Search Results - (Author, Cooperation:L. Launer)

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  1. 1
    H. F. Zheng ; V. Forgetta ; Y. H. Hsu ; K. Estrada ; A. Rosello-Diez ; P. J. Leo ; C. L. Dahia ; K. H. Park-Min ; J. H. Tobias ; C. Kooperberg ; A. Kleinman ; U. Styrkarsdottir ; C. T. Liu ; C. Uggla ; D. S. Evans ; C. M. Nielson ; K. Walter ; U. Pettersson-Kymmer ; S. McCarthy ; J. Eriksson ; T. Kwan ; M. Jhamai ; K. Trajanoska ; Y. Memari ; J. Min ; J. Huang ; P. Danecek ; B. Wilmot ; R. Li ; W. C. Chou ; L. E. Mokry ; A. Moayyeri ; M. Claussnitzer ; C. H. Cheng ; W. Cheung ; C. Medina-Gomez ; B. Ge ; S. H. Chen ; K. Choi ; L. Oei ; J. Fraser ; R. Kraaij ; M. A. Hibbs ; C. L. Gregson ; D. Paquette ; A. Hofman ; C. Wibom ; G. J. Tranah ; M. Marshall ; B. B. Gardiner ; K. Cremin ; P. Auer ; L. Hsu ; S. Ring ; J. Y. Tung ; G. Thorleifsson ; A. W. Enneman ; N. M. van Schoor ; L. C. de Groot ; N. van der Velde ; B. Melin ; J. P. Kemp ; C. Christiansen ; A. Sayers ; Y. Zhou ; S. Calderari ; J. van Rooij ; C. Carlson ; U. Peters ; S. Berlivet ; J. Dostie ; A. G. Uitterlinden ; S. R. Williams ; C. Farber ; D. Grinberg ; A. Z. LaCroix ; J. Haessler ; D. I. Chasman ; F. Giulianini ; L. M. Rose ; P. M. Ridker ; J. A. Eisman ; T. V. Nguyen ; J. R. Center ; X. Nogues ; N. Garcia-Giralt ; L. L. Launer ; V. Gudnason ; D. Mellstrom ; L. Vandenput ; N. Amin ; C. M. van Duijn ; M. K. Karlsson ; O. Ljunggren ; O. Svensson ; G. Hallmans ; F. Rousseau ; S. Giroux ; J. Bussiere ; P. P. Arp ; F. Koromani ; R. L. Prince ; J. R. Lewis ; B. L. Langdahl ; A. P. Hermann ; J. E. Jensen ; S. Kaptoge ; K. T. Khaw ; J. Reeve ; M. M. Formosa ; A. Xuereb-Anastasi ; K. Akesson ; F. E. McGuigan ; G. Garg ; J. M. Olmos ; M. T. Zarrabeitia ; J. A. Riancho ; S. H. Ralston ; N. Alonso ; X. Jiang ; D. Goltzman ; T. Pastinen ; E. Grundberg ; D. Gauguier ; E. S. Orwoll ; D. Karasik ; G. Davey-Smith ; A. V. Smith ; K. Siggeirsdottir ; T. B. Harris ; M. C. Zillikens ; J. B. van Meurs ; U. Thorsteinsdottir ; M. T. Maurano ; N. J. Timpson ; N. Soranzo ; R. Durbin ; S. G. Wilson ; E. E. Ntzani ; M. A. Brown ; K. Stefansson ; D. A. Hinds ; T. Spector ; L. A. Cupples ; C. Ohlsson ; C. M. Greenwood ; R. D. Jackson ; D. W. Rowe ; C. A. Loomis ; D. M. Evans ; C. L. Ackert-Bicknell ; A. L. Joyner ; E. L. Duncan ; D. P. Kiel ; F. Rivadeneira ; J. B. Richards
    Nature Publishing Group (NPG)
    Published 2015
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    Publication Date:
    2015-09-15
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Bone Density/*genetics ; Bone and Bones/metabolism ; Disease Models, Animal ; Europe/ethnology ; European Continental Ancestry Group/genetics ; Exome/genetics ; Female ; Fractures, Bone/*genetics ; Gene Frequency/genetics ; Genetic Predisposition to Disease/genetics ; Genetic Variation/genetics ; Genome, Human/*genetics ; Genomics ; Genotype ; Homeodomain Proteins/*genetics ; Humans ; Mice ; Sequence Analysis, DNA ; Wnt Proteins/genetics
    Published by:
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  2. 2
    G. B. Ehret ; P. B. Munroe ; K. M. Rice ; M. Bochud ; A. D. Johnson ; D. I. Chasman ; A. V. Smith ; M. D. Tobin ; G. C. Verwoert ; S. J. Hwang ; V. Pihur ; P. Vollenweider ; P. F. O'Reilly ; N. Amin ; J. L. Bragg-Gresham ; A. Teumer ; N. L. Glazer ; L. Launer ; J. H. Zhao ; Y. Aulchenko ; S. Heath ; S. Sober ; A. Parsa ; J. Luan ; P. Arora ; A. Dehghan ; F. Zhang ; G. Lucas ; A. A. Hicks ; A. U. Jackson ; J. F. Peden ; T. Tanaka ; S. H. Wild ; I. Rudan ; W. Igl ; Y. Milaneschi ; A. N. Parker ; C. Fava ; J. C. Chambers ; E. R. Fox ; M. Kumari ; M. J. Go ; P. van der Harst ; W. H. Kao ; M. Sjogren ; D. G. Vinay ; M. Alexander ; Y. Tabara ; S. Shaw-Hawkins ; P. H. Whincup ; Y. Liu ; G. Shi ; J. Kuusisto ; B. Tayo ; M. Seielstad ; X. Sim ; K. D. Nguyen ; T. Lehtimaki ; G. Matullo ; Y. Wu ; T. R. Gaunt ; N. C. Onland-Moret ; M. N. Cooper ; C. G. Platou ; E. Org ; R. Hardy ; S. Dahgam ; J. Palmen ; V. Vitart ; P. S. Braund ; T. Kuznetsova ; C. S. Uiterwaal ; A. Adeyemo ; W. Palmas ; H. Campbell ; B. Ludwig ; M. Tomaszewski ; I. Tzoulaki ; N. D. Palmer ; T. Aspelund ; M. Garcia ; Y. P. Chang ; J. R. O'Connell ; N. I. Steinle ; D. E. Grobbee ; D. E. Arking ; S. L. Kardia ; A. C. Morrison ; D. Hernandez ; S. Najjar ; W. L. McArdle ; D. Hadley ; M. J. Brown ; J. M. Connell ; A. D. Hingorani ; I. N. Day ; D. A. Lawlor ; J. P. Beilby ; R. W. Lawrence ; R. Clarke ; J. C. Hopewell ; H. Ongen ; A. W. Dreisbach ; Y. Li ; J. H. Young ; J. C. Bis ; M. Kahonen ; J. Viikari ; L. S. Adair ; N. R. Lee ; M. H. Chen ; M. Olden ; C. Pattaro ; J. A. Bolton ; A. Kottgen ; S. Bergmann ; V. Mooser ; N. Chaturvedi ; T. M. Frayling ; M. Islam ; T. H. Jafar ; J. Erdmann ; S. R. Kulkarni ; S. R. Bornstein ; J. Grassler ; L. Groop ; B. F. Voight ; J. Kettunen ; P. Howard ; A. Taylor ; S. Guarrera ; F. Ricceri ; V. Emilsson ; A. Plump ; I. Barroso ; K. T. Khaw ; A. B. Weder ; S. C. Hunt ; Y. V. Sun ; R. N. Bergman ; F. S. Collins ; L. L. Bonnycastle ; L. J. Scott ; H. M. Stringham ; L. Peltonen ; M. Perola ; E. Vartiainen ; S. M. Brand ; J. A. Staessen ; T. J. Wang ; P. R. Burton ; M. Soler Artigas ; Y. Dong ; H. Snieder ; X. Wang ; H. Zhu ; K. K. Lohman ; M. E. Rudock ; S. R. Heckbert ; N. L. Smith ; K. L. Wiggins ; A. Doumatey ; D. Shriner ; G. Veldre ; M. Viigimaa ; S. Kinra ; D. Prabhakaran ; V. Tripathy ; C. D. Langefeld ; A. Rosengren ; D. S. Thelle ; A. M. Corsi ; A. Singleton ; T. Forrester ; G. Hilton ; C. A. McKenzie ; T. Salako ; N. Iwai ; Y. Kita ; T. Ogihara ; T. Ohkubo ; T. Okamura ; H. Ueshima ; S. Umemura ; S. Eyheramendy ; T. Meitinger ; H. E. Wichmann ; Y. S. Cho ; H. L. Kim ; J. Y. Lee ; J. Scott ; J. S. Sehmi ; W. Zhang ; B. Hedblad ; P. Nilsson ; G. D. Smith ; A. Wong ; N. Narisu ; A. Stancakova ; L. J. Raffel ; J. Yao ; S. Kathiresan ; C. J. O'Donnell ; S. M. Schwartz ; M. A. Ikram ; W. T. Longstreth, Jr. ; T. H. Mosley ; S. Seshadri ; N. R. Shrine ; L. V. Wain ; M. A. Morken ; A. J. Swift ; J. Laitinen ; I. Prokopenko ; P. Zitting ; J. A. Cooper ; S. E. Humphries ; J. Danesh ; A. Rasheed ; A. Goel ; A. Hamsten ; H. Watkins ; S. J. Bakker ; W. H. van Gilst ; C. S. Janipalli ; K. R. Mani ; C. S. Yajnik ; A. Hofman ; F. U. Mattace-Raso ; B. A. Oostra ; A. Demirkan ; A. Isaacs ; F. Rivadeneira ; E. G. Lakatta ; M. Orru ; A. Scuteri ; M. Ala-Korpela ; A. J. Kangas ; L. P. Lyytikainen ; P. Soininen ; T. Tukiainen ; P. Wurtz ; R. T. Ong ; M. Dorr ; H. K. Kroemer ; U. Volker ; H. Volzke ; P. Galan ; S. Hercberg ; M. Lathrop ; D. Zelenika ; P. Deloukas ; M. Mangino ; T. D. Spector ; G. Zhai ; J. F. Meschia ; M. A. Nalls ; P. Sharma ; J. Terzic ; M. V. Kumar ; M. Denniff ; E. Zukowska-Szczechowska ; L. E. Wagenknecht ; F. G. Fowkes ; F. J. Charchar ; P. E. Schwarz ; C. Hayward ; X. Guo ; C. Rotimi ; M. L. Bots ; E. Brand ; N. J. Samani ; O. Polasek ; P. J. Talmud ; F. Nyberg ; D. Kuh ; M. Laan ; K. Hveem ; L. J. Palmer ; Y. T. van der Schouw ; J. P. Casas ; K. L. Mohlke ; P. Vineis ; O. Raitakari ; S. K. Ganesh ; T. Y. Wong ; E. S. Tai ; R. S. Cooper ; M. Laakso ; D. C. Rao ; T. B. Harris ; R. W. Morris ; A. F. Dominiczak ; M. Kivimaki ; M. G. Marmot ; T. Miki ; D. Saleheen ; G. R. Chandak ; J. Coresh ; G. Navis ; V. Salomaa ; B. G. Han ; X. Zhu ; J. S. Kooner ; O. Melander ; P. M. Ridker ; S. Bandinelli ; U. B. Gyllensten ; A. F. Wright ; J. F. Wilson ; L. Ferrucci ; M. Farrall ; J. Tuomilehto ; P. P. Pramstaller ; R. Elosua ; N. Soranzo ; E. J. Sijbrands ; D. Altshuler ; R. J. Loos ; A. R. Shuldiner ; C. Gieger ; P. Meneton ; A. G. Uitterlinden ; N. J. Wareham ; V. Gudnason ; J. I. Rotter ; R. Rettig ; M. Uda ; D. P. Strachan ; J. C. Witteman ; A. L. Hartikainen ; J. S. Beckmann ; E. Boerwinkle ; R. S. Vasan ; M. Boehnke ; M. G. Larson ; M. R. Jarvelin ; B. M. Psaty ; G. R. Abecasis ; A. Chakravarti ; P. Elliott ; C. M. van Duijn ; C. Newton-Cheh ; D. Levy ; M. J. Caulfield ; T. Johnson
    Nature Publishing Group (NPG)
    Published 2011
    Staff View
    Publication Date:
    2011-09-13
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Africa/ethnology ; Asia/ethnology ; Blood Pressure/*genetics/physiology ; Cardiovascular Diseases/*genetics ; Coronary Artery Disease/genetics ; Europe/ethnology ; Genetic Predisposition to Disease/*genetics ; Genome-Wide Association Study ; Humans ; Hypertension/genetics ; Kidney Diseases/genetics ; Polymorphism, Single Nucleotide/*genetics ; Stroke/genetics
    Published by:
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  3. 3
    J. Yang ; R. J. Loos ; J. E. Powell ; S. E. Medland ; E. K. Speliotes ; D. I. Chasman ; L. M. Rose ; G. Thorleifsson ; V. Steinthorsdottir ; R. Magi ; L. Waite ; A. V. Smith ; L. M. Yerges-Armstrong ; K. L. Monda ; D. Hadley ; A. Mahajan ; G. Li ; K. Kapur ; V. Vitart ; J. E. Huffman ; S. R. Wang ; C. Palmer ; T. Esko ; K. Fischer ; J. H. Zhao ; A. Demirkan ; A. Isaacs ; M. F. Feitosa ; J. Luan ; N. L. Heard-Costa ; C. White ; A. U. Jackson ; M. Preuss ; A. Ziegler ; J. Eriksson ; Z. Kutalik ; F. Frau ; I. M. Nolte ; J. V. Van Vliet-Ostaptchouk ; J. J. Hottenga ; K. B. Jacobs ; N. Verweij ; A. Goel ; C. Medina-Gomez ; K. Estrada ; J. L. Bragg-Gresham ; S. Sanna ; C. Sidore ; J. Tyrer ; A. Teumer ; I. Prokopenko ; M. Mangino ; C. M. Lindgren ; T. L. Assimes ; A. R. Shuldiner ; J. Hui ; J. P. Beilby ; W. L. McArdle ; P. Hall ; T. Haritunians ; L. Zgaga ; I. Kolcic ; O. Polasek ; T. Zemunik ; B. A. Oostra ; M. J. Junttila ; H. Gronberg ; S. Schreiber ; A. Peters ; A. A. Hicks ; J. Stephens ; N. S. Foad ; J. Laitinen ; A. Pouta ; M. Kaakinen ; G. Willemsen ; J. M. Vink ; S. H. Wild ; G. Navis ; F. W. Asselbergs ; G. Homuth ; U. John ; C. Iribarren ; T. Harris ; L. Launer ; V. Gudnason ; J. R. O'Connell ; E. Boerwinkle ; G. Cadby ; L. J. Palmer ; A. L. James ; A. W. Musk ; E. Ingelsson ; B. M. Psaty ; J. S. Beckmann ; G. Waeber ; P. Vollenweider ; C. Hayward ; A. F. Wright ; I. Rudan ; L. C. Groop ; A. Metspalu ; K. T. Khaw ; C. M. van Duijn ; I. B. Borecki ; M. A. Province ; N. J. Wareham ; J. C. Tardif ; H. V. Huikuri ; L. A. Cupples ; L. D. Atwood ; C. S. Fox ; M. Boehnke ; F. S. Collins ; K. L. Mohlke ; J. Erdmann ; H. Schunkert ; C. Hengstenberg ; K. Stark ; M. Lorentzon ; C. Ohlsson ; D. Cusi ; J. A. Staessen ; M. M. Van der Klauw ; P. P. Pramstaller ; S. Kathiresan ; J. D. Jolley ; S. Ripatti ; M. R. Jarvelin ; E. J. de Geus ; D. I. Boomsma ; B. Penninx ; J. F. Wilson ; H. Campbell ; S. J. Chanock ; P. van der Harst ; A. Hamsten ; H. Watkins ; A. Hofman ; J. C. Witteman ; M. C. Zillikens ; A. G. Uitterlinden ; F. Rivadeneira ; L. A. Kiemeney ; S. H. Vermeulen ; G. R. Abecasis ; D. Schlessinger ; S. Schipf ; M. Stumvoll ; A. Tonjes ; T. D. Spector ; K. E. North ; G. Lettre ; M. I. McCarthy ; S. I. Berndt ; A. C. Heath ; P. A. Madden ; D. R. Nyholt ; G. W. Montgomery ; N. G. Martin ; B. McKnight ; D. P. Strachan ; W. G. Hill ; H. Snieder ; P. M. Ridker ; U. Thorsteinsdottir ; K. Stefansson ; T. M. Frayling ; J. N. Hirschhorn ; M. E. Goddard ; P. M. Visscher
    Nature Publishing Group (NPG)
    Published 2012
    Staff View
    Publication Date:
    2012-09-18
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Body Height/genetics ; *Body Mass Index ; Co-Repressor Proteins ; Female ; *Genetic Variation ; Genome-Wide Association Study ; Humans ; Male ; Nerve Tissue Proteins/genetics ; *Phenotype ; Polymorphism, Single Nucleotide ; Proteins/*genetics ; Repressor Proteins/genetics
    Published by:
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  4. 4
    Lin, H., van Setten, J., Smith, A. V., Bihlmeyer, N. A., Warren, H. R., Brody, J. A., Radmanesh, F., Hall, L., Grarup, N., Muller-Nurasyid, M., Boutin, T., Verweij, N., Lin, H. J., Li-Gao, R., van den Berg, M. E., Marten, J., Weiss, S., Prins, B. P., Haessler, J., Lyytikainen, L.-P., Mei, H., Harris, T. B., Launer, L. J., Li, M., Alonso, A., Soliman, E. Z., Connell, J. M., Huang, P. L., Weng, L.-C., Jameson, H. S., Hucker, W., Hanley, A., Tucker, N. R., Chen, Y.-D. I., Bis, J. C., Rice, K. M., Sitlani, C. M., Kors, J. A., Xie, Z., Wen, C., Magnani, J. W., Nelson, C. P., Kanters, J. K., Sinner, M. F., Strauch, K., Peters, A., Waldenberger, M., Meitinger, T., Bork-Jensen, J., Pedersen, O., Linneberg, A., Rudan, I., de Boer, R. A., van der Meer, P., Yao, J., Guo, X., Taylor, K. D., Sotoodehnia, N., Rotter, J. I., Mook-Kanamori, D. O., Trompet, S., Rivadeneira, F., Uitterlinden, A., Eijgelsheim, M., Padmanabhan, S., Smith, B. H., Volzke, H., Felix, S. B., Homuth, G., Volker, U., Mangino, M., Spector, T. D., Bots, M. L., Perez, M., Kahonen, M., Raitakari, O. T., Gudnason, V., Arking, D. E., Munroe, P. B., Psaty, B. M., van Duijn, C. M., Benjamin, E. J., Rosand, J., Samani, N. J., Hansen, T., Kaab, S., Polasek, O., van der Harst, P., Heckbert, S. R., Jukema, J. W., Stricker, B. H., Hayward, C., Dorr, M., Jamshidi, Y., Asselbergs, F. W., Kooperberg, C., Lehtimaki, T., Wilson, J. G., Ellinor, P. T., Lubitz, S. A., Isaacs, A.
    American Heart Association (AHA)
    Published 2018
    Staff View
    Publication Date:
    2018-05-11
    Publisher:
    American Heart Association (AHA)
    Print ISSN:
    1942-325X
    Electronic ISSN:
    1942-3268
    Topics:
    Medicine
    Keywords:
    Electrophysiology, Epidemiology, Genetic, Association Studies
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  5. 5
    Bihlmeyer, N. A., Brody, J. A., Smith, A. V., Warren, H. R., Lin, H., Isaacs, A., Liu, C.-T., Marten, J., Radmanesh, F., Hall, L. M., Grarup, N., Mei, H., Muller-Nurasyid, M., Huffman, J. E., Verweij, N., Guo, X., Yao, J., Li-Gao, R., van den Berg, M., Weiss, S., Prins, B. P., van Setten, J., Haessler, J., Lyytikainen, L.-P., Li, M., Alonso, A., Soliman, E. Z., Bis, J. C., Austin, T., Chen, Y.-D. I., Psaty, B. M., Harrris, T. B., Launer, L. J., Padmanabhan, S., Dominiczak, A., Huang, P. L., Xie, Z., Ellinor, P. T., Kors, J. A., Campbell, A., Murray, A. D., Nelson, C. P., Tobin, M. D., Bork-Jensen, J., Hansen, T., Pedersen, O., Linneberg, A., Sinner, M. F., Peters, A., Waldenberger, M., Meitinger, T., Perz, S., Kolcic, I., Rudan, I., de Boer, R. A., van der Meer, P., Lin, H. J., Taylor, K. D., de Mutsert, R., Trompet, S., Jukema, J. W., Maan, A. C., Stricker, B. H. C., Rivadeneira, F., Uitterlinden, A., Volker, U., Homuth, G., Volzke, H., Felix, S. B., Mangino, M., Spector, T. D., Bots, M. L., Perez, M., Raitakari, O. T., Kahonen, M., Mononen, N., Gudnason, V., Munroe, P. B., Lubitz, S. A., van Duijn, C. M., Newton-Cheh, C. H., Hayward, C., Rosand, J., Samani, N. J., Kanters, J. K., Wilson, J. G., Kaab, S., Polasek, O., van der Harst, P., Heckbert, S. R., Rotter, J. I., Mook-Kanamori, D. O., Eijgelsheim, M., Dorr, M., Jamshidi, Y., Asselbergs, F. W., Kooperberg, C., Lehtimaki, T., Arking, D. E., Sotoodehnia, N.
    American Heart Association (AHA)
    Published 2018
    Staff View
    Publication Date:
    2018-01-12
    Publisher:
    American Heart Association (AHA)
    Print ISSN:
    1942-325X
    Electronic ISSN:
    1942-3268
    Topics:
    Medicine
    Keywords:
    Electrophysiology, Genetic, Association Studies
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  6. 6
    Staff View
    Publication Date:
    2018-08-24
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Geosciences
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Engineering, Genetics
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  7. 7
    Staff View
    ISSN:
    1432-0428
    Keywords:
    Diabetes mellitus ; glucose intolerance ; insulin ; cognition ; aged ; epidemiology
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary Cognitive impairment is highly prevalent among the elderly. Subjects with disturbed glucose metabolism may be at risk of impaired cognitive function, as these disturbances can influence cognition through atherosclerosis, thrombosis and hypertension. We therefore studied the cross-sectional association of cognitive function with hyperinsulinaemia, impaired glucose tolerance and diabetes mellitus in a population-based cohort of 462 men aged 69 to 89 years. Cognitive function was measured by the 30-point Mini-Mental State Examination. Results were expressed as the rate ratio (95% confidence interval) of the number of erroneous answers given on the Mini-Mental State Examination by the index compared to the reference group. Compared to subjects with normal glucose tolerance, known diabetic patients had a rate ratio of 1.23 (1.04–1.46), newly-diagnosed diabetic patients of 1.16 (0.91–1.48) and subjects with impaired glucose tolerance of 1.18 (0.98–1.41), after adjustment for confounding due to age, occupation and cigarette smoking (p-trend=0.01). Non-diabetic subjects in the highest compared to the lowest quartile of the area under the insulin curve had a rate ratio of 1.24 (1.03–1.50), after adjustment for confounding (p-trend=0.02). The results did not change appreciably when potentially mediating factors, including cardiovascular diseases and risk factors associated with the insulin resistance syndrome, were taken into account. These results suggest that diabetes, as well as impaired glucose tolerance and hyperinsulinaemia in non-diabetic subjects are associated with cognitive impairment.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  8. 8
    Staff View
    ISSN:
    1432-0428
    Keywords:
    Key words Diabetes mellitus ; glucose intolerance ; insulin ; cognition ; aged ; epidemiology.
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary Cognitive impairment is highly prevalent among the elderly. Subjects with disturbed glucose metabolism may be at risk of impaired cognitive function, as these disturbances can influence cognition through atherosclerosis, thrombosis and hypertension. We therefore studied the cross-sectional association of cognitive function with hyperinsulinaemia, impaired glucose tolerance and diabetes mellitus in a population-based cohort of 462 men aged 69 to 89 years. Cognitive function was measured by the 30-point Mini-Mental State Examination. Results were expressed as the rate ratio (95 % confidence interval) of the number of erroneous answers given on the Mini-Mental State Examination by the index compared to the reference group. Compared to subjects with normal glucose tolerance, known diabetic patients had a rate ratio of 1.23 (1.04–1.46), newly-diagnosed diabetic patients of 1.16 (0.91–1.48) and subjects with impaired glucose tolerance of 1.18 (0.98–1.41), after adjustment for confounding due to age, occupation and cigarette smoking (p-trend = 0.01). Non-diabetic subjects in the highest compared to the lowest quartile of the area under the insulin curve had a rate ratio of 1.24 (1.03–1.50), after adjustment for confounding (p-trend = 0.02). The results did not change appreciably when potentially mediating factors, including cardiovascular diseases and risk factors associated with the insulin resistance syndrome, were taken into account. These results suggest that diabetes, as well as impaired glucose tolerance and hyperinsulinaemia in non-diabetic subjects are associated with cognitive impairment. [Diabetologia (1995) 38: 1096–1102]
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses