Search Results - (Author, Cooperation:L. Kruidenier)
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1Latest Papers from Table of Contents or Articles in PressL. Kruidenier ; C. W. Chung ; Z. Cheng ; J. Liddle ; K. Che ; G. Joberty ; M. Bantscheff ; C. Bountra ; A. Bridges ; H. Diallo ; D. Eberhard ; S. Hutchinson ; E. Jones ; R. Katso ; M. Leveridge ; P. K. Mander ; J. Mosley ; C. Ramirez-Molina ; P. Rowland ; C. J. Schofield ; R. J. Sheppard ; J. E. Smith ; C. Swales ; R. Tanner ; P. Thomas ; A. Tumber ; G. Drewes ; U. Oppermann ; D. J. Patel ; K. Lee ; D. M. Wilson
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-10-04Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Enzyme Inhibitors/*pharmacology ; Humans ; Jumonji Domain-Containing Histone Demethylases/*antagonists & inhibitors ; Macrophages/*drug effects/*immunologyPublished by: -
2Latest Papers from Table of Contents or Articles in PressP. Ntziachristos ; A. Tsirigos ; G. G. Welstead ; T. Trimarchi ; S. Bakogianni ; L. Xu ; E. Loizou ; L. Holmfeldt ; A. Strikoudis ; B. King ; J. Mullenders ; J. Becksfort ; J. Nedjic ; E. Paietta ; M. S. Tallman ; J. M. Rowe ; G. Tonon ; T. Satoh ; L. Kruidenier ; R. Prinjha ; S. Akira ; P. Van Vlierberghe ; A. A. Ferrando ; R. Jaenisch ; C. G. Mullighan ; I. Aifantis
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-08-19Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Benzazepines/pharmacology ; Epigenesis, Genetic/drug effects ; Histone Demethylases/genetics/*metabolism ; Histones/chemistry/metabolism ; Jumonji Domain-Containing Histone Demethylases/antagonists & ; inhibitors/*metabolism ; Lysine/metabolism ; Methylation/drug effects ; Mice ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug ; therapy/*enzymology/genetics/pathology ; Pyrimidines/pharmacology ; Tumor Suppressor Proteins/genetics/metabolismPublished by: -
3Latest Papers from Table of Contents or Articles in PressL. Kruidenier ; C. W. Chung ; Z. Cheng ; J. Liddle ; K. Che ; G. Joberty ; M. Bantscheff ; C. Bountra ; A. Bridges ; H. Diallo ; D. Eberhard ; S. Hutchinson ; E. Jones ; R. Katso ; M. Leveridge ; P. K. Mander ; J. Mosley ; C. Ramirez-Molina ; P. Rowland ; C. J. Schofield ; R. J. Sheppard ; J. E. Smith ; C. Swales ; R. Tanner ; P. Thomas ; A. Tumber ; G. Drewes ; U. Oppermann ; D. J. Patel ; K. Lee ; D. M. Wilson
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-07-31Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Amino Acid Sequence ; Animals ; Biocatalysis/drug effects ; Catalytic Domain ; Cells, Cultured ; Enzyme Inhibitors/metabolism/*pharmacology ; Evolution, Molecular ; Histones/chemistry/metabolism ; Humans ; Inhibitory Concentration 50 ; Jumonji Domain-Containing Histone Demethylases/*antagonists & ; inhibitors/chemistry/classification/metabolism ; Lysine/metabolism ; Macrophages/*drug effects/enzymology/*immunology/metabolism ; Methylation/drug effects ; Mice ; Models, Molecular ; Substrate Specificity ; Tumor Necrosis Factor-alpha/biosynthesisPublished by: -
4Articles: DFG German National LicensesStaff View
ISSN: 1365-2036Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Virtually all inflammatory mediators investigated to date seem to be dysregulated in the inflamed intestinal mucosa of patients with inflammatory bowel disease. However, which of these are actually involved in the initiation and perpetuation of intestinal tissue damage is still not fully understood. Amongst these mediators are the reactive oxygen metabolites, produced in large amounts by the massively infiltrating leucocytes. These reactive oxygen metabolites are believed to constitute a major tissue-destructive force and may contribute significantly to the pathogenesis of inflammatory bowel disease.This paper provides a concise overview of reactive oxygen metabolite biochemistry, the types of cell and tissue damage potentially inflicted by them, and the endogenous antioxidants which should prevent these harmful effects. An up-to-date summary of the available human experimental data suggests that reactive oxygen metabolite-mediated injury is important in both the primary and downstream secondary pathophysiological mechanisms underlying intestinal inflammation. Nonetheless, how the individual components of the mucosal antioxidant enzymatic cascade respond to inflammatory conditions is a neglected area of research. This particular aspect of intestinal mucosal oxidative stress therefore merits further study, in order to provide a sound, scientific basis for the design of antioxidant-directed treatment strategies for inflammatory bowel disease patients.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesJanssen, A. M. L. ; Bosman, C. B. ; Kruidenier, L. ; Griffioen, G. ; Lamers, C. B. H. W. ; van Krieken, J. H. J. M. ; van de Velde, C. J. H. ; Verspaget, H. W.
Springer
Published 1999Staff ViewISSN: 1432-1335Keywords: Key words Adenomas ; Colorectal cancer ; Liver metastases ; Superoxide dismutasesSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Purpose : The oxidant-antioxidant balance within tissues is thought to contribute to the development and progression of cancer. Previous investigations have indicated changes in this balance during the colorectal oncogenic process that merit further investigation. The aim of the present study was to evaluate whether the human colorectal cancer sequence is accompanied by changes in the protein and activity levels of the antioxidant enzymes manganese- and copper/zinc-superoxide dismutase (Mn-SOD and Cu/Zn-SOD). Patients and methods : SOD levels were assessed in colorectal adenomas, carcinomas, and liver metastases and were compared with those in the corresponding normal tissues (n=35 in each group). Mn- and Cu/Zn-SOD expression was first evaluated semiquantitatively by electrophoretic activity analysis, immunoblotting, and immunohistochemistry and was subsequently quantified by enzyme-linked immunosorbent assays (ELISAs) and spectrophotometric activity assays. Results : The semiquantitative analyses showed enhanced Mn-SOD levels, primarily localized in (neoplastic) epithelial cells, in carcinomas, and in liver metastases as compared with adenomas and normal mucosa, whereas no consistent pattern was observed for Cu/Zn-SOD. Normal liver tissue expressed the highest levels of both SODs. The quantitative SOD analyses confirmed these observations and revealed that carcinomas and liver metastases expressed 2–4 times more Mn-SOD protein and enzymatic activity (0.0005 〈 P ≤ 0.01) than did the normal mucosa. Adenomas expressed intermediate Mn-SOD levels, which increased significantly with the diameter and tended to increase with the grade of dysplasia and presence of a villous component. In contrast, adenomas, carcinomas, and the corresponding normal mucosa were found to have a similar Cu/Zn-SOD content, whereas liver metastases contained significantly (P 〈 0.02) more Cu/Zn-SOD as compared with these tissues. In addition, the Cu/Zn-SOD content was not related to any histopathological characteristic of the carcinomas or adenomas. Conclusions : Our study indicates that the development of neoplasia in the human colorectum is accompanied by major changes in the level and activity of Mn-SOD. This observation illustrates that Mn-SOD might have a functional role in human colorectal carcinogenesis.Type of Medium: Electronic ResourceURL: