Search Results - (Author, Cooperation:M. C. Holmes)
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1Latest Papers from Table of Contents or Articles in PressP. Genovese ; G. Schiroli ; G. Escobar ; T. Di Tomaso ; C. Firrito ; A. Calabria ; D. Moi ; R. Mazzieri ; C. Bonini ; M. C. Holmes ; P. D. Gregory ; M. van der Burg ; B. Gentner ; E. Montini ; A. Lombardo ; L. Naldini
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-05-30Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Antigens, CD34/metabolism ; DNA, Complementary/genetics ; Endonucleases/metabolism ; Fetal Blood/cytology/metabolism/transplantation ; Gene Targeting/*methods ; Genome, Human/*genetics ; Hematopoiesis/genetics ; Hematopoietic Stem Cell Transplantation ; Hematopoietic Stem Cells/*cytology/*metabolism ; Humans ; Interleukin Receptor Common gamma Subunit/genetics ; Male ; Mice ; Mutation/genetics ; Targeted Gene Repair/*methods ; X-Linked Combined Immunodeficiency Diseases/*genetics/therapyPublished by: -
2Latest Papers from Table of Contents or Articles in PressK. Yusa ; S. T. Rashid ; H. Strick-Marchand ; I. Varela ; P. Q. Liu ; D. E. Paschon ; E. Miranda ; A. Ordonez ; N. R. Hannan ; F. J. Rouhani ; S. Darche ; G. Alexander ; S. J. Marciniak ; N. Fusaki ; M. Hasegawa ; M. C. Holmes ; J. P. Di Santo ; D. A. Lomas ; A. Bradley ; L. Vallier
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-10-14Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Cell Line ; DNA Transposable Elements/genetics ; Hepatocytes/metabolism/transplantation ; Humans ; Induced Pluripotent Stem Cells/*physiology ; Liver/cytology ; Mice ; Serum Albumin/genetics/metabolism ; *Targeted Gene Repair ; Time Factors ; alpha 1-Antitrypsin/*genetics/metabolism ; alpha 1-Antitrypsin Deficiency/*geneticsPublished by: -
3Latest Papers from Table of Contents or Articles in PressH. Li ; V. Haurigot ; Y. Doyon ; T. Li ; S. Y. Wong ; A. S. Bhagwat ; N. Malani ; X. M. Anguela ; R. Sharma ; L. Ivanciu ; S. L. Murphy ; J. D. Finn ; F. R. Khazi ; S. Zhou ; D. E. Paschon ; E. J. Rebar ; F. D. Bushman ; P. D. Gregory ; M. C. Holmes ; K. A. High
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-06-28Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Base Sequence ; Cell Line, Tumor ; DNA Breaks, Double-Stranded ; DNA Repair/*genetics ; *Disease Models, Animal ; Endonucleases/chemistry/genetics/metabolism ; Exons/genetics ; Factor IX/analysis/genetics ; Gene Targeting/*methods ; Genetic Therapy/*methods ; Genetic Vectors/genetics ; Genome/*genetics ; HEK293 Cells ; Hemophilia B/*genetics/physiopathology ; *Hemostasis ; Humans ; Introns/genetics ; Liver/metabolism ; Liver Regeneration ; Mice ; Mice, Inbred C57BL ; Mutation/genetics ; Phenotype ; Sequence Homology ; Zinc FingersPublished by: -
4Articles: DFG German National LicensesSomponpun, S. J. ; Holmes, M. C. ; Seckl, J. R. ; Russell, J. A.
Oxford, UK : Blackwell Science Ltd
Published 2004Staff ViewISSN: 1365-2826Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Magnocellular neurosecretory neurones in the hypothalamic paraventricular (PVN) and supraoptic (SON) nuclei express oestrogen receptor β (ERβ) but not ERα. In the PVN, ERβ is strongly expressed in the ventromedial parvocellular neurones projecting to the brainstem. We used quantitative in situ hybridization, with 35S-labelled riboprobes, to study heterologous regulation by manipulating adrenal steroid hormones (72 h after adrenalectomy ± corticosterone replacement; repeated stress: halothane inhalation, environmental cold, immobilization, each daily for 3 days) in male rats. Adrenalectomy increased ERβ mRNA expression in the magnocellular PVN and SON, by 2.2 and 2.5-fold, respectively, with no effect in the ventromedial parvocellular PVN neurones. Corticosterone replacement partially prevented the increases in ERβ mRNA expression in magnocellular PVN and SON neurones. Repeated stress over 72 h had no effect on ERβ mRNA expression in the magnocellular PVN or SON, but increased expression 1.4-fold in the ventromedial parvocellular PVN neurones. Although consequences of hydromineral balance derangement after adrenalectomy may stimulate magnocellular neurones, strongly stimulating the neurones by giving intact male rats 2% saline to drink for 72 h decreased ERβ mRNA expression in the magnocellular PVN and SON neurones by approximately 60%, and in the ventromedial parvocellular PVN neurones by 13%. Thus, ERβ mRNA expression is negatively regulated by basal glucocorticoid secretion in magnocellular PVN and SON neurones, and positively regulated by stress in ventromedial parvocellular PVN neurones. However, ERβ mRNA expression in magnocellular neurones is negatively linked to hyperosmotic stimulation of the neurones. The 6.25-fold variation in ERβ mRNA expression in magnocellular neurones from salt-loading to adrenalectomy could alter their sensitivity to oestrogens. Consequently, regulation of oxytocin and vasopressin neurone activity via ERβ is expected to vary according to their functional state and, in particular, on basal glucocorticoid actions.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesBAERTSCHI, A. J. ; GÄHWILER, B. ; ANTONI, F. A. ; HOLMES, M. C. ; MAKARA, G. B.
[s.l.] : Nature Publishing Group
Published 1984Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] RECENTLY, Mormède1 reported that exposure of conscious rats to a novel environment induced the secretion of adrenocorticotropic hormone (ACTH) and corticosterone. As this secretion could not be blocked by an anti-pressor vasopressin antagonist, 1-deaminopenicil-lamine, 2-(O-methyl)tyrosine ...Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] (1) Two conducting wires or rods about five feet in length are stretched in a wedge shape, the gap being one-half inch at the bottom and three-quarters of an inch at the top. The upper three feet of the wires are covered with a glass tube. It is well known that if an induction coil is connected ...Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 1435-1536Source: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyMechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsType of Medium: Electronic ResourceURL: