Search Results - (Author, Cooperation:L. Kenner)

Showing 1 - 6 results of 6, query time: 0.15s Refine Results
  1. 1
    Staff View
    Publication Date:
    2015-04-30
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Staff View
    Publication Date:
    2018-03-23
    Publisher:
    American Society of Hematology (ASH)
    Print ISSN:
    0006-4971
    Electronic ISSN:
    1528-0020
    Topics:
    Biology
    Medicine
    Keywords:
    Lymphoid Neoplasia
    Published by:
    Latest Papers from Table of Contents or Articles in Press
  3. 3
  4. 4
  5. 5
  6. 6
    Staff View
    ISSN:
    1432-2307
    Keywords:
    Key words BCR-ABL ; Amplification ; CML ; Blast crisis
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract  Although chronic phase myelogenous leukaemia (CML) is characterised by the Philadelphia (Ph) chromosome leading to a fusion of the BCR and ABL genes, additional genetic alterations involved in blast crisis are poorly understood. We report an at least 15-fold amplification of the ABL oncogene in a 29-year-old male patient with a variant Ph-positive t(19;22)(p13;q11.2) CML who presented in lymphoid blast crisis. Our finding suggests that an amplification of the ABL oncogene might play a part in the appearance of an aggressive phenotype in some cases of CML.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses