Search Results - (Author, Cooperation:K. Takada)

2018-01-09

The Company of Biologists

0950-1991

1477-9129

Biology

Chromatin & epigenetics, Musculoskeletal system

2013-03-30

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Absorption ; Alkynes/chemistry ; Analytic Sample Preparation Methods/*methods ; Animals ; Biological Products/chemistry ; Crystallization/*methods ; Crystallography, X-Ray/*methods ; Fatty Alcohols/chemistry ; Microchemistry/*methods ; Nanotechnology/*methods ; Porifera/chemistry ; Porosity

2014-01-31

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Animals ; Biosynthetic Pathways/genetics ; Deltaproteobacteria/*classification/genetics/*metabolism/physiology ; *Drug Discovery ; Environmental Microbiology ; Genes, Bacterial/genetics ; Genome, Bacterial/genetics ; Metagenomics ; Molecular Sequence Data ; Multigene Family/genetics ; Peptides/metabolism ; Polyketides/metabolism ; Porifera/metabolism/microbiology ; Single-Cell Analysis ; Symbiosis

2018-03-28

American Physical Society (APS)

0556-2813

1089-490X

Physics

Nuclear Reactions

1089-7550

AIP Digital Archive

Physics

UV light irradiation effects on prebaking and silicon epitaxial growth is studied. An ArF excimer laser, a KrF excimer laser, and a Hg-Xe lamp are used as light sources. The epitaxial growth is carried out using a SiH2Cl2/H2 system under reduced pressure. ArF radiation and Hg-Xe radiation are found to be effective for volatilizing native SiO2 on silicon-substrate surfaces even at low temperatures. When a substrate surface is irradiated with these UV radiations during prebaking and epitaxial growth, epilayer surface morphology and crystalline quality are much improved. Furthermore, the epitaxial growth rate seems to be enhanced photothermally by excimer laser radiations, and photochemically by Hg-Xe radiation.

Electronic Resource

1468-2494

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

We have confirmed that more female subjects than male subjects evaluate male body odor as significantly unpleasant. Through an investigation on sexual differentiation in sensitivity to male body odor, we concluded that one of the volatile steroids, androstenone, had two effects on female olfactory sense. First, female subjects perceived androstenone itself to be more unpleasant than male subjects. Second, for only female subjects, androstenone, at a concentration of one-tenth of detection threshold, enhanced the intensity and unpleasantness of body-odor constituents such as short-chain fatty acids.

Electronic Resource

1077-3118

AIP Digital Archive

Physics

This letter shows theoretically and experimentally that Fresnel end reflection of the waveguide under test degrades the sensitivity of low coherence optical time domain reflectometry (OTDR). Optical mixing of end reflection and reference light in the OTDR produces the phase noise in proportion to end reflectivity. With the balanced detection technique, the excess photon noise is subdued and the phase noise becomes the dominant source of sensitivity degradation. At 3.2% end reflection and 300 μA mean photocurrent, the noise floor due to the phase noise is −138 dB/Hz. By reducing the fiber end reflection with matching oil, a shot-noise limited sensitivity of −140 dB at a 3 Hz bandwidth has been demonstrated at submillimeter resolution.

Electronic Resource

1365-2044

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

In this study, we examined the usefulness of the earlobe crease sign as a marker of coronary artery disease in the pre-operative assessment of patients. We were interested in evaluating this sign for use in emergency patients. We investigated 530 patients, aged 〉 40 years, undergoing elective surgery. If the electrocardiogram was abnormal or the patient reported symptoms suggesting coronary artery disease, further cardiac examinations were performed. Patients who demonstrated evidence of coronary artery disease in the additional investigations or had a clear history of coronary artery disease were classified as the abnormal coronary group. Other patients with no history and/or normal investigations were classified as the normal coronary group. The assessment of earlobe crease sign was performed prior to anaesthesia, and the sensitivity, specificity and positive predictive value of this sign were calculated. We found that the sensitivity and specificity was high regardless of age, except for specificity in patients 〉 70 years old. The data suggest that the earlobe crease sign may be a useful marker for the presence of coronary artery disease in patients undergoing emergency operations in which little or no history and investigations are available. However, more work is required to assess the use of this sign in other ethnic groups.

Electronic Resource

1600-0714

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Fibroblast growth factor-1 (FGF-1) and FGF-2 are mitogenic polypeptides that may contribute to neoplastic cell proliferation. In the present study, we established a serum-free culture system for ameloblastoma cells and demonstrated that the addition of FGF-1 and FGF-2 enhanced cell growth in a dose-dependent manner. Immunoperoxidase staining of cultured cells demonstrated strong expression of FGF-1 and FGF-2. In tissue specimens, FGF-1 was localized in epithelial cell components of ameloblastomas, whereas FGF-2 was mainly found in the basement membranes with only moderate staining in epithelium. These data suggest that both FGF-1 and FGF-2 may contribute to the growth and development of ameloblastomas.

Electronic Resource

1365-2842

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Cross-sectional data were obtained from 1182 Japanese high school girls of 12 and 15 years old. The data were analysed for the prevalence of specific occlusal features and the prevalence of cardinal Temporomandibular Joint Dysfunction (TMJD) symptoms in different occlusion groups. The associations between occlusal features and TMJD symptoms were analysed by the Z-analysis. The results were as follows: the prevalence of TMJD symptoms (total) was about 23% in both age groups examined. Noise had the highest prevalence of the specific TMJD symptoms in both age groups (16% and 11%). With age and for different occlusion groups, there was a significant increase in deviation on opening (P 〈 0.001) and a decrease in pain and noise (P 〈 0.05). No significant associations were found between the occurrence of TMJD symptoms (total) and occlusal features in all the examined occlusion groups. With respect to specific TMJD symptoms, however, the investigation of the different groups revealed a significant association (P 〈 0.05) of intra-arch occlusal (crowding) features with the occurrence of deviation on opening and with the occurrence of the combined TMJD symptoms which include deviation on opening. This indicates that crowding may be an important sign for predisposing TMJD. For the other single disorder symptoms (except pain), we did not find a significant relationship (P 〈 0.05) with aspects of occlusion, which may confirm a multifactorial TMJD problem wherein occlusal features can have a contribution to TMJD.

Electronic Resource

1365-2842

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

summary  Humans with normal occlusion usually perform gum-chewing movements in a characteristic manner. The purpose of present study was to examine whether the variability of masticatory jaw movement in children with incisor crossbite is greater than that in children with normal occlusions, and if so, to examine whether correction of the crossbite results in a significant reduction in the variability. The variance in masticatory jaw movement trajectory was investigated in 10 children with acceptable occlusion and 11 children with crossbite of one or two incisors. The lower incisor-point movements during chewing of standardized gum were monitored using a 3D tracking device. The deviation of the jaw-closing trajectory from a best-fit plane was then evaluated for each chewing cycle. Subsequently, variance in angles of the best-fit planes and variance in the instantaneous curvature of the jaw-closing trajectories were evaluated. Pitch angles of the best-fit planes and curvature of the trajectories during closing in patients were more variable than those in control subjects (P 〈 0·05). After treatment, the variances decreased significantly (P 〈 0·05). These findings suggest that the achievement of good occlusion is associated with a reduction of variability of jaw movements in a gum-chewing task.

Electronic Resource

1365-2842

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

summary Longitudinal data were obtained for 4 years from 361 Japanese high school girls between the ages of 12 and 16. The data were analysed for the occurrence of pain and its associations with the occurrence of other cardinal TMJ dysfunction symptoms and occlusal states. It was determined that even if pain or noise or jaw-deviation symptoms appeared, those symptoms did not necessarily last thereafter. The symptoms were not persistent but rather appeared and disappeared repetitively. Those who exhibited noise during at least one of the surveys of the 4-year survey period showed a significantly higher prevalence of pain than those who did not exhibit noise at all (P 〈 0.05). Those who exhibited noise by the age of 13 showed a significantly higher prevalence of pain than those who exhibited noise after age 14 (P 〈 0.1). The temporal occurrence of pain depended upon the appearance of noise and the age at which noise first appeared. On the other hand, the occurrence of pain symptoms was not necessarily related to specific types of malocclusions, which suggests the significance of multifactorial contributions in understanding the aetiology of pain rather than the occlusal factor.

Electronic Resource

1546-1718

Nature Archives 1869 - 2009

Biology

Medicine

[Auszug] Fukuyama type congenital muscular dystrophy (FCMD) is an autosomal recessive severe muscular dystrophy associated with an anomaly of the brain. Twenty–one FCMD families, 13 of them with consanguineous marriages, were analysed by genetic linkage analyses with polymorphic microsatellite markers ...

Electronic Resource

1365-2133

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Background  Chronic ultraviolet (UV) radiation from sunlight induces wrinkle formation. Retinoic acid (RA) can markedly improve wrinkles, although RA does have some side-effects, such as skin irritation. As the efficacy and cytotoxicity of RA has been traced to its free carboxylic acid, we synthesized a new molecule, N-retinoyl-D-glucosamine (GRA), in which a glucosamine has been attached to the polar end group of all-trans retinoic acid.Objectives  To analyse the effect of topical GRA in wrinkle repair and anti-irritation in photoaged mice compared with topical RA, as well as to determine retinoic acid receptor (RAR) and retinoid X receptor (RXR) transactivation activity in vitro.Methods  Hairless mice were irradiated with 60 mJ cm−2 of UVB for 10 weeks, and then topically treated with 0·05% GRA or 0·05% RA for 8 weeks. An in vitro transcriptional assay was performed and the activity of GRA in 293 cells transfected with RAR-α or RXR-α expression plasmid and luciferase reporter plasmid then determined.Results  Topical GRA and RA brought about almost complete disappearance of the wrinkles caused by UVB irradiation. The two ligands promoted both a wide repair zone histologically, and the expression of type 1 collagen in the skin. In contrast, topical GRA treatment did not produce irritation such as erythema or roughness, or alteration of transepidermal water loss values, compared with RA. In the in vitro luciferase assay, GRA resulted in significant dose-dependent RAR transactivation activity in a 100 times higher concentration range than RA. GRA did not mediate RXR transactivation activity at all.Conclusions  Topical GRA appears to be able to repair photoaged skin damage without any of the irritation caused by topical RA, probably via RAR transactivation activity.

Electronic Resource

0005-2760

(Rat skin) ; 7-Dehydrocholesterol ; Fatty acid ester ; HPLC ; Ultraviolet irradiation ; Vitamin D"3

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Biology

Chemistry and Pharmacology

Medicine

Physics

Electronic Resource

0005-2760

(Rat skin) ; 7-Dehydrocholesterol ; Tachysterol"3 ; Ultraviolet radiation ; Vitamin D"3

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Biology

Chemistry and Pharmacology

Medicine

Physics

Electronic Resource

0005-2736

(Rat intestine) ; Carboxyfluorescein ; Intestinal absorption ; Membrane permeability ; N-Ethylmaleimide ; Sulfhydryl reagent ; Unsaturated fatty acid

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Biology

Chemistry and Pharmacology

Medicine

Physics

Electronic Resource

0006-291X

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Biology

Chemistry and Pharmacology

Physics

Electronic Resource

0006-291X

[abr] GM"1; Galβ1-〉 3GalNAcβ1-〉 4[NeuAcβ2 -〉3]Galβ1-〉 4Glcβ1 Cer ; [abr] GM"3; NeuAcβ2-〉 3Galβ1 -〉 4Glcβ1 -〉 Cer ; [abr] IBMX; 3-isobutyl-1-methylxanthine

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Biology

Chemistry and Pharmacology

Physics

Electronic Resource

0006-291X

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Biology

Chemistry and Pharmacology

Physics

Electronic Resource