Search Results - (Author, Cooperation:K. Wen)
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1Staff View
Publication Date: 2018-06-02Publisher: BMJ PublishingElectronic ISSN: 2044-6055Topics: MedicineKeywords: Open access, EpidemiologyPublished by: -
2Chang, K., Bai, H. X., Zhou, H., Su, C., Bi, W. L., Agbodza, E., Kavouridis, V. K., Senders, J. T., Boaro, A., Beers, A., Zhang, B., Capellini, A., Liao, W., Shen, Q., Li, X., Xiao, B., Cryan, J., Ramkissoon, S., Ramkissoon, L., Ligon, K., Wen, P. Y., Bindra, R. S., Woo, J., Arnaout, O., Gerstner, E. R., Zhang, P. J., Rosen, B. R., Yang, L., Huang, R. Y., Kalpathy-Cramer, J.
The American Association for Cancer Research (AACR)
Published 2018Staff ViewPublication Date: 2018-03-06Publisher: The American Association for Cancer Research (AACR)Print ISSN: 1078-0432Electronic ISSN: 1557-3265Topics: MedicinePublished by: -
3Lee, E. Q., Duda, D. G., Muzikansky, A., Gerstner, E. R., Kuhn, J. G., Reardon, D. A., Nayak, L., Norden, A. D., Doherty, L., La; Frankie, D., Stefanik, J., Vardam, T., Smith, K. H., McCluskey, C., Gaffey, S., Batchelor, T. T., Jain, R. K., Wen, P. Y.
The American Association for Cancer Research (AACR)
Published 2018Staff ViewPublication Date: 2018-10-02Publisher: The American Association for Cancer Research (AACR)Print ISSN: 1078-0432Electronic ISSN: 1557-3265Topics: MedicinePublished by: -
4M. B. Gerstein ; J. Rozowsky ; K. K. Yan ; D. Wang ; C. Cheng ; J. B. Brown ; C. A. Davis ; L. Hillier ; C. Sisu ; J. J. Li ; B. Pei ; A. O. Harmanci ; M. O. Duff ; S. Djebali ; R. P. Alexander ; B. H. Alver ; R. Auerbach ; K. Bell ; P. J. Bickel ; M. E. Boeck ; N. P. Boley ; B. W. Booth ; L. Cherbas ; P. Cherbas ; C. Di ; A. Dobin ; J. Drenkow ; B. Ewing ; G. Fang ; M. Fastuca ; E. A. Feingold ; A. Frankish ; G. Gao ; P. J. Good ; R. Guigo ; A. Hammonds ; J. Harrow ; R. A. Hoskins ; C. Howald ; L. Hu ; H. Huang ; T. J. Hubbard ; C. Huynh ; S. Jha ; D. Kasper ; M. Kato ; T. C. Kaufman ; R. R. Kitchen ; E. Ladewig ; J. Lagarde ; E. Lai ; J. Leng ; Z. Lu ; M. MacCoss ; G. May ; R. McWhirter ; G. Merrihew ; D. M. Miller ; A. Mortazavi ; R. Murad ; B. Oliver ; S. Olson ; P. J. Park ; M. J. Pazin ; N. Perrimon ; D. Pervouchine ; V. Reinke ; A. Reymond ; G. Robinson ; A. Samsonova ; G. I. Saunders ; F. Schlesinger ; A. Sethi ; F. J. Slack ; W. C. Spencer ; M. H. Stoiber ; P. Strasbourger ; A. Tanzer ; O. A. Thompson ; K. H. Wan ; G. Wang ; H. Wang ; K. L. Watkins ; J. Wen ; K. Wen ; C. Xue ; L. Yang ; K. Yip ; C. Zaleski ; Y. Zhang ; H. Zheng ; S. E. Brenner ; B. R. Graveley ; S. E. Celniker ; T. R. Gingeras ; R. Waterston
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-08-29Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Caenorhabditis elegans/embryology/*genetics/growth & development ; Chromatin/genetics ; Cluster Analysis ; Drosophila melanogaster/*genetics/growth & development ; *Gene Expression Profiling ; Gene Expression Regulation, Developmental/genetics ; Histones/metabolism ; Humans ; Larva/genetics/growth & development ; Models, Genetic ; Molecular Sequence Annotation ; Promoter Regions, Genetic/genetics ; Pupa/genetics/growth & development ; RNA, Untranslated/genetics ; Sequence Analysis, RNA ; Transcriptome/*geneticsPublished by: -
5Staff View
Publication Date: 2018-05-10Publisher: Institute of Physics Publishing (IOP)Electronic ISSN: 1748-0221Topics: PhysicsPublished by: -
6B. A. Trump; S. M. Koohpayeh; K. J. T. Livi; J.-J. Wen; K. E. Arpino; Q. M. Ramasse; R. Brydson; M. Feygenson; H. Takeda; M. Takigawa; K. Kimura; S. Nakatsuji; C. L. Broholm; T. M. McQueen
Nature Publishing Group (NPG)
Published 2018Staff ViewPublication Date: 2018-07-06Publisher: Nature Publishing Group (NPG)Electronic ISSN: 2041-1723Topics: BiologyChemistry and PharmacologyNatural Sciences in GeneralPhysicsPublished by: -
7Staff View
Publication Date: 2018-10-03Publisher: Institute of Physics Publishing (IOP)Electronic ISSN: 1748-0221Topics: PhysicsPublished by: -
8Staff View
ISSN: 0021-9673Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
9Staff View
ISSN: 0021-9673Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
10Staff View
ISSN: 0021-9673Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
11Chen, Wei-Shone ; Lin, Wen-chang ; Kou, Yu Ru ; Kuo, H. Sung ; Hsu, Hung ; Yang, Wen K.
Springer
Published 1997Staff ViewISSN: 1530-0358Keywords: Colon cancer ; Liver metastasis ; Pneumoperitoneum ; Laparoscopic surgerySource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract PURPOSE: By using a murine hepatic metastatic model, we tried to investigate the possible influence of gas insufflation in colon cancer cells spreading from the portal system to the liver. METHODS: After transducing the human placental ALP gene into murine colon cancer cell line CT26, we successfully selected a clone of CT26/DAP that would yield a specific color following histochemical staining. Fifty mice were assigned into two groups, receiving either an intrasplenic injection of 10 6 CT26/DAP cells alone or the cells followed by intra-abdominal helium insufflation with the pressure of 15 cm H 2 O for ten minutes. Five mice in each group were used to observe their survival and the other mice were killed at four different time periods: 10 minutes, 24 hours, 48 hours, and 72 hours following cell injection. The livers and spleens were removed for histochemical staining. By counting the numbers of specific dark reddish spots of CT26/DAP cells, we could estimate the number of tumor cells on the hepatic surface. RESULTS: At the very beginning following tumor cell injection, we found a significantly greater number of tumor cells on the hepatic surface in mice with gas insufflation (6354±1072 vs.2133±223, respectively;P=0.012). But the difference of these two groups became smaller and smaller as time went by. The number of tumor cells on the hepatic surface would reach the lowest level at postoperative 48 hours, and the tumor foci then began to grow both in size and number. The above patterns of dynamic change in tumor cell distribution were similar in mice both with and without gas insufflation. Average survival was slightly shorter in mice with gas insufflation, but the difference was not statistically significant. CONCLUSION: Pneumoperitoneum caused by gas insufflation may increase tumor cell spread from the portal system to the liver at the very beginning stage; however, there was no significant difference in long-term survival between mice with and without gas insufflation in this murine animal model.Type of Medium: Electronic ResourceURL: -
12Zhao, W. Z. ; Xu, X. Y. ; Ma, W. Y. ; Cheng, Y. ; Hui, Q. ; Wen, K. L. ; Chen, D. Y.
Springer
Published 1991Staff ViewISSN: 1432-0649Keywords: 32.70 ; 32.80DSource: Springer Online Journal Archives 1860-2000Topics: PhysicsNotes: Abstract This paper describes the investigation of the autoionizing states of AuI by exciting the states of 6d 2 D 3/2 and 6d D 5/2 with tunable dye lasers by means of a resonance ionization time-of-flight mass spectrometer (RI-TOFMS). Many new autoionizing states were found, a few of which have narrow-linewidths of about 0.1 cm−1. The photoionization efficiencies for different channels were compared. Among the autoionizing states found so far, the highest photoionization yield is given by two newly obtained states from the state 6d 2 D 5/2, 3683.6 cm−1 and 4636.5 cm−1 above the first ionization limit. In addition, the Shore-Fano profile parameters of several autoionizing resonances were determined by a nonlinear fitting program.Type of Medium: Electronic ResourceURL: -
13Staff View
ISSN: 0144-8188Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: LawEconomicsType of Medium: Electronic ResourceURL: -
14Staff View
ISSN: 0040-4039Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
15Staff View
ISSN: 1432-1297Source: Springer Online Journal Archives 1860-2000Topics: MathematicsType of Medium: Electronic ResourceURL: -
16Staff View
ISSN: 0006-3592Keywords: Chemistry ; Biochemistry and BiotechnologySource: Wiley InterScience Backfile Collection 1832-2000Topics: BiologyProcess Engineering, Biotechnology, Nutrition TechnologyAdditional Material: 1 Ill.Type of Medium: Electronic ResourceURL: -
17Staff View
ISSN: 0006-3592Keywords: Chemistry ; Biochemistry and BiotechnologySource: Wiley InterScience Backfile Collection 1832-2000Topics: BiologyProcess Engineering, Biotechnology, Nutrition TechnologyNotes: A laboratory investigation has been undertaken to asses the effects of two operating parameters, mean cell residence time (MCRT) and anoxic hydraulic retention time (HRT), on the performance of an anoxic/oxic activated sludge system. The performance of the system was evaluated in terms of its COD, nitrogen, and biomass characteristics. An activated sludge system is capable of producing a better effluent, in terms of COD and nitrogen characteristics, when it is operated in an anoxic/oxic fashion. A longer MCRT and an adequate anoxic HRT are desirable in the operation of an anoxic/oxic activated sludge system. For the wastewater used in this investigation, the anoxic/oxic unit was capable of producing an effluent with the following characteristics when it was operated at MCRT = 20 days, total system HRT = 10 h, and anoxic HRT = 3-5 h: COD = 15 mg/L; VSS = 10 mg/L; TKN = 1.30 mg/L; NH3 - N = 0.60 mg/L; and NO2 + NO3 - N = 5.0 mg/L. A uniform distribution of biomass is achievable in an anoxic/oxic activated sludge system because of the intensive recirculation/convection maintained. The provision of an anoxic zone in the aeration tank promotes a rapid adsorption of feed COD into the biomass without an immediate utilization for cell synthesis. This, in turn, results in a high microbial activity and a lower observed biomass yield in the system. A tertiary treatment efficiency is achievable in an anoxic/oxic activated sludge system with only secondary treatment operations and costs. A conventional activated sludge system can be easily upgraded by converting to the anoxic/oxic operation with minor process modifications.Additional Material: 10 Ill.Type of Medium: Electronic ResourceURL: -
18Staff View
ISSN: 0006-3592Keywords: Chemistry ; Biochemistry and BiotechnologySource: Wiley InterScience Backfile Collection 1832-2000Topics: BiologyProcess Engineering, Biotechnology, Nutrition TechnologyAdditional Material: 5 Ill.Type of Medium: Electronic ResourceURL: -
19Staff View
ISSN: 0006-3592Keywords: Chemistry ; Biochemistry and BiotechnologySource: Wiley InterScience Backfile Collection 1832-2000Topics: BiologyProcess Engineering, Biotechnology, Nutrition TechnologyNotes: The anoxic-oxic activated-sludge process has been evaluated in a laboratory investigation as a means for effective treatment of cyanide-laden wastewaters, with phenols used as the organic carbon sources for denitrification reactions. The performance of the process was evaluated at different levels of feed cyanide concentration and mean cell residence time (MCRT). The results obtained indicate that the phenolic compounds used can be effectively used as the organic carbon sources to promote denitrification reactions. The effects of cyanide inhibition on overall TOC removal can be alleviated at longer MCRTs. Between 1.2 and 2.2 g TOC can be utilized per gram NO2 + NO3- -N removed in the anoxic chamber depending on the prevailing MCRT. Microbial oxidation of cyanide and thiocyanate which yields ammonia is the main mechanism responsible for the removal of cyanide and thiocyanate observed in the anoxic-oxic activated-sludge process. Excellent removal efficiencies have been observed with feed concentrations up to 60 mg CN-/L and 100 mg SCN-/L Frequent exposure of autotrophic and aerobic cyanideutilizing microbes does not impede their activities in the oxic environment. Good nitrification and denitrification efficiencies are attainable in the anoxic-oxic activated-sludge process in the presence of high feed cyanide and thiocyanate concentrations, provided that MCRT is maintained at a desirable level. As a result, the microbial degradation of cyanide and thiocyanate in conjunction with nitrification and denitrification to produce innocuous nitrogen gas is feasible in the anoxic-oxic activated-sludge process.Additional Material: 6 Ill.Type of Medium: Electronic ResourceURL: -
20Shieh, Wen K. ; Chen, Chiu Y. ; Chang, Sheng D.
New York, NY [u.a.] : Wiley-Blackwell
Published 1982Staff ViewISSN: 0006-3592Keywords: Chemistry ; Biochemistry and BiotechnologySource: Wiley InterScience Backfile Collection 1832-2000Topics: BiologyProcess Engineering, Biotechnology, Nutrition TechnologyNotes: A laboratory study has been conducted to obtained preliminary process information of a suspended growth Predenitrification (SGPDN)system. System performance was evaluated, in terms of chemical oxygen demand (COD) removal, NH3-N removal, system biomass yield and inventory, and effluent qualities, at different solids retention times (SRTs) and recycle ratios. Chemical oxygen demand removal in an SGPDN system occurs mainly in the anoxic reactor, which accounts for 94% of total COD removal. The overall COD removal rate is independent of recycle ratio (ranging from 2-5) used in this study; however, effluent COD increase with increasing recycle ratio. The observed anoxic and aerobic COD removal rates decrease with increasing SRT. The NH3-N removal in an SGPDN system is induced by two mechanisms: assimilatory NH3-N requirement for biomass production in the anoxic reactor and nitrification in the aerobic reactor. The observed anoxic NH3-N removal rate relates directly to the anoxic COD removal rate and agrees fairly well with the assimilatory NH3-N requirement theoretically predicted. The overall NH3-N removal rate is independent of SRTs and recycle ratios used in this study. Biomass yield in an SGPDN system occurs mainly in the anoxic reactor. However, uniform distribution of biomass throughout the entire system is obtained because of the high recycle rate used. The observed biomass yield (YO) decreases with increasing STR. Tertiary treatment efficiency can be achieved in an SGPDN system. More than 90% reduction in feed COD., feed NH3-N, and NO2 + NO3-N is obtained at all SRTs and recycle ratios used in this study. Higher MLVSS loading rates can be applied to a final clarifier without impairing its separation efficiency because of the excellent settleability of the Predenitrification activated sludge.Additional Material: 9 Ill.Type of Medium: Electronic ResourceURL: