Search Results - (Author, Cooperation:L. Studer)
-
1Latest Papers from Table of Contents or Articles in PressJ. Kimmelman ; I. Hyun ; N. Benvenisty ; T. Caulfield ; H. E. Heslop ; C. E. Murry ; D. Sipp ; L. Studer ; J. Sugarman ; G. Q. Daley
Nature Publishing Group (NPG)
Published 2016Staff ViewPublication Date: 2016-05-20Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsPublished by: -
2Latest Papers from Table of Contents or Articles in PressF. Fattahi ; J. A. Steinbeck ; S. Kriks ; J. Tchieu ; B. Zimmer ; S. Kishinevsky ; N. Zeltner ; Y. Mica ; W. El-Nachef ; H. Zhao ; E. de Stanchina ; M. D. Gershon ; T. C. Grikscheit ; S. Chen ; L. Studer
Nature Publishing Group (NPG)
Published 2016Staff ViewPublication Date: 2016-02-11Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Aging ; Animals ; Cell Differentiation ; Cell Line ; *Cell Lineage ; Cell Movement ; Cell Separation ; *Cell- and Tissue-Based Therapy/methods ; Chick Embryo ; Colon/drug effects/pathology ; Disease Models, Animal ; Drug Discovery/*methods ; Enteric Nervous System/*pathology ; Female ; Gastrointestinal Tract/drug effects/pathology ; Hirschsprung Disease/*drug therapy/*pathology/therapy ; Humans ; Male ; Mice ; Neurons/drug effects/*pathology ; Pepstatins/metabolism ; Pluripotent Stem Cells/pathology ; Receptor, Endothelin B/metabolism ; Signal TransductionPublished by: -
3Latest Papers from Table of Contents or Articles in PressS. Kriks ; J. W. Shim ; J. Piao ; Y. M. Ganat ; D. R. Wakeman ; Z. Xie ; L. Carrillo-Reid ; G. Auyeung ; C. Antonacci ; A. Buch ; L. Yang ; M. F. Beal ; D. J. Surmeier ; J. H. Kordower ; V. Tabar ; L. Studer
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-11-08Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; *Brain Tissue Transplantation ; Cell Differentiation ; Cell Line ; Cell Survival ; Dopaminergic Neurons/*cytology/*transplantation ; Embryonic Stem Cells/*cytology ; Female ; Humans ; Macaca mulatta ; Mesencephalon/cytology ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Parkinson Disease/*therapy ; Rats ; Rats, Sprague-DawleyPublished by: -
4Latest Papers from Table of Contents or Articles in PressF. G. Lafaille ; I. M. Pessach ; S. Y. Zhang ; M. J. Ciancanelli ; M. Herman ; A. Abhyankar ; S. W. Ying ; S. Keros ; P. A. Goldstein ; G. Mostoslavsky ; J. Ordovas-Montanes ; E. Jouanguy ; S. Plancoulaine ; E. Tu ; Y. Elkabetz ; S. Al-Muhsen ; M. Tardieu ; T. M. Schlaeger ; G. Q. Daley ; L. Abel ; J. L. Casanova ; L. Studer ; L. D. Notarangelo
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-10-30Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Astrocytes/immunology/virology ; Biomarkers ; Cell Differentiation ; Cell Lineage ; Cell Separation ; Cells, Cultured ; Central Nervous System/cytology/immunology/*pathology/virology ; Child ; Disease Susceptibility ; Encephalitis, Herpes Simplex/immunology/metabolism/pathology/virology ; Herpesvirus 1, Human/*immunology/pathogenicity ; Humans ; Immunity, Innate ; Induced Pluripotent Stem Cells/*cytology/virology ; Interferons/immunology ; Membrane Transport Proteins/deficiency/genetics ; Neural Stem Cells/immunology/virology ; Neurons/immunology/pathology/virology ; Oligodendroglia/immunology/pathology/virology ; Toll-Like Receptor 3/*deficiency/geneticsPublished by: -
5Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2018-10-11Publisher: American Physical Society (APS)Print ISSN: 1050-2947Electronic ISSN: 1094-1622Topics: PhysicsKeywords: Atomic and molecular structure and dynamics ; high-precision measurementsPublished by: -
6Latest Papers from Table of Contents or Articles in PressYamazaki, T., Liu, L., Lazarev, D., Al-Zain, A., Fomin, V., Yeung, P. L., Chambers, S. M., Lu, C.-W., Studer, L., Manley, J. L.
Cold Spring Harbor Laboratory Press
Published 2018Staff ViewPublication Date: 2018-09-05Publisher: Cold Spring Harbor Laboratory PressPrint ISSN: 0890-9369Topics: BiologyPublished by: -
7Articles: DFG German National LicensesThe UA6 Collaboration ; Camilleri, L. ; Dick, L. ; Jeanneret, J.-B. ; Von Dardel, G. ; Baumann, S. ; Bernasconi, A. ; Gabioud, B. ; Vacchi, A. ; Joseph, C. ; Morel, C. ; Rivers, C. ; Hubbard, D. ; Ruegger, D. ; Steiner, D. ; Dukes, E.C. ; Gaille, F. ; Sozzi, G. ; Valenti, G. ; Snow, G.R. ; Loude, J.-F. ; Perroud, J.-P. ; Pages, J.L. ; Studer, L. ; Tran, M.-T.
Amsterdam : ElsevierStaff ViewISSN: 0168-9002Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 1432-0770Source: Springer Online Journal Archives 1860-2000Topics: BiologyComputer SciencePhysicsNotes: Abstract. The present model of the motoneuronal (MN) pool – muscle complex (MNPMC) is deterministic and designed for steady isometric muscle activation. Time-dependent quantities are treated as time-averages. The character of the model is continuous in the sense that the motor unit (MU) population is described by a continuous density function. In contrast to most already published models, the wiring (synaptic weight) between the input fibers to the MNPMC and the MNs (about which no detailed data are known) is deduced, whereas the input–force relation is given. As suggested by experimental data, this relation is assumed to be linear during MU recruitment, but the model allows other, nonlinear relations. The input to the MN pool is defined as the number of action potentials per second in all input fibers, and the excitatory postsynaptic potential (EPSP) conductance in MNs evoked by the input is assumed to be proportional to the input. A single compartment model with a homogeneous membrane is used for a MN. The MNs start firing after passing a constant voltage threshold. The synaptic current–frequency relation is described by a linear function and the frequency–force transformation of a MU by an exponential function. The sum of the MU contraction forces is the muscle force, and the activation of the MUs obeys the size principle. The model parameters were determined a priori, i.e., the model was not used for their estimation. The analysis of the model reveals special features of the activation curve which we define as the relation between the input normalized by the threshold input of the MN pool and the force normalized by the maximal muscle force. This curve for any muscle turned out to be completely determined by the activation factor, the slope of the linear part of the activation curve (during MU recruitment). This factor determines quantitatively the relation between MU recruitment and rate modulation. This property of the model (the only known model with this property) allows a quantification of the recruitment gain (Kernell and Hultborn 1990). The interest of the activation factor is illustrated using two human muscles, namely the first dorsal interosseus muscle, a small muscle with a relatively small force at the end of recruitment, and the medial gastrocnemius muscle, a strong muscle with a relatively large force at the end of recruitment. It is concluded that the present model allows us to reproduce the main features of muscle activation in the steady state. Its analytical character facilitates a deeper understanding of these features.Type of Medium: Electronic ResourceURL: