Search Results - (Author, Cooperation:L. Schild)
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1Latest Papers from Table of Contents or Articles in PressJ. J. Molenaar ; J. Koster ; D. A. Zwijnenburg ; P. van Sluis ; L. J. Valentijn ; I. van der Ploeg ; M. Hamdi ; J. van Nes ; B. A. Westerman ; J. van Arkel ; M. E. Ebus ; F. Haneveld ; A. Lakeman ; L. Schild ; P. Molenaar ; P. Stroeken ; M. M. van Noesel ; I. Ora ; E. E. Santo ; H. N. Caron ; E. M. Westerhout ; R. Versteeg
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-03-01Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Aging/genetics ; Chromosomes, Human/*genetics ; Cluster Analysis ; DNA Helicases/genetics ; DNA Mutational Analysis ; Gene Expression Regulation, Neoplastic ; Genome, Human/genetics ; Growth Cones/metabolism/pathology ; Guanine Nucleotide Exchange Factors/genetics ; Humans ; Mutation ; Neoplasm Staging ; Neurites/*metabolism ; Neuroblastoma/diagnosis/*genetics/metabolism/*pathology ; Nuclear Proteins/genetics ; Prognosis ; rac GTP-Binding Proteins/metabolism ; rho GTP-Binding Proteins/metabolismPublished by: -
2Articles: DFG German National LicensesKhuchua, Z. ; Belikova, Y. ; Kuznetsov, A.V. ; Gellerich, F.N. ; Schild, L. ; Neumann, H.W. ; Kunz, W.S.
Amsterdam : ElsevierStaff ViewISSN: 0005-2728Keywords: (Human) ; Caffeine ; Calcium ; Oxidative phosphorylation ; Saponin-skinned fiber ; Skeletal muscleSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyMedicinePhysicsType of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesStaff View
ISSN: 0005-2728Keywords: (Rat liver mitochondria) ; Lipid peroxidation ; Malondialdehyde ; Membrane potential ; RespirationSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyMedicinePhysicsType of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesKunz, W.S. ; Kuznetsov, A.V. ; Schulze, W. ; Eichhorn, K. ; Schild, L. ; Striggow, F. ; Bohnensack, R. ; Neuhof, S. ; Gellerich, F.N. ; Grasshoff, H. ; Neumann, H.W.
Amsterdam : ElsevierStaff ViewISSN: 0005-2728Keywords: (Human) ; Fluorescence microscopy ; Mitochondrial encephalomyopathy ; Mitochondrial myopathy ; Oxidative phosphorylation ; Saponin-skinned fiber ; Skeletal muscleSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyMedicinePhysicsType of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 0005-2728Keywords: Adenine nucleotide translocator ; Flux control coefficient ; Mitochondrial respiration ; Oxidative phosphorylationSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyMedicinePhysicsType of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 0005-2728Keywords: ANT,; denine nucleotide translocase ; CAT,; darboxyatractyloside ; DCCD,; N, N'-dicyclohexylcarbodiimide ; DDA^+,; dimethyldibenzylammonium ; DNP; 2,4-dinitrophenol ; Fatty acid ; LCFA,; long-chain fatty acids ; Membrane potential ; Mitochondrion ; Proton conductance ; TPB^-; tetraphenylboron ; TTFB,; 4,5,6,7-tetrachloro-2-trifluoromethylbenzimidazole ; Uncoupling ; V"r"e"s"p,; rate of respiration ; Δψ,; transmembrane potentialSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyMedicinePhysicsType of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 0885-4505Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: MedicineType of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 0014-5793Keywords: Adenine nucleotide translocator ; Delocalized chemiosmotic coupling ; Flux control coefficient ; H^+-ATPase ; Phosphorylation potential ; Proton electrochemical gradientSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1432-2013Keywords: Proximal tubule ; Chloride transport ; Formate transport ; Anion exchange ; Electroneutral transport ; Nonionic diffusion ; Proximal tubule pHSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Possible transport mechanisms of chloride across the mammalian proximal tubule include both active and passive components and, accordingly, transcellular and intercellular transport routes. Experiments are described in which the possibility of electroneutral anion exchange across the apical cell membrane of proximal tubule cells is evaluated. Experiments in brushborder vesicles of the rabbit kidney cortex have shown the existence of a chloride/formate exchange process. In addition, evidence is presented that formic acid is crossing the brushborder membrane of rabbit renal cortex by non-ionic diffusion. A transport schema is developed in which formate/chloride exchange and sodium/hydrogen exchange in parallel with recycling of formic acid by non-ionic diffusion can account for the electroneutral transport of sodium chloride. Perfusion studies in isolated rabbit straight and convoluted tubules show significant transport stimulation by submillimolar concentrations of formate. Thus, chloride/formate exchange is a possible mechanism for active, transcellular chloride movement across the mammalian proximal tubule.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 1432-2013Keywords: Alanine scanning Aldosterone Amiloride Epithelial Na+ channel Gating kineticsSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract. The epithelial Na+ channel (ENaC) is responsible for Na+ reabsorption in aldosterone target tissues such as distal nephron and colon. ENaC is a heterotetramer composed of three homologous subunits, α, β, and γENaC. Mutations leading to loss of function or reduced channel activity have been identified in all three subunits in patients with pseudohypoaldosteronism type-1. One missense mutation substituting a glycine (G95S) which is completely conserved throughout the gene family reduced ENaC open probability, P o. In this study we have performed systematic alanine substitutions of 28 residues of αENaC encompassing the glycine (G95). This screen identified a stretch of ten consecutive amino acids (αT92–αC101) which, when mutated, lead to a decrease in Na+ current (I Na) expressed with no significant changes in channel surface expression. This inhibitory effect was strongest for G95 and for two additional highly conserved amino acids – H94 and R98. The R98A mutant led to an important reduction in channel P o with no change in single-channel conductance, indicating that the segment encompassing H94, G95 and R98 is involved in modulation of channel gating kinetics.Type of Medium: Electronic ResourceURL: