Search Results - (Author, Cooperation:L. Lau)
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1Latest Papers from Table of Contents or Articles in PressS. C. Mack ; H. Witt ; R. M. Piro ; L. Gu ; S. Zuyderduyn ; A. M. Stutz ; X. Wang ; M. Gallo ; L. Garzia ; K. Zayne ; X. Zhang ; V. Ramaswamy ; N. Jager ; D. T. Jones ; M. Sill ; T. J. Pugh ; M. Ryzhova ; K. M. Wani ; D. J. Shih ; R. Head ; M. Remke ; S. D. Bailey ; T. Zichner ; C. C. Faria ; M. Barszczyk ; S. Stark ; H. Seker-Cin ; S. Hutter ; P. Johann ; S. Bender ; V. Hovestadt ; T. Tzaridis ; A. M. Dubuc ; P. A. Northcott ; J. Peacock ; K. C. Bertrand ; S. Agnihotri ; F. M. Cavalli ; I. Clarke ; K. Nethery-Brokx ; C. L. Creasy ; S. K. Verma ; J. Koster ; X. Wu ; Y. Yao ; T. Milde ; P. Sin-Chan ; J. Zuccaro ; L. Lau ; S. Pereira ; P. Castelo-Branco ; M. Hirst ; M. A. Marra ; S. S. Roberts ; D. Fults ; L. Massimi ; Y. J. Cho ; T. Van Meter ; W. Grajkowska ; B. Lach ; A. E. Kulozik ; A. von Deimling ; O. Witt ; S. W. Scherer ; X. Fan ; K. M. Muraszko ; M. Kool ; S. L. Pomeroy ; N. Gupta ; J. Phillips ; A. Huang ; U. Tabori ; C. Hawkins ; D. Malkin ; P. N. Kongkham ; W. A. Weiss ; N. Jabado ; J. T. Rutka ; E. Bouffet ; J. O. Korbel ; M. Lupien ; K. D. Aldape ; G. D. Bader ; R. Eils ; P. Lichter ; P. B. Dirks ; S. M. Pfister ; A. Korshunov ; M. D. Taylor
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-02-21Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Brain Neoplasms/drug therapy/genetics ; CpG Islands/*genetics ; DNA Methylation/drug effects ; Embryonic Stem Cells/metabolism ; Ependymoma/drug therapy/*genetics ; Epigenesis, Genetic/*genetics ; Epigenomics ; Female ; Gene Expression Regulation, Neoplastic ; Gene Silencing/drug effects ; Histones/drug effects/metabolism ; Humans ; Infant ; Mice ; Mice, Inbred NOD ; Mice, SCID ; Mutation/genetics ; Phenotype ; Polycomb Repressive Complex 2/metabolism ; Prognosis ; Rhombencephalon/pathology ; Xenograft Model Antitumor AssaysPublished by: -
2Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2018-05-11Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyGeosciencesComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Medicine, DiseasesPublished by: -
3Latest Papers from Table of Contents or Articles in PressChan, E., Martelli, P., Hui, S.-W., Teng, J. L. L., Lau, S. K. P., Woo, P. C. Y.
The American Society for Microbiology (ASM)
Published 2018Staff ViewPublication Date: 2018-04-27Publisher: The American Society for Microbiology (ASM)Print ISSN: 0066-4804Electronic ISSN: 1098-6596Topics: BiologyMedicinePublished by: -
4Latest Papers from Table of Contents or Articles in PressL. Lau ; E. E. Gray ; R. L. Brunette ; D. B. Stetson
American Association for the Advancement of Science (AAAS)
Published 2015Staff ViewPublication Date: 2015-09-26Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Adenovirus E1A Proteins/chemistry/genetics/*metabolism ; Amino Acid Motifs ; Amino Acid Sequence ; DNA Tumor Viruses/*immunology ; DNA, Neoplasm/immunology ; DNA-Binding Proteins/chemistry/genetics/*metabolism ; Evolution, Molecular ; HEK293 Cells ; HeLa Cells ; Host-Pathogen Interactions ; Humans ; Membrane Proteins/*antagonists & inhibitors ; Metabolic Networks and Pathways ; Molecular Sequence Data ; Nucleotides, Cyclic/*antagonists & inhibitors ; Oncogene Proteins, Viral/chemistry/genetics/*metabolism ; Retinoblastoma Protein/antagonists & inhibitors ; *Tumor EscapePublished by: -
5Latest Papers from Table of Contents or Articles in PressL. C. Katzelnick ; J. M. Fonville ; G. D. Gromowski ; J. Bustos Arriaga ; A. Green ; S. L. James ; L. Lau ; M. Montoya ; C. Wang ; L. A. VanBlargan ; C. A. Russell ; H. M. Thu ; T. C. Pierson ; P. Buchy ; J. G. Aaskov ; J. L. Munoz-Jordan ; N. Vasilakis ; R. V. Gibbons ; R. B. Tesh ; A. D. Osterhaus ; R. A. Fouchier ; A. Durbin ; C. P. Simmons ; E. C. Holmes ; E. Harris ; S. S. Whitehead ; D. J. Smith
American Association for the Advancement of Science (AAAS)
Published 2015Staff ViewPublication Date: 2015-09-19Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; Antigens, Viral/*immunology ; Cercopithecus aethiops ; Dengue Vaccines/immunology ; Dengue Virus/*classification/genetics/*immunology ; Evolution, Molecular ; Humans ; Immune Sera/immunology ; Phylogeny ; Serogroup ; Serotyping ; Vaccination ; Viral Envelope Proteins/geneticsPublished by: -
6Articles: DFG German National LicensesStaff View
ISSN: 1752-1688Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Architecture, Civil Engineering, SurveyingGeographyNotes: : Surrounded by an ocean, the Hawaiian Islands are limited in their natural fresh water resources. The major readily developable potable sources are the high quality ground water sources which serve both domestic uses and sugarcane irrigation although irrigation water does not require as high a quality as drinking water.The increasing overall fresh water requirements for the island of Oahu will outstrip the potential yield of fresh ground water sources, as developed by present technology, by the year 2000 according to Honolulu Board of Water Supply projections. There are water shortage regions on other islands. Water reuse from sewage effluent for irrigation will augment natural water resources, furnish supplemental or alternative fertilizer, and reduce ocean water pollution and the costs of engineering systems.In cooperative field testing from 1971 to 1975, it was demonstrated that effluent can be applied as supplemental water for furrow irrigation of sugarcane without detriment to ground water quality and sugar yield. Studies are in progress to test different dilutions of effluent and its use with chemical ripeners to improve crop yield. Sugarcane plantations on Oahu, Maui, and Kauai are in various stages of water reuse by effluent irrigation. Reuse is presently practiced for irrigation of golf courses and is being planned for forage crops in Hawaii.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 1745-6584Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Energy, Environment Protection, Nuclear Power EngineeringGeosciencesType of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesLiu, Clark C. K. ; Lau, L. Stephen ; Mink, John F.
Oxford, UK : Blackwell Publishing Ltd
Published 1983Staff ViewISSN: 1745-6584Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Energy, Environment Protection, Nuclear Power EngineeringGeosciencesNotes: The Pearl Harbor aquifer, an important ground-water resource for southern Oahu, Hawaii, contains an enormous fresh-water lens, up to 300 m (1,000 ft) thick, floating above saline water. The upper boundary of the fresh-water lens is confined near the coast and phreatic inland, whereas its lower boundary is not confined. A finite-difference flow model was used to simulate the Pearl Harbor aquifer system. The location of the fresh-water/salt-water interface, which constitutes the lower boundary of the flow system model, was estimated by Hubbert's formula. Known geohydrologic boundaries and aquifer parameters were also simulated. First, formation of the lens by filling the aquifer with fresh water from natural recharge was simulated to reconstruct the initial conditions before exploitation of the lens and to partially calibrate the model against the hydraulic-head distribution in 1879. The model then was calibrated fully by simulating the lens’reponse to actual historical pumping patterns covering a time span of 100 years (1880 to 1980). Simulated heads compared favorably with the observed heads over time and space. The calibrated flow model may serve as a useful tool in the management of the Pearl Harbor aquifer.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesGupta, S. K. ; Lau, L. Stephen ; Moravcik, Philip S.
Oxford, UK : Blackwell Publishing Ltd
Published 1994Staff ViewISSN: 1745-6584Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Energy, Environment Protection, Nuclear Power EngineeringGeosciencesNotes: Helium has several characteristics that make it attractive for use as a tracer in hydrological studies. Two types of experiments were conducted to investigate applicability of helium as a tracer of ground-water movement. The experiments included studies using laboratory sand and soil columns and field ground-water tracing in a basaltic aquifer. A water helium analyzer comprised of a thin quartz glass membrane and diode ion pump (making use of the preferential permeation of helium through the quartz glass into an evacuated space) was developed and used for the experiments.Results of our studies demonstrated that breakthrough curves of specific conductance and helium were similar under saturated conditions. In the unsaturated sand/soil columns, breakthrough curves of helium were retarded relative to specific conductance reducing the usefulness of helium as a tracer.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 1365-2222Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: The mediators released during the allergic inflammatory reaction induce the clinical symptoms of the allergic disease and although there have been numerous studies investigating mediator release in allergen challenge models of allergic rhinitis very few have extended this approach to the study of natural disease.〈section xml:id="abs1-2"〉〈title type="main"〉ObjectiveThe aim of this investigation was therefore to measure mast cell and eosinophil mediator levels and indices of vascular permeability in naturally occurring rhinitis.〈section xml:id="abs1-3"〉〈title type="main"〉MethodsThree groups of subjects were studied, normal non-rhinitics, seasonal allergic rhinitics in and out of the grass pollen season and perennial allergic rhinitics. Mediators were recovered using the technique of nasal lavage and the levels of tryptase, histamine, eosinophil cationic protein and albumin were determined. In addition, eosinophils were enumerated in nasal smears as an indices of underlying inflammation.〈section xml:id="abs1-4"〉〈title type="main"〉ResultsThe levels of tryptase, eosinophil cationic protein and albumin were significantly higher in the lavage recovered from the symptomatic seasonal allergic rhinitics than when asymptomatic (P = 0.05, P = 0.003, P = 0.009, respectively). These levels of eosinophil cationic protein and albumin were also significantly higher than those of the normal non-rhinitics (P = 0.0008, P = 0.0.003, respectively). In the perennial allergic rhinitics the levels of tryptase, eosinophil cationic protein and albumin were higher than the normal non-rhinitics (P 〈 0.0001, P = 0.0003, P = 0.0001, respectively). The levels of tryptase and histamine were higher in the perennial allergic rhinitics than the seasonal allergic rhinitics (P = 0.0003, P = 0.006, respectively). These changes in mediator levels were accompanied by a significant influx of eosinophils into the nasal mucosa of both the symptomatic seasonal rhinitics, compared with asymptomatic (P = 0.04) and normal controls (P = 0.0006) and the perennial rhinitics compared to normal controls (P = 0.03).〈section xml:id="abs1-5"〉〈title type="main"〉ConclusionThese results indicate that in both naturally occurring seasonal allergic rhinitis and perennial allergic rhinitis mast cell and eosinophil activation occurs and this is accompanied by an increase in vascular permeability. These measurements in lavage fluid provide a method of monitoring the mucosal cellular events in response to therapy.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesBARDIN, P. G. ; FRAENKEL, D. J. ; SANDERSON, G. ; DORWARD, M. ; LAU, L. C. K. ; JOHNSTON, S. L. ; HOLGATE, S. T.
Oxford, UK : Blackwell Publishing Ltd
Published 1994Staff ViewISSN: 1365-2222Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Abstract. Evidence suggests that atopic individuals may be predisposed to more severe rhinoviral colds coupled to a worsening of existing airway disease than those with asthma. The role of atopy and IgE levels, as well as their relationship to clinical disease expression have not been defined. We hypothesized that an allergic diathesis modulates rhinoviral colds and have initiated studies of normal, atopic and asthmatic subjects employing experimental rhinoviral infection, with measurements of symptom scores, viral shedding and cultures, albumin in nasal washes and serological responses. Twenty-two subjects (11 normal, 5 atopic, 6 atopic and asthmatic) participated and were inoculated with human rhinovirus serotype 16 (HRV 16). Measurements of neutralizing antibody and viral culture were performed at screening, pre-inoculation, during the cold and at 8–10 weeks convalescence. Daily symptoms were noted, nasal washes done, IgE measured and atopy was diagnosed by skin tests. Seventeen volunteers developed clinical colds as assessed by symptom scores, virus shedding was demonstrated (with positive culture) in all subjects and a fourfold or higher seroconversion occurred in 11/22. Neutralizing HRV antibody developed unexpectedly in 10 subjects between screening and inoculation and the presence or absence of this pre-inoculation antibody determined subsequent severity of colds in normal but not in atopic subjects. Atopic antibody positive individuals developed severe clinical colds that were independent of preinoculation antibody in contrast to normal subjects who developed mild colds in the presence of a neutralizing antibody (.P= 0.01). Both atopic and normal antibody negative subjects developed severe colds. This differential response was matched by nasal wash albumin levels which were significantly increased (P= 0–01) during the cold in atopic (but not in normal) volunteers with pre-inoculation antibody. Levels of IgE were not correlated with severity of clinical disease or viral shedding. Our studies of HRV disease in atopic subjects suggest heightened susceptibility to the detrimental effects of colds; additional studies are needed to clarify the relevant mechanisms.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesRAJAKULASINGAM, K. ; POLOSA, R. ; LAU, L. C. K. ; CHURCH, M. K. ; HOLGATE, S. T. ; HOWARTH, P. H.
Oxford, UK : Blackwell Publishing Ltd
Published 1992Staff ViewISSN: 1365-2222Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Nasal instillation of bradykinin elicits many of the characteristic features of rhinitis. To assess the relevance of histamine release from metachromatic cells and the activation of cholinergic pathways, we investigated the effects of terfenadine, a histamine H1-receptor antagonist, and ipratroprium bromide, a selective antimuscarinic agent, on bradykinin induced rhinorrhoea, nasal airways resistance (NAR), nasal pain and plasma protein leakage. Oral terfenadine (120 mg) or matched placebo and nasal ipratropium bromide (80 μg) or matched placebo were administered at 4 hr and 30 min respectively prior to bradykinin nasal challenge in two randomized, double-blind and cross-over studies on eight non-rhinitic subjects. Thus subjects received either double-placebo, oral terfenadine and nasal placebo, oral placebo and nasal ipratopium bromide or oral terfenadine and nasal ipratropium bromide, as pretreatment. Bradykinin challenge induced mean maximal increases of 57%, 59%, 77% and 72% in NAR on the placebo, terfenadine, ipratropium bromide and terfenadine plus ipratropium bromide pretreatment days respectively. These increments were not significantly different. Similarly rhinorrhoea and nasal pain induced by bradykinin nasal challenge were not significantly different on the four challenge days. Bradykinin nasal challenge caused a mean maximal increase in albumin levels in recovered nasal lavages of 11.5, 13.0, 12.2 and 12.3 times of baseline levels on the placebo, terfenadine, ipratropium bromide and terfenadine plus ipratroprium bromide pretreatment days respectively. Similarly total protein levels achieved a mean maximal increase of 8.0, 8.2, 7.9 and 8.8 times of baseline levels on these challenge days. The increments in both albumin and total protein did not significantly differ on the 4 challenge days. This study, therefore, demonstrates that cholinergic pathways and mast cell release of histamine do not contribute to increase in NAR, rhinorrhoea and plasma protein extravasation induced by bradykinin.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 1365-2222Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Background The epithelial accumulation of mast cells is a feature of allergic rhinitis and this has been linked to the expression of the known mast cell chemoattractant transforming growth factor-β (TGF-β) at this site. Little is known concerning the regulation of TGF-β gene expression or protein release by nasal epithelial cells. To address this we have utilized the RPMI 2650 human nasal epithelial cell line, which has some features that closely resemble normal nasal epithelium and has been reported to secrete a TGF-β-like molecule.Objectives To investigate the regulation of TGF-β gene expression and protein secretion in RPMI 2650 nasal epithelial cells following exposure to allergens (house dust mite (HDM) and grass pollen) and mast cell associated T-helper type 2 (Th2) cytokines (IL-4, IL-13, and TNF-α).Methods Light and scanning electron microscopy was used to evaluate the morphology of RPMI 2650 cells in culture, enzyme-linked immunosorbent assay was used to investigate their TGF-β secretory capacity and the identification of the TGF-β isotype(s) involved, flow cytometry was used to demonstrate the presence of TGF-β receptors on the RPMI 2650 cells, and the quantitative real-time TaqMan PCR was used to measure TGF-β gene expression.Results TGF-β2 was identified as the main isotype secreted by the RPMI 2650 cells. HDM allergens and TNF-α increased both TGF-β gene expression and protein release from these cells, whereas grass pollen, IL-4, and IL-13 were without effect.Conclusions The RPMI 2650 nasal epithelial cell line represents a valid in vitro model to evaluate the regulation of TGF-β biology. In this system HDM allergens have stimulatory activity that is fundamentally different from that of grass pollen allergens, and the Th2 cytokines IL-4 and IL-13 are without effect. The ability of TNF-α to up-regulate both TGF-β gene expression and protein release indicates that mast cell–epithelial interactions concerning TGF-β are bi-directional and this may be fundamental to epithelial immunoregulation. The availability of a model system, such as the RPMI 2650 cells, will enable the early evaluation of future novel and targeted interventions directed toward the aberrant responses of upper airway structural cells.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 1365-2222Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Background Eotaxin-1 (CCL11) is a CC chemokine whose nasal eosinophilic chemotactic activity in vivo and in vitro has been demonstrated primarily using nasal allergen challenge models. The extension of these challenge findings to the in vivo setting has been limited.Objective To obtain nasal lavage fluid from volunteers with perennial and seasonal (in- and out-of-season) allergic rhinitis (AR) and non-atopic non-rhinitic controls for the measurement of eotaxin-1 concentrations and to relate these findings to the symptomatic disease severity, the percentage of lavage eosinophils, and to α2-macroglobulin (α2-MG) lavage concentrations, as a marker of vascular permeability and an index of airway inflammation.Methods Thirty-seven volunteers with AR (16 seasonal and 21 perennial) and 20 non-atopic non-rhinitic volunteers were recruited and phenotyped. Nasal lavage fluid was obtained by standardized protocol. The nasal lavage fluid concentrations of eotaxin and α2-MG were measured by ELISA, and differential cell counts performed on cytospins.Results Eotaxin-1 nasal lavage fluid concentrations were significantly higher in both the perennial and seasonal (in-season) AR groups compared with the controls, and significantly related to the severity of symptom expression and to the percentage of lavage eosinophils. The lavage eosinophil counts were significantly higher in both the symptomatic rhinitis groups compared with the control groups and correlated with the lavage concentrations of α2-MG. α2-MG levels were significantly increased in seasonal (in-season) rhinitics compared with both non-atopic controls and seasonal (out-of-season) rhinitics. A significant correlation was observed between the levels of α2-MG and levels of eotaxin in the symptomatic allergic rhinitic groups.Conclusions This study clearly demonstrates the relevance of eotaxin-1 to the pathogenesis of naturally occurring AR.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesHOWARTH, P. H. ; WILSON, S. ; LAU, L. ; RAJ AKULASINGAM, K.
Oxford, UK : Blackwell Publishing Ltd
Published 1991Staff ViewISSN: 1365-2222Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 1432-1920Keywords: Pseudotumour ; computed tomography (CT) ; aneurysm ; subarachnoid haemorrhage ; corpus callosumSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Summary Two patients were scanned 2–5 weeks following onset of subarachnoid haemorrhage. A similar CT appearance was seen in each case. A ring enhancing mass lesion was present within the corpus callosum, suggesting an underlying tumour. However subsequent angiogrphy showed that each case was in fact due to rupture of a pericallosal artery aneurysm. The enhancing membrane of the haematoma gave the false impression of a corpus callosum tumour.Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 1435-8921Source: Springer Online Journal Archives 1860-2000Topics: EconomicsNotes: Abstract In two previous papers by the same authors the data basis for the trade flows and the export prices in the Pacific Basin has presented and documented. In this third report the changing pattern of Pacific Basin trade over the period 1955–1975 is analyzed, using as tools export growth decomposition indexes, trend analysis, and regression analysis of the price elasticity of import market shares.Type of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 1573-2932Source: Springer Online Journal Archives 1860-2000Topics: Energy, Environment Protection, Nuclear Power EngineeringNotes: Abstract A commercial model of a portable virus concentrator operating on the principle of the membrane virus adsorption-elution technique was used to examine the recovery and distribution of human enteropathogenic viruses in Hawaiian waters receiving sewage wastes. Although operating at an efficiency of 20%, a variety of human enteric viruses was isolated, including polioviruses, Coxsackievirus and Echoviruses. Positive virus isolations were consistently made and at high concentrations at sampling stations closest to the sewage outfall. The frequency of virus isolations decreased with increasing distance from the discharge site. viruses were recovered in all directions from the outfall and even as far as 3.2 km east but not 6.4 km away from the discharge site. Tidal conditions to some degree were found to influence the dissemination of viruses. However, since sampling was generally performed at the surface of the water (0.3 to 0.6 m depth), the influence of winds and surface currents was more difficult to assess. Although a positive correlation was found between the presence of high concentrations of indicator coliforms and viruses in waters closest to the discharge site, this relationship was not seen at sampling stations farther away. At these latter stations, positive virus isolations with corresponding low to negligible coliform counts were made which reaffirmed previous published observations that human enteric viruses are relatively more stable in ocean water than coliform bacteria. Furthermore, the instability of the coliform bacteria consequently affected the fecal coliform/fecal streptococci ratios which thus invalidated the use of such ratios to indicate contamination by human wastes.Type of Medium: Electronic ResourceURL: