Search Results - (Author, Cooperation:M. A. Miller)

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  1. 1
    K. McKnight ; H. D. Hoang ; J. K. Prasain ; N. Brown ; J. Vibbert ; K. A. Hollister ; R. Moore ; J. R. Ragains ; J. Reese ; M. A. Miller
    American Association for the Advancement of Science (AAAS)
    Published 2014
    Staff View
    Publication Date:
    2014-05-17
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Caenorhabditis elegans/genetics/metabolism/*physiology ; Caenorhabditis elegans Proteins/genetics/*metabolism ; Environmental Exposure ; Female ; *Fertilization ; Male ; Neurons, Afferent/*physiology ; Neurosecretory Systems/physiology ; Oocytes/metabolism/physiology ; Ovum/metabolism/physiology ; Perception ; Pheromones/*physiology ; Prostaglandin-Endoperoxide Synthases/metabolism ; Prostaglandins/biosynthesis ; *Sperm Motility ; Spermatozoa/*physiology ; Transforming Growth Factor beta/genetics/*metabolism
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Staff View
    Publication Date:
    2018-07-12
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Electronic ISSN:
    2375-2548
    Topics:
    Natural Sciences in General
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Staff View
    Publication Date:
    2018-07-05
    Publisher:
    Royal Society
    Electronic ISSN:
    2054-5703
    Topics:
    Natural Sciences in General
    Keywords:
    ecology, health and disease and epidemiology
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  4. 4
    Yuter, S. E., Hader, J. D., Miller, M. A., Mechem, D. B.
    American Association for the Advancement of Science (AAAS)
    Published 2018
    Staff View
    Publication Date:
    2018-08-17
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Geosciences
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Geochemistry, Geophysics
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  5. 5
    Noffsinger, A E ; Belli, J M ; Miller, M A ; Fenoglio-Preiser, C M

    Oxford UK : Blackwell Science Ltd
    Published 2001
    Staff View
    ISSN:
    1365-2559
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    A unique basal pattern of p53 expression in ulcerative colitis is associated with mutation in the p53 gene Aims: The p53 protein is implicated in the control of cell proliferation, differentiation, and death. As part of a study characterizing p53 alterations in colonic mucosa of patients with ulcerative colitis, we identified a unique pattern of basal p53 immunoreactivity. Methods and results: Tissue samples (n=180) from 42 ulcerative colitis patients were evaluated for p53 alterations by immunohistochemistry, loss of heterozygosity analysis, polymerase chain reaction-single-strand conformation polymorphism and direct sequencing. In addition, the expression of the p53- associated proteins p21waf1/cip1 and MDM2 was evaluated immunohistochemically. Three basic patterns of p53 immunoreactivity were observed: (i) isolated immunoreactive cells in the crypt bases; (ii) strongly positive cells confined to the basal half of the glands; and (iii) diffusely staining cells. The basal staining pattern was observed in both non-neoplastic tissues and in some areas of dysplasia, and was associated with normal expression of p21waf1/cip1 in all cases, and with p53 mutation in seven of 11 cases. Conclusions: The basal pattern of p53 expression is associated with mutation in the p53 gene, and appears to be an early change in a subgroup of ulcerative colitis patients. The significance of this pattern of immunoreactivity and the mechanism by which it develops are discussed.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  6. 6
    Miller, M. A. ; Amrhein, J. F.
    Springer
    Published 1995
    Staff View
    ISSN:
    1432-0800
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Energy, Environment Protection, Nuclear Power Engineering
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  7. 7
    Miller, M. A.
    Springer
    Published 1994
    Staff View
    ISSN:
    1432-0703
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Energy, Environment Protection, Nuclear Power Engineering
    Medicine
    Notes:
    Abstract To investigate how trophic level and physiological processes influence organochlorine (OC) chemical concentrations in chinook salmon (Oncorhynchus tshawytscha) and their offspring, data on polychlorinated biphenyl (PCB), and OC pesticides and metabolite concentrations in Lake Michigan chinook salmon muscle tissue, eggs, sac fry, and prey fish were analyzed. Total concentrations of PCBs in chinook salmon decreased exponentially from the mid-1970s to mid-1980s, but the concentrations have since shown an asymptotic response, a trend also seen in alewife (Alosa pseudoharengus), an exotic planktivore that is the principal prey of chinook salmon in western Lake Michigan, and bloater (Coregonus hoyi) an endemic planktivore. The total concentration of PCBs in chinook salmon were positively correlated with fish length. OC concentrations in chinook salmon eggs were positively correlated with the concentrations of these compounds in the muscle tissue of the gravid fish. Egg and sac fry OC concentrations were also positively correlated. Estimates of the quantities of various OCs in chinook salmon muscle tissue and eggs, reveal that between 22% and 40% of the quantities of these compounds are eliminated through spawning.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  8. 8
    Miller, M. A. W. ; Schiavi, R. C.
    Springer
    Published 1994
    Staff View
    ISSN:
    1432-0428
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  9. 9
    Staff View
    ISSN:
    1420-908X
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  10. 10
    Staff View
    ISSN:
    1432-1041
    Keywords:
    Perindopril ; Hypertension ; pharmacodynamic ; plasma renin activity ; plasma aldosterone ; essential hypertension
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Chemistry and Pharmacology
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  11. 11
    Staff View
    ISSN:
    1432-1041
    Keywords:
    tobramycin ; newborn infants ; intrapatient variations ; pharmacokinetics
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Chemistry and Pharmacology
    Medicine
    Notes:
    Summary Nineteen newborn infants receiving tobramycin, 2.5 mg/kg every 12 h were studied on two occasions at steady-state during the first week of postnatal age. The two studies were separated by two to four days. Total body clearance of tobramycin averaged 1.15 and 1.14 ml/min/kg (p〉0.05), apparent volume of distribution averaged 0.82 and 0.68 l/kg (p〉0.05), and elimination half-life averaged 8.6 and 7.1 h (p〉0.05), during the first and second study, respectively. When the data were further analyzed based on the birth weight, tobramycin kinetics changed during the second study compared to the first study in very low birth weight infants. In eight infants ⩽1.5 kg birth weight, although total clearance of tobramycin was similar, the average apparent volume of distribution decreased from 1.04 l/kg during the first study to 0.73 l/kg during the second study (p〈0.05) and elimination half-life from 11.1 h during the first study to 8.7 h during the second study (p〈0.05). These data indicate that these infants may require a change in dosing interval with continued tobramycin therapy during the first week of postnatal age. Intrapatient variation in tobramycin kinetics should be considered, in addition to the interpatient variation reported previously, when monitoring the serum concentration to individualize tobramycin therapy in newborn infants ⩽1.5 kg birth weight.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  12. 12
    Staff View
    ISSN:
    1432-1041
    Keywords:
    acetaminophen ; pediatric patients ; fever therapy ; accumulation ; pharmacokinetics
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Chemistry and Pharmacology
    Medicine
    Notes:
    Summary Acetaminophen serum concentrations were studied in 21 infants and children with fever. The maximum serum concentrations ranged from 9.96 to 19.6 µg/ml after a single dose of 12–14 mg/kg and 13.9 to 40.1 µg/ml after a single dose of 22–27 mg/kg. Ten patients were restudied at steadystate after repeat doses had been given every 4 or 8 h for 1 to 3 days. Total area under the acetaminophen serum concentration-time curve normalized for dose averaged 0.181 (ml/min/kg)−1 after the first dose and 0.202 (ml/min/kg)−1 at steady-state (p〈0.05). Five patients showed a 13 to 44% increase in the AUC; one had a 10% decrease in the AUC; and four had less than 6% change in the AUC. There was no evidence of hepatotoxicity. These data suggest that acetaminophen may accumulate after repeated therapeutic doses in children with fever.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  13. 13
    Staff View
    ISSN:
    1432-1041
    Keywords:
    acetaminophen ; pediatric patients ; fever therapy ; accumulation ; pharmacokinetics
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Chemistry and Pharmacology
    Medicine
    Notes:
    Summary Acetaminophen serum concentrations were studied in 21 infants and children with fever. The maximum serum concentrations ranged from 9.96 to 19.6 µg/ml after a single dose of 12–14 mg/kg and 13.9 to 40.1 µg/ml after a single dose of 22–27 mg/kg. Ten patients were restudied at steadystate after repeat doses had been given every 4 or 8 h for 1 to 3 days. Total area under the acetaminophen serum concentration-time curve normalized for dose averaged 0.181 (ml/min/kg)−1 after the first dose and 0.202 (ml/min/kg)−1 at steady-state (p〈0.05). Five patients showed a 13 to 44% increase in the AUC; one had a 10% decrease in the AUC; and four had less than 6% change in the AUC. There was no evidence of hepatotoxicity. These data suggest that acetaminophen may accumulate after repeated therapeutic doses in children with fever.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  14. 14
    McLean, D. M. ; Grass, P. N. ; Miller, M. A. ; Wong, K. S. K.
    Springer
    Published 1975
    Staff View
    ISSN:
    1432-8798
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary After intrathoracic inoculation of laboratory-bredAedes aegypti mosquitoes with 3 Yukon isolates of California encephalitis (CE) virus (snowshoe hare subtype), Northway (NOR) and Murray Valley encephalitis (MVE) viruses, viral replication was observed following incubation at 13, 21, 35 and 39° C, which constituted the full temperature range of viability ofA. aegypti. Rates of viral replication were reduced at low temperatures and accelerated at high temperatures. Virus-specific immunoperoxidase staining of mosquito salivary glands occurred regularly after thoraces attained maximum infectivity levels. At 13 and 21° C, mosquitoes were infected by 10 to 100 times less CE and MVE viruses than mice, but about 10 times more NOR virus was required to infect mosquitoes than mice.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  15. 15
    Staff View
    ISSN:
    1432-203X
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Notes:
    Abstract Friable, embryogenic callus cultures of maize are normally maintained as a heterogeneous mixture of various morphotypes in different stages of development (Fransz and Schel 1991). With stringent selection during subculture, three Type II callus morphotypes have been enriched and maintained. Cultured tissue segments from the three morphotypes referred to as “pre-embryogenic”, “early embryogenic”, and “late embryogenic” were analyzed using light and scanning electron microscopy. The results suggest a developmental relationship between the three morphotypes. Regeneration studies substantiated that all morphotypes were capable of regenerating through somatic embryogenesis.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  16. 16
    Kondrat'ev, I. G. ; Miller, M. A.
    Springer
    Published 1965
    Staff View
    ISSN:
    1573-9120
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Electrical Engineering, Measurement and Control Technology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  17. 17
    Miller, M. A.
    Springer
    Published 1993
    Staff View
    ISSN:
    1573-9120
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Electrical Engineering, Measurement and Control Technology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  18. 18
    Staff View
    ISSN:
    1573-9120
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Electrical Engineering, Measurement and Control Technology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  19. 19
    Egorov, L. A. ; Miller, M. A.
    Springer
    Published 1968
    Staff View
    ISSN:
    1573-9120
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Electrical Engineering, Measurement and Control Technology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  20. 20
    Kondrat'ev, I. G. ; Miller, M. A.
    Springer
    Published 1968
    Staff View
    ISSN:
    1573-9120
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Electrical Engineering, Measurement and Control Technology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses