Search Results - (Author, Cooperation:K. Voss)

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  1. 1
    J. S. Kargel ; G. J. Leonard ; D. H. Shugar ; U. K. Haritashya ; A. Bevington ; E. J. Fielding ; K. Fujita ; M. Geertsema ; E. S. Miles ; J. Steiner ; E. Anderson ; S. Bajracharya ; G. W. Bawden ; D. F. Breashears ; A. Byers ; B. Collins ; M. R. Dhital ; A. Donnellan ; T. L. Evans ; M. L. Geai ; M. T. Glasscoe ; D. Green ; D. R. Gurung ; R. Heijenk ; A. Hilborn ; K. Hudnut ; C. Huyck ; W. W. Immerzeel ; J. Liming ; R. Jibson ; A. Kaab ; N. R. Khanal ; D. Kirschbaum ; P. D. Kraaijenbrink ; D. Lamsal ; L. Shiyin ; L. Mingyang ; D. McKinney ; N. K. Nahirnick ; N. Zhuotong ; S. Ojha ; J. Olsenholler ; T. H. Painter ; M. Pleasants ; K. C. Pratima ; Q. I. Yuan ; B. H. Raup ; D. Regmi ; D. R. Rounce ; A. Sakai ; S. Donghui ; J. M. Shea ; A. B. Shrestha ; A. Shukla ; D. Stumm ; M. van der Kooij ; K. Voss ; W. Xin ; B. Weihs ; D. Wolfe ; W. Lizong ; Y. Xiaojun ; M. R. Yoder ; N. Young
    American Association for the Advancement of Science (AAAS)
    Published 2015
    Staff View
    Publication Date:
    2015-12-18
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Disasters/*prevention & control ; Earthquakes/*mortality ; Environmental Monitoring/*methods ; Floods ; Humans ; Lakes ; Landslides/*mortality ; Nepal ; Safety Management/*methods ; Satellite Imagery
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    L. Chen ; M. Kostadima ; J. H. Martens ; G. Canu ; S. P. Garcia ; E. Turro ; K. Downes ; I. C. Macaulay ; E. Bielczyk-Maczynska ; S. Coe ; S. Farrow ; P. Poudel ; F. Burden ; S. B. Jansen ; W. J. Astle ; A. Attwood ; T. Bariana ; B. de Bono ; A. Breschi ; J. C. Chambers ; F. A. Choudry ; L. Clarke ; P. Coupland ; M. van der Ent ; W. N. Erber ; J. H. Jansen ; R. Favier ; M. E. Fenech ; N. Foad ; K. Freson ; C. van Geet ; K. Gomez ; R. Guigo ; D. Hampshire ; A. M. Kelly ; H. H. Kerstens ; J. S. Kooner ; M. Laffan ; C. Lentaigne ; C. Labalette ; T. Martin ; S. Meacham ; A. Mumford ; S. Nurnberg ; E. Palumbo ; B. A. van der Reijden ; D. Richardson ; S. J. Sammut ; G. Slodkowicz ; A. U. Tamuri ; L. Vasquez ; K. Voss ; S. Watt ; S. Westbury ; P. Flicek ; R. Loos ; N. Goldman ; P. Bertone ; R. J. Read ; S. Richardson ; A. Cvejic ; N. Soranzo ; W. H. Ouwehand ; H. G. Stunnenberg ; M. Frontini ; A. Rendon
    American Association for the Advancement of Science (AAAS)
    Published 2014
    Staff View
    Publication Date:
    2014-09-27
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    *Alternative Splicing ; Cell Lineage/*genetics ; Genetic Variation ; Hematopoiesis/*genetics ; Hematopoietic Stem Cells/*cytology/metabolism ; Humans ; NFI Transcription Factors/genetics/metabolism ; RNA-Binding Proteins/metabolism ; Thrombopoiesis/genetics ; Transcriptome
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    F. K. Voss ; F. Ullrich ; J. Munch ; K. Lazarow ; D. Lutter ; N. Mah ; M. A. Andrade-Navarro ; J. P. von Kries ; T. Stauber ; T. J. Jentsch
    American Association for the Advancement of Science (AAAS)
    Published 2014
    Staff View
    Publication Date:
    2014-05-03
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Agammaglobulinemia/genetics ; *Cell Size ; Chloride Channels/*metabolism ; Gene Knockout Techniques ; Genome-Wide Association Study ; HCT116 Cells ; HEK293 Cells ; Humans ; Membrane Proteins/genetics/*metabolism ; Mutation ; Protein Multimerization ; RNA Interference ; RNA, Small Interfering/genetics ; Taurine/metabolism ; Transfection
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  4. 4
    P. van der Harst ; W. Zhang ; I. Mateo Leach ; A. Rendon ; N. Verweij ; J. Sehmi ; D. S. Paul ; U. Elling ; H. Allayee ; X. Li ; A. Radhakrishnan ; S. T. Tan ; K. Voss ; C. X. Weichenberger ; C. A. Albers ; A. Al-Hussani ; F. W. Asselbergs ; M. Ciullo ; F. Danjou ; C. Dina ; T. Esko ; D. M. Evans ; L. Franke ; M. Gogele ; J. Hartiala ; M. Hersch ; H. Holm ; J. J. Hottenga ; S. Kanoni ; M. E. Kleber ; V. Lagou ; C. Langenberg ; L. M. Lopez ; L. P. Lyytikainen ; O. Melander ; F. Murgia ; I. M. Nolte ; P. F. O'Reilly ; S. Padmanabhan ; A. Parsa ; N. Pirastu ; E. Porcu ; L. Portas ; I. Prokopenko ; J. S. Ried ; S. Y. Shin ; C. S. Tang ; A. Teumer ; M. Traglia ; S. Ulivi ; H. J. Westra ; J. Yang ; J. H. Zhao ; F. Anni ; A. Abdellaoui ; A. Attwood ; B. Balkau ; S. Bandinelli ; F. Bastardot ; B. Benyamin ; B. O. Boehm ; W. O. Cookson ; D. Das ; P. I. de Bakker ; R. A. de Boer ; E. J. de Geus ; M. H. de Moor ; M. Dimitriou ; F. S. Domingues ; A. Doring ; G. Engstrom ; G. I. Eyjolfsson ; L. Ferrucci ; K. Fischer ; R. Galanello ; S. F. Garner ; B. Genser ; Q. D. Gibson ; G. Girotto ; D. F. Gudbjartsson ; S. E. Harris ; A. L. Hartikainen ; C. E. Hastie ; B. Hedblad ; T. Illig ; J. Jolley ; M. Kahonen ; I. P. Kema ; J. P. Kemp ; L. Liang ; H. Lloyd-Jones ; R. J. Loos ; S. Meacham ; S. E. Medland ; C. Meisinger ; Y. Memari ; E. Mihailov ; K. Miller ; M. F. Moffatt ; M. Nauck ; M. Novatchkova ; T. Nutile ; I. Olafsson ; P. T. Onundarson ; D. Parracciani ; B. W. Penninx ; L. Perseu ; A. Piga ; G. Pistis ; A. Pouta ; U. Puc ; O. Raitakari ; S. M. Ring ; A. Robino ; D. Ruggiero ; A. Ruokonen ; A. Saint-Pierre ; C. Sala ; A. Salumets ; J. Sambrook ; H. Schepers ; C. O. Schmidt ; H. H. Sillje ; R. Sladek ; J. H. Smit ; J. M. Starr ; J. Stephens ; P. Sulem ; T. Tanaka ; U. Thorsteinsdottir ; V. Tragante ; W. H. van Gilst ; L. J. van Pelt ; D. J. van Veldhuisen ; U. Volker ; J. B. Whitfield ; G. Willemsen ; B. R. Winkelmann ; G. Wirnsberger ; A. Algra ; F. Cucca ; A. P. d'Adamo ; J. Danesh ; I. J. Deary ; A. F. Dominiczak ; P. Elliott ; P. Fortina ; P. Froguel ; P. Gasparini ; A. Greinacher ; S. L. Hazen ; M. R. Jarvelin ; K. T. Khaw ; T. Lehtimaki ; W. Maerz ; N. G. Martin ; A. Metspalu ; B. D. Mitchell ; G. W. Montgomery ; C. Moore ; G. Navis ; M. Pirastu ; P. P. Pramstaller ; R. Ramirez-Solis ; E. Schadt ; J. Scott ; A. R. Shuldiner ; G. D. Smith ; J. G. Smith ; H. Snieder ; R. Sorice ; T. D. Spector ; K. Stefansson ; M. Stumvoll ; W. H. Tang ; D. Toniolo ; A. Tonjes ; P. M. Visscher ; P. Vollenweider ; N. J. Wareham ; B. H. Wolffenbuttel ; D. I. Boomsma ; J. S. Beckmann ; G. V. Dedoussis ; P. Deloukas ; M. A. Ferreira ; S. Sanna ; M. Uda ; A. A. Hicks ; J. M. Penninger ; C. Gieger ; J. S. Kooner ; W. H. Ouwehand ; N. Soranzo ; J. C. Chambers
    Nature Publishing Group (NPG)
    Published 2012
    Staff View
    Publication Date:
    2012-12-12
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Cell Cycle/genetics ; Cytokines/metabolism ; Drosophila melanogaster/genetics ; Erythrocytes/cytology/*metabolism ; Female ; Gene Expression Regulation/genetics ; *Genetic Loci ; *Genome-Wide Association Study ; Hematopoiesis/genetics ; Hemoglobins/genetics ; Humans ; Male ; Mice ; Organ Specificity ; *Phenotype ; Polymorphism, Single Nucleotide/genetics ; RNA Interference ; Signal Transduction/genetics
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  5. 5
    C. Gieger ; A. Radhakrishnan ; A. Cvejic ; W. Tang ; E. Porcu ; G. Pistis ; J. Serbanovic-Canic ; U. Elling ; A. H. Goodall ; Y. Labrune ; L. M. Lopez ; R. Magi ; S. Meacham ; Y. Okada ; N. Pirastu ; R. Sorice ; A. Teumer ; K. Voss ; W. Zhang ; R. Ramirez-Solis ; J. C. Bis ; D. Ellinghaus ; M. Gogele ; J. J. Hottenga ; C. Langenberg ; P. Kovacs ; P. F. O'Reilly ; S. Y. Shin ; T. Esko ; J. Hartiala ; S. Kanoni ; F. Murgia ; A. Parsa ; J. Stephens ; P. van der Harst ; C. Ellen van der Schoot ; H. Allayee ; A. Attwood ; B. Balkau ; F. Bastardot ; S. Basu ; S. E. Baumeister ; G. Biino ; L. Bomba ; A. Bonnefond ; F. Cambien ; J. C. Chambers ; F. Cucca ; P. D'Adamo ; G. Davies ; R. A. de Boer ; E. J. de Geus ; A. Doring ; P. Elliott ; J. Erdmann ; D. M. Evans ; M. Falchi ; W. Feng ; A. R. Folsom ; I. H. Frazer ; Q. D. Gibson ; N. L. Glazer ; C. Hammond ; A. L. Hartikainen ; S. R. Heckbert ; C. Hengstenberg ; M. Hersch ; T. Illig ; R. J. Loos ; J. Jolley ; K. T. Khaw ; B. Kuhnel ; M. C. Kyrtsonis ; V. Lagou ; H. Lloyd-Jones ; T. Lumley ; M. Mangino ; A. Maschio ; I. Mateo Leach ; B. McKnight ; Y. Memari ; B. D. Mitchell ; G. W. Montgomery ; Y. Nakamura ; M. Nauck ; G. Navis ; U. Nothlings ; I. M. Nolte ; D. J. Porteous ; A. Pouta ; P. P. Pramstaller ; J. Pullat ; S. M. Ring ; J. I. Rotter ; D. Ruggiero ; A. Ruokonen ; C. Sala ; N. J. Samani ; J. Sambrook ; D. Schlessinger ; S. Schreiber ; H. Schunkert ; J. Scott ; N. L. Smith ; H. Snieder ; J. M. Starr ; M. Stumvoll ; A. Takahashi ; W. H. Tang ; K. Taylor ; A. Tenesa ; S. Lay Thein ; A. Tonjes ; M. Uda ; S. Ulivi ; D. J. van Veldhuisen ; P. M. Visscher ; U. Volker ; H. E. Wichmann ; K. L. Wiggins ; G. Willemsen ; T. P. Yang ; J. Hua Zhao ; P. Zitting ; J. R. Bradley ; G. V. Dedoussis ; P. Gasparini ; S. L. Hazen ; A. Metspalu ; M. Pirastu ; A. R. Shuldiner ; L. Joost van Pelt ; J. J. Zwaginga ; D. I. Boomsma ; I. J. Deary ; A. Franke ; P. Froguel ; S. K. Ganesh ; M. R. Jarvelin ; N. G. Martin ; C. Meisinger ; B. M. Psaty ; T. D. Spector ; N. J. Wareham ; J. W. Akkerman ; M. Ciullo ; P. Deloukas ; A. Greinacher ; S. Jupe ; N. Kamatani ; J. Khadake ; J. S. Kooner ; J. Penninger ; I. Prokopenko ; D. Stemple ; D. Toniolo ; L. Wernisch ; S. Sanna ; A. A. Hicks ; A. Rendon ; M. A. Ferreira ; W. H. Ouwehand ; N. Soranzo
    Nature Publishing Group (NPG)
    Published 2011
    Staff View
    Publication Date:
    2011-12-06
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Blood Platelets/*cytology/metabolism ; Cell Size ; Drosophila Proteins/genetics ; Drosophila melanogaster/genetics ; Europe ; Gene Expression Profiling ; Gene Silencing ; Genome, Human/genetics ; Genome-Wide Association Study ; Hematopoiesis/*genetics ; Humans ; Megakaryocytes/*cytology/metabolism ; Platelet Count ; Protein Interaction Maps ; Transcription, Genetic/genetics ; Zebrafish/genetics ; Zebrafish Proteins/genetics
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  6. 6
    Lynch, M. A. ; Voss, K. L.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1991
    Staff View
    ISSN:
    1471-4159
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Abstract: In this report, two changes that occur in the presynaptic terminal following induction of long-term potentiation in the dentate gyrus are examined, and the results demonstrate that the same changes are stimulated by the putative retrograde messenger arachidonic acid. First, there is an increase in the concentration of intracellular calcium in synaptosomes prepared from potentiated tissue compared with control tissue. This effect on intracellular calcium concentration was mimicked in control tissue by treatment of synaptosomes with either arachidonic acid or inositol 1,4,5-trisphosphate in a dose-dependent but nonadditive manner. Second, there is an increase in phosphoinositide turnover in synaptosomes prepared from potentiated tissue compared with control tissue, and this change can also be mimicked in control tissue by exposure of synaptosomes to arachidonic acid. These findings are consistent with the hypothesis that the increase in glutamate release associated with long-term potentiation may be stimulated by arachidonic acid, as a result of an increase in intrasynaptosomal calcium concentration, perhaps occurring as a result of arachidonate-stimulated phosphoinositide metabolism.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1471-4159.1991.tb02569.x

    Articles: DFG German National Licenses
  7. 7
    Lynch, M. A. ; Voss, K. L.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1990
    Staff View
    ISSN:
    1471-4159
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Abstract: We have been interested in the possibility that arachidonic acid or one of its 12-lipoxygenase metabolites may function as a retrograde messenger in long-term potentiation (LTP) in the dentate gyrus of the hippocampus. One criterion required of a retrograde messenger is that it stimulates presynaptic changes. Here, two possible presynaptic actions of arachidonic acid and its 12-lipoxygenase metabolites, 12-hydroxyeicosatetraenoic acid (HETE) and 12-hydroperoxyeicosatetraenoic acid (HPETE), are examined. We report that arachidonic acid, HETE, and HPETE significantly increase both K+-stimulated release of [3H]glutamate and [3H]inositol labelling of inositol phosphates in synaptosomes, whereas other biologically important fatty acids (oleic, palmitic, and stearic) failed to induce a similar response. The findings of these experiments are consistent with the hypothesis that arachidonic acid, HETE, or HPETE may play the role of a retrograde messenger in LTP.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1471-4159.1990.tb08841.x

    Articles: DFG German National Licenses
  8. 8
    Voss, K. E. ; Fisch, N. J.

    New York, NY : American Institute of Physics (AIP)
    Published 1993
    Staff View
    ISSN:
    1089-7666
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1063/1.860980

    Articles: DFG German National Licenses
  9. 9
    Voss, K. E. ; Fisch, N. J.

    New York, NY : American Institute of Physics (AIP)
    Published 1992
    Staff View
    ISSN:
    1089-7666
    Source:
    AIP Digital Archive
    Topics:
    Physics
    Notes:
    Information about the momentum distribution of electrons in a plasma is often of great importance, for example, when superthermal electrons are created by noninductive means. For such predominantly one-dimensional distribution functions, an analytic inversion has been found that yields the velocity distribution of superthermal electrons given their bremsstrahlung radiation.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1063/1.860221

    Articles: DFG German National Licenses
  10. 10
    French, P. J. ; O'Connor, V. ; Voss, K. ; Stean, T. ; Hunt, S. P. ; Bliss, T. V. P.

    Oxford, UK : Blackwell Science Ltd
    Published 2001
    Staff View
    ISSN:
    1460-9568
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Synaptic plasticity in the hippocampus requires activity-dependent gene expression. We have therefore profiled gene expression in area CA1 following the induction of an electroshock-evoked maximal seizure. Using cDNA microarrays, the differential expression of ≈ 9000 cDNAs was examined. In situ hybridization on 14 transcripts that showed strongest modulation in the microarray screen (1.8–2-fold) confirmed the differential expression of a single gene that encodes for the nuclear hormone receptor NGFI-B (Nur77, N10). Although this gene is only modestly up-regulated (≈ 2-fold) in area CA1, in situ hybridization revealed that maximal seizures induce a marked (≈ 12-fold) up-regulation of NGFI-B in the dentate gyrus. These data support the notion [French et al. (2001) Eur. J. Neurosci., 13, 968–976] that CA1 pyramidal neurons are more refractory than granule cells of the dentate gyrus with respect to activity-dependent gene transcription. Furthermore, our results argue against a large cohort of activity-dependent genes in area CA1.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1046/j.0953-816x.2001.01818.x

    Articles: DFG German National Licenses
  11. 11
    Staff View
    ISSN:
    1460-9568
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    It is not known whether NMDA receptor-dependent long-term potentiation (LTP) is mediated by similar molecular mechanisms in different hippocampal areas. To address this question we have investigated changes in immediate early gene and protein expression in two hippocampal subfields following the induction of LTP in vivo and in vitro. In granule cells of the dentate gyrus, LTP induced in vivo by tetanic stimulation of the perforant path was followed by strong induction of the immediate early genes (IEGs) Zif268, Arc and Homer. The increase in Zif268 mRNA was accompanied by an increase in protein expression. In contrast, we were unable to detect modulation of the IEGs Zif268, Arc, Homer and HB-GAM following induction of LTP by high-frequency stimulation of the commissural projection to CA1 pyramidal cells in vivo. In this pathway, we also failed to detect modulation of Zif268 protein levels. Zif268, Arc and Homer can be modulated in CA1 pyramidal cells approximately twofold after electroshock-induced maximal seizure, which demonstrates potential responsiveness to electrical stimuli. When LTP was induced in vitro neither CA1 pyramidal cells nor granule cells showed an increase in Zif268, Arc or Homer mRNA. However, in the slice preparation, granule cells have a different transcriptional state as basal IEG levels are elevated. These results establish the existence of subfield-specific transcriptional responses to LTP-inducing stimulation in the hippocampus of the intact animal, and demonstrate that in area CA1-enhanced transcription of Zif268, Arc and Homer is not required for the induction of late LTP.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1046/j.0953-816x.2001.01467.x

    Articles: DFG German National Licenses
  12. 12
    Staff View
    ISSN:
    1460-9568
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    A major role has been postulated for a maintained increase in the autonomous activity of CaMKII in the expression of long-term potentiation (LTP). However, attempts to inhibit the expression of LTP with CaMKII inhibitors have yielded inconsistent results. Here we compare the changes in CaMKII autonomous activity and phosphorylation at Thr286 of αCaMKII in rat hippocampal slices using chemical or tetanic stimulation to produce either LTP or short-term potentiation (STP). Tetanus-induced LTP in area CA1 requires CaMKII activation and Thr286 phosphorylation of αCaMKII, but we did not observe an increase in autonomous activity. Next we induced LTP by 10 min exposure to 25 mm tetraethyl-ammonium (TEA) or 5 min exposure to 41 mm potassium (K) after pretreatment with calyculin A. Exposure to K alone produced STP. These protocols allowed us to monitor temporal changes in autonomous activity during and after exposure to the potentiating chemical stimulus. In chemically induced LTP, autonomous activity was maximally increased within 30 s whereas this increase was significantly delayed in STP. However, in both LTP and STP the two-fold increase in autonomous activity measured immediately after stimulation was short-lived, returning to baseline within 2–5 min after re-exposure to normal ACSF. In LTP, but not in STP, the phosphorylation of αCaMKII at Thr286 persisted for at least 60 min after stimulation. These results confirm that LTP is associated with a maintained increase in autophosphorylation at Thr286 but indicate that a persistent increase in the autonomous activity οf CaMKII is not required for the expression of LTP.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1460-9568.2004.03748.x

    Articles: DFG German National Licenses
  13. 13
    Lynch, M. A. ; Voss, K. L.

    Oxford, UK : Blackwell Publishing Ltd
    Published 1994
    Staff View
    ISSN:
    1460-9568
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    We examined the induction and maintenance of long-term potentiation (LTP) in vivo in the dentate gyrus of 4-month-old and 22-month-old urethane-anaesthetized rats. High-frequency stimulation of the perforant path induced an immediate increase in the slope of the population excitatory postsynaptic potential (EPSP), which was sustained in the 4-month-old animals for the duration of the experiment (45 min post-tetanus). In the 22-month-old group, the mean slope of the population EPSP decreased almost to baseline by the end of the experiment. Examination of the individual records indicated that LTP was sustained for the duration of the experiment in half of the 22-month-old animals, while in the others only post-tetanic potentiation was observed. Membrane arachidonic acid concentration was reduced in aged compared with young animals and was lowest in the subgroup of aged animals which failed to sustain LTP. Potassium-stimulated, calcium-dependent release of glutamate was also decreased in aged compared with young animals, but LTP was associated with an increase in glutamate release in the 4-month-old group and 22-month-old subgroup in which LTP was successfully sustained; no change was observed in the 22-month-old group in which LTP was not sustained. The results indicate a correlation between membrane arachidonic acid concentration, glutamate release and ability to sustain LTP in aged animals.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1460-9568.1994.tb00595.x

    Articles: DFG German National Licenses
  14. 14
    Richter, J. ; Voss, K.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0375-9601
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Physics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0375-9601(68)90347-2

    Articles: DFG German National Licenses
  15. 15
    Voss, K.
    Springer
    Published 1955
    Staff View
    ISSN:
    1420-8938
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Mathematics
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01899403

    Articles: DFG German National Licenses
  16. 16
    Voss, K.

    Berlin : Periodicals Archive Online (PAO)
    Published 1975
    Staff View
    ISSN:
    0012-1045
    Topics:
    Philosophy
    Notes:
    DISKUSSION
    URL:
    http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:4085-1975-023-02-000006

    Articles: DFG German National Licenses
  17. 17
    Voss, K.

    Berlin : Periodicals Archive Online (PAO)
    Published 1978
    Staff View
    ISSN:
    0012-1045
    Topics:
    Philosophy
    URL:
    http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pao:&rft_dat=xri:pao:article:4085-1978-026-08-000004

    Articles: DFG German National Licenses
  18. 18
    Martin, H. ; Voss, K.
    Springer
    Published 1982
    Staff View
    ISSN:
    1432-0533
    Keywords:
    Gliomas ; Automated image analysis ; Karyometry ; Automated classification ; Discrimination
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary A karyometric analysis of 346 Feulgenstained biopsy preparations (4 μm) of gliomas (glioblastomas; fibrillar, protoplasmic and gemistocytic astrocytomas; pilocytic astrocytomas; oligodendrogliomas) using the automated microscope picture analysis (AMPA) was carried out in continuation of a previous paper (Martin and Voss 1982). Fifteen morphometrical, densitometrical and mitotic preparation features were evaluated: Parameters of the spatial density of nuclei — KRNZ, AREA; Parameters of nuclear size — KOFL, KFRL, P 250; Parameters of nuclear shape — FOFK, FOFR, P 150; Parameters of chromatin density — EXTU, EXTS, EXSR, EXTM, EXMR; Mitotic parameters — MITZ, VHMK. On the basis of these and some additional data (TIM 1, AGE, SEX, LOC) an automatic classifier has been elaborated which differentiates in an optimum manner the four tumour classes under study from one another. This classifier was elaborated on 172 slide preparations that had, on four occasions, been consistently classified and graded by three pathologists (“classified” sample). Subsequently, the classifier was used for the automatic classification of the whole material (346 slide preparations). From among the classified sample (n=172) the computer classified 159 tumours (92.4%) correctly and rejected 13 (7.6%); no tumour was classified wrongly. From among the whole material 295 tumours (85.3%) were classified correctly, 26 (7.5%) were rejected and 25 (7.2%) were classified wrongly. The following were the most important parameters for the discrimination and hence the automatic classification of the tumour classes: FOFK (form factor), FOFR (relative variation of form factors), KRNZ (number of nuclei), KFRL (relative variation of nuclear areas) and EXTS (mean extinction sum of tumour cell nuclei). Consequently, karyometrical data permit a reliable classification of glioblastomas and other gliomas. With the help of AMPA the necessary karyometrical data can be obtained in an easily objectifyable and reproducible manner requiring just about 10 min for each slide preparation.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00688607

    Articles: DFG German National Licenses
  19. 19
    Martin, H. ; Voss, K.
    Springer
    Published 1982
    Staff View
    ISSN:
    1432-0533
    Keywords:
    Brain tumour ; Nuclear morphometry ; Nuclear densitometry ; Automated image analysis ; Grading
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary Tumours of the neuroglia, 172 in all (50 glioblastomas, 65 fibrillar and gemistocytic astrocytomas, 26 pilocytic astrocytomas and 31 oligodendrogliomas), were studied by automated microscopic picture analysis. Thirteen morphometric and densitometric parameters of the tumour cell nuclei as well as two mitotic parameters were determined on 4 μm thick Feulgen slide preparations. The correlation of the results with subjectively established grade of malignancy was examined. A close correlation was found between almost all morphometric-densitometric nuclear parameters and the morphologically established behaviour of the tumours under study. Based on these results both the method of automated microscopic picture analysis and the selected parameters have been assessed as efficient for the evaluation of the behaviour of glial tumours. The results are readily reproducible and can be obtained without requiring much time. An other advantage of this method is the use of histological preparations, which allows a comparison of the overall structure of the tumour as well as a pinpointed examination of those regions that are representative of the tumour. Subjective grading of glial tumours has been greatly objective by automation.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00692692

    Articles: DFG German National Licenses
  20. 20
    Martin, H. ; Voss, K. ; Hufnagl, P. ; Frölich, K.
    Springer
    Published 1984
    Staff View
    ISSN:
    1432-0533
    Keywords:
    Glioma ; Nuclear morphometry ; Nuclear densitometry ; Automated image analysis ; Automated grading
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary A system of automated microscopic picture analysis was used in an examination of 272 gliomas (70 glioblastomas, 91 astrocytomas, 56 pilocytic astrocytomas or spongioblastomas, and 55 oligodendrogliomas). The specimens were prepared as Feulgen sections, 4μm in thickness. Thirteen morphometricdensitometric parameters of tumor cell nuclei were tested together with two mitotic parameters. Objective and reproducible data on numerical nuclear density (KRNZ, AREA), nuclear size (KOFL, KFRL, P250), nuclear shape (FOFK, FOFR, P150), optical density (EXTU, EXTS, EXSR, EXTM, EXMR), and mitotic activity (MITZ, VHMK) of the gliomas were obtained from the morphometric-densitometric parameters. All gliomas but glioblastomas were subdivided by four tumor grades. The morphometric-densitometric and mitotic data recorded were statistically checked, depending on tumor grade (Student'st-test, Wilcoxon's test, α=0.05). Numerical nuclear density, deformation of nuclei, and mitotic activity were found to grow with significance along with increasing tumor grade up to glioblastoma. The relative standard deviation (SD) of nuclear size (KFRL), relative SD of shape factors (FOFR), and relative SD of extinction sums (EXSR) are high-accuracy parameters for the pathologist to describe variability of sizes, polymorphism, and polychromasia of nuclei. These parameters show a significant increase of values in parallel with rising tumor grades, with maximum values being recordable from cases of glioblastomas. In cases of astrocytomas, optical values of nuclei decrease along with rising tumor grade. The data thus obtained were used as reference values for objective, reproducibel automatic glioma grading. The classifier method, described in an earlier publication, proved to be more effective than the regression method.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00697198

    Articles: DFG German National Licenses