Search Results - (Author, Cooperation:M. Boada)
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1S. Heilmann ; D. Drichel ; J. Clarimon ; V. Fernandez ; A. Lacour ; H. Wagner ; M. Thelen ; I. Hernandez ; J. Fortea ; M. Alegret ; R. Blesa ; A. Mauleon ; M. R. Roca ; J. Kornhuber ; O. Peters ; R. Heun ; L. Frolich ; M. Hull ; M. T. Heneka ; E. Ruther ; S. Riedel-Heller ; M. Scherer ; J. Wiltfang ; F. Jessen ; T. Becker ; L. Tarraga ; M. Boada ; W. Maier ; A. Lleo ; A. Ruiz ; M. M. Nothen ; A. Ramirez
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-04-04Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Alzheimer Disease/*genetics ; Female ; Genetic Predisposition to Disease/*genetics ; Genetic Variation/*genetics ; Humans ; Male ; Phospholipase D/*geneticsPublished by: -
2Staff View
Publication Date: 2018-06-22Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyGeosciencesComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Genetics, Medicine, Diseases, Online OnlyPublished by: -
3Boada, M. ; Carrera, M. ; De La Iglesia, C. ; Sandalinas, M. ; Barri, P. N. ; Veiga, A.
Springer
Published 1998Staff ViewISSN: 1573-7330Keywords: diode laser beam ; embryo biopsy ; microdrilling ; preimplantation diagnosis ; zona pellucidaSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Purpose: The use of Tyrode's acid to drill the zona pellucida for embryo biopsy is the most widely used methodology in preimplantation genetic diagnosis. Instead of this, we propose the use of a 1.48-μm diode noncontact laser, which is quicker, simpler, and safer. Methods: The laser beam was tangentially guided to the zona pellucida of the embryo. Depending on zona pellucida measurement, two to four consecutive shots of 8–22 msec were necessary to drill the zona pellucida of the 13 embryos biopsied for two patients (hemophilia carriers). Results: Female embryos were replaced into the uterus of the patients (1.5 embryos/replacement). One single pregnancy was established (33.3% implantation rate). Coculture of untransferable embryos showed a blastocyst rate of 66.7% (4/6) for male embryos and 25% (1/4) for abnormal ones. Conclusions: These results demonstrate the safety and usefulness of laser methodology in preimplantation genetic diagnosis.Type of Medium: Electronic ResourceURL: -
4Staff View
ISSN: 1573-7330Keywords: oocyte aging ; zona pellucida ; mouse oocytes ; scanning electron microscopySource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract In a scanning microscopy study of mouse oocytes from immature, young, and aged females and of oocytes agedin vivo orin vitro, we have observed four types of zona pellucida, which we classify as types A, B, C, and D. Oocyte aging gives rise to a significant increase in predegenerative (type C) oocytes; this type of zona pellucida surface could result from a zona hardening effect and decrease the rate of fertilization of the oocytes affected.Type of Medium: Electronic ResourceURL: -
5Van Golde, R. ; Boada, M. ; Veiga, A. ; Evers, J. ; Geraedts, J. ; Barri, P.
Springer
Published 1999Staff ViewISSN: 1573-7330Keywords: ICSI ; retrospective follow-up ; pregnancy ; childrenSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Purpose: Genetic aspects of male subfertility and the novelty of intracytoplasmic sperm injection (ICSI) as a new technique can influence the development of zygotes and children born after ICSI. Therefore, we evaluated the outcome of ICSI compared to in vitro fertilization (IVF). Methods: Data from medical records of 233 total pregnancies and the follow-up of 132 children born after IVF and 120 after ICSI were retrospectively analyzed. Results: No differences were found between ICSI and IVF for early embryonic development and obstetric outcome. In both groups the rate of women undergoing prenatal chromosomal diagnosis was low, 30.0%. The congenital malformation rate was 3.0% after IVF and 1.7% after ICSI, which was not significantly different. Follow-up on development of children born after IVF and ICSI also showed no significant differences. Conclusions: Our results indicate that at this moment ICSI is a safe procedure. However, a consistent prospective follow-up is still mandatory to exclude possible risks.Type of Medium: Electronic ResourceURL: