Search Results - (Author, Cooperation:L. Clarke)

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  1. 1
    Magnus B. Widegren, Matthew L. Clarke
    American Chemical Society (ACS)
    Published 2018
    Staff View
    Publication Date:
    2018-04-20
    Publisher:
    American Chemical Society (ACS)
    Print ISSN:
    1523-7060
    Electronic ISSN:
    1523-7052
    Topics:
    Chemistry and Pharmacology
    Published by:
    http://www.acs.org/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    L. Chen ; M. Kostadima ; J. H. Martens ; G. Canu ; S. P. Garcia ; E. Turro ; K. Downes ; I. C. Macaulay ; E. Bielczyk-Maczynska ; S. Coe ; S. Farrow ; P. Poudel ; F. Burden ; S. B. Jansen ; W. J. Astle ; A. Attwood ; T. Bariana ; B. de Bono ; A. Breschi ; J. C. Chambers ; F. A. Choudry ; L. Clarke ; P. Coupland ; M. van der Ent ; W. N. Erber ; J. H. Jansen ; R. Favier ; M. E. Fenech ; N. Foad ; K. Freson ; C. van Geet ; K. Gomez ; R. Guigo ; D. Hampshire ; A. M. Kelly ; H. H. Kerstens ; J. S. Kooner ; M. Laffan ; C. Lentaigne ; C. Labalette ; T. Martin ; S. Meacham ; A. Mumford ; S. Nurnberg ; E. Palumbo ; B. A. van der Reijden ; D. Richardson ; S. J. Sammut ; G. Slodkowicz ; A. U. Tamuri ; L. Vasquez ; K. Voss ; S. Watt ; S. Westbury ; P. Flicek ; R. Loos ; N. Goldman ; P. Bertone ; R. J. Read ; S. Richardson ; A. Cvejic ; N. Soranzo ; W. H. Ouwehand ; H. G. Stunnenberg ; M. Frontini ; A. Rendon
    American Association for the Advancement of Science (AAAS)
    Published 2014
    Staff View
    Publication Date:
    2014-09-27
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    *Alternative Splicing ; Cell Lineage/*genetics ; Genetic Variation ; Hematopoiesis/*genetics ; Hematopoietic Stem Cells/*cytology/metabolism ; Humans ; NFI Transcription Factors/genetics/metabolism ; RNA-Binding Proteins/metabolism ; Thrombopoiesis/genetics ; Transcriptome
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Staff View
    Publication Date:
    2013-10-05
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Binding Sites/genetics ; *Genetic Variation ; Genome, Human ; Genomics ; Humans ; Kruppel-Like Transcription Factors/metabolism ; Molecular Sequence Annotation/*methods ; Mutation ; Neoplasms/*genetics ; Polymorphism, Single Nucleotide ; Population/genetics ; RNA, Untranslated/genetics ; Selection, Genetic
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  4. 4
    P. H. Sudmant ; T. Rausch ; E. J. Gardner ; R. E. Handsaker ; A. Abyzov ; J. Huddleston ; Y. Zhang ; K. Ye ; G. Jun ; M. Hsi-Yang Fritz ; M. K. Konkel ; A. Malhotra ; A. M. Stutz ; X. Shi ; F. Paolo Casale ; J. Chen ; F. Hormozdiari ; G. Dayama ; K. Chen ; M. Malig ; M. J. Chaisson ; K. Walter ; S. Meiers ; S. Kashin ; E. Garrison ; A. Auton ; H. Y. Lam ; X. Jasmine Mu ; C. Alkan ; D. Antaki ; T. Bae ; E. Cerveira ; P. Chines ; Z. Chong ; L. Clarke ; E. Dal ; L. Ding ; S. Emery ; X. Fan ; M. Gujral ; F. Kahveci ; J. M. Kidd ; Y. Kong ; E. W. Lameijer ; S. McCarthy ; P. Flicek ; R. A. Gibbs ; G. Marth ; C. E. Mason ; A. Menelaou ; D. M. Muzny ; B. J. Nelson ; A. Noor ; N. F. Parrish ; M. Pendleton ; A. Quitadamo ; B. Raeder ; E. E. Schadt ; M. Romanovitch ; A. Schlattl ; R. Sebra ; A. A. Shabalin ; A. Untergasser ; J. A. Walker ; M. Wang ; F. Yu ; C. Zhang ; J. Zhang ; X. Zheng-Bradley ; W. Zhou ; T. Zichner ; J. Sebat ; M. A. Batzer ; S. A. McCarroll ; R. E. Mills ; M. B. Gerstein ; A. Bashir ; O. Stegle ; S. E. Devine ; C. Lee ; E. E. Eichler ; J. O. Korbel
    Nature Publishing Group (NPG)
    Published 2015
    Staff View
    Publication Date:
    2015-10-04
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Amino Acid Sequence ; Genetic Predisposition to Disease ; Genetic Variation/*genetics ; Genetics, Medical ; Genetics, Population ; Genome, Human/*genetics ; Genome-Wide Association Study ; Genomics ; Genotype ; Haplotypes/genetics ; Homozygote ; Humans ; Molecular Sequence Data ; Mutation Rate ; *Physical Chromosome Mapping ; Polymorphism, Single Nucleotide/genetics ; Quantitative Trait Loci/genetics ; Sequence Analysis, DNA ; Sequence Deletion/genetics
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  5. 5
    Staff View
    Publication Date:
    2013-04-12
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Aquatic Organisms/chemistry/isolation & purification ; Archaeology ; Ceramics/*history ; Cooking/*history ; Dietary Fats/analysis ; Gas Chromatography-Mass Spectrometry ; Greenland ; History, Ancient ; Japan ; Lipids/analysis/chemistry ; Oxygen Isotopes ; Seafood/analysis/history
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  6. 6
    Toth, E. L., Li, H., Dzierlenga, A. L., Clarke, J. D., Vildhede, A., Goedken, M., Cherrington, N. J.
    The American Society for Pharmacology and Experimental Therapeutics (ASPET)
    Published 2018
    Staff View
    Publication Date:
    2018-10-13
    Publisher:
    The American Society for Pharmacology and Experimental Therapeutics (ASPET)
    Print ISSN:
    0090-9556
    Electronic ISSN:
    1521-009X
    Topics:
    Chemistry and Pharmacology
    Medicine
    Published by:
    http://www.aspet.org/

    Latest Papers from Table of Contents or Articles in Press
  7. 7
    H. McJeon ; J. Edmonds ; N. Bauer ; L. Clarke ; B. Fisher ; B. P. Flannery ; J. Hilaire ; V. Krey ; G. Marangoni ; R. Mi ; K. Riahi ; H. Rogner ; M. Tavoni
    Nature Publishing Group (NPG)
    Published 2014
    Staff View
    Publication Date:
    2014-10-16
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Carbon Dioxide/analysis ; Climate Change/*statistics & numerical data ; *Environmental Policy ; Greenhouse Effect/prevention & control/statistics & numerical data ; Models, Theoretical ; Natural Gas/economics/supply & distribution/*utilization ; Time Factors
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  8. 8
    Clarke, L. ; Wybourne, M. N.

    Woodbury, NY : American Institute of Physics (AIP)
    Published 1997
    Staff View
    ISSN:
    1077-3118
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Notes:
    The near-room temperature current-voltage (I-V) characteristics of small structures made from the metal-cluster material Au55[P(C6H5)3]12Cl6 were studied. It is shown that these electron-beam defined structures have highly nonlinear characteristics with features, including a threshold voltage and scaling behavior, which are consistent with Coulomb charging of individual Au55 cores in a disordered array. Applied radio frequency signals introduce plateaus in the I-V characteristics, which demonstrates the presence of coherent tunneling in these cluster systems. © 1997 American Institute of Physics.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1063/1.120568

    Articles: DFG German National Licenses
  9. 9
    Clarke, J. ; Clarke, L. ; Helm, K. ; Zaenglein, A.

    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.
    Published 2005
    Staff View
    ISSN:
    1600-0560
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    We report two unrelated infants that presented for evaluation of large dermal plaques that histologically resembled dermatofibromas. The clinical appearance and histochemical staining, however, support a myofibroblastic origin of the neoplasms. The patients were a 13 month old female with a slowly growing, pink, firm, irregular plaque that was first noticed at 3 months of age, and an 11 month old boy who presented with a pruritic, slowly growing, irregular, nodular plaque that was noticed shortly after birth. MRI revealed no extension of tumor into deeper subcutaneous tissues in either infant. Both infants had normal growth and development. Biopsies of both infants’ plaques revealed spindle cell neoplasms dissecting through collagen bundles throughout the entire dermis with overlying psoriasiform epidermal hyplerplasia. The spindle cells were predominantly haphazardly arranged but in a few areas were arranged in small fascicles. Both tumors stained positively for Factor XIIIa and were focally smooth muscle actin positive. Staining for CD34 was negative in both neoplasms. Histologically, both tumors resembled dermatofibromas; however the clinical appearance and positive smooth muscle actin staining best fit with a myofibroblastic neoplasm. The features of this neoplasm and the differential of other spindle cell tumors of infancy will be reviewed.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.0303-6987.2005.320av.x

    Articles: DFG German National Licenses
  10. 10
    Clarke, L. ; Clarke, J. ; Helm, K.

    Oxford, UK; Malden, USA : Blackwell Publishing Ltd/Inc.
    Published 2005
    Staff View
    ISSN:
    1600-0560
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Localized chronic fibrosing vasculitis is a rare dermatosis that histologically resembles late-stage erythema elevatum diutinum (EED) but has a different clinical presentation. A 62-year-old male presented with bilateral nodules on his heels that first appeared two years ago and over the past six months had become extremely painful. He denied any recent trauma to the sites, and his medical history was significant only for diabetes mellitus, coronary artery disease, and osteoarthritis. Physical exam demonstrated focally ulcerated violet-red three-centimeter nodules on the medial aspects of both heels. Biopsy revealed dense concentric and lamellar fibrosis with foci of leukocytoclastic debris and a sparse infiltrate of histiocytes, neutrophils, eosinophils, and lymphocytes. No granulomas were present, and histochemical stains and tissue cultures for microorganisms were negative. Imaging studies showed no evidence of underlying osteomyelitis, cellulitis, or abscess formation. Laboratory studies demonstrated a markedly elevated IgA level that was shown to be polyclonal on serum immunofixation studies. All peripheral blood cell counts were normal. Thorough evaluations for systemic vasculitides and connective tissue disorders were negative. A diagnosis of localized chronic fibrosing vasculitis was made. This case illustrates the clinicopathologic overlap between this disorder and EED.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.0303-6987.2005.320aw.x

    Articles: DFG German National Licenses
  11. 11
    Clarke, L. R. ; Vidergar, D. T. ; Bennett, D. H.

    Oxford, UK : Munksgaard International Publishers
    Published 2005
    Staff View
    ISSN:
    1600-0633
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Biology
    Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes:
    Abstract –  In past dietary studies kokanee Oncorhynchus nerka were prominent in the diet of Pend Oreille Lake's large piscivores: native bull trout Salvelinus confluentus, cutthroat trout O. clarki and northern pikeminnow Ptychocheilus oregonensis, and introduced lake trout S. namaycush and Kamloops rainbow trout O. mykiss gairdneri. However, kokanee have declined to 10–20% of their former abundance. We therefore initiated this study to understand current predation demands on kokanee and diet overlap among piscivores, using gut content samples and analysis of stable nitrogen (δ15N) and carbon (δ13C) isotopes from the lake's fish and invertebrate community. In gut content samples, kokanee were the main prey item of large [i.e., ≥400 mm total length (TL)] bull and lake trout; a conclusion that was affirmed by stable isotope analysis. Rainbow trout 〉500 mm TL consumed mostly kokanee, thus there was a high degree of diet overlap among large bull, lake and rainbow trout. Small (i.e., 〈400 mm TL) rainbow and cutthroat trout diets overlapped, and were composed mostly of littoral benthic invertebrates. However, gut content and stable isotope analysis did not accord for 400–500 mm TL rainbow trout, small lake trout, and large cutthroat trout. In these instances, a linear mixing model using stable isotope results predicted kokanee consumption for each species, but no kokanee were identified in rainbow or lake trout gut content. Gut content and stable isotope analysis of native northern pikeminnow indicated a diet of mostly littoral benthic invertebrates at smaller (100–150 mm TL) lengths, with kokanee becoming more prominent in the diet of individuals 〉300 mm TL. Percent of kokanee in the diet of northern pikeminnow has declined from a prior study; otherwise piscivore diets have apparently remained unchanged. In this study, judgments as to the feeding of some piscvores, based on gut content alone, would be tenuous because of small sample sizes, but stable isotope analysis provided an efficient means for confirming diets.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1600-0633.2005.00103.x

    Articles: DFG German National Licenses
  12. 12
    Dunbrack, R. L. ; Clarke, L. ; Bassler, C.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1996
    Staff View
    ISSN:
    1095-8649
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Biology
    Notes:
    The hypothesis that stream salmonids from habitats with low food density will be more aggressive than conspecifics from habitats with higher food density was tested through behavioural observations of wild-caught young-of-the-year brook charr Salvelinus fontinalis in aquaria. Standing stocks of benthic invertebrates in a high food density habitat were more than double those in a low density habitat and charr from the latter were significantly smaller than those from the former. Charr from the low food density habitat were significantly more aggressive, as indicated by nipping attempts within pairs, than were those from the high food density habitat. Both populations were genetically isolated and food density differences seemed to be related to persistent features of their habitats. This suggests that the observed behavioural differences may have both genotypic and phenotypic Components
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1095-8649.1996.tb01456.x

    Articles: DFG German National Licenses
  13. 13
    Clarke, L. M. ; Friedland, K. D.

    Oxford, UK; Malden, USA : Blackwell Science Ltd
    Published 2004
    Staff View
    ISSN:
    1095-8649
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Biology
    Notes:
    Sr : Ca ratios measured in the otoliths of sea-caged Atlantic salmon Salmo salar showed distinct seasonal peaks that were unrelated to water temperature and somatic growth, suggesting other factors have a greater influence on strontium deposition. Atlantic salmon remained in the sea-cages for two seasons, or equivalent to two-seawinter fish in the wild and were subjected to seasonally varying temperatures. Water temperature appeared to be inversely related to the Sr : Ca ratios, but this relationship was statistically not significant. Furthermore, water temperature could not explain the distinct increase in the strontium during the second year. The intensity of the Sr peaks increased in the second season while average winter water temperatures were consistent between years. Additionally, strontium deposition in the otoliths was unrelated to somatic growth. Somatic growth, as evidenced by circuli spacings on the scales, was largely invariant and therefore could not explain the observed peaks. Though not explicitly measured, the data are consistent with the notion that strontium deposition is a function of maturity state in Atlantic salmon.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.0022-1112.2004.00480.x

    Articles: DFG German National Licenses
  14. 14
    Staff View
    ISSN:
    1350-4177
    Keywords:
    carboxylate electro-oxidation ; electrochemiluminescence ; ultrasonic enhancement
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Chemistry and Pharmacology
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/1350-4177(94)90021-3

    Articles: DFG German National Licenses
  15. 15
    EVANS, R. C. ; CLARKE, L. ; HEATH, P. ; STEPHENS, S. ; MORRIS, A. I. ; RHODES, J. M.

    Oxford, UK : Blackwell Science Ltd
    Published 1997
    Staff View
    ISSN:
    1365-2036
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Tumour Necrosis Factor-alpha (TNFα) is a pro-inflammatory cytokine whose expression is increased in the colonic mucosa of patients with active ulcerative colitis. TNFα antibodies have been shown to be beneficial in animal models of bowel inflammation and in Crohn's disease but have not previously been studied in ulcerative colitis.〈section xml:id="abs1-2"〉〈title type="main"〉Methods:Patients with mild/moderate ulcerative colitis were treated openly with a single intravenous infusion of 5 mg/kg of an engineered human IgGγ4 antibody CDP571 and monitored for 8 weeks.〈section xml:id="abs1-3"〉〈title type="main"〉Results:Fifteen patients entered the study, eight males and seven females, with a mean age of 44 years. Eleven had left-sided disease, four extensive disease and six patients were steroid-unresponsive. The treatment was well tolerated and plasma half-life of CDP571 was ≈7 days. There was a significant reduction from 6.7 to 4.6 (P = 0.023) in the mean Powell–Tuck score by 1 week post-infusion and a reduction to 5.5 was seen at 2 weeks (P = 0.218). Significant but modest reductions also occurred in erythrocyte sedimentation rate and serum C reactive protein in the first 2 weeks. Mean Interleukin-6 plasma concentrations fell from 6.9 to 5.4 pg/mL by week 1, and to 6.1 pg/mL by week 2 (NS). Reductions in sigmoidoscopic score and number of liquid stools were noted but failed to reach statistical significance.〈section xml:id="abs1-4"〉〈title type="main"〉Conclusion:A consistent improvement in disease activity was seen in the initial 2 weeks after infusion and the treatment was well tolerated. These promising results support the testing of CDP571 in a larger controlled trial.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1046/j.1365-2036.1997.00251.x

    Articles: DFG German National Licenses
  16. 16
    Clarke, L. ; Waxman, D.J.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0003-9861
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Chemistry and Pharmacology
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0003-9861(87)90616-3

    Articles: DFG German National Licenses
  17. 17
    KELSEY, KATHLEEN E. ; CLARKE, L. N.

    [s.l.] : Nature Publishing Group
    Published 1955
    Staff View
    ISSN:
    1476-4687
    Source:
    Nature Archives 1869 - 2009
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Notes:
    [Auszug] It can be shown thermodynamically3 that if the heat of sorption is dependent on the temperature, T, the following relation holds : cm = 1 +m p,m J (i) i 002 004 006 008 OiO 0-20 0?Z by 1 gm. of pure sorbent, and cm, c0 and cw are the specific heats at constant pressure of the sorbent at ...
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1038/176083a0

    Articles: DFG German National Licenses
  18. 18
    Kingsman, A.J. ; Clarke, L. ; Mortimer, R.K. ; Carbon, J.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0378-1119
    Keywords:
    E. coli-yeast recombinant DNA ; Southern hybridization ; Transformation ; spheroplast fusion ; yeast cloning vector
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0378-1119(79)90029-5

    Articles: DFG German National Licenses
  19. 19
    Newton, N. ; Morell, D.B. ; Clarke, L.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0005-2787
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0005-2787(65)90563-0

    Articles: DFG German National Licenses
  20. 20
    Newton, N. ; Morell, D.B. ; Clarke, L. ; Clezy, P.S.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0005-2787
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0005-2787(65)90564-2

    Articles: DFG German National Licenses