Search Results - (Author, Cooperation:M. C. Mihm)

2012-11-06

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Animals ; Cell Line, Tumor ; Cell Proliferation/drug effects ; Gene Expression Regulation/drug effects ; Hair Color/*genetics ; Indoles/pharmacology ; Melanins/metabolism ; Melanoma/*genetics ; Mice ; Mice, Inbred C57BL ; Monophenol Monooxygenase/genetics ; Peroxidases/metabolism ; Protein Kinase Inhibitors/pharmacology ; Proto-Oncogene Proteins B-raf/genetics ; Receptor, Melanocortin, Type 1/genetics ; Skin Pigmentation/*genetics ; Sulfonamides/pharmacology ; Survival Analysis ; Tumor Cells, Cultured ; *Ultraviolet Rays

1600-0560

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Image analysis of histologic sections of II patients with clinical Stage 1 melanoma, 1.00 mm – 2.50 mm, who developed metastasis, was done to determine the significance of lymphocytic infiltrates relative to metastasis and survival. An ago, sex, site, and thickness matched control group of non-metastasizing clinical Stage 1 melanoma revealed no significant difference in the lymphocytic infiltrate parameters from the metastasizing group with the exception of the ratio of lymphocyte infiltrate width lo the tumor width (p = 0.003). Increased lymphocytic infiltrates within the tumor and subjacent lo its base significantly correlated with delayed lime to metastasis (p = 0.014 and p 〈 0.001, respectively) and longer survival period (p = 0.045 and p 〈 0.001, respectively). Lymphocytic infiltrate area at the tumor base in relation to tumor area was of prognostic value: the larger the ratio, the greater the time interval from metastasis to death (p = 0.008).

Electronic Resource

1600-0560

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

We report a case of melanoma arising in a large nevus spilus. On histologic examination, the nexus spilus had diagnostic' features of melanocytic dysplasia. Further characterization by flow cytometry showed DNA-aneuploidy within the melanoma as well as in one of the darker pigmented papules within the nevus spilus. The significance of this finding and a review of melanomas originating in nevi spili are presented.

Electronic Resource

1600-0560

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

The relationship between the disorder known in Japanese and Chinese literature as Kimura's disease and that known in Western literature as angiolymphoid hyperplasia with eosinophilia (ALHE) has been the subject of debate. Many reports have used the terms synonymously. We have reviewed the histological and clinical features of 4 cases, all occurring in Caucasians, 2 of which are typical of Kimura's disease and 2 of ALHE. Analysis of the cases indicates that the histological features of the 2 disorders are sufficiently different to warrant their recognition as 2 distinct entities. The histological and clinical features of Kimura's disease are most consistent with an allergic or autoimmune process in which blood vessels, lymphocytes and eosinophils participate. Those of ALHE suggest a primary, probably neoplastic disorder of vascular endothelium with a variable and secondary inflammatory response. Although there is some clinical overlap between patients with the 2 disorders, the histological features are distinctive, and the 2 terms should not be used synonymously.

Electronic Resource

1600-0560

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Electronic Resource

1365-2559

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Dermal dendritic melanocytic proliferations are a broad group of congenital and acquired melanocytic lesions characterized by the presence of dermal spindled and dendritic cells resembling melanocytes migrating from the neural crest to the epidermis. Historically, they were subdivided into dermal melanocytoses (naevus of Ota, Ito, Mongolian spot and related conditions), blue naevi and malignant blue naevi. The purpose of this review is to provide an update on recent developments in the field with emphasis on new entities and their differential diagnosis.

Electronic Resource

1365-2133

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Biopsy specimens of papules taken from eight patients with polymorphic light eruption were examined by immunoperoxidase techniques employing monoclonal antibodies. In each case, most infiltrating mononuclear cells were T cells. The majority of T cells were T8-positive (cytotoxic/suppressor) in four cases and T4-positive (helper/inducer) in two. In two cases, approximately equal numbers of both T cell subsets were present. In only three cases were rare B cells identified by their reactivity with anti-IgM antibody. M1-positive mononuclear cells (macrophages) represented less than 5% of cells infiltrating the dermis. In five subjects, anti-T6 antibody stained increased numbers of dermal mononuclear cells considered to be Langerhans/indeterminate cells. The pathogenesis of papular polymorphic light eruption may involve injury to upper dermal venules mediated by T cells and Langerhans/indeterminate cells.

Electronic Resource