Search Results - (Author, Cooperation:K. Yoshimura)

2018-08-03

American Physical Society (APS)

1098-0121

1095-3795

Physics

Magnetism

2018-05-30

American Physical Society (APS)

1098-4402

Physics

Targets, Collimators, and Beam Dumps

2018-10-05

American Physical Society (APS)

1098-0121

1095-3795

Physics

Electronic structure and strongly correlated systems

2018-07-27

The American Society for Pharmacology and Experimental Therapeutics (ASPET)

0026-895X

1521-0111

Chemistry and Pharmacology

Medicine

2011-01-29

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Acetates/*metabolism ; Animals ; Bifidobacterium/genetics/*metabolism ; Cercopithecus aethiops ; Escherichia coli Infections/microbiology/*prevention & control ; Escherichia coli O157/*physiology ; Gene Expression Profiling ; Genome, Bacterial ; Mice ; Molecular Sequence Data ; Vero Cells

2011-10-01

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Atmosphere/*chemistry ; Carbon Cycle/physiology ; Carbon Dioxide/*analysis/*chemistry ; Crops, Agricultural/metabolism ; *El Nino-Southern Oscillation ; Humidity ; Oxygen Isotopes/*analysis ; Rain ; Soil/analysis/chemistry ; Trees/metabolism ; Water/metabolism

1089-7550

AIP Digital Archive

Physics

The dependence of polar direction of GaN film on growth conditions has been investigated by changing either the group-V/group-III ratio (V/III ratio) in supplying the source gas or the deposition rate. GaN films were deposited on a nitrided sapphire by two-step metalorganic chemical vapor deposition. The surface morphology changed from flat hexagonal to pyramidal hexagonal facet with the increase of V/III ratio. However, the polar direction of GaN on an optimized buffer layer of 20 nm thickness was N-face (−c) polarity, independent of both the V/III ratio and the deposition rate. The polarity of the GaN epitaxtial layer can be determined by that of an interface (nitrided sapphire, annealed buffer layer or GaN substrate) at the deposition of GaN epitaxial layer. The higher V/III ratio enhanced the nucleation density, and reduced the size of hexagonal facets. The nuclei, forming the favorable hexagonal facets of wurtzite GaN, should grow laterally along the {101¯0} directions to cover a room among the facets until coalescence. After coalescence, −c GaN growth on a flat hexagonal facet results in a pyramidal hexagonal facet. The growth mode for −c GaN has been discussed with respect to surface structure and migration length of adsorbing precursors, in comparison with Ga-face (+c) GaN. © 2000 American Institute of Physics.

Electronic Resource

1077-3118

AIP Digital Archive

Physics

We have investigated the dependence of impurity incorporation on the polar direction of GaN growth by using secondary ion mass spectroscopy (SIMS). GaN films were deposited under conditions used for growing device-quality materials on sapphire substrates while controlling their polar direction. It was found that the polarity of the GaN film influences the incorporation of impurities. SIMS analysis has revealed that the impurities related to carbon, oxygen, and aluminum are more readily incorporated into N-face GaN films. © 2000 American Institute of Physics.

Electronic Resource

1089-7690

AIP Digital Archive

Physics

Chemistry and Pharmacology

Singly charged cations of silver atoms and clusters (Agn+, n=1,3,5,7,9) were deposited on highly oriented pyrolytic graphite substrates at well-controlled, various collision energies. The total amount of Ag atoms remaining on the substrates after collision was quantified by measuring the Ag 3d5/2 photoelectron intensities. The collision energy dependence of the amount of deposited Ag atoms revealed that, for all the species, there are three distinct energy regions, for which soft landing, rebounding, or implantation is a dominant process, and that the energy ranges for the processes strongly depend on the cluster size. The deposition efficiency vs collision energy curve for each cluster is well fitted to that for Ag1, by considering the difference between the contact area of Ag1 with the surface and that of the cluster, reflecting the compactness of the clusters. Boundaries between the different deposition regimes for the clusters were less distinct than those for Ag1. Considering anisotropy in shape of a cluster, deposition efficiency around the implantation threshold was calculated, which well explains the indistinctness of the threshold observed in the experimental data. This supports the picture that the energy given to a unit surface area determines the collision process. © 2000 American Institute of Physics.

Electronic Resource

1365-2559

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Systemic necrotizing vasculitis involving cerebral blood vessels is described in a 30-year-old man with rheumatic heart disease and subacute bacterial endocarditis. Fever, anaemia, splenomegaly and positive blood cultures for Gram-negative bacteria were found on admission. The fever resolved with antibiotic therapy on the third hospital day but he then developed hemiplegia and multifocal seizures. The seizures progressed to uncontrollable status epilepticus accompanied by congestive heart failure and the patient died 20 d after admission. At autopsy, exudative and necrotizing vasculitis involving medium- to small-sized arteries was seen in the brain, the heart and the skeletal muscles. Rheumatic myocarditis and endocarditis and old rheumatic mitral valve deformities were also present. In addition, verrucous endocarditis in the mitral valve and Löhlein's focal glomerulonephritis were noted. We discuss the possible mechanism of the systemic necrotizing vasculitis in relation to rheumatic fever.

Electronic Resource

1750-3841

Blackwell Publishing Journal Backfiles 1879-2005

Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition

Process Engineering, Biotechnology, Nutrition Technology

: Gelatin samples conjugated with acidic saccharides such as glucuronic acid, alginic acid oligosac-charide, and low-molecular-weight alginic acid were prepared to improve the functional properties of ossein gelatin by the Maillard reaction. The conjugation resulted in a decreased isoelectric point, retardate gelation time, low storage modulus, and low melting temperature and enthalpy of gelatin gel; in particular, low-molecular-weight alginic acid resulted in a large improvement. The alginic acid oligosaccharide-conjugated gelatins and low-molecular-weight alginic acid-conjugated gelatins had calcium-retaining ability, and the latter exhibited calcium-aggregating ability. It is thus considered that conjugation with low-molecular-weight alginic acid could be effective for providing a new type of gelatin with a soft texture and calcium-retaining and calcium-aggregating ability.

Electronic Resource

0008-6215

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Chemistry and Pharmacology

Electronic Resource

1460-2695

Blackwell Publishing Journal Backfiles 1879-2005

Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics

This paper presents the results of an experimental and theoretical investigation of the magnetic fracture behaviour of double cantilever beam (DCB) specimens. DCB tests were conducted on ferritic stainless steel SUS430 in the bore of a superconducting magnet at room temperature. A simple experimental technique using strain gauges was used to determine the stress intensity factor. The experiments show the predicted increase in the stress intensity factor with increasing magnetic field. The theoretical analysis is based on a beam-plate theory for magnetoelastic interactions in a soft ferromagnetic material. Numerical calculations are carried out, and the stress intensity factor is obtained for several values of magnetic field. A comparison of the stress intensity factor is made between theory and experiment, and the agreement is good for the magnetic field considered.

Electronic Resource

1365-2036

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Background: Gastric antisecretory agents may inhibit the synthesis or secretion of gastric mucin during acid suppression, which would interfere with mucosal protection and limit the efficacy of the agents. Methods: Rats were dosed with famotidine, omeprazole, or buffer control for 4 weeks. Mucin synthesis, mucin histochemistry, mucin carbohydrate composition and prostaglandin E2 (PGE2) release were measured during and after drug treatment. Results: PGE2 release was maximally inhibited after 2 weeks of omeprazole or 4 weeks of famotidine. Total glycoprotein synthesis was inhibited at all times by omeprazole, but only after the cessation of dosing with famotidine. Sulphated glycoprotein synthesis was inhibited by both drugs at 2 weeks. PGE2 release and sulphated glycoprotein synthesis were restored to control values or more by the 5th day after the end of dosing, at which time total glycoprotein synthesis was significantly suppressed in both groups. Histologically, a reduction of PAS-positive surface mucus was observed after 2 weeks of dosing in both groups. Both famotidine and omeprazole reduced the sialic acid content during and after treatment. Conclusions: These results suggest that long-term anti-secretory therapy also affects the production of factors involved in primary gastric mucosal defence, which should be considered in the assessment of response to treatment in clinical trials.

Electronic Resource

1365-2133

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Background  The majority of skin changes associated with ageing are caused by photoageing and reflect cumulative sun exposure. Although the actinic damage plays a major role in skin pigmentation, it is also important to examine the effects of chronological cellular ageing on the pigmentation. The chief cellular components of the skin other than melanocytes are keratinocytes and fibroblasts, and the influences of age-related changes in those cells on skin pigmentation have not been elucidated.Objective  To clarify the effects of cellular ageing of keratinocytes and fibroblasts on age-related skin pigmentation.Methods  Using ELISA analysis, we measured the level of melanogenic cytokines secreted by cultured keratinocytes and fibroblasts derived from skin of various chronological ages. We also compared the cytokine secretion by cultured keratinocytes between the second and fifth cultures.Results  There was no correlation between age and hepatocyte growth factor (HGF), stem cell factor (SCF), and basic fibroblast growth factor (bFGF) secretion by fibroblasts. On the other hand, a significant positive correlation existed between age and interleukin ((IL)-1α secretion (R2 = 0·50, P = 0·002), and a relatively weak correlation existed between age and endothelin-1 (ET-1) secretion (R2 = 0·17, P = 0·051, not significant). The IL-1α secretion by keratinocytes was significantly increased in the fifth cultures compared with the second cultures (P 〈 0·005).Conclusions  These findings suggest that IL-1α secretion increases as cells grow older, and the increased secretion of IL-1α by aged keratinocytes may stimulate HGF production in dermal fibroblasts paracrinely and ET-1 production in keratinocytes autocrinely, which stimulates melanocyte proliferation and induces an increase of tyrosinase activity in melanocytes. Because IL-1α is a primary mediator that responds to inflammation and injury, the transcription of genes involved in skin inflammation may be persistently induced in the aged skin. Thus the increased secretion of IL-1α by aged keratinocytes in the aged skin may play a role in the accentuated cutaneous pigmentation and other skin ageing.

Electronic Resource

1365-2133

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

The clinical and histological features of 49 lesions induced by human papillomavirus type 1 (HPV-1) were studied. The majority of cases showed the typical clinical features and location of such lesions. They were usually located on the ventral or lateral surfaces of the hands or feet, and were dome-shaped lesions with a central depression.However, HPV-1-induced lesions located on other hody areas displayed different clinical features, such as those of common warts, a digitate wart, and a cutaneous horn. One lesion on a healing burn scar had a herpes-like appearance. As these 49 lesions were induced by the same type of HPV(HPV-1). differences in their clinical features are likely to have been due to host-related factors.

Electronic Resource

1365-2133

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Summary Background The mechanism of the accentuated melanization in café-au-lait macules (CALMs) in patients with neurofibromatosis type 1 (NF1; von Recklinghausen's disease) has not been elucidated. Objectives To clarify the mechanism involved in the hyperpigmentation of CALMs in NF1. Methods Using enzyme-linked immunosorbent assay (ELISA) and reverse transcriptase-polymerase chain reaction (RT-PCR) analysis of cultured cells, we measured the levels of cytokines produced and secreted by keratinocytes and fibroblasts derived from CALMs (group RC: Recklinghausen CALM) skin, compared with cells derived from the skin of normal individuals (group NN: Normal skin of Normal individuals) and cells derived from non-CALM skin of NF1 patients (group RN: Recklinghausen Non-CALM). Results ELISA revealed that the secretion of hepatocyte growth factor (HGF) and stem cell factor (SCF) by cultured fibroblasts was significantly elevated in group RC compared with groups RN and NN. In parallel, semiquantitative real-time RT-PCR of HGF and SCF mRNAs demonstrated increased expression of both types of transcripts by cultured fibroblasts in group RC compared with group NN. In contrast, the secretion of endothelin-1 and granulocyte/macrophage colony-stimulating factor by cultured keratinocytes occurred at a similar level among all three groups, RC, RN and NN. Conclusions These findings suggest that increased secretion of HGF and SCF by dermal fibroblasts may be associated with the accentuated epidermal melanization observed in CALMs in the skin of NF1 patients.

Electronic Resource

0006-291X

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Biology

Chemistry and Pharmacology

Physics

Electronic Resource

1476-4687

Nature Archives 1869 - 2009

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

[Auszug] Conventional high-temperature reactions limit the control of coordination polyhedra in transition-metal oxides to those obtainable within the bounds of known coordination geometries for a given transition metal. For example, iron atoms are almost exclusively coordinated by three-dimensional ...

Electronic Resource

0003-2670

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Chemistry and Pharmacology

Electronic Resource