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1Latest Papers from Table of Contents or Articles in PressD. P. Hibar ; J. L. Stein ; M. E. Renteria ; A. Arias-Vasquez ; S. Desrivieres ; N. Jahanshad ; R. Toro ; K. Wittfeld ; L. Abramovic ; M. Andersson ; B. S. Aribisala ; N. J. Armstrong ; M. Bernard ; M. M. Bohlken ; M. P. Boks ; J. Bralten ; A. A. Brown ; M. M. Chakravarty ; Q. Chen ; C. R. Ching ; G. Cuellar-Partida ; A. den Braber ; S. Giddaluru ; A. L. Goldman ; O. Grimm ; T. Guadalupe ; J. Hass ; G. Woldehawariat ; A. J. Holmes ; M. Hoogman ; D. Janowitz ; T. Jia ; S. Kim ; M. Klein ; B. Kraemer ; P. H. Lee ; L. M. Olde Loohuis ; M. Luciano ; C. Macare ; K. A. Mather ; M. Mattheisen ; Y. Milaneschi ; K. Nho ; M. Papmeyer ; A. Ramasamy ; S. L. Risacher ; R. Roiz-Santianez ; E. J. Rose ; A. Salami ; P. G. Samann ; L. Schmaal ; A. J. Schork ; J. Shin ; L. T. Strike ; A. Teumer ; M. M. van Donkelaar ; K. R. van Eijk ; R. K. Walters ; L. T. Westlye ; C. D. Whelan ; A. M. Winkler ; M. P. Zwiers ; S. Alhusaini ; L. Athanasiu ; S. Ehrlich ; M. M. Hakobjan ; C. B. Hartberg ; U. K. Haukvik ; A. J. Heister ; D. Hoehn ; D. Kasperaviciute ; D. C. Liewald ; L. M. Lopez ; R. R. Makkinje ; M. Matarin ; M. A. Naber ; D. R. McKay ; M. Needham ; A. C. Nugent ; B. Putz ; N. A. Royle ; L. Shen ; E. Sprooten ; D. Trabzuni ; S. S. van der Marel ; K. J. van Hulzen ; E. Walton ; C. Wolf ; L. Almasy ; D. Ames ; S. Arepalli ; A. A. Assareh ; M. E. Bastin ; H. Brodaty ; K. B. Bulayeva ; M. A. Carless ; S. Cichon ; A. Corvin ; J. E. Curran ; M. Czisch ; G. I. de Zubicaray ; A. Dillman ; R. Duggirala ; T. D. Dyer ; S. Erk ; I. O. Fedko ; L. Ferrucci ; T. M. Foroud ; P. T. Fox ; M. Fukunaga ; J. R. Gibbs ; H. H. Goring ; R. C. Green ; S. Guelfi ; N. K. Hansell ; C. A. Hartman ; K. Hegenscheid ; A. Heinz ; D. G. Hernandez ; D. J. Heslenfeld ; P. J. Hoekstra ; F. Holsboer ; G. Homuth ; J. J. Hottenga ; M. Ikeda ; C. R. Jack, Jr. ; M. Jenkinson ; R. Johnson ; R. Kanai ; M. Keil ; J. W. Kent, Jr. ; P. Kochunov ; J. B. Kwok ; S. M. Lawrie ; X. Liu ; D. L. Longo ; K. L. McMahon ; E. Meisenzahl ; I. Melle ; S. Mohnke ; G. W. Montgomery ; J. C. Mostert ; T. W. Muhleisen ; M. A. Nalls ; T. E. Nichols ; L. G. Nilsson ; M. M. Nothen ; K. Ohi ; R. L. Olvera ; R. Perez-Iglesias ; G. B. Pike ; S. G. Potkin ; I. Reinvang ; S. Reppermund ; M. Rietschel ; N. Romanczuk-Seiferth ; G. D. Rosen ; D. Rujescu ; K. Schnell ; P. R. Schofield ; C. Smith ; V. M. Steen ; J. E. Sussmann ; A. Thalamuthu ; A. W. Toga ; B. J. Traynor ; J. Troncoso ; J. A. Turner ; M. C. Valdes Hernandez ; D. van 't Ent ; M. van der Brug ; N. J. van der Wee ; M. J. van Tol ; D. J. Veltman ; T. H. Wassink ; E. Westman ; R. H. Zielke ; A. B. Zonderman ; D. G. Ashbrook ; R. Hager ; L. Lu ; F. J. McMahon ; D. W. Morris ; R. W. Williams ; H. G. Brunner ; R. L. Buckner ; J. K. Buitelaar ; W. Cahn ; V. D. Calhoun ; G. L. Cavalleri ; B. Crespo-Facorro ; A. M. Dale ; G. E. Davies ; N. Delanty ; C. Depondt ; S. Djurovic ; W. C. Drevets ; T. Espeseth ; R. L. Gollub ; B. C. Ho ; W. Hoffmann ; N. Hosten ; R. S. Kahn ; S. Le Hellard ; A. Meyer-Lindenberg ; B. Muller-Myhsok ; M. Nauck ; L. Nyberg ; M. Pandolfo ; B. W. Penninx ; J. L. Roffman ; S. M. Sisodiya ; J. W. Smoller ; H. van Bokhoven ; N. E. van Haren ; H. Volzke ; H. Walter ; M. W. Weiner ; W. Wen ; T. White ; I. Agartz ; O. A. Andreassen ; J. Blangero ; D. I. Boomsma ; R. M. Brouwer ; D. M. Cannon ; M. R. Cookson ; E. J. de Geus ; I. J. Deary ; G. Donohoe ; G. Fernandez ; S. E. Fisher ; C. Francks ; D. C. Glahn ; H. J. Grabe ; O. Gruber ; J. Hardy ; R. Hashimoto ; H. E. Hulshoff Pol ; E. G. Jonsson ; I. Kloszewska ; S. Lovestone ; V. S. Mattay ; P. Mecocci ; C. McDonald ; A. M. McIntosh ; R. A. Ophoff ; T. Paus ; Z. Pausova ; M. Ryten ; P. S. Sachdev ; A. J. Saykin ; A. Simmons ; A. Singleton ; H. Soininen ; J. M. Wardlaw ; M. E. Weale ; D. R. Weinberger ; H. H. Adams ; L. J. Launer ; S. Seiler ; R. Schmidt ; G. Chauhan ; C. L. Satizabal ; J. T. Becker ; L. Yanek ; S. J. van der Lee ; M. Ebling ; B. Fischl ; W. T. Longstreth, Jr. ; D. Greve ; H. Schmidt ; P. Nyquist ; L. N. Vinke ; C. M. van Duijn ; L. Xue ; B. Mazoyer ; J. C. Bis ; V. Gudnason ; S. Seshadri ; M. A. Ikram ; N. G. Martin ; M. J. Wright ; G. Schumann ; B. Franke ; P. M. Thompson ; S. E. Medland
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-01-22Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adolescent ; Adult ; Aged ; Aged, 80 and over ; Aging/genetics ; Apoptosis/genetics ; Brain/*anatomy & histology ; Caudate Nucleus/anatomy & histology ; Child ; Female ; Gene Expression Regulation, Developmental/genetics ; Genetic Loci/genetics ; Genetic Variation/*genetics ; *Genome-Wide Association Study ; Hippocampus/anatomy & histology ; Humans ; Magnetic Resonance Imaging ; Male ; Membrane Proteins/genetics ; Middle Aged ; Organ Size/genetics ; Putamen/anatomy & histology ; Sex Characteristics ; Skull/anatomy & histology ; Young AdultPublished by: -
2Articles: DFG German National LicensesNyberg, L. ; Mclntosh, A. R. ; Houle, S. ; Nilsson, L.-G. ; Tulving, E.
[s.l.] : Nature Publishing Group
Published 1996Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] The experiment included four conditions in which regional cerebral blood flow (rCBF) was estimated from PET counts8: visual recognition of words following meaning based encoding; visual recognition of words following perceptual encoding; visual recognition of non-studied words; and a baseline ...Type of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesStaff View
ISSN: 0028-3932Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PsychologyType of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesKarlsson, T. ; Backman, L. ; Herlitz, A. ; Nilsson, L.-G. ; Winblad, B. ; Osterlind, P.-O.
Amsterdam : ElsevierStaff ViewISSN: 0028-3932Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PsychologyType of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 0378-4347Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 0378-4347Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 0001-6918Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PsychologyType of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 0001-6918Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PsychologyType of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 0001-6918Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PsychologyType of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 0001-6918Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PsychologyType of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 0278-2626Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: MedicinePsychologyType of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesVinge, E. ; Andersson, K. -E. ; Brandt, L. ; Ljunggren, B. ; Nilsson, L. -G. ; Rosendal-Helgesen, S.
Springer
Published 1986Staff ViewISSN: 1432-1041Keywords: nimodipine ; subarachnoid haemorrhage ; pharmacokineticsSource: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyMedicineNotes: Summary Patients with a ruptured supratentorial aneurysm undergoing early surgery after the subarachnoid haemorrhage were treated postoperatively with nimodipine to prevent delayed ischaemic dysfunction. It was given first as a continuous intravenous infusion 2 mg/h (mean dose 0.5 µg/kg/min) for at least 7 days, and then orally (45 mg × 6) for at least a further 7 days. During the i.v. infusion, the mean plasma concentration was 26.6±1.8 ng/ml. The plasma clearance ranged from 0.57 to 1.77 l/kg/h and was negatively correlated with the age of the patient. Immediately prior to successive oral doses, the mean plasma concentration was 13.2 ng/ml (range〈3–38.8 ng/ml). The peak level was usually found after 1 h; it ranged from 7.0–96.0 ng/ml. Mean bioavailability was 15.9%. The nitropyridine metabolite was found in measurable concentrations only after oral treatment with nimodipine. In some cases, the concentration of metabolite exceeded that of the parent compound. The three patients investigated who developed delayed ischaemic dysfunction had plasma concentrations well within the range in patients who did not, so it seems unlikely that the therapeutic failure could be attributed to individual deviations in the pharmacokinetics of the drug.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 1432-1041Keywords: Key words Cloxacillin ; Hip replacement ; Knee replacement; pharmacokinetics ; sex differencesSource: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyMedicineNotes: Abstract Objective: The pharmacokinetics of cloxacillin was investigated in 14 men and 24 women undergoing cemented hip (n = 19; age range 56–90) or knee replacement surgery (n = 19; age range 51–84) for osteoarthritis. Cloxacillin 1 g was given intravenously as a bolus dose at the induction of anesthesia, and plasma samples and urine were collected for 6 h. Drug levels were determined using HPLC. Results: Preoperative serum creatinine levels were 84 μmol · l−1 in hip patients and 72 μmol · l−1 in knee patients. The calculated values for creatinine clearance were 63 and 85 ml · min−1 · 1.73 m−2, respectively. Total clearance of cloxacillin was 134 ml · min−1 · 1.73 m−2 in eighteen evaluated patients undergoing hip replacement, and 162 ml · min−1 · 1.73 m−2 in eighteen patients undergoing knee surgery. Renal clearance was 72 and 79 ml · min−1 · 1.73 m−2, respectively. Non-renal clearance was 57 ml · min−1 · 1.73 m−2 in hip patients and 77 ml · min−1 · 1.73 m−2 in knee patients. Renal clearance of cloxacillin correlated with the estimated creatinine clearance (r = 0.652). Although women received higher doses than men (median 2.02 vs 2.32 mmol · 1.73 m−2), there were no sex differences in clearance corrected for body surface area. Conclusion: Total clearance of cloxacillin was lower in patients undergoing hip replacement than in patients undergoing replacement of the knee, but there was no difference between men and women.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 1432-1041Keywords: acetylator phenotype ; isoniazid ; age distribution ; sex distributionSource: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyMedicineNotes: Summary In 310 Swedish patients, the distribution of acetylator phenotype was studied by determination of the half-life of isoniazid (INH T1/2). The expected bimodal distribution was found in the complete study group, but was not always clearly apparent after subgrouping for age and sex. Mean INH T1/2 was higher in males and tended to increase with age. The difference in INH T1/2 between males and females was small in younger individuals (below 46 years of age) and showed a gradual increase with age. In older individuals (above 65 y) mean INH T1/2 was 42 min longer in males than in females. In the females, mean INH T1/2 was relatively constant in all age groups. The effect of age on acetylator phenotype, previously reported by other workers, appears to have been confirmed but only in males. It may be influenced by concurrent treatment for certain diseases.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 1432-1041Keywords: theophylline ; erythromycin ; drug interaction ; aminophylline ; pharmacokineticsSource: Springer Online Journal Archives 1860-2000Topics: Chemistry and PharmacologyMedicineNotes: Summary We have studied the interaction of erythromycin with theophylline. We gave ten healthy volunteers theophylline as an intravenous loading dose (5 mg·kg−1) over 1 h, followed by a maintenance infusion (0.5 mg·kg−1·h−1) for 5 h. A second infusion of theophylline was given after 9 days of treatment with 1 g erythromycin base daily, and the concentrations of theophylline were determined during the infusion periods. The concentrations of erythromycin were measured for 8 h, after one week of treatment, and also after the last erythromycin dose, simultaneously with the second theophylline infusion. Concentrations within the therapeutic range were obtained with both drugs. A significant increase in both AUC and mean plasma concentrations of theophylline was seen during erythromycin treatment. The plasma clearance of theophylline was reduced in 9 of the 10 subjects. Renal clearance increased correspondingly, but the change was not statistically significant. Serum concentrations of erythromycin fell significantly, by more than 30%, with concurrent theophylline medication. We conclude that an interaction between theophylline and erythromycin, affecting both drugs, can be shown with concentrations of the drugs within the therapeutic range.Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesNilsson, L. -G. ; Sikström, C. ; Adolfsson, R. ; Erngrund, K. ; Nylander, P. -O. ; Beckman, L.
Springer
Published 1996Staff ViewISSN: 1573-3297Keywords: Episodic memory ; genetic markers ; sex differencesSource: Springer Online Journal Archives 1860-2000Topics: BiologyPsychologyNotes: Abstract Associations were studied between six serum protein polymorphisms (C3, BF, HP, ORM, TF, and GC) and high versus low scoring on episodic memory tasks in an attempt to identify QTL (quantitative trait loci) contributing to the heritability of this quantitative trait. Since a highly significant sex difference (p=.00002) was found with respect to the distribution of high and low scoring, with men showing a poorer performance, associations were studied separately for males and females. In females significant differences (p〈.05) between the high and the low groups were found in four of six marker systems (C3, HP, TF, and CG), whereas in males a significant difference was found only in the HP system. Significant differences from population frequencies were also found more frequently in females than in males. The strongest marker associations were found with complement C3 and the acute-phase reactant HP, which suggests that immune response factors may be of importance in preserving episodic memory function. The overall results appear to indicate that episodic memory is a multifactorial and heritable quantitative trait where sex is an important determinant.Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesRandomised double-blind study of norfloxacin and cefadroxil in the treatment of acute pyelonephritisStaff View
ISSN: 1435-4373Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract In a coordinated, double-blind multi-centre trial, adults with symptoms of acute pyelonephritis were randomly assigned to receive a two-week course of oral treatment with either 400 mg norfloxacin twice daily or 1 g cefadroxil twice daily. Of 197 patients enrolled in the study, 140 could be evaluated for drug efficacy and 193 for drug safety. Norfloxacin gave a significantly higher bacteriological cure rate than cefadroxil, both at 3 to 10 days (98 % versus 65 %; p〈0.0001; 95 % confidence interval (CI) for difference in proportions 21–46 %) and up to eight weeks (87 % versus 48 %; p〈0.0001; 95 % CI 25–54 %) after cessation of treatment. The differences between the two regimens were most pronounced in men and in patients with complicating factors such as diabetes mellitus and urinary tract abnormalities. The clinical response during treatment did not differ between the two groups, but symptomatic recurrences at follow-up were more common in the cefadroxil group (28 % versus 3 %; p〈0.0001; 95 % CI 14–36 %). Adverse events were more often reported by patients receiving cefadroxil (39 % versus 22 %; p=0.011; 95 % CI 4–30 %) and consisted mainly of gastrointestinal disturbances and vulvo-vaginitis. In terms of bacteriological and clinical efficacy and safety, a two-week course of norfloxacin was superior to a two-week course of cefadroxil for oral treatment of community-acquired acute pyelonephritis.Type of Medium: Electronic ResourceURL: