Search Results - (Author, Cooperation:L. E. Peter)
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1Latest Papers from Table of Contents or Articles in PressJ. B. Whitney ; A. L. Hill ; S. Sanisetty ; P. Penaloza-MacMaster ; J. Liu ; M. Shetty ; L. Parenteau ; C. Cabral ; J. Shields ; S. Blackmore ; J. Y. Smith ; A. L. Brinkman ; L. E. Peter ; S. I. Mathew ; K. M. Smith ; E. N. Borducchi ; D. I. Rosenbloom ; M. G. Lewis ; J. Hattersley ; B. Li ; J. Hesselgesser ; R. Geleziunas ; M. L. Robb ; J. H. Kim ; N. L. Michael ; D. H. Barouch
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-07-22Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Anti-Retroviral Agents/administration & dosage/pharmacology/therapeutic use ; Carrier State/drug therapy/virology ; DNA, Viral/analysis/biosynthesis/blood ; Disease Models, Animal ; Female ; Kinetics ; Macaca mulatta/immunology/*virology ; Male ; Proviruses/genetics ; RNA, Viral/blood ; Rectum/virology ; Simian Acquired Immunodeficiency Syndrome/drug therapy/immunology/*virology ; Simian Immunodeficiency Virus/drug effects/*growth & ; development/immunology/physiology ; Time Factors ; Treatment Failure ; *Viral Load/drug effects ; Viremia/drug therapy/*virology ; Virus Replication/drug effectsPublished by: -
2Articles: DFG German National LicensesLent, Peter L. E. M. ; Joosten, Leo A. B. ; Bersselaar, Liduine ; Berg, Wim B.
Springer
Published 1991Staff ViewISSN: 1420-908XSource: Springer Online Journal Archives 1860-2000Topics: MedicineType of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesHolmberg, Stig B. ; Naredi, Peter L. J. ; Lindnér, Per G. O. ; Karlberg, Ingvar H. ; Daneryd, Peter L-E. ; Karlsson, Lilian M. ; Pettersson, Anders ; Stenram, Unne ; Hafström, Larsolof R.
Springer
Published 1995Staff ViewISSN: 1432-1335Keywords: Indomethacin ; Tumour growth ; Zymosan ; RES ; Liver tumour ; Kupffer cellsSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Zymosan—a non-specific macrophage-stimulating agent-reduces tumour take in the liver. The mechanism for this effect is not clear, but it may be mediated via the Kupffer cells and prostaglandins. On the other hand, the Prostaglandin-synthesis inhibitor, indomethacin, inhibits tumour growth. Pretreatment with zymosan (3 mg 100 g−1) for 3 days of two different strains of rats, inoculated in the liver with a hepatoma or an adenocarcinoma cell suspension respectively, reduced tumour take and also initial tumour growth. The effect on tumour take and initial growth was inhibited by concomitant administration of indomethacin (0.2 mg 100 g−1). When zymosan was administered after tumour cell inoculation the growth rate of the hepatoma was retarded, but this effect was not abrogated by indomethacin. Pretreatment with indomethacin had no significant effect on tumour take or initial growth. When given after the tumour was established in the liver, indomethacin reduced the growth rate of the hepatoma, but not of the adenocarcinoma. These results suggest that there are different mechanisms for the effects of zymosan on tumour take and on growth of an established tumour. In immunoincompetent nude mice the effect on the hepatoma was similar to the effect in the rat. In vitro both tumours were insensitive to zymosan and indomethacin. This study confirms that pretreatment with a non-specific macrophage stimulator (zymosan) diminishes tumour take and growth in the liver, that the effect of zymosan on tumour take in the liver is abrogated by indomethacin and that the zymosan effect on tumour take in the liver is at least partly mediated by the Kupffer cells and prostaglandins.Type of Medium: Electronic ResourceURL: