Search Results - (Author, Cooperation:M. Bushell)
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1Latest Papers from Table of Contents or Articles in PressH. A. Meijer ; Y. W. Kong ; W. T. Lu ; A. Wilczynska ; R. V. Spriggs ; S. W. Robinson ; J. D. Godfrey ; A. E. Willis ; M. Bushell
American Association for the Advancement of Science (AAAS)
Published 2013Staff ViewPublication Date: 2013-04-06Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Eukaryotic Initiation Factor-4A/*biosynthesis ; *Gene Expression Regulation ; HEK293 Cells ; HeLa Cells ; Humans ; MicroRNAs/*metabolism ; *Protein Biosynthesis ; *RNA Stability ; RNA, Messenger/*metabolismPublished by: -
2Latest Papers from Table of Contents or Articles in PressW. J. Faller ; T. J. Jackson ; J. R. Knight ; R. A. Ridgway ; T. Jamieson ; S. A. Karim ; C. Jones ; S. Radulescu ; D. J. Huels ; K. B. Myant ; K. M. Dudek ; H. A. Casey ; A. Scopelliti ; J. B. Cordero ; M. Vidal ; M. Pende ; A. G. Ryazanov ; N. Sonenberg ; O. Meyuhas ; M. N. Hall ; M. Bushell ; A. E. Willis ; O. J. Sansom
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-11-11Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adenomatous Polyposis Coli Protein/deficiency/genetics ; Animals ; Cell Proliferation ; Cell Transformation, Neoplastic/metabolism/*pathology ; Elongation Factor 2 Kinase/deficiency/genetics/metabolism ; Enzyme Activation ; Genes, APC ; Intestinal Neoplasms/genetics/*metabolism/*pathology ; Male ; Mice ; Mice, Inbred C57BL ; Multiprotein Complexes/*metabolism ; Oncogene Protein p55(v-myc)/metabolism ; *Peptide Chain Elongation, Translational ; Peptide Elongation Factor 2/metabolism ; Ribosomal Protein S6 Kinases/metabolism ; Signal Transduction ; TOR Serine-Threonine Kinases/*metabolism ; Wnt Proteins/metabolismPublished by: -
3Latest Papers from Table of Contents or Articles in PressJ. A. Moreno ; H. Radford ; D. Peretti ; J. R. Steinert ; N. Verity ; M. G. Martin ; M. Halliday ; J. Morgan ; D. Dinsdale ; C. A. Ortori ; D. A. Barrett ; P. Tsaytler ; A. Bertolotti ; A. E. Willis ; M. Bushell ; G. R. Mallucci
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-05-25Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Cell Death/drug effects ; Cinnamates/pharmacology ; Eukaryotic Initiation Factor-2/analysis/*chemistry/*metabolism ; Hippocampus/cytology/metabolism/pathology ; Kaplan-Meier Estimate ; Mice ; Mice, Inbred C57BL ; Neurodegenerative Diseases/etiology/*metabolism/pathology ; Neurons/drug effects/pathology ; Neuroprotective Agents ; Phosphoproteins/analysis/*metabolism ; Phosphorylation ; PrPSc Proteins/analysis/metabolism/toxicity ; Prion Diseases/pathology ; Prions/biosynthesis/genetics/*metabolism ; *Protein Biosynthesis/drug effects ; Protein Folding/drug effects ; Protein Phosphatase 1/genetics/metabolism ; Repressor Proteins/analysis/chemistry/*metabolism ; Synapses/drug effects/metabolism/pathology ; Synaptic Transmission/drug effects ; Thiourea/analogs & derivatives/pharmacology ; Unfolded Protein Response/physiologyPublished by: -
4Articles: DFG German National LicensesStaff View
ISSN: 1432-1041Keywords: captopril ; enalapril ; asthma ; histamine inhalation test ; cough threshold ; atenolol ; metoprololSource: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyMedicineNotes: Summary The non-specific bronchial reactivity and cough threshold of hypertensive patients on an ACE-I monotherapy regimen (either captopril or enalapril), a β1-antagonist monotherapy regimen (either atenolol or metoprolol) or a combination of an ACE-I with a β1-antagonist were determined in the present study. Forty-six hypertensives who were on these medications performed a histamine inhalation test (to assess bronchial reactivity) and a further 36 of these individuals participated in the citric acid test (to assess cough threshold). A control cohort consisting of 25 age-matched, drug-free subjects also performed the citric acid test. The incidence of bronchial hyperreactivity was not significantly different between the ACE-I monotherapy regimen and the β1-antagonist monotherapy regimen (Chi-squared =0.248). However, when the monotherapy regimens were pooled and compared with the ACE-I and β1-antagonist combination regimen, the combination regimen was found to be associated with a significantly higher incidence of bronchial hyperreactivity (Chi-squared =6.69). No difference was observed between the age-matched controls and the hypertensive patients in terms of their cough threshold.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesBushell, M. E. ; Bell, S. L. ; Scott, M. F. ; Snell, K. ; Spier, R. E. ; Wardell, J. N. ; Sanders, P. G.
New York, NY [u.a.] : Wiley-Blackwell
Published 1993Staff ViewISSN: 0006-3592Keywords: hybridoma ; kinetics ; curve fitting ; fermentation ; Chemistry ; Biochemistry and BiotechnologySource: Wiley InterScience Backfile Collection 1832-2000Topics: BiologyProcess Engineering, Biotechnology, Nutrition TechnologyNotes: The use of partial cubic spline data interpolation for the calculation of volumetric metabolite exchange rates suggested the existence of three distinct metabolic phases during bioreactor culture of a hybridoma cell line. During phase 1, a rapid amino acid uptake rate and ammonia release rate were observed. The growth rate was low and glutamine synthetase activity fell. In phase 2, maximum growth rate and minimum glutamine assimilation and ammonium production rates were observed. Attempts to corroborate the apparent ammonia assimilation in this phase using 15NH4Cl resulted in low incorporation rates into alanine and glutamine. Maximum glutamine synthetase activity took place during this period. Maximum antibody production rate was observed during phase 3 during which peaks in glutamine assimilation, ammonia release, and glutamine synthetase activity were observed. The apparent existence of the three phases prompted us to carry out Northern blot analysis of glutamine synthetase RNA at appropriate times during the process. This revealed a pattern of appearance and dis-appearance of mRNA consistent with the three phases indicated by the fermentation parameters. © 1993 John Wiley & Sons, Inc.Additional Material: 7 Ill.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesBushell, M. E. ; Bell, S. L. ; Scott, M. F. ; Spier, R. E. ; Wardell, J. N. ; Sanders, P. G.
New York, NY [u.a.] : Wiley-Blackwell
Published 1994Staff ViewISSN: 0006-3592Keywords: hybridoma ; fed batch ; materials balancing ; fermentation ; Chemistry ; Biochemistry and BiotechnologySource: Wiley InterScience Backfile Collection 1832-2000Topics: BiologyProcess Engineering, Biotechnology, Nutrition TechnologyNotes: Hybridoma batch cultures were extended using feed formulations based on nutrient consumption measured during different batch culture phases when (a) growth but negligible antibody production was taking place; (b) maximum antibody production rate and declining viable cell growth rate were observed. Strategy (a) was the more successful (2.8-fold compared with 1.8-fold antibody titer increase) and maintained cell viability for longer. Analysis of the effects of omitting individual amino acids yielded results which were consistent with those from the feeding experiment © 1994 John Wiley & Sons, Inc.Additional Material: 8 Ill.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 0268-2575Keywords: Chemistry ; Biochemistry and BiotechnologySource: Wiley InterScience Backfile Collection 1832-2000Topics: Process Engineering, Biotechnology, Nutrition TechnologyNotes: No Abstracts.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 0268-2575Keywords: Chemistry ; Biochemistry and BiotechnologySource: Wiley InterScience Backfile Collection 1832-2000Topics: Process Engineering, Biotechnology, Nutrition TechnologyType of Medium: Electronic ResourceURL: