Search Results - (Author, Cooperation:M. Bush)
-
1Staff View
Publication Date: 2013-12-07Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Apoproteins/chemistry/metabolism ; Binding Sites ; Crystallography, X-Ray ; Disulfides/chemistry/metabolism ; GABA-B Receptor Agonists/pharmacology ; GABA-B Receptor Antagonists/pharmacology ; Humans ; Ligands ; Models, Molecular ; Protein Multimerization ; Protein Structure, Tertiary ; Protein Subunits/chemistry/metabolism ; Receptors, GABA-B/*chemistry/*metabolism ; Substrate SpecificityPublished by: -
2Nolan, C., Overpeck, J. T., Allen, J. R. M., Anderson, P. M., Betancourt, J. L., Binney, H. A., Brewer, S., Bush, M. B., Chase, B. M., Cheddadi, R., Djamali, M., Dodson, J., Edwards, M. E., Gosling, W. D., Haberle, S., Hotchkiss, S. C., Huntley, B., Ivory, S. J., Kershaw, A. P., Kim, S.-H., Latorre, C., Leydet, M., Lezine, A.-M., Liu, K.-B., Liu, Y., Lozhkin, A. V., McGlone, M. S., Marchant, R. A., Momohara, A., Moreno, P. I., Müller, S., Otto-Bliesner, B. L., Shen, C., Stevenson, J., Takahara, H., Tarasov, P. E., Tipton, J., Vincens, A., Weng, C., Xu, Q., Zheng, Z., Jackson, S. T.
American Association for the Advancement of Science (AAAS)
Published 2018Staff ViewPublication Date: 2018-08-31Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyGeosciencesComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Atmospheric Science, EcologyPublished by: -
3Fain, S. C. ; Barry, K. A. ; Bush, M. G. ; Pittenger, B. ; Louie, R. N.
Woodbury, NY : American Institute of Physics (AIP)
Published 2000Staff ViewISSN: 1077-3118Source: AIP Digital ArchiveTopics: PhysicsNotes: A method to measure the average normal force on a surface produced by intermittent-contact (tapping) force microscopy is presented. This force is determined by measuring the average deflection of a calibrated piezoresistive cantilever in intermittent contact with an oscillating active cantilever. Results obtained with this method are presented for a two-state cantilever motion where the piezolever force is higher for the state with the lower amplitude of vibration. © 2000 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
4Staff View
ISSN: 1089-7666Source: AIP Digital ArchiveTopics: PhysicsNotes: A viscous jet is not usually observed to separate from a sharp edge in the manner expected theoretically. In the present paper the separation of a creeping jet emerging from a tube with a rounded exit is considered. As a separation criterion, in the absence of surface tension, we propose that the traction normal to the nozzle surface drops to zero at the separation point. Boundary-element calculations then show a behavior that agrees with experimental data and with previous finite-element computations. They also permit the Michael condition to be observed at separation, so that the discrepancy between finite-element calculations and theory is removed.Type of Medium: Electronic ResourceURL: -
5Staff View
ISSN: 0011-2240Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
6Staff View
ISSN: 1399-3054Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyNotes: The relative growth rate of pot-grown plants of Poa pratensis L. cv. Holt, origin 69s°N, was increased by 20–40% by photoperiod extension with low intensity incandescent light from 8 to 24 h at 9–21°C. The main increase occurred over the 14 to 18 h photoperiod range. The true photoperiodic nature of the response was demonstrated by the effectiveness of night interruption in stimulating growth. Fortnightly sprayings with gibberellic acid (GA3) (3 × 10-6 to 3 × 10-5M) mimicked all the effects of long days, whereas (2-chloroethyl)-trimethylammonium chloride (CCC) counteracted the effects of long days. Both growth substances exhibited pronounced interactions with photoperiod, GA3 being most effective in short days and CCC in long days. The growth stimulation, whether caused by long days or GA3, was exerted mainly through increases in individual and total leaf area. This was associated with a reduction in CO2, exchange rate and a parallel fall in specific leaf weight. Proportionally, however, the increase in leaf area was greater than the fall in CO2 exchange rate, resulting in a 38 to 118% increase in photosynthesis per leaf. No evidence was found of any direct and promotive effect of transition to long days on the CO2 exchange rate of already expanded leaves.Type of Medium: Electronic ResourceURL: -
7Powell, J. S. ; Bush, M. ; Harrison, J. ; Abildgaard, C. ; Vosburgh, E. ; Thompson, A. R. ; Hurst, D.
Oxford UK : Blackwell Science Ltd
Published 2000Staff ViewISSN: 1365-2516Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Plasma-derived factor VIII concentrates remain an important resource for haemophilia A patients. To improve the safety of these preparations, various methods of viral removal and inactivation have been used that are designed to eliminate both enveloped and non-enveloped viruses. There have been rare reports that some viral inactivation processes altered the immunogenicity of some concentrates, leading to the development of factor VIII inhibitors in previously treated haemophilia A patients. This study evaluated the safety, efficacy and lack of neo-antigenicity of a highly purified factor VIII preparation which undergoes both solvent/detergent treatment and final dry heat treatment at 80 °C for 72 h. The study included: (i) a single blind, single-dose crossover pharmacokinetic study in 18 previously treated patients, comparing sibling lots of the unheated preparation (Koate®-HP) and the heat-treated preparation (Koate®-DVI), and (ii) an extended home treatment programme for 36 patients at two haemophilia treatment centres primarily to assess immunogenicity. Clinical parameters were assessed at regular intervals. The results confirm that Koate®-HP and Koate®-DVI are bioequivalent, and that Koate®-DVI is safe and efficacious for treatment of acute bleeding episodes and for surgery. Furthermore, the heat-treated preparation is not associated with the development of inhibitors in previously treated patients.Type of Medium: Electronic ResourceURL: -
8Staff View
ISSN: 0011-2240Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
9Staff View
ISSN: 0891-5849Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyMedicineType of Medium: Electronic ResourceURL: -
10Staff View
ISSN: 0013-8266Topics: HistoryURL: -
11Staff View
ISSN: 0022-328XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
12Staff View
ISSN: 1399-3054Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: BiologyNotes: Flowering in Poa pratensis L. cv. Holt and Bromus inermis Leyss. cv. Manchar requires exposure to short days (SD) for primary induction to occur, followed by long days (LD) to allow the inflorescence to develop. Weekly sprays with gibberellic acid (GA3) during primary induction inhibited flower initiation in both P. pratensis and B. inermis. With 10−4M GA3 flowering of P. pratensis was suppressed even after an induction period of 10 weeks. Since both GA3 and non-inductive LD conditions greatly stimulate leaf elongation, the degree of primary induction was closely negatively correlated with plant height (leaf sheath and blade length) at the end of the induction period. GA3 application or the interpolation of LD during SD induction were most inhibitory during the later middle part of the SD period, whereas they were stimulatory near the beginning or immediately before the SD period. We suggest that changes in the portfolio or levels of endogenous gibberellins mediate photoperiodic control of growth and floral initiation in these plants. However, GA3 sprays could not substitute for LD in causing heading and culm elongation in SD induced plants of the two species. The results are discussed in the light of results with other plants with dual floral induction requirements.Type of Medium: Electronic ResourceURL: -
13Staff View
ISSN: 1433-3023Keywords: Micturition ; Muscle force ; Pelvic floor ; Urethral resistance ; Urine flowSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Our objective was to analyze the factors contributing to the development of detrusor pressure during micturition in the female with reference to a mathematical model. One hundred patients with predominantly stress incontinence were investigated with micturition pressure studies. Frictional and dynamic losses were estimated at various flow rates using a mathematical model. Almost 25% of patients recorded a micturition pressure below 11 cmH2O at peak flow (mean 23 cmH2O, range 0–91). Large inter- and intrapatient variations in micturition pressures were recorded on retesting. The low pressures were explained by a recently described external opening mechanism, backward stretching of the vagina during micturition by the muscles of the pelvic floor. This opened out the outflow tract and created the potential for a falsely high Pabd. The large variability in micturition pressures on retesting was attributed to changes in urethral radius being magnified to the fourth power. It was concluded that, micturition itself, and the components for pressure generation, are complex non-linear entities which appear to be greatly modified by the external striated pelvic floor opening mechanism. Addressing anatomical defects in this mechanism may be a fruitful route of future enquiry in females with emptying problems.Type of Medium: Electronic ResourceURL: -
14Staff View
ISSN: 0093-691XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: MedicineType of Medium: Electronic ResourceURL: -
15Staff View
ISSN: 0093-691XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: MedicineType of Medium: Electronic ResourceURL: -
16Staff View
ISSN: 0093-691XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: MedicineType of Medium: Electronic ResourceURL: -
17Staff View
ISSN: 0093-691XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: MedicineType of Medium: Electronic ResourceURL: -
18Wildt, D.E. ; Schiewe, M.C. ; Schmidt, P.M. ; Goodrowe, K.L. ; Howard, J.G. ; Phillips, L.G. ; O'Brien, S.J. ; Bush, M.
Amsterdam : ElsevierStaff ViewISSN: 0093-691XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: MedicineType of Medium: Electronic ResourceURL: -
19Staff View
ISSN: 0093-691XKeywords: Embryo Transfer ; Laparoscopy ; SheepSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: MedicineType of Medium: Electronic ResourceURL: -
20Staff View
ISSN: 0040-4020Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: