Search Results - (Author, Cooperation:L. Galli)

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  1. 1
    Staff View
    Publication Date:
    2018-04-03
    Publisher:
    Rockefeller University Press
    Print ISSN:
    0022-1007
    Electronic ISSN:
    1540-9538
    Topics:
    Medicine
    Published by:
    http://www.rupress.org/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Staff View
    Publication Date:
    2018-06-27
    Publisher:
    Institute of Physics Publishing (IOP)
    Electronic ISSN:
    1748-0221
    Topics:
    Physics
    Published by:
    http://www.iop.org/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Staff View
    Publication Date:
    2012-12-01
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Amino Acid Sequence ; Animals ; Catalytic Domain ; Cathepsin B/antagonists & inhibitors/*chemistry ; Crystallization ; Crystallography, X-Ray ; Enzyme Precursors/chemistry ; Glycosylation ; Models, Molecular ; Molecular Sequence Data ; Protein Conformation ; Protozoan Proteins/antagonists & inhibitors/*chemistry ; Sf9 Cells ; Spodoptera ; Trypanosoma brucei brucei/*enzymology ; X-Rays
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  4. 4
    Staff View
    Publication Date:
    2016-02-13
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Crystallization ; Crystallography, X-Ray/*methods ; Models, Molecular ; Photosystem II Protein Complex/*chemistry
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  5. 5
    C. Kupitz ; S. Basu ; I. Grotjohann ; R. Fromme ; N. A. Zatsepin ; K. N. Rendek ; M. S. Hunter ; R. L. Shoeman ; T. A. White ; D. Wang ; D. James ; J. H. Yang ; D. E. Cobb ; B. Reeder ; R. G. Sierra ; H. Liu ; A. Barty ; A. L. Aquila ; D. Deponte ; R. A. Kirian ; S. Bari ; J. J. Bergkamp ; K. R. Beyerlein ; M. J. Bogan ; C. Caleman ; T. C. Chao ; C. E. Conrad ; K. M. Davis ; H. Fleckenstein ; L. Galli ; S. P. Hau-Riege ; S. Kassemeyer ; H. Laksmono ; M. Liang ; L. Lomb ; S. Marchesini ; A. V. Martin ; M. Messerschmidt ; D. Milathianaki ; K. Nass ; A. Ros ; S. Roy-Chowdhury ; K. Schmidt ; M. Seibert ; J. Steinbrener ; F. Stellato ; L. Yan ; C. Yoon ; T. A. Moore ; A. L. Moore ; Y. Pushkar ; G. J. Williams ; S. Boutet ; R. B. Doak ; U. Weierstall ; M. Frank ; H. N. Chapman ; J. C. Spence ; P. Fromme
    Nature Publishing Group (NPG)
    Published 2014
    Staff View
    Publication Date:
    2014-07-22
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    *Crystallography, X-Ray ; Cyanobacteria/*chemistry ; *Models, Molecular ; Photosystem II Protein Complex/*chemistry ; Protein Structure, Tertiary
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  6. 6
    Martino, M. de ; Peruzzi, M. ; Galli, L. ; Lega, L. ; Zammarchi, E. ; Vierucci, A.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1992
    Staff View
    ISSN:
    1399-3038
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    A total of 120 placebo-negative children with intermittent or recurrent urticaria-angiodema (U-A) were orally challenged with 7 food-additives (F-A): tartrazine (E102), sunset yellow (E110), erythrosine (E127), annatto (E160b), sodium benzoate (E211), acetyl-salicylic acid (ASA) and aspartame. The results of the challenges were correlated with familial and personal history of atopic diseases, the presence of inhalantand food-specific IgE (evaluated by skin testing and RAST), total IgE levels, values of circulating eosinophils, physical urticaria, C3, C4 and Cl-inhibitor levels, the presence of circulating immune complexes, and of Candida albicans, parasite, hepatitis B virus and Epstein-Barr virus infection. Fifty-six (46. 4%) children had one or more positive challenge (s). Among them the following frequencies of positive challenges were recorded: E110 = 64. 2%, E160b = 60. 7%, E211: 57. 1%; E102 = 50.0%, aspartame = 48. 2%, E127 = 35. 7%, ASA = 12. 5%. Positive challenges correlated with none of the variables considered. In particular, positive challenges were clearly unrelated to an atopic condition. It is suggested that: a) F-A intolerance is frequent in children with recurrent or intermittent U-A; b) aspartame may be a causative agent of U-A in childhood; c) F-A intolerance is unrelated to other causes of U-A in children.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1399-3038.1992.tb00024.x

    Articles: DFG German National Licenses
  7. 7
    Rossi, M. E. ; Resti, M. ; Azzari, C. ; Calabri, G. ; Martino, M. De ; Galli, L. ; Carbonella, R. ; Vierucci, A.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1994
    Staff View
    ISSN:
    1399-3038
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    The specificity of IgA against food, inhalant, bacterial and fungine antigens as well as for HIV-1 proteins was investigated in 14 HIV-1-infected children (CDC stage P-2) and 15 controls. IgA against food- and inhalant antigens as well as against tetanus toxoid were significantly more often present in the HIV positive children than in controls. No difference between the two groups was present for IgA against Candida albicans. A significant increase of substance P, a strong IgA synthesis inducing neuropeptide, was demonstrated in the plasma of HIV-1 infected children. In conclusion, high levels of IgA seem to reflect a complex immune dys-function in which many factors are involved. The importance of neuro-immune dysregulation is discussed.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1399-3038.1994.tb00247.x

    Articles: DFG German National Licenses
  8. 8
    Galli, L.

    Milano : Periodicals Archive Online (PAO)
    Published 1992
    Staff View
    ISSN:
    0001-9593
    Topics:
    Linguistics and Literary Studies
    History
    Notes:
    Recensioni
    URL:
    http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:4009-1992-066-01-000020

    Articles: DFG German National Licenses
  9. 9
    Beccaria, M. ; Curci, G. ; Galli, L.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0920-5632
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0920-5632(94)90513-4

    Articles: DFG German National Licenses
  10. 10
    Galli, L. ; Chalupa, L. ; Maffei, L. ; Bisti, S.
    Springer
    Published 1988
    Staff View
    ISSN:
    1432-1106
    Keywords:
    Area 18 ; Receptive field ; Velocity ; Spatial frequency ; Cat
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary The spatial frequency tuning curves of neurones of area 18 depend upon the velocity of the visual stimulus. The higher the velocity the lower the spatial frequencies to which the cell is tuned. Since in area 17 the size of the cell receptive field is inversely related with the optimal spatial frequency to which the cell responds, we have investigated whether the shift of the optimal spatial frequency with the velocity corresponds to a “change” in the receptive field size. We recorded extracellularly from neurones in area 18; for each cell we selected two gratings, one of high spatial frequency drifting at low velocity and another of low spatial frequency drifting at high velocity to which the cell gave comparable responses. The results show that the masking of the cells receptive field which abolishes the response to the high frequency low velocity grating does not prevent the cell from responding to the low frequency high velocity grating. We conclude that the size of the receptive field of neurones in area 18 depends upon the characteristics (spatial frequency and velocity) of the visual stimulus.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00247517

    Articles: DFG German National Licenses
  11. 11
    Berardi, N. ; Galli, L. ; Maffei, L. ; Siliprandi, R.
    Springer
    Published 1986
    Staff View
    ISSN:
    1432-1106
    Keywords:
    Visual neurons ; Contrast ; Binocular interactions ; Cat
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary Dichoptic presentation of patterns similar in shape but of very different contrast results in the perception of only the high contrast pattern (binocular suppression). When recording from binocular neurons of the cat visual cortex, we have found an effect which is strikingly similar to this perceptual phenomenon. If a high and a low contrast grating are presented simultaneously, one to each eye, the cell's response to the low contrast stimulus is suppressed.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00237480

    Articles: DFG German National Licenses
  12. 12
    Galli, L. ; Rao, K. ; Lund, R. D.
    Springer
    Published 1989
    Staff View
    ISSN:
    1432-1106
    Keywords:
    Retinotectal maps ; Visual system ; Transplants ; Topography
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary We report here that transplanted rat retinae do not project in a topographically organized fashion onto the host tectum. In fact, following the injection of two small non-overlapping regions of the host tectum, one with Fluorogold, the other with Rhodamine conjugated latex microspheres, groups of ganglion cells labelled with either dye are found interspersed throughout the ganglion cell layer of the retinal transplant. The absence of topography in the projections of transplanted retinae offers a new opportunity to examine the mechanisms which lead to topographically ordered projections in normal development.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00248878

    Articles: DFG German National Licenses
  13. 13
    Gravina, A. ; Domenici, L. ; Berardi, N. ; Galli, L. ; Maffei, L.
    Springer
    Published 1990
    Staff View
    ISSN:
    1432-1106
    Keywords:
    Transplant ; Neurotrophic factors ; Retinal ganglion cells ; ERG ; Rat
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary We have investigated the effectiveness of embryonal tectal tissue transplants in preserving the physiological activity of lesioned ganglion cells by recording the visual responses from the adult rat retina after section of the optic nerve, with or without transplants of embryonal nervous tissue on the stump. We have found that transplant of embryonal nervous tissue at the level of the optic nerve section has dramatic effects in preserving visual retinal responses to patterned stimuli for times as long as five months after surgery. By this time retinal responses to patterned stimuli have almost completely disappeared in control animals with optic nerve section alone.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00228004

    Articles: DFG German National Licenses
  14. 14
    Galli, L. ; Martino, M. ; Mannelli, F. ; Vierucci, A.
    Springer
    Published 1993
    Staff View
    ISSN:
    1432-1076
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01955913

    Articles: DFG German National Licenses
  15. 15
    Ignjatovic, J. ; Galli, L.
    Springer
    Published 1994
    Staff View
    ISSN:
    1432-8798
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary The S1, N and M proteins, obtained from the nephropathogenic N1/62 strain of infectious bronchitis virus (IBV) by immunoaffinity purification with monoclonal antibodies, were used for immunization of chickens. For all three antigens multiple immunizations were necessary for induction of an antibody response. Protection of chickens vaccinated with the S1 glycoprotein against virulent challenge was demonstrated by the complete absence of virus in tracheas and kidneys of vaccinated chickens. Following four immunizations with the S1 glycoprotein 71% and 86% of chickens were protected at the level of tracheas and kidneys, respectively. Three immunizations with the S1 glycoprotein protected 70% and 10% of chickens at the level of kidney and trachea, respectively. Neither the N nor the M antigen induced protection to a virulent challenge with the nephropathogenic N1/62 strain of IBV after four immunizations. Virus neutralizing, haemagglutination inhibiting and ELISA antibodies were detected in chickens immunized with the S1 glycoprotein and inactivated N1/62 virus, however there was no correlation between the presence of any of these antibodies and protection.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01310043

    Articles: DFG German National Licenses
  16. 16
    Staff View
    ISSN:
    1569-8041
    Keywords:
    depot lanreotide ; neuroendocrine tumors ; octreotide LAR
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract Background:In the present study we investigated the efficacy andtolerability of i.m. octreotide acetate (octreotide LAR) in patients withmetastatic neuroendocrine tumors (NETs) previously treated and failed on i.m.lanreotide. Patients and methods:Fifteen patients (8 females, 7 males, medianage 67 years, range 28–81 years) with metastatic NETs (8 endocrinepancreatic tumors, 7 midgut carcinoids) were enrolled in the study. Allpatients were in progressive disease (objective: 11 patients, symptomatic: 10patients, biochemical: 11 patients) after treatment with slow releaselanreotide, 30 mg every 14 days for a median time of 8 months (range3–19 months). All patients had measurable disease; 12 patients hadelevated serum and/or urine markers and 11 were symptomatic. Octreotidescintigraphy was positive in 13 of 15 patients. Octreotide LAR wasadministered as i.m. injection at the dose of 20 mg every four weeks untildisease progression. Results:An objective partial response (PR) was documented in onepatient (7%), no change (NC) in six (40%), and progressivedisease (PD) in eight patients (53%). The PR was observed in onepatient with non-functioning endocrine pancreatic tumor with progressive liverand lymph node metastases after 16 months of i.m. lanreotide therapy. Themedian duration of disease stabilization was 7.5 months (range 6–12+months). The overall biochemical response rate was 41%, including CRs(33%) and PRs (8%); biochemical responses were observed incarcinoids as well as in endocrine pancreatic tumors; the median duration ofresponse was 5 months for CRs and 7.5 months for PRs. The overall symptomaticresponse rate was 82%. The median duration of response for diarrhoea,abdominal pain, or both was 6.5 months (range 3–12+ months). Improvementin performance status (PS) was obtained in 5 of 11 patients with PS of 1 atstudy entry. Median duration of octreotide LAR treatment was seven months (range3–12+ months). No serious adverse events were reported; mild sideeffects were reported in 26% of patients. Conclusions:Octreotide LAR 20 mg shows significant efficacy interms of objective response rate (PR + SD), biochemical and symptomaticcontrol in patients with metastatic NETs of the GEP system pretreated andprogressing on slow release lanreotide.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1023/A:1008383132024

    Articles: DFG German National Licenses
  17. 17
    Pontiroli, A. E. ; Galli, L.
    Springer
    Published 1998
    Staff View
    ISSN:
    1432-5233
    Keywords:
    Key words Duration of obesity ; Type 2 diabetes ; Hyperlipidaemia ; Arterial hypertension ; Insulin resistance
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract Obesity is often accompanied by non-insulin-dependent diabetes mellitus (type 2), arterial hypertension, and hyperlipidaemia. The aim of this study was to evaluate whether duration of obesity is a risk factor for the appearance of type 2 diabetes, hypertension, and hyperlipidaemia. We studied 760 obese subjects, 207 of whom had normal glucose tolerance, 125 impaired glucose tolerance, and 428 type 2 diabetes; in addition, 560 had hypertension and 315 had hyperlipidaemia. At univariate analysis, passing from normal through impaired glucose tolerance to type 2 diabetes there was a progressive increase of age and of duration of obesity, hypertension and hyperlipidaemia. Compared to subjects without hypertension, hypertensive subjects were older, had a longer duration of obesity, a greater body mass index (BMI, kg/m2), and more frequently a family history of hypertension; they also more frequently showed impaired glucose tolerance and type 2 diabetes and hyperlipidaemia. Compared to subjects without hyperlipidaemia, hyperlipidaemic subjects were older, had a longer duration of obesity, and more frequently showed impaired glucose tolerance and type 2 diabetes, and hypertension. Diabetes, hypertension, and hyperlipidaemia were highly associated, as up to 80% of subjects with type 2 diabetes had hypertension, and more than 80% of hyperlipidaemic subjects had hypertension. Type 2 diabetes was less frequent than hypertension and hyperlipidaemia during the first 10 years of obesity, and progressively increased thereafter; in contrast the frequency of hypertension and of hyperlipidaemia increased only after 30 years of obesity. In 359 subjects undergoing an oral glucose tolerance test (168 with simultaneous determination of insulin release), increasing durations of obesity were accompanied by an increasing prevalence of type 2 diabetes, and in deterioration of glucose response, with no decrease in insulin release. At logistic regression analysis, age was a common risk factor for diabetes, hypertension, and hyperlipidaemia; duration of obesity and hyperlipidaemia were additional risk factors for diabetes; family history of hypertension, BMI and hyperlipidaemia were additional risk factors for hypertension, as were impaired glucose tolerance or diabetes, and hypertension for hyperlipidaemia. These data indicate that duration of obesity is a risk factor for type 2 diabetes, and emphasize the importance of preventing obesity in young subjects.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/s005920050117

    Articles: DFG German National Licenses
  18. 18
    Staff View
    ISSN:
    1619-7089
    Keywords:
    Myocardial perfusion ; Myocardial metabolism ; Radionuclide imaging ; Myocardial viability ; Coronary artery bypass grafting
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract We tested the possibility of identifying areas of hibernating myocardium by the combined assessment of perfusion and metabolism using single photon emission tomography (SPET) with technetium-99m hexakis 2-methoxyisobutylisonitrile (99mTc-MIBI) and positron emission tomography (PET) with fluorine-18 fluoro-2-deoxy-d-glucose (18F-FDG). Segmental wall motion, perfusion and 18F-FDG uptake were scored in 5 segments in 14 patients with coronary artery disease (CAD), for a total number of 70 segments. Each subject underwent the following studies prior to and following coronary arterybypass grafting (CABG): first-pass radionuclide angiography, electrocardiography gated planar perfusion scintigraphy and SPET perfusion scintigraphy with 99mTc-MIBI and, after 16 h fasting, 18F-FDG/PET metabolic scintigraphy. Wall motion impairment was either decreased or completely reversed by CABG in 95% of the asynergic segments which exhibited 18F-FDG uptake, whereas it was unmodified in 80% of the asynergic segments with no 18-FDG uptake. A stepwise multiple logistic analysis was carried out on the asynergic segments to estimate the postoperative probability of wall motion improvement on the basis of the preoperative regional perfusion and metabolic scores. The segments with the highest probability (96%) of functional recovery from preoperative asynergy after revascularization were those with a marked 18F-FDG uptake prior to CABG. High probabilities of functional recovery were also estimated for the segments presenting with moderate and low 18F-FDG uptake (92% and 79%, respectively). A low probability of functional recovery (13 %) was estimated in the segments with no 18F-FDG uptake. Despite the potential limitations due to the semiquantitative analysis of the images, the method appears to provide reliable information for the diagnostic and prognostic evaluation of patients with CAD undergoing CABG and confirms that the identification of hibernating myocardium with 18F-FDG is of paramount importance in the diagnosis of patients undergoing CABG.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00168164

    Articles: DFG German National Licenses
  19. 19
    Staff View
    ISSN:
    1619-7089
    Keywords:
    Single-photon emission tomography ; Positron emission tomography ; Myocardial perfusion ; Myocardial viability
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Abstract We compare thallium-201 rest redistribution and fluorine-18 fluorodeoxyglucose ([18F]FDG) for the assessment of myocardial viability within technetium-99m methoxyisobutylisonitrile (MIBI) perfusion defects in 27 patients with chronic stable coronary artery disease. The following studies were performed: (1) stress99mTc-MIBI, (2) rest99mTc-MIBI, (3)201T1 rest-redistribution single-photon emission tomography, (4) [18F]FDG positron emission tomography. The left ventricle was devided into 11 segments on matched tomographic images. The segment with the highest activity at stress was taken as the reference (activity=100%). Perfusion defects at99mTc-MIBI rest were classified as severe (activity〈50%), moderate (activity 50%–60%) or mild (activity 60%–85%). Uptakes of [18F]FDG and rest-redistributed201Tl were recognized as significant if they exceeded 50% of that in the reference segment. Among the 33 segments with severe99mTc-MIBI rest perfusion defects, 21 had significant [18F]FDG and 10 significant rest-redistributed201Tl uptake. As regards the 37 segments with moderate defects, [18F]FDG was present in 29 and201Tl in 31, while of the 134 segments with mild defects, 128 showed [18F]FDG uptake, and 131,201Tl uptake. In conclusion, there is an inverse relationship between the severity of99mTc-MIBI perfusion defects and the uptake of rest-redistributed201Tl and [18F]FDG. Both tracers are adequate markers of viability in mild and moderate defects; in severe defects201Tl might underestimate the presence of viability as assessed by [18F]FDG.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00801618

    Articles: DFG German National Licenses