Search Results - (Author, Cooperation:L. Partridge)
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1Latest Papers from Table of Contents or Articles in PressC. Burnett ; S. Valentini ; F. Cabreiro ; M. Goss ; M. Somogyvari ; M. D. Piper ; M. Hoddinott ; G. L. Sutphin ; V. Leko ; J. J. McElwee ; R. P. Vazquez-Manrique ; A. M. Orfila ; D. Ackerman ; C. Au ; G. Vinti ; M. Riesen ; K. Howard ; C. Neri ; A. Bedalov ; M. Kaeberlein ; C. Soti ; L. Partridge ; D. Gems
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-09-23Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Aging/genetics/physiology ; Animals ; Animals, Genetically Modified ; Caenorhabditis elegans/genetics/metabolism/*physiology ; Caenorhabditis elegans Proteins/*genetics/metabolism ; Caloric Restriction ; Crosses, Genetic ; Drosophila Proteins/*genetics/metabolism ; Drosophila melanogaster/genetics/metabolism/*physiology ; Female ; Gene Expression ; Histone Deacetylases/*genetics/metabolism ; Longevity/genetics/*physiology ; Male ; RNA, Messenger/analysis/genetics ; Sirtuins/*genetics/metabolismPublished by: -
2Latest Papers from Table of Contents or Articles in PressS. Mizielinska ; S. Gronke ; T. Niccoli ; C. E. Ridler ; E. L. Clayton ; A. Devoy ; T. Moens ; F. E. Norona ; I. O. Woollacott ; J. Pietrzyk ; K. Cleverley ; A. J. Nicoll ; S. Pickering-Brown ; J. Dols ; M. Cabecinha ; O. Hendrich ; P. Fratta ; E. M. Fisher ; L. Partridge ; A. M. Isaacs
American Association for the Advancement of Science (AAAS)
Published 2014Staff ViewPublication Date: 2014-08-12Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Amyotrophic Lateral Sclerosis/*genetics/pathology ; Animals ; Cell Line, Tumor ; DNA Repeat Expansion/*genetics ; Dipeptides/metabolism ; Disease Models, Animal ; Drosophila melanogaster/*genetics ; Escherichia coli ; Frontotemporal Dementia/*genetics/pathology ; Humans ; Neurons/metabolism/pathology ; Proteins/*geneticsPublished by: -
3Articles: DFG German National LicensesWu, Jie ; Chan, Piu ; Schroeder, Katherine M. ; Ellsworth, Kevin ; Partridge, L. Donald L.
Oxford, UK : Blackwell Science Ltd
Published 2002Staff ViewISSN: 1471-4159Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: We have evaluated GABAA receptor function during treatment of 1-methyl-4-phenylpridinium (MPP+) using patch-clamp perforated whole-cell recording techniques in acutely dissociated dopaminergic (DAergic) neurons from rat substantia nigra compacta (SNc). γ-Aminobutyric acid (GABA), glutamate or glycine induced inward currents (IGABA, IGlu, IGly) at a holding potential (VH) of −45 mV. The IGABA was reversibly blocked by the GABAA receptor antagonist, bicuculline, suggesting that IGABA is mediated through the activation of GABAA receptors. During extracellular perfusion of MPP+ (1–10 μm), IGABA, but neither IGlu nor IGly, declined (termed run-down) with repetitive agonist applications, indicating that the MPP+-induced IGABA run-down occurred earlier than IGly or IGlu under our experimental conditions. The MPP+-induced IGABA run-down can be prevented by a DA transporter inhibitor, mazindol, and can be mimicked by a metabolic inhibitor, rotenone. Using conventional whole-cell recording with different concentrations of ATP in the pipette solution, IGABA run-down can be induced by decreasing intracellular ATP concentrations, or prevented by supplying intracellular ATP, indicating that IGABA run-down is dependent on intracellular ATP concentrations. A GABAA receptor positive modulator, pentobarbital (PB), potentiated the declined IGABA and eliminated IGABA run-down. Corresponding to these patch-clamp data, tyrosine hydroxylase (TH) immunohistochemical staining showed that TH-positive cell loss was protected by PB during MPP+ perfusion. It is concluded that extracellular perfusion of MPP+ induces a functional run-down of GABAA receptors, which may cause an imbalance of excitation and inhibition of DAergic neurons.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] PARTRIDGE REPLIES-The central cri ticism by Kingett et al is that they say I stated1 that female choice of males as mates must be responsible for my results. In reply, I quote the last paragraph of my paper: "The result could be produced by various genetic mechanisms. First, fitness may indeed be ...Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 0022-1910Keywords: Mating ; fertility ; lifespan ; sperm transfer ; survivalSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 0022-1910Keywords: Drosophila ; Mating ; ejaculate molecules ; nutrition ; seminal fluid ; yolk proteinsSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 0022-1910Keywords: Survival ; fertility ; longevity ; reproductionSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 0022-1910Keywords: Ageing ; Drosophila melanogaster ; longevity ; senescenceSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 0022-1910Keywords: Survival ; ageing ; anaesthesia ; body size ; fertility ; longevity ; senescenceSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 0022-1910Keywords: Costs of reproduction ; Drosophila melanogaster ; egg-laying ; fertility ; lifespan ; mating ; sexual activitySource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 0022-1910Keywords: Nutrition ; egg-deposition ; remating ; sperm depletionSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 0003-3472Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 0003-3472Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 0003-3472Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 0003-3472Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 0003-3472Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 0003-3472Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 0003-3472Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesStaff View
ISSN: 0003-3472Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesStaff View
ISSN: 0003-3472Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: