Search Results - (Author, Cooperation:M. A. Martin)

2018-02-02

American Physical Society (APS)

1098-0121

1095-3795

Physics

Superfluidity and superconductivity

2018-03-13

American Physical Society (APS)

1098-0121

1095-3795

Physics

Electronic structure and strongly correlated systems

2013-05-11

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

Animals ; Antibodies, Neutralizing/blood/*immunology ; Epitope Mapping ; HIV Antibodies/blood/*immunology ; HIV Infections/blood/*immunology ; HIV-1/*immunology/isolation & purification ; Humans ; Immunodominant Epitopes/chemistry/immunology ; Macaca ; Neutralization Tests ; Protein Conformation ; Serum/immunology

2014-06-14

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

2016-04-28

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

AIDS Vaccines/administration & dosage/immunology ; Animals ; Antibodies, Monoclonal/administration & dosage/blood/genetics/immunology ; Antibodies, Neutralizing/administration & dosage/blood/genetics/immunology ; Female ; HIV Antibodies/*administration & dosage/blood/genetics/*immunology ; HIV Infections/immunology/prevention & control/transmission ; Half-Life ; Immunoglobulin Fc Fragments/chemistry/genetics/immunology ; Macaca mulatta/immunology/virology ; Male ; Mutation/genetics ; Protein Structure, Tertiary ; SAIDS Vaccines/administration & dosage/immunology ; Simian Acquired Immunodeficiency Syndrome/blood/*immunology/*prevention & control ; Simian Immunodeficiency Virus/*immunology ; Time Factors

2013-11-01

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Animals ; Antibodies, Neutralizing/*therapeutic use ; Antigens, CD4/metabolism ; Binding Sites/immunology ; HIV Antibodies/*therapeutic use ; HIV Envelope Protein gp120/immunology ; HIV-1/*immunology ; *Immunotherapy ; Macaca/immunology ; Molecular Sequence Data ; Peptide Fragments/immunology ; Simian Acquired Immunodeficiency Syndrome/prevention & control/*therapy ; Simian Immunodeficiency Virus/*physiology ; Time Factors ; Viral Load ; Viremia/*therapy

2012-12-14

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Antarctic Regions ; Computer Simulation ; Global Warming ; *Ice Cover ; *Models, Theoretical ; *Snow

2018-11-06

The American Association of Immunologists (AAI)

0022-1767

1550-6606

Medicine

2013-05-04

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

Animals ; Antelopes/*physiology ; Female ; Male ; *Mating Preference, Animal ; *Predatory Behavior ; *Sexual Behavior, Animal

2018-11-29

American Physical Society (APS)

1098-0121

1095-3795

Physics

Structure, structural phase transitions, mechanical properties, defects

1398-9995

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Electronic Resource

0013-6662

Classical Studies

EDICIONES Y TÉCNICA FILOLÓGICA

RESEÑA DE LIBROS

1433-2965

Bone resorption markers ; CTX ; Hydroxyproline ; ICTP ; Postmenopausal osteoporosis ; Pyridinoline

Springer Online Journal Archives 1860-2000

Medicine

Abstract The aim of this work was to perform a comparative study between three recently developed biochemical markers of bone resorption derived from collagen metabolism — (1) total urinary free pyridinolines (Pyr), (2) serum pyridinoline cross-linked carboxy-terminal telopeptides of type I collagen (ICTP) and (3) a urinary-specific sequence for a part of the C-telopeptide of the α1 chain of type I collagen (CTX) — in the diagnosis and follow-up of postmenopausal osteoporosis. Results were also evaluated relative to the classical biochemical marker urinary hydroxyproline (Hyp). The study included 20 untreated osteoporotic postmenopausal women (OSP), age 60 ±6 years, range 46–69 years; 27 osteoporotic postmenopausal women treated (OSP-T) by cyclic therapy with disodium etidronate, 25-hydroxyvitamin D and calcium for a period between 3 months and 4 years (25±15 months), age 59±7 years, range 41–67 years; 17 osteopenic postmenopausal women, age 57±6 years, range 46±68 years; and 29 healthy control postmenopausal women, age 56±7 years, range 41–70 years. The diagnostic criterion for postmenopausal osteoporosis was a bone mineral density (BMD) (Hologic QDR-1000) in lumbar spine and/or femoral neck more than 2 SD below the mean value corresponding to an age- and sex-matched healthy control group. For inclusion in the osteopenic group BMD values had to be between 1 and 2 SD below the mean BMD value corresponding to the control group. We found a significant increase (p〈0.01) in the levels of Pyr/Cr and CTX/Cr (Cr=creatinine) in OSP patients with respect to the control group and we did not obeserve any significant difference between control and OSP-T or osteopenic women. It is interesting to note that there was a mean increase in CTX/Cr in OSP patients of 101% of the control values, while the mean increase found in Pyr/Cr concentration was only 33%. However, we did not find significant differences in the concentrations of ICTP and Hyp/Cr between groups. In a comparison of Pyr/Cr and CTX/Cr, urinary CTX showed the higher diagnostic accuracy, as can be deduced from the receiver operating characteristic (ROC) curves. CTX sensitivity was 40% with a specificity of 100%, whereas the sensitivity was 25% for urinary Pyr/Cr. In conclusion, the results of the present work suggest that in osteoporotic women CTX has the highest diagnostic accuracy among the markers of bone resporption studied.

Electronic Resource

1420-9071

Key Words. Kinesin; kinesin-like proteins; microtubule-based motors; axonal transport; neurons.

Springer Online Journal Archives 1860-2000

Biology

Medicine

Abstract. Both the development and the maintenance of neurons require a great deal of active cytoplasmic transport. Much of this transport is driven by microtubule motor proteins. Membranous organelles and other macromolecular assemblies bind motor proteins that then use cycles of adenosine 5′-triphosphate hydrolysis to move these ‘cargoes’ along microtubules. Different sets of cargoes are transported to distinct locations in the cell. The resulting differential distribution of materials almost certainly plays an important part in generating polarized neuronal morphologies and in maintaining their vectorial signalling activities. A number of different microtubule motor proteins function in neurons; presumably they are specialized for accomplishing different transport tasks. Questions about specific motor functions and the functional relationships between different motors present a great challenge. The answers will provide a much deeper understanding of fundamental transport mechanisms, as well as how these mechanisms are used to generate and sustain cellular asymmetries.

Electronic Resource

1432-1041

Acebutolol ; N-acetyl metabolite ; drug plasma concentrations ; plasma renin activity ; hypertension ; β-blockade

Springer Online Journal Archives 1860-2000

Chemistry and Pharmacology

Medicine

Summary Relationships between plasma concentrations of acebutolol (Ac) and its N-acetyl metabolite (Am) and pharmacological effects were studied in patients with essential hypertension. In an acute study (N=7) 400 mg oral acebutolol produced similar peak plasma levels of Ac and Am but Am had a longer half life. Group mean pulse and blood pressure fell significantly, although the size of individual blood pressure fall varied five-fold. There was no significant change in plasma renin activity. Correlations were found between drug concentration and β-blockade, assessed as % reduction in exercise tachycardia, and between both of these and the fall in post exercise systolic blood pressure. Similar comparisons were made in a chronic optimum dose study (N=11) both pre-dose and three hours post-dose. Am concentration was consistently higher than Ac at both times. Blood pressure was lowered equally pre-and post-dose when compared to placebo and plasma renin activity (PRA) was reduced on active treatment. Correlations were again shown between drug concentrations and β-blockade but none were found with changes in blood pressure or PRA. Between subject differences in blood pressure response could not be fully explained in terms of the other measurements but it is unlikely that pharmacokinetic differences are the major source of this variability.

Electronic Resource

1573-2665

Springer Online Journal Archives 1860-2000

Medicine

Electronic Resource

1432-5195

Springer Online Journal Archives 1860-2000

Medicine

Résumé Les auteurs présentent deux patients souffrant d'une douleur externe de la cheville et du pied depuis plusieurs années et d'étiologie rare: Teno-synovite sténosante des tendons péroniers à la suite du développement d'un ostéochondrome du tubercule des péroniers. Le traitement chirurgical a donné de bons résultats dans les deux cas. L'un des patients présente une symptomatologie similaire du côté opposé. Il ne faut pas oublier cette possibilité de diagnostic face à d'autres étiologies beaucoup plus fréquentes.

Summary We report two patients with pain on the lateral side of the ankle and foot which was due to stenosing tenosynovitis of the peroneal tendons caused by an osteochondroma of the peroneal tubercle. Surgical treatment produced a good result in both cases. The condition is uncommon, but should be borne in mind as a possible cause of pain in this region.

Electronic Resource

1573-2665

Springer Online Journal Archives 1860-2000

Medicine

Electronic Resource

1573-2665

Springer Online Journal Archives 1860-2000

Medicine

Electronic Resource

0886-9383

Derivatization reaction ; Factorial design ; Chemistry ; Analytical Chemistry and Spectroscopy

Wiley InterScience Backfile Collection 1832-2000

Chemistry and Pharmacology

A number of nucleophiles have been successfully identified and quantified using the Kröhnke reaction with 2,3-diphenyl derivatives of quinolizinium salts. Optimization of the reaction conditions by means of a mathematical model involving analysis of the response surface has led to a better understanding of the factors exerting an influence on the above reaction.The parameters chosen were temperature, reaction time, base concentration, water concentration and nucleophile concentration. The reaction was developed in polar aprotic solvents (acetone, acetonitrile). To facilitate the nucleophilic attack, the presence of an organic base (triethylamine) was necessary, although concentrations in excess of 0·15M did not alter the development of the reaction. Since pharmaceutical solutions are often aqueous, the influence of water on the reaction was studied. Low water volumes have no significant influence on the opening of the quinolizinium ring by the nucleophilic reagent. However, when the water proportion exceeded that of the organic solvent, the fluorescence intensity was lower than expected. Development of the fluorescent reaction product was first detected 5 min after the reaction started. The fluorescence intensity reached its optimum value after 138 min.

2 Ill.

Electronic Resource