Search Results - (Author, Cooperation:M. A. Miller)
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1Latest Papers from Table of Contents or Articles in PressK. McKnight ; H. D. Hoang ; J. K. Prasain ; N. Brown ; J. Vibbert ; K. A. Hollister ; R. Moore ; J. R. Ragains ; J. Reese ; M. A. Miller
American Association for the Advancement of Science (AAAS)
Published 2014Staff ViewPublication Date: 2014-05-17Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Caenorhabditis elegans/genetics/metabolism/*physiology ; Caenorhabditis elegans Proteins/genetics/*metabolism ; Environmental Exposure ; Female ; *Fertilization ; Male ; Neurons, Afferent/*physiology ; Neurosecretory Systems/physiology ; Oocytes/metabolism/physiology ; Ovum/metabolism/physiology ; Perception ; Pheromones/*physiology ; Prostaglandin-Endoperoxide Synthases/metabolism ; Prostaglandins/biosynthesis ; *Sperm Motility ; Spermatozoa/*physiology ; Transforming Growth Factor beta/genetics/*metabolismPublished by: -
2Latest Papers from Table of Contents or Articles in PressJeong, S.-J., Bloom, A. A., Schimel, D., Sweeney, C., Parazoo, N. C., Medvigy, D., Schaepman-Strub, G., Zheng, C., Schwalm, C. R., Huntzinger, D. N., Michalak, A. M., Miller, C. E.
American Association for the Advancement of Science (AAAS)
Published 2018Staff ViewPublication Date: 2018-07-12Publisher: American Association for the Advancement of Science (AAAS)Electronic ISSN: 2375-2548Topics: Natural Sciences in GeneralPublished by: -
3Latest Papers from Table of Contents or Articles in PressBurgess, T. L., Tim Tinker, M., Miller, M. A., Bodkin, J. L., Murray, M. J., Saarinen, J. A., Nichol, L. M., Larson, S., Conrad, P. A., Johnson, C. K.
Royal Society
Published 2018Staff ViewPublication Date: 2018-07-05Publisher: Royal SocietyElectronic ISSN: 2054-5703Topics: Natural Sciences in GeneralKeywords: ecology, health and disease and epidemiologyPublished by: -
4Latest Papers from Table of Contents or Articles in PressYuter, S. E., Hader, J. D., Miller, M. A., Mechem, D. B.
American Association for the Advancement of Science (AAAS)
Published 2018Staff ViewPublication Date: 2018-08-17Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyGeosciencesComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Geochemistry, GeophysicsPublished by: -
5Articles: DFG German National LicensesNoffsinger, A E ; Belli, J M ; Miller, M A ; Fenoglio-Preiser, C M
Oxford UK : Blackwell Science Ltd
Published 2001Staff ViewISSN: 1365-2559Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: A unique basal pattern of p53 expression in ulcerative colitis is associated with mutation in the p53 gene Aims: The p53 protein is implicated in the control of cell proliferation, differentiation, and death. As part of a study characterizing p53 alterations in colonic mucosa of patients with ulcerative colitis, we identified a unique pattern of basal p53 immunoreactivity. Methods and results: Tissue samples (n=180) from 42 ulcerative colitis patients were evaluated for p53 alterations by immunohistochemistry, loss of heterozygosity analysis, polymerase chain reaction-single-strand conformation polymorphism and direct sequencing. In addition, the expression of the p53- associated proteins p21waf1/cip1 and MDM2 was evaluated immunohistochemically. Three basic patterns of p53 immunoreactivity were observed: (i) isolated immunoreactive cells in the crypt bases; (ii) strongly positive cells confined to the basal half of the glands; and (iii) diffusely staining cells. The basal staining pattern was observed in both non-neoplastic tissues and in some areas of dysplasia, and was associated with normal expression of p21waf1/cip1 in all cases, and with p53 mutation in seven of 11 cases. Conclusions: The basal pattern of p53 expression is associated with mutation in the p53 gene, and appears to be an early change in a subgroup of ulcerative colitis patients. The significance of this pattern of immunoreactivity and the mechanism by which it develops are discussed.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 1432-0800Source: Springer Online Journal Archives 1860-2000Topics: Energy, Environment Protection, Nuclear Power EngineeringMedicineType of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 1432-0703Source: Springer Online Journal Archives 1860-2000Topics: Energy, Environment Protection, Nuclear Power EngineeringMedicineNotes: Abstract To investigate how trophic level and physiological processes influence organochlorine (OC) chemical concentrations in chinook salmon (Oncorhynchus tshawytscha) and their offspring, data on polychlorinated biphenyl (PCB), and OC pesticides and metabolite concentrations in Lake Michigan chinook salmon muscle tissue, eggs, sac fry, and prey fish were analyzed. Total concentrations of PCBs in chinook salmon decreased exponentially from the mid-1970s to mid-1980s, but the concentrations have since shown an asymptotic response, a trend also seen in alewife (Alosa pseudoharengus), an exotic planktivore that is the principal prey of chinook salmon in western Lake Michigan, and bloater (Coregonus hoyi) an endemic planktivore. The total concentration of PCBs in chinook salmon were positively correlated with fish length. OC concentrations in chinook salmon eggs were positively correlated with the concentrations of these compounds in the muscle tissue of the gravid fish. Egg and sac fry OC concentrations were also positively correlated. Estimates of the quantities of various OCs in chinook salmon muscle tissue and eggs, reveal that between 22% and 40% of the quantities of these compounds are eliminated through spawning.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 1432-0428Source: Springer Online Journal Archives 1860-2000Topics: MedicineType of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesSpillert, C. R. ; Bonthu, S. ; Ponnudurai, R. ; Miller, M. A. ; Lazaro, E. J.
Springer
Published 1995Staff ViewISSN: 1420-908XSource: Springer Online Journal Archives 1860-2000Topics: MedicineType of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesSagnella, G. A. ; Markandu, N. D. ; Singer, D. R. J. ; Buckley, M. G. ; Miller, M. A. ; MacGregor, G. A.
Springer
Published 1991Staff ViewISSN: 1432-1041Keywords: Perindopril ; Hypertension ; pharmacodynamic ; plasma renin activity ; plasma aldosterone ; essential hypertensionSource: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyMedicineType of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesNahata, M. C. ; Powell, D. A. ; Durrell, D. E. ; Miller, M. A. ; Glazer, J. P.
Springer
Published 1984Staff ViewISSN: 1432-1041Keywords: tobramycin ; newborn infants ; intrapatient variations ; pharmacokineticsSource: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyMedicineNotes: Summary Nineteen newborn infants receiving tobramycin, 2.5 mg/kg every 12 h were studied on two occasions at steady-state during the first week of postnatal age. The two studies were separated by two to four days. Total body clearance of tobramycin averaged 1.15 and 1.14 ml/min/kg (p〉0.05), apparent volume of distribution averaged 0.82 and 0.68 l/kg (p〉0.05), and elimination half-life averaged 8.6 and 7.1 h (p〉0.05), during the first and second study, respectively. When the data were further analyzed based on the birth weight, tobramycin kinetics changed during the second study compared to the first study in very low birth weight infants. In eight infants ⩽1.5 kg birth weight, although total clearance of tobramycin was similar, the average apparent volume of distribution decreased from 1.04 l/kg during the first study to 0.73 l/kg during the second study (p〈0.05) and elimination half-life from 11.1 h during the first study to 8.7 h during the second study (p〈0.05). These data indicate that these infants may require a change in dosing interval with continued tobramycin therapy during the first week of postnatal age. Intrapatient variation in tobramycin kinetics should be considered, in addition to the interpatient variation reported previously, when monitoring the serum concentration to individualize tobramycin therapy in newborn infants ⩽1.5 kg birth weight.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1432-1041Keywords: acetaminophen ; pediatric patients ; fever therapy ; accumulation ; pharmacokineticsSource: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyMedicineNotes: Summary Acetaminophen serum concentrations were studied in 21 infants and children with fever. The maximum serum concentrations ranged from 9.96 to 19.6 µg/ml after a single dose of 12–14 mg/kg and 13.9 to 40.1 µg/ml after a single dose of 22–27 mg/kg. Ten patients were restudied at steadystate after repeat doses had been given every 4 or 8 h for 1 to 3 days. Total area under the acetaminophen serum concentration-time curve normalized for dose averaged 0.181 (ml/min/kg)−1 after the first dose and 0.202 (ml/min/kg)−1 at steady-state (p〈0.05). Five patients showed a 13 to 44% increase in the AUC; one had a 10% decrease in the AUC; and four had less than 6% change in the AUC. There was no evidence of hepatotoxicity. These data suggest that acetaminophen may accumulate after repeated therapeutic doses in children with fever.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 1432-1041Keywords: acetaminophen ; pediatric patients ; fever therapy ; accumulation ; pharmacokineticsSource: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyMedicineNotes: Summary Acetaminophen serum concentrations were studied in 21 infants and children with fever. The maximum serum concentrations ranged from 9.96 to 19.6 µg/ml after a single dose of 12–14 mg/kg and 13.9 to 40.1 µg/ml after a single dose of 22–27 mg/kg. Ten patients were restudied at steadystate after repeat doses had been given every 4 or 8 h for 1 to 3 days. Total area under the acetaminophen serum concentration-time curve normalized for dose averaged 0.181 (ml/min/kg)−1 after the first dose and 0.202 (ml/min/kg)−1 at steady-state (p〈0.05). Five patients showed a 13 to 44% increase in the AUC; one had a 10% decrease in the AUC; and four had less than 6% change in the AUC. There was no evidence of hepatotoxicity. These data suggest that acetaminophen may accumulate after repeated therapeutic doses in children with fever.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 1432-8798Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary After intrathoracic inoculation of laboratory-bredAedes aegypti mosquitoes with 3 Yukon isolates of California encephalitis (CE) virus (snowshoe hare subtype), Northway (NOR) and Murray Valley encephalitis (MVE) viruses, viral replication was observed following incubation at 13, 21, 35 and 39° C, which constituted the full temperature range of viability ofA. aegypti. Rates of viral replication were reduced at low temperatures and accelerated at high temperatures. Virus-specific immunoperoxidase staining of mosquito salivary glands occurred regularly after thoraces attained maximum infectivity levels. At 13 and 21° C, mosquitoes were infected by 10 to 100 times less CE and MVE viruses than mice, but about 10 times more NOR virus was required to infect mosquitoes than mice.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 1432-203XSource: Springer Online Journal Archives 1860-2000Topics: BiologyNotes: Abstract Friable, embryogenic callus cultures of maize are normally maintained as a heterogeneous mixture of various morphotypes in different stages of development (Fransz and Schel 1991). With stringent selection during subculture, three Type II callus morphotypes have been enriched and maintained. Cultured tissue segments from the three morphotypes referred to as “pre-embryogenic”, “early embryogenic”, and “late embryogenic” were analyzed using light and scanning electron microscopy. The results suggest a developmental relationship between the three morphotypes. Regeneration studies substantiated that all morphotypes were capable of regenerating through somatic embryogenesis.Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 1573-9120Source: Springer Online Journal Archives 1860-2000Topics: Electrical Engineering, Measurement and Control TechnologyPhysicsType of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 1573-9120Source: Springer Online Journal Archives 1860-2000Topics: Electrical Engineering, Measurement and Control TechnologyPhysicsType of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 1573-9120Source: Springer Online Journal Archives 1860-2000Topics: Electrical Engineering, Measurement and Control TechnologyPhysicsType of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesStaff View
ISSN: 1573-9120Source: Springer Online Journal Archives 1860-2000Topics: Electrical Engineering, Measurement and Control TechnologyPhysicsType of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesStaff View
ISSN: 1573-9120Source: Springer Online Journal Archives 1860-2000Topics: Electrical Engineering, Measurement and Control TechnologyPhysicsType of Medium: Electronic ResourceURL: