Search Results - (Author, Cooperation:L. Lawton)

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  1. 1
    M. R. Mansour ; B. J. Abraham ; L. Anders ; A. Berezovskaya ; A. Gutierrez ; A. D. Durbin ; J. Etchin ; L. Lawton ; S. E. Sallan ; L. B. Silverman ; M. L. Loh ; S. P. Hunger ; T. Sanda ; R. A. Young ; A. T. Look
    American Association for the Advancement of Science (AAAS)
    Published 2014
    Staff View
    Publication Date:
    2014-11-15
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Acetylation ; Base Sequence ; Basic Helix-Loop-Helix Transcription Factors/*genetics ; Binding Sites ; Cell Line, Tumor ; *DNA, Intergenic ; *Enhancer Elements, Genetic ; *Gene Expression Regulation, Neoplastic ; Histones/metabolism ; Humans ; *INDEL Mutation ; Molecular Sequence Data ; *Mutation ; Oncogenes ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/*genetics ; Protein Interaction Domains and Motifs ; Proto-Oncogene Proteins/*genetics ; Proto-Oncogene Proteins c-myb/metabolism
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  2. 2
  3. 3
    Keshavanath, P. ; Beveridge, M. C. M. ; Baird, D. J. ; Lawton, L. A. ; Nimmo, A. ; Codd, G. A.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1994
    Staff View
    ISSN:
    1095-8649
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Biology
    Notes:
    Small (10 g) tilapia (Oreochromis niloticus) were exposed to pure and mixed populations of toxic and non-toxic strains of the cyanobacterium Microcystis aeruginosa (100% toxic, 50% toxic, 25% toxic, 0% toxic) at two particle concentrations (1 × 106 and 5 × 10sparticles ml−1). At both concentrations there was a progressive decrease in grazing rate as the percentage of toxic cells increased. Differences in opercular beat rates, and hence the volumes of water passed over the gills, were also recorded among treatments, opercular beat rates decreasing as the percentage of toxic cells increased. Although in all treatment groups with toxic cells present, the medium had detectable levels (〉250 ng I−1) of extracellular microcystin-LR toxin present, grazing was correlated with particle-bound rather than extracellular levels.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  4. 4
    Beveridge, M. C. M. ; Baird, D. J. ; Rahmatullah, S. M. ; Lawton, L. A. ; Beattie, K. A. ; Codd, G. A.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1993
    Staff View
    ISSN:
    1095-8649
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Biology
    Notes:
    The tilapia Oreochromis niloticus and the silver carp Hypophthalmichthys molitrix were exposed to toxic and non-toxic strains of the cyanobacterium Microcystis aeruginosa in order to determine if cells of the toxic strain were ingested and, if not, by what mechanism they were excluded. Enumeration of cyanobacterial particles before and after exposure to fish showed that there were no significant differences (P〈0.05) at the end of the trial between the toxic treatment and the control consisting of toxic M. aeruginosa with no fish. Fish exposed to the non-toxic strain increased opercular beat rate, elevating the volumes of water and food material passed over the gills whereas those that were held in the toxic strain did not. Of the cyanobacterial toxins (microcystins) presented to the fish, most were in the cyanobacterial cells, toxin levels in the water being below the level of detectability (〈250 ng l−1), The ability of the fish to differentiate between toxic and non-toxic cyanobacterial strains may thus be determined by very low levels of extracellular microcystins or/and other features which distinguish toxic from non-toxic M. aeruginosa strains, such as cell surface components.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  5. 5
    Avery, R. ; Speare, A. ; Lawton, L.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0890-4065
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Medicine
    Sociology
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  6. 6
    Staff View
    ISSN:
    1432-1203
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Notes:
    Abstract A study was conducted on the feasibility of isolating genes and pseudogenes that map to chromosome 13 by a hybridization-based approach using a 13-specific library and pools of repeat-free cDNA clones. Five pairs of cDNA and chromosome 13 genomic clones were identified and characterized. Partial or full-length sequence was derived from all cDNAs, and database searches were performed for putative gene identification. Partial sequence was also obtained from the chromosome 13 genomic clones for comparison with those of the hybridizing cDNAs. As a result of these analyses we identified three genes, a putative homologue of a porcine mRNA encoding an unidentified hepatic protein, a putative homologue of a yeast integral membrane protein, and a gene for a translationally controlled tumor protein, and two processed pseudogenes, ribosomal proteins L23a and S3a. The latter was formerly identified as the v-fos transformation effector gene, Fte-1, and recently cited as a possible candidate for the BRCA2 gene on chromosome 13. All genes and pseudogenes were localized to cytogenetic bands by in situ hybridization of metaphase chromosomes with probes derived from the chromosome 13 genomic clones.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses