Search Results - (Author, Cooperation:L. Qian)
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1Ladomersky, E., Zhai, L., Lenzen, A., Lauing, K. L., Qian, J., Scholtens, D. M., Gritsina, G., Sun, X., Liu, Y., Yu, F., Gong, W., Liu, Y., Jiang, B., Tang, T., Patel, R., Platanias, L. C., James, C. D., Stupp, R., Lukas, R. V., Binder, D. C., Wainwright, D. A.
The American Association for Cancer Research (AACR)
Published 2018Staff ViewPublication Date: 2018-06-02Publisher: The American Association for Cancer Research (AACR)Print ISSN: 1078-0432Electronic ISSN: 1557-3265Topics: MedicinePublished by: -
2G. Zhang ; X. Fang ; X. Guo ; L. Li ; R. Luo ; F. Xu ; P. Yang ; L. Zhang ; X. Wang ; H. Qi ; Z. Xiong ; H. Que ; Y. Xie ; P. W. Holland ; J. Paps ; Y. Zhu ; F. Wu ; Y. Chen ; J. Wang ; C. Peng ; J. Meng ; L. Yang ; J. Liu ; B. Wen ; N. Zhang ; Z. Huang ; Q. Zhu ; Y. Feng ; A. Mount ; D. Hedgecock ; Z. Xu ; Y. Liu ; T. Domazet-Loso ; Y. Du ; X. Sun ; S. Zhang ; B. Liu ; P. Cheng ; X. Jiang ; J. Li ; D. Fan ; W. Wang ; W. Fu ; T. Wang ; B. Wang ; J. Zhang ; Z. Peng ; Y. Li ; N. Li ; M. Chen ; Y. He ; F. Tan ; X. Song ; Q. Zheng ; R. Huang ; H. Yang ; X. Du ; L. Chen ; M. Yang ; P. M. Gaffney ; S. Wang ; L. Luo ; Z. She ; Y. Ming ; W. Huang ; B. Huang ; Y. Zhang ; T. Qu ; P. Ni ; G. Miao ; Q. Wang ; C. E. Steinberg ; H. Wang ; L. Qian ; X. Liu ; Y. Yin
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-09-21Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adaptation, Physiological/*genetics ; Animal Shells/chemistry/*growth & development ; Animals ; Apoptosis Regulatory Proteins/genetics ; Crassostrea/*genetics ; DNA Transposable Elements/genetics ; Evolution, Molecular ; Female ; Gene Expression Regulation, Developmental/genetics ; Genes, Homeobox/genetics ; Genome/*genetics ; Genomics ; HSP70 Heat-Shock Proteins/genetics ; Humans ; Larva/genetics/growth & development ; Mass Spectrometry ; Molecular Sequence Annotation ; Molecular Sequence Data ; Polymorphism, Genetic/genetics ; Repetitive Sequences, Nucleic Acid/genetics ; Sequence Analysis, DNA ; Stress, Physiological/genetics/*physiology ; Transcriptome/geneticsPublished by: -
3Staff View
Publication Date: 2011-07-22Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Biomimetics ; *Computers, Molecular ; DNA/analysis/*chemistry ; Decision Making ; Memory ; Models, Biological ; Nanotechnology ; *Neural Networks (Computer) ; Neurons ; Synthetic BiologyPublished by: -
4L. Qian ; Y. Huang ; C. I. Spencer ; A. Foley ; V. Vedantham ; L. Liu ; S. J. Conway ; J. D. Fu ; D. Srivastava
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-04-24Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Biomarkers/analysis ; Cell Lineage ; *Cell Transdifferentiation ; *Cellular Reprogramming ; Cicatrix/pathology/therapy ; Female ; Fibroblasts/*cytology/drug effects/metabolism/pathology ; GATA4 Transcription Factor/genetics/metabolism ; Gene Expression Regulation ; Genetic Vectors/genetics ; Heart/physiology/physiopathology ; MEF2 Transcription Factors ; Male ; Mice ; Myocardial Infarction/drug therapy/pathology/physiopathology/therapy ; Myocardium/cytology/pathology ; Myocytes, Cardiac/*cytology/drug effects/metabolism/*physiology ; Myogenic Regulatory Factors/genetics/metabolism ; Regenerative Medicine/*methods ; T-Box Domain Proteins/genetics/metabolism ; Thymosin/pharmacology/therapeutic usePublished by: -
5Staff View
Publication Date: 2011-06-04Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Base Sequence ; Computer Simulation ; *Computers, Molecular ; DNA/*chemistry/*metabolism ; DNA, Single-Stranded/*chemistry/*metabolism ; Logic ; Nucleic Acid Conformation ; *Nucleic Acid HybridizationPublished by: -
6Staff View
Publication Date: 2018-03-06Publisher: Wiley-BlackwellPrint ISSN: 0148-0227Topics: GeosciencesPhysicsPublished by: -
7Feng, Q., Miao, Y., Ge, J., Yuan, Y., Zuo, Y., Qian, L., Liu, J., Cheng, Q., Guo, T., Zhang, L., Yu, Z., Zheng, H.
The American Association of Immunologists (AAI)
Published 2018Staff ViewPublication Date: 2018-07-10Publisher: The American Association of Immunologists (AAI)Print ISSN: 0022-1767Electronic ISSN: 1550-6606Topics: MedicinePublished by: -
8G. T. Lin, Y. Q. Wang, X. Luo, J. Ma, H. L. Zhuang, D. Qian, L. H. Yin, F. C. Chen, J. Yan, R. R. Zhang, S. L. Zhang, W. Tong, W. H. Song, P. Tong, X. B. Zhu, and Y. P. Sun
American Physical Society (APS)
Published 2018Staff ViewPublication Date: 2018-02-13Publisher: American Physical Society (APS)Print ISSN: 1098-0121Electronic ISSN: 1095-3795Topics: PhysicsKeywords: MagnetismPublished by: -
9Staff View
Publication Date: 2018-11-29Publisher: Royal SocietyElectronic ISSN: 2054-5703Topics: Natural Sciences in GeneralKeywords: biomaterials, biomechanicsPublished by: -
10Wei, R., Xu, L. W., Liu, J., Li, Y., Zhang, P., Shan, B., Lu, X., Qian, L., Wu, Z., Dong, K., Zhu, H., Pan, L., Yuan, J., Pan, H.
Cold Spring Harbor Laboratory Press
Published 2018Staff ViewPublication Date: 2018-12-04Publisher: Cold Spring Harbor Laboratory PressPrint ISSN: 0890-9369Topics: BiologyPublished by: -
11Staff View
ISSN: 1077-3118Source: AIP Digital ArchiveTopics: PhysicsNotes: Scanning tunneling optical spectroscopy has been used to determine the optical properties of semiconductor quantum wells. With this technique, photoenhanced tunneling currents are measured with a scanning tunneling microscope on heterostructures illuminated with monochromatic light. For the InAsxP1−x/InP strained single quantum well structures, the 295 K spectra exhibit well-resolved transitions attributable to interband transitions involving the heavy-hole valence band and the n=1 conduction subband. The observed transition energies are in good agreement with values measured using photoconductivity and photoluminescence spectroscopy on the same samples.Type of Medium: Electronic ResourceURL: -
12Staff View
ISSN: 1077-3118Source: AIP Digital ArchiveTopics: PhysicsNotes: Photoenhanced tunneling currents are measured with a scanning tunneling microscope (STM) for semiconductors illuminated with monochromatic light. The spectral response of the STM tunnel junction was measured over the spectral range of 0.8–1.5 eV. Optical spectra for p-type (111)Si, epitaxial n-type (100)InP, and p-type (100)GaAs were obtained.Type of Medium: Electronic ResourceURL: -
13Mao, J. M. ; Sun, L. F. ; Qian, L. X. ; Pan, Z. W. ; Chang, B. H. ; Zhou, W. Y. ; Wang, G. ; Xie, S. S.
Woodbury, NY : American Institute of Physics (AIP)
Published 1998Staff ViewISSN: 1077-3118Source: AIP Digital ArchiveTopics: PhysicsNotes: We have successfully grown carbon nanotubes on cobalt-implanted silicon with various doses. The morphology of such tubes has been examined by scanning electron microscopy, transmission electron microscopy, and Raman scattering. On contrary to the commonly used transition-metal nanoparticle catalysts, nanometer-sized CoSi2 precipitates produced in the as-implanted substrates are believed to act as nucleation centers for the formation of carbon nanotubes. © 1998 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
14Staff View
ISSN: 1077-3118Source: AIP Digital ArchiveTopics: PhysicsNotes: InSb/GaSb quantum well structures have been prepared by atmospheric pressure metalorganic vapor phase epitaxy. Strong sharp photoluminescence emission peaks with a full width at half- maximum of 6–11 meV were obtained for the quantum well structures with well thicknesses of 0.35–0.88 nm, suggesting nearly atomically planar interfaces. The observed photoluminescence transition energies are in excellent agreement with the calculated values using a standard finite square well model taking into account strain. A broadening of the predominant photoluminescence emission peak was observed for quantum well structures with well thicknesses above 1 nm, indicating nonplanar growth.Type of Medium: Electronic ResourceURL: -
15Sun, L. F. ; Mao, J. M. ; Pan, Z. W. ; Chang, B. H. ; Zhou, W. Y. ; Wang, G. ; Qian, L. X. ; Xie, S. S.
Woodbury, NY : American Institute of Physics (AIP)
Published 1999Staff ViewISSN: 1077-3118Source: AIP Digital ArchiveTopics: PhysicsNotes: In this letter, we report the catalytic synthesis of a large amount of straight carbon nanotubes using a transition-metal cobalt–nickel/zeolite catalyst. High-resolution transmission electron microscopy images show that they are well graphitized. Raman spectrum shows its peak at 1349 cm−1 (D band) is much weaker than that at 1582 cm−1 (G band). We believe that straight carbon nanotubes contain much less defects than curved nanotubes and might have potential applications in the future. © 1999 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
16Sun, L. F. ; Xie, S. S. ; Mao, J. M. ; Pan, Z. W. ; Chang, B. H. ; Zhou, W. Y. ; Wang, G. ; Qian, L. X.
Woodbury, NY : American Institute of Physics (AIP)
Published 2000Staff ViewISSN: 1077-3118Source: AIP Digital ArchiveTopics: PhysicsNotes: We have grown carbon nanotubes at oscillatory growth temperature by chemical vapor deposition. The high-resolution transmission electron microscopy (HRTEM) images show that they contain a number of incomplete carbon layers both on the outer and inner periphery and dislocations in the middle part of the carbon nanotubes walls. The defect structure of these nanotubes depends on the period of the T oscillation. In addition, HRTEM examinations of these carbon nanotubes from end-on reveal that some have polyhedral sections and contain dislocations. These features make them more active chemically and might have significant influence on the properties and applications of the carbon nanotubes. © 2000 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
17Qian, L. ; Wang, Y. ; Xie, J. ; Rose, C. M. ; Yang, T. ; Nakamura, T. ; Sandberg, M. ; Zeng, H. ; Schechter, J. E. ; Chow, R. H. ; Hamm-Alvarez, S. F. ; Mircheff, A. K.
Oxford, UK : Blackwell Science Ltd
Published 2003Staff ViewISSN: 1365-3083Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Profound secretory dysfunction can be associated with relatively modest lymphocytic infiltration of the lacrimal and salivary glands of Sjögren's syndrome (SjS) patients. SjS patients' sera contain autoantibodies to M3 muscarinic acetylcholine receptors (MAChR) that have variously been reported to have agonistic and antagonistic effects. We sought to identify consequences of chronic agonist stimulation by maintaining acinar cells from rabbit lacrimal glands for 20 h in the presence or absence of 10 µm carbachol (CCh). Exposure to CCh diminished the cells' ability to elevate cytosolic Ca2+ and secrete β-hexosaminidase in response to acute stimulation with 100 µm CCh, but it enhanced their secretory responses to phenylephrine and ionomycin. Secretory vesicles appeared normal by electron microscopy, but confocal fluorescence microscopy revealed depletion of the secretory vesicle membrane marker, rab3D, and decreased ability to recruit secretory transport vesicles in response to acute 100 µm CCh. Additionally, the apical cortical actin cytoskeleton was disrupted and diminished compared to the basal–lateral cortical network. Subcellular fractionation analyses revealed that total membrane phase protein content was increased. The contents of β-hexosaminidase and MAChR relative to total protein were not significantly altered, and MAChR abundance in the plasma membrane fraction was increased as the result of redistribution from endomembrane pools. However, relative cellular contents of the heterotrimeric guanosine triphosphate (GTP)-binding proteins, Gq and G11, were decreased. Additional biochemical changes included decreased contents of 47 kDa Gs and Gi3, protein kinase Cα and rab3D and polymeric immunoglobulin (Ig) receptors; internalization of Na,K-ATPase from the plasma membranes to endomembrane compartments and decreased content of β-hexosaminidase in the lysosomes. The observations demonstrate that chronic exposure to a MAChR agonist induces refractoriness to optimal stimulation, without causing receptor downregulation, by downregulating postreceptor-signalling mediators and effectors. The cells' secretory mechanisms for IgA and electrolytes also appear to be impaired, as does their ability to properly sort proteins to the lysosomes.Type of Medium: Electronic ResourceURL: -
18Rose, C. M. ; Qian, L. ; Hakim, L. ; Wang, Y. ; Jerdeva, G. Y. ; Marchelletta, R. ; Nakamura, T. ; Hamm-Alvarez, S. F. ; Mircheff, A. K.
Oxford, UK; Malden, USA : Blackwell Science Ltd
Published 2005Staff ViewISSN: 1365-3083Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Chronic muscarinic stimulation induces functional quiescence (Scand J Immunol 2003;58:550–65) and alters the traffic of immature cathepsin B (Exp Eye Res 2004;79:665–75) in lacrimal acinar cells. To test whether active proteases aberrantly accumulate in the endosomes, cell samples were cultured 20 h with and without 10-µm carbachol (CCh), incubated with [125I]-bovine serum albumin and then lysed and analysed by subcellular fractionation. CCh decreased total cysteine protease and cathepsin S activities in the isolated lysosome, redistributing them to early endocytic and biosynthetic compartments. CCh decreased [125I] accumulation in all compartments of cells loaded in the absence of protease inhibitors; the cysteine protease inhibitor, leupeptin, prevented the endosomal decrease but not the lysosomal decrease. Sodium dodecyl sulphate-polyacrylamide gel electrophoresis and autoradiography demonstrated [125I]-labelled proteolytic products in endomembrane compartments of both control and CCh-stimulated cells, even in the presence of leupeptin, but analysis indicated that CCh increased the amount in endosomes. Two-dimensional fractionation analyses suggest that the CCh-induced redistributions result from blocks in traffic to the late endosome from both the early endosome and the trans-Golgi network. Therefore, we conjecture that chronic muscarinic acetylcholine receptor stimulation leads to aberrant proteolytic processing of autoantigens in endosomes, from whence previously cryptic epitopes may be secreted to the underlying interstitial space.Type of Medium: Electronic ResourceURL: -
19Pan, Z. W. ; Xie, S. S. ; Chang, B. H. ; Wang, C. Y. ; Lu, L. ; Liu, W. ; Zhou, W. Y. ; Li, W. Z. ; Qian, L. X.
[s.l.] : Macmillan Magazines Ltd.
Published 1998Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Carbon nanotubes can now be produced in large quantities by either arc methods, or thermal decomposition of hydrocarbons,. Here we report that pyrolysis of acetylene over iron/silica substrates is an effective method with which to produce very long, multiwalled carbon nanotubes that reach about ...Type of Medium: Electronic ResourceURL: -
20Staff View
ISSN: 1359-0197Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyEnergy, Environment Protection, Nuclear Power EngineeringPhysicsType of Medium: Electronic ResourceURL: