Search Results - (Author, Cooperation:L. W. Enquist)
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1Latest Papers from Table of Contents or Articles in PressK. I. Berns ; A. Casadevall ; M. L. Cohen ; S. A. Ehrlich ; L. W. Enquist ; J. P. Fitch ; D. R. Franz ; C. M. Fraser-Liggett ; C. M. Grant ; M. J. Imperiale ; J. Kanabrocki ; P. S. Keim ; S. M. Lemon ; S. B. Levy ; J. R. Lumpkin ; J. F. Miller ; R. Murch ; M. E. Nance ; M. T. Osterholm ; D. A. Relman ; J. A. Roth ; A. K. Vidaver
American Association for the Advancement of Science (AAAS)
Published 2012Staff ViewPublication Date: 2012-02-02Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Adaptation, Biological ; Advisory Committees ; Animals ; Biological Warfare Agents ; Containment of Biohazards ; Humans ; Influenza A Virus, H5N1 Subtype/*pathogenicity ; Influenza, Human/epidemiology/transmission/*virology ; National Institutes of Health (U.S.) ; Orthomyxoviridae Infections/transmission/*virology ; *Public Health ; *Publishing ; Risk Assessment ; Security Measures ; United StatesPublished by: -
2Latest Papers from Table of Contents or Articles in PressK. I. Berns ; A. Casadevall ; M. L. Cohen ; S. A. Ehrlich ; L. W. Enquist ; J. P. Fitch ; D. R. Franz ; C. M. Fraser-Liggett ; C. M. Grant ; M. J. Imperiale ; J. Kanabrocki ; P. S. Keim ; S. M. Lemon ; S. B. Levy ; J. R. Lumpkin ; J. F. Miller ; R. Murch ; M. E. Nance ; M. T. Osterholm ; D. A. Relman ; J. A. Roth ; A. K. Vidaver
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-02-02Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Bioterrorism/prevention & control/*trends ; Humans ; Influenza A Virus, H5N1 Subtype/*genetics/*pathogenicity/physiology ; Influenza, Human/*transmission/*virology ; Public Health ; Risk Assessment ; Zoonoses/transmission/virologyPublished by: -
3Articles: DFG German National LicensesStaff View
ISSN: 1572-994XKeywords: Pseudorabies virus ; glycoprotein gIII ; herpesvirus ; signal sequence ; protein export ; hydrophobicitySource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract We have described three mutant strains of Pseudorabies virus that contain mutations in the signal sequence coding region of a nonessential envelope glycoprotein, gIII. The alterations disrupt, truncate, or eliminate the hydrophobic core domain of the signal sequence. Each mutant was assayed for its ability to promote the translocation of gIII across the endoplasmic reticulum membrane and the subsequent localization of the mature form of the glycoprotein to the infected cell surface or the virus envelope. Our results confirm and extend findings in other systems that the overall hydrophobicity of the signal sequence core region is a major determinant of translocation efficiency. We were unable to correlate simply the length of the core or the average hydrophobicity of core residues with export efficiency. Because our work involved the use of infectious virus mutants, we were able to identify a virus defect associated with a complete block in gIII export. This defect will facilitate a pseudoreversion analysis of gIII signal sequence function.Type of Medium: Electronic ResourceURL: