Anda ; S. Schmiedel ; B. Kreuels ; D. Wichmann ; M. M. Addo ; A. W. Lohse ; H. De Clerck ; C. Nanclares ; S. Jonckheere ; M. Van Herp ; A. Sprecher ; G. Xiaojiang ; M. Carrington ; O. Miranda ; C. M. Castro ; M. Gabriel ; P. Drury ; P. Formenty ; B. Diallo ; L. Koivogui ; N. Magassouba ; M. W. Carroll ; S. Gunther ; C. Munoz-Fontela
    Nature Publishing Group (NPG)
    Published 2016
    Staff View
    Publication Date:
    2016-05-07
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    CTLA-4 Antigen/metabolism ; Ebolavirus/*immunology ; Female ; Flow Cytometry ; Guinea/epidemiology ; Hemorrhagic Fever, Ebola/*immunology/mortality/*physiopathology ; Humans ; Inflammation Mediators/immunology ; Longitudinal Studies ; Lymphocyte Activation ; Male ; Patient Discharge ; Programmed Cell Death 1 Receptor/metabolism ; Survivors ; T-Lymphocytes/*immunology/metabolism ; Viral Load
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  4. 4
    Staff View
    Publication Date:
    2011-04-19
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    3' Untranslated Regions/genetics ; Alleles ; Base Sequence ; Cell Line ; *Gene Expression Regulation/genetics/immunology ; Genes, Reporter/genetics ; HIV/*immunology ; HIV Infections/*genetics/*immunology/therapy ; HLA-C Antigens/*genetics ; Humans ; MicroRNAs/*genetics ; Polymorphism, Single Nucleotide/genetics ; Viral Load
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  5. 5
    R. Apps ; M. Carrington
    American Association for the Advancement of Science (AAAS)
    Published 2013
    Staff View
    Publication Date:
    2013-09-14
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    *Gene Expression Regulation ; HIV/*immunology ; HIV Infections/*genetics/*immunology ; HLA-C Antigens/*genetics ; Humans ; T-Lymphocytes, Cytotoxic/*immunology
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  6. 6
    Staff View
    Publication Date:
    2013-04-06
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    African Americans/genetics ; Alleles ; Amino Acid Sequence ; Anti-Retroviral Agents/therapeutic use ; Crohn Disease/genetics/immunology ; *Gene Expression Regulation ; HIV/genetics/*immunology ; HIV Infections/drug therapy/*genetics/*immunology ; HLA-C Antigens/*genetics ; Humans ; Immunodominant Epitopes/genetics ; Molecular Sequence Data ; Mutation ; Peptide Fragments/immunology ; Polymorphism, Single Nucleotide ; T-Lymphocytes, Cytotoxic/*immunology ; Viral Load/genetics
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  7. 7
    Staff View
    Publication Date:
    2011-08-05
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Adaptation, Physiological/genetics/*immunology ; Antibodies, Neutralizing/immunology ; CD4-Positive T-Lymphocytes/immunology/virology ; Decision Trees ; *Evolution, Molecular ; Genotype ; HIV Infections/*immunology/*virology ; HIV-1/genetics/*immunology/physiology ; Host-Pathogen Interactions/immunology ; Human Immunodeficiency Virus Proteins/genetics/immunology/metabolism ; Humans ; Immune Evasion/*immunology ; Killer Cells, Natural/*immunology ; Polymorphism, Genetic ; Receptors, KIR/deficiency/genetics/immunology/metabolism ; Receptors, KIR2DL2/chemistry/deficiency/genetics/immunology ; Viral Regulatory and Accessory Proteins/genetics/immunology/metabolism ; Virus Replication ; env Gene Products, Human Immunodeficiency Virus/genetics/immunology/metabolism
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  8. 8
    Staff View
    Publication Date:
    2018-02-14
    Publisher:
    The American Society for Microbiology (ASM)
    Print ISSN:
    0022-538X
    Electronic ISSN:
    1098-5514
    Topics:
    Medicine
    Published by:
    http://www.asm.org/

    Latest Papers from Table of Contents or Articles in Press
  9. 9
    Staff View
    Publication Date:
    2018-01-31
    Publisher:
    The American Society for Microbiology (ASM)
    Print ISSN:
    0022-538X
    Electronic ISSN:
    1098-5514
    Topics:
    Medicine
    Published by:
    http://www.asm.org/

    Latest Papers from Table of Contents or Articles in Press
  10. 10
    Staff View
    ISSN:
    1546-170X
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Medicine
    Notes:
    [Auszug] Major histocompatibility complex (MHC) genes (HLA in humans) regulate the immune response to foreign antigens. Molecular and serologic techniques were used to identify products of HLA class I, class II and transporter (TAP) genes (also part of the MHC) in homosexual seroconverters to human ...
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1038/nm0496-405

    Articles: DFG German National Licenses
  11. 11
    Staff View
    ISSN:
    0022-2836
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/S0022-2836(05)80066-X

    Articles: DFG German National Licenses
  12. 12
    Staff View
    ISSN:
    0166-6851
    Keywords:
    Antigen ; Polymorphism ; Sporozoite ; Theileria ; Vaccine ; [abr] RFLP; restriction fragment length polymorphism
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0166-6851(94)90090-6

    Articles: DFG German National Licenses
  13. 13
    Carrington, M. ; Walters, D. ; Webb, H.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0309-1651
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0309-1651(91)90058-Q

    Articles: DFG German National Licenses
  14. 14
    Yeager, M. ; Carrington, M. ; Hughes, A. L.
    Springer
    Published 2000
    Staff View
    ISSN:
    1432-1211
    Keywords:
    Key words Antigen presentation ; Autoimmune disease ; Evolution ; MHC ; Self peptides
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Notes:
    Abstract  Comparison of peptides eluted from human class I and class II major histocompatibility complex (MHC) molecules and the proteins from which they are derived (source proteins) revealed that class I MHC bind peptides derived from proteins that are highly conserved, hydrophilic, and universally expressed, while the peptides themselves are hydrophobic and even more conserved than their source proteins. In contrast, source proteins for class II-bound peptides were not significantly more conserved than a random sample of proteins. Class II-bound peptides were generally more conserved than their source proteins but were significantly less conserved than class I-bound peptides. The characteristics of class I-bound peptides can probably be explained by the selectivity of processing and transport of peptides for binding by class I, while the relative lack of selectivity of peptide binding for class II may explain the high incidence of autoimmune diseases associated with alleles of these molecules.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s002510050002

    Articles: DFG German National Licenses
  15. 15
    Staff View
    ISSN:
    0166-6851
    Keywords:
    Gene family ; Stage specific transcription ; Theileria parva ; [abr] ECF; East Coast Fever ; [abr] ORF; open reading frame ; [abr] RFLP; restriction fragment length polymorphism ; [abr] SDS; sodium dodecyl sulphate ; [abr] SSC; saline sodium citrate
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0166-6851(91)90136-T

    Articles: DFG German National Licenses
  16. 16
    Baylis, H.A. ; Allsopp, B.A. ; Hall, R. ; Carrington, M.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0166-6851
    Keywords:
    Glutamine-rich protein ; Proline rich protein ; Repeated sequence ; Schizont ; Theileria parva ; [abr] GST; glutathione S-transferase ; [abr] IFA; Indirect immunofluorescence assay ; [abr] PAGE; polyacrylamide gel electrophoresis ; [abr] SSC; standard saline citrate
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0166-6851(93)90063-4

    Articles: DFG German National Licenses
  17. 17
    Staff View
    ISSN:
    1432-1211
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s002510050392

    Articles: DFG German National Licenses
  18. 18
    Staff View
    ISSN:
    1432-1211
    Keywords:
    Key words Interferon gamma ; Polymorphism ; Promoter ; AIOS ; 3′UTR
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Notes:
    Abstract  Interferon gamma (IFN-gamma) is a multifunctional cytokine that is essential in the development of Th1 cells and in cellular responses to a variety of intracellular pathogens including human immunodeficiency virus (HIV-1). We screened genomic DNA samples from a predominately Caucasian male population of HIV-infected and healthy donors for polymorphisms in the human IFNG gene from –777 to +5608 by single-stranded conformational polymorphism. Surprisingly, the proximal promoter (–777 to transcription start) is invariant as no polymorphisms were found in over 100 samples tested. However, further screening revealed polymorphisms in other regions of the gene including a single base insertion in a poly-T tract in the first intron, three single base pair substitutions in the third intron, and another single base pair substitution in the 3′ untranslated region (UTR). Electrophoretic mobility shift assay was used to investigate whether these variants have altered DNA-binding abilities, since intronic enhancer elements have been reported for the IFNG gene. Oligonucleotides constructed for two third intron variants showed no difference in DNA-binding abilities as compared with wild-type sequences. However, the 3′UTR variant showed the formation of unique DNA-binding complexes to radiolabeled oligonucleotide probes as compared with the wild-type sequence. The influence of a CA-repeat microsatellite on AIDS disease progression in HIV-1 seroconverters was tested by a Cox proportional hazards model. There is no evidence of an association between alleles and infection with HIV-1 or progression to AIDS. We report an invariant proximal human IFNG promoter and the existence of multiple intronic variants and a potentially functional 3′UTR polymorphism.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s002510050008

    Articles: DFG German National Licenses
  19. 19
    Staff View
    ISSN:
    1432-1211
    Keywords:
    Key words HLA ; Microsatellite loci ; Microsatellite typing ; Human ; MHC
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Notes:
    Abstract  The human genome contains a large number of interspersed microsatellite repeats which exhibit a high degree of polymorphism and are inherited in a Mendelian fashion, making them extremely useful genetic markers. Several microsatellites have been described in the HLA region, but allele nomenclature, a set of broadly distributed controls, and typing methods have not been standardized, which has resulted in discrepant microsatellite data between laboratories. In this report we present a detailed protocol for genotyping microsatellites using a semi-automated fluorescence-based method. Twelve microsatellites within or near the major histocompatibility complex (MHC) were typed in the 10th International Histocompatibility Workshop homozygous typing cell lines (HTCs) and alleles were designated based on size. All loci were sequenced in two HTCs providing some information on the level of complexity of the repeat sequence. A comparison of allele size obtained by genotyping versus that obtained by direct sequencing showed minor discrepancies in some cases, but these were not unexpected given the technical differences in the methodologies. Fluorescence-based typing of microsatellites in the MHC described herein is highly efficient, accurate, and reproducible, and will allow comparison of results between laboratories.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s002510050338

    Articles: DFG German National Licenses
  20. 20
    Staff View
    ISSN:
    1432-1211
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Notes:
    Abstract We examined the possibility that one mechanism for controlling HLA-DR-α gene expression involves the alteration of chromatin structure. Chromatin structure was analyzed by measuring the susceptibility of DR α genes in intact nuclei to nuclease treatment. We first examined a somatic cell hybrid of a T-lymphoblastoid cell line (LCL) and a B-LCL, since the DR αgene, which is inactive in the T-LCL parent, is expressed in the hybrid, thus providing a system to study DR αgene induction. The hybrid line 174 × CEM.T1 contains and expresses solely the DR αgene from the T-LCL parent, since the DR αgene from the B-LCL parent, 174, is deleted. Using cytoplasmic dot blot analysis and RNA-DNA Northern hybridization, we detected DR α-specific transcripts in the hybrid, but not in the parental lines, indicating activation of the DR αgene in the hybrid. The transcribed DR αgene from the hybrid was compared with the untranscribed gene from the T-LCL parental line, and an association between DR αgene expression and increased sensitivity to DNase I was observed. A switch in the chromatin structure of the DR αgene from a closed to an open configuration apparently occurred in this hybrid. Such a change is associated with DR αgene expression. Comparison of a DR-positive B-LCL and an isogenic DR-negative T-LCL also showed that the chromatin of the former is more sensitive to DNase I digestion. There were no restriction enzyme fragment length differences between the DR αgenes from 174 × CEM.T1 and CEMR, indicating that the process of somatic cell hybridization did not result in DNA rearrangement or translocation.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00430305

    Articles: DFG German National Licenses