Search Results - (Author, Cooperation:K. Sakamoto)

2012-04-21

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

AMP-Activated Protein Kinases/genetics/*metabolism ; Amino Acid Substitution ; Animals ; Aspirin/pharmacology ; Binding Sites ; Carbohydrate Metabolism/drug effects ; Cell Line ; Enzyme Activation ; Enzyme Activators/pharmacology ; HEK293 Cells ; Humans ; Lipid Metabolism/drug effects ; Liver/drug effects/metabolism ; Mice ; Mice, Knockout ; Mutation ; Oxygen Consumption/drug effects ; Phosphorylation ; Pyrones/pharmacology ; Rats ; Salicylates/blood/*metabolism/*pharmacology ; Thiophenes/pharmacology

2018-07-31

Institute of Physics (IOP)

1755-1307

1755-1315

Geography

Geosciences

Physics

2016-02-24

Nature Publishing Group (NPG)

0028-0836

1476-4687

Biology

Chemistry and Pharmacology

Medicine

Natural Sciences in General

Physics

Amino Acid Motifs ; Binding Sites ; Biocatalysis ; Cross-Linking Reagents/chemistry ; Crystallography, X-Ray ; Eukaryotic Initiation Factor-2B/*chemistry/metabolism ; Guanosine Diphosphate/metabolism ; Guanosine Triphosphate/metabolism ; Models, Molecular ; Phosphorylation ; Protein Binding ; Protein Biosynthesis ; Protein Structure, Quaternary ; Protein Subunits/chemistry/metabolism ; Schizosaccharomyces/*chemistry

2018-09-15

The American Association for Cancer Research (AACR)

1078-0432

1557-3265

Medicine

2018-07-19

The American Society for Pharmacology and Experimental Therapeutics

0022-3565

1521-0103

Medicine

2018-06-22

American Physical Society (APS)

0031-9007

1079-7114

Physics

Condensed Matter: Electronic Properties, etc.

2018-06-19

The American Association of Immunologists (AAI)

0022-1767

1550-6606

Medicine

1089-7674

AIP Digital Archive

Physics

In a free-electron laser (FEL) with a long wiggler, an additional focusing field is required to keep beam particles from diverging. An additional long scale transverse motion induced by the focusing field modulates the longitudinal motion and sometimes destroys the axial phase relation between the beam particles and radiation field, even if the beam is successfully transmitted. In order to investigate such a delicate phase relation under a complex wiggler configuration, a systematic perturbation method that employs noncanonical variables and a Lie transformation developed by Cary and Littlejohn [Ann. Phys. 151, 1 (1983)] is presented. The method is applied to a focusing wiggler, which has a parabolically curved pole face. Radial space charge force is taken into account in the analysis and the maximum current that can propagate the wiggler is estimated for an electron beam whose energy is around 1 MeV. The effect of the beam current on the axial phase relation is also investigated and found to be small. The present noncanonical approach is found to be transparent and comprehensive for this kind of problem, compared with the standard canonical perturbation method and applicable to arbitrarily complex wigglers. © 1995 American Institute of Physics.

Electronic Resource

1089-7623

AIP Digital Archive

Physics

Electrical Engineering, Measurement and Control Technology

To satisfy the electrical and thermomechanical requirements for a continuous wave millimeter wave beam transmission, a window assembly using a large size synthesized diamond disk has been developed. Such window systems are needed as a vacuum barrier and tritium shielding in future electron cyclotron heating systems for fusion plasma heating and noninductive electron cyclotron current drive. The diamond used in this study was manufactured by chemical vapor deposition (CVD) and consists of a polycrystalline diamond disk 96 mm in diameter and 2.23 mm thick. The disk was built into an assembly in which two Inconel tubes were bonded on both sides of the plate to provide vacuum shielding and water cooling to the edge of the disk, leaving an effective window aperture of 83 mm. It will be shown that, as a result of the high thermal conductivity and low dielectric loss exhibited by this grade of CVD diamond, the temperature increase of the window due to the absorption of high-power millimeter wave radiation could be minimized by simple water edge cooling at room temperature. During transmission of a focused Gaussian beam of 170 GHz, 110 kW, 10 s, the temperature increase at the center of the window reached a steady state condition at a value of approximately 40 K, in good agreement with calculated values. Water-edge-cooled CVD diamond windows promise to provide a practical technical solution for the transmission of continuous millimeter wave transmission in excess of 1 MW. © 1998 American Institute of Physics.

Electronic Resource

1089-7550

AIP Digital Archive

Physics

To determine the molecular orientation of rubbed and unrubbed poly[4,4′-oxydiphenylene- pyromellitimide] (PMDA-ODA) films, we have measured the infrared (IR) absorption spectra of PMDA-ODA films on Si substrates as a function of the incident angle. The molecular orientation was determined by fitting the incident angle dependence and the IR dichroic ratio with the theoretical curves. The IR absorption was calculated by a transfer matrix method to take account of the multiple reflection and refraction at the interfaces. The vibrational response of the polyimide film in the IR region was represented by a Lorentz oscillator model. We found that the molecules in a spin-coated polyimide film are oriented parallel to the substrate surface with a standard deviation of 6.5°. For a rubbed film, the polymer chains are oriented along the rubbing direction and are tilted up on average by 8.5° from the surface plane. We observed a blueshift of the C=O asymmetric stretching band at oblique incidence. The blueshift is explained by anomalous dispersion of the dielectric constant of the polyimide film, and is reproduced by our calculation. © 1996 American Institute of Physics.

Electronic Resource

1077-3118

AIP Digital Archive

Physics

We have determined the inclination angle of the backbone structure of polyimide with alkyl side-chains in rubbed films. Four different polyimides with the same backbone structure but different lengths of alkyl side-chains were used in this study. The inclination angle of the backbone structure increases with the number of carbon atoms in the alkyl side-chains. We found a linear relation between the inclination angle of the backbone structure and the pretilt angle of liquid crystal (LC) that is in contact with the polyimide films. We conclude that the inclination of the polyimide backbone structure determines the pretilt angle of LC. © 1997 American Institute of Physics.

Electronic Resource

1089-7550

AIP Digital Archive

Physics

Segregation and transport coefficients of impurities at the Si/SiO2 interface have been studied. A brief model has been proposed which relates the two coefficients to the oxidation rate and the impurity concentrations at both sides of a Si/SiO2 interface. The model enables us to obtain the transport coefficients from the measured impurity profiles for the first time. The transport coefficients of arsenic and phosphorus are, for example, 0.12 and 5.0 μm/min at 1100 °C, respectively. The segregation coefficients can be also calculated from this model. They are more than 1000 for arsenic and phosphorus, and less than 1 for boron at 1000–1100 °C.

Electronic Resource

1089-7623

AIP Digital Archive

Physics

Electrical Engineering, Measurement and Control Technology

A pressure resistant polycrystalline chemical vapor deposition (CVD) diamond disk for a microwave window is used for a vacuum and a tritium confinement boundary in fusion applications. A pressure test of a CVD diamond window disk (2.25 mm in thickness and 100 mm in diameter) was carried out. It was demonstrated that the diamond window tolerated 1.0 MPa (10 atm) in the plenum. The displacement of the window center for both the growth and the nucleation side on the unpressurized side is 40±1 and 41±1 μm, respectively, at the pressure of 1.0 MPa, and these values agree well with those calculated. No damage in the disk and the braze, and no vacuum leakage in the assembly was observed. This result demonstrates that the diamond window assembly could tolerate up to 1.45 MPa. It was experimentally proved that the diamond window satisfied the safety requirement of 0.5 MPa resistance for the vacuum and the tritium confinement boundary of an International Thermonuclear Experimental Reactor. The design prospect for the diamond window of the electron cyclotron heating and current drive system is also discussed, based on the stress analysis using the ABAQUS code. © 2000 American Institute of Physics.

Electronic Resource

1077-3118

AIP Digital Archive

Physics

Using polarized infrared (IR) absorption, we have investigated the surface anisotropy of a poly [4, 4′-oxydiphenylene-pyromellitimide] (PMDA-ODA) film that arises from anisotropic decomposition of the polyimide chain during irradiation with linearly polarized ultraviolet (LPUV) light. To monitor the surface anisotropy, we designed the sample structure so that the polyimide films decomposed uniformly over the entire film thickness. The surface anisotropy has a maximum at an irradiation energy of 105 J/cm2. For PMDA-ODA, the maximum surface anisotropy is significantly smaller than the surface anisotropy generated by rubbing. By analyzing the irradiation energy dependence of an IR absorption band, we found that the decomposition rate of the polyimide chain oriented parallel to the polarization direction of the LPUV light is greater only by ∼23% than that oriented perpendicular to it. This is the reason for the small surface anisotropy induced by the LPUV light irradiation. © 1998 American Institute of Physics.

Electronic Resource

1439-0523

Blackwell Publishing Journal Backfiles 1879-2005

Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition

Self-incompatibility in Brassicaceae plants is sporophytically controlled by a single multi-allelic locus (S locus), which contains at least three highly polymorphic genes expressed in the stigma (SLG and SRK) and in the pollen (SCR/SP11). Using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis with SXG-specific primer pairs, the S haplotypes of F1 hybrid and open-pollinated commercial cultivars of Brassica rapa were identified. The number of S haplotypes detected in the F1 hybrid cultivars of Chinese cabbage, komatsuna, pak-choi, turnip, open-pollinated cultivars of Chinese cabbage and turnip were 9, 9, 4, 11, 13 and 12, respectively. Nine of them had different PCR-RFLP profiles from those of the S-tester lines that determined the SLG sequences. Four SLG sequences in the F1 hybrid cultivars were determined and named S53, S54, S55 and S56, respectively. It is demonstrated that the PCR-RFLP analysis using specific primer pairs of SLG and SRK is useful for identification of the S haplotypes, in both, S homozygous and S heterozygous plants of B. rapa. The possibility of using this method routinely in breeding programmes, and in the evaluation of F1 hybrid seed purity, is discussed.

Electronic Resource

1089-7550

AIP Digital Archive

Physics

A mm wave amplifier experiment on a free electron laser was performed using an intense, mildly relativistic electron beam (0.7–0.9 MeV) with a combination of a focusing planar wiggler and a weak additional axial magnetic field in the so-called "group 1'' region. A beam transport ratio of over 80%, through the whole wiggler length, was realized. In an amplification experiment, a spatial growth rate of 56 dB/m was obtained at a frequency of 45 GHz, and a power saturation was observed at a level of 6 MW, where the total gain was estimated to be 52 dB. It was shown that the off-axis component of the beam contributes considerably to the rf amplification in the focusing wiggler.

Electronic Resource

1365-2559

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Aims:  Invasive micropapillary carcinoma (IMPC) is associated with frequent lymph node metastasis and adverse clinical outcome. IMPC has been reported in breast, urinary bladder, ureter, lung and parotid gland but not in colon. We present the clinicopathological features of three cases of primary IMPC of the colon with a review of the literature.Methods and results:  The patients (one man and two women) were 53, 67 and 68 years old, respectively. The size of the tumour ranged from 20 to 100 mm in diameter. Histologically, all cases were composed predominantly of papillary tumour cell clusters with spaces in a background of fine fibrocollagenous stroma. One of the tumours (case 1) was nearly completely composed of IMPC, but the other two were associated with foci of adenocarcinoma and concurrent mucinous carcinoma, respectively. MUC1 was positive in all cases, suggestive of reverse cell orientation which is responsible for its unique histological features.Conclusions:  We report three cases of primary IMPC of the colon. Its clinical significance remains undetermined but the presence of this component may represent a poor prognostic factor.

Electronic Resource

1365-2559

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Electronic Resource

0167-4781

(Bacteriophage) ; CD spectrum ; Hairpin structure ; Synthetic oligoribonucleotide ; T"m value ; catalytic RNA ; mutant RNA

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Biology

Chemistry and Pharmacology

Medicine

Physics

Electronic Resource

1365-2133

Blackwell Publishing Journal Backfiles 1879-2005

Medicine

Rifampicin therapy caused exacerbation of skin lesions, rising serum pemphigus antibody titres, and decreased serum betamethasone levels in a 59-year-old man with pemphigus vulgaris. Exacerbation of pemphigus was confined to the period of rifampicin therapy and seems to be best explained by the effect of rifampicin on the metabolism of betamethasone. Physicians prescribing rifampicin for the treatment of tuberculosis should be aware of its potential to produce such an important adverse reaction.

Electronic Resource