Search Results - (Author, Cooperation:K. Svenson)

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  1. 1
    K. C. Lloyd ; T. Meehan ; A. Beaudet ; S. Murray ; K. Svenson ; C. McKerlie ; D. West ; I. Morse ; H. Parkinson ; S. Brown ; A. M. Mallon ; M. Moore
    American Association for the Advancement of Science (AAAS)
    Published 2015
    Staff View
    Publication Date:
    2015-07-25
    Publisher:
    American Association for the Advancement of Science (AAAS)
    Print ISSN:
    0036-8075
    Electronic ISSN:
    1095-9203
    Topics:
    Biology
    Chemistry and Pharmacology
    Computer Science
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animal Experimentation/*standards ; Animals ; Electronic Health Records ; Female ; Genomics ; Humans ; Male ; Metabolomics ; Mice ; Mice, Knockout ; National Institutes of Health (U.S.) ; Precision Medicine/*economics/*trends ; United States
    Published by:
    http://www.aaas.org/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Staff View
    ISSN:
    1432-1440
    Keywords:
    Cyclosporin ; Nephropathy ; Side effects ; Autoimmune disease
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Medicine
    Notes:
    Summary Renal biopsy specimens were evaluated from patients with different autoimmune diseases treated with cyclosporin (CyA). Ten biopsies were done before CyA, 10 biopsies after low-dose (〈7.5 mg/kg/day, initial dose or mean daily dose within the first month, respectively), and 9 after high-dose (〉7.5 mg/kg/day) treatment. Definite chronic CyA nephrotoxicity (cyclosporin-associated arteriolopathy and/or interstitial fibrosis striped form with tubular atrophy) was only present in the initial high-dose group. In this group a significant serum creatinine increase was noted and 8 of the 9 patients were hypertensive. No significant correlation was found between the severity of morphologic lesions and the mean daily dose during total treatment, cumulative dose, and duration of therapy. The morphologic changes in the low-dose group did not differ from the control biopsy specimens before CyA treatment. Based on these results, it can be concluded that major nephrotoxicity can be avoided by initial low CyA doses.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF01713009

    Articles: DFG German National Licenses
  3. 3
    Staff View
    ISSN:
    1432-1777
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Medicine
    Notes:
    Abstract We typed 147 simple sequence length polymorphisms in the SWXJ recombinant inbred (RI) strain set spanning Chromosomes (Chrs) 1–6. The strain distribution pattern for these loci was combined with data from 18 previously typed loci for SWXJ, resulting in new chromosome maps for this RI set, with an average density of 3.5 cM between loci. This is the first systematic effort to develop a more highly resolved genetic map for the SWXJ RI set and thereby improves the usefulness of this genetic tool for mapping genes underlying both simple and complex genetic disorders.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00292437

    Articles: DFG German National Licenses