Search Results - (Author, Cooperation:Karbe)

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  1. 1
    Amin, M. ; Uhlig, H. H. ; Kamprad, M. ; Karbe, J. ; Osman, A. A. ; Grahmann, F. ; Hummelsheim, H. ; Mothes, T.

    Oxford, UK : Blackwell Science Ltd
    Published 2001
    Staff View
    ISSN:
    1365-3083
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Screening a human small intestinal library with human serum yielded a clone which encoded a protein res4-22 the gene of which was highly homologous to a recently described gene located in the Huntington's disease locus. Autoantibodies against res4-22 (anti-res4-22), mainly of the immunoglobulin (Ig)A type, were detected in patients with neurological disorders at a higher frequency (18.4%) than in healthy blood donors (8.0%). In neurological patients with cerebral ischaemia anti-res4-22 was found significantly more often (47.4%) than in the total group of neurological patients. Anti-res4-22 positive sera showed significantly more frequently myelin staining in cerebellum and nerve sections than anti-res4-22 negative sera. Our findings demonstrate a new species of human autoantibodies against a newly described protein the function of which is still unknown.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  2. 2
    Karbe, C. ; Margaretha, P.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    1010-6030
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Chemistry and Pharmacology
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  3. 3
    Staff View
    ISSN:
    1437-1596
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Law
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  4. 4
  5. 5
    Hinrichsen ; Walcher ; Abegg ; Böhmig ; Karbe ; Ossenkopp ; Reich ; Oblath
    Springer
    Published 1933
    Staff View
    ISSN:
    1437-1596
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Law
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  6. 6
    Staff View
    ISSN:
    1437-1596
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Law
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  7. 7
    Staff View
    ISSN:
    1437-1596
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Law
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  8. 8
    Staff View
    ISSN:
    1437-1596
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Law
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  9. 9
    Staff View
    ISSN:
    1435-1463
    Keywords:
    Positron emission tomography ; (18F)methylspiperone ; clozapine ; haloperidol ; D2 dopamine receptors ; schizophrenia
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary Four schizophrenic patients were investigated with dynamic positron emission tomography (PET) using (18F)fluorodeoxyglucose (FDG) and (18F)methylspiperone (MSP) as tracers. Two schizophrenics were on haloperidol therapy at the time of MSP PET. The other two schizophrenics were treated with clozapine, in one of them MSP PET was carried out twice with different daily doses (100 mg and 450 mg respectively). Neuroleptic serum levels were measured in all patients. Results were compared with MSP PET of two drug-free male control subjects and with a previous fluoroethylspiperone (FESP) study of normals. Three hours after tracer injection specific binding of MSP was observed in the striatum in all cases. The striatum to cerebellum ratio was used to estimate the degree of neuroleptic-caused striatal D2 dopamine receptor occupancy. In the haloperidol treated patients MSP binding was significantly decreased, whereas in the clozapine treated patients striatum to cerebellum ratio was normal. Even the increase of clozapine dose in the same patient had no influence on this ratio. Despite the smaller number of patients the study shows for the first time in humans that striatal MSP binding reflects the different D2 dopamine receptor affinities of clozapine and haloperidol.
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  10. 10
    Karbe, Manfred
    Springer
    Published 1985
    Staff View
    ISSN:
    1420-8938
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Mathematics
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  11. 11
    Karbe, M. J. ; Kurdačenko, L. A.
    Springer
    Published 1988
    Staff View
    ISSN:
    1420-8938
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Mathematics
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  12. 12
    Staff View
    ISSN:
    1437-1596
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Law
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  13. 13
    Staff View
    ISSN:
    1437-1596
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Law
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  14. 14
    Staff View
    ISSN:
    1437-1596
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Law
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  15. 15
    Staff View
    ISSN:
    1437-1596
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Law
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  16. 16
    Klix ; Walcher ; Meixner ; Nippe ; Spiecker ; Karbe ; Klestadt ; Löhlein ; Giese
    Springer
    Published 1935
    Staff View
    ISSN:
    1437-1596
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Law
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  17. 17
    Staff View
    ISSN:
    1437-1596
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Law
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  18. 18
    Staff View
    ISSN:
    1437-1596
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Law
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  19. 19
    Staff View
    ISSN:
    1437-1596
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Law
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses
  20. 20
    Staff View
    ISSN:
    1437-1596
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Law
    Type of Medium:
    Electronic Resource
    URL:
    Articles: DFG German National Licenses