Search Results - (Author, Cooperation:K. S. Mohammad)
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1J. Hoggatt ; K. S. Mohammad ; P. Singh ; A. F. Hoggatt ; B. R. Chitteti ; J. M. Speth ; P. Hu ; B. A. Poteat ; K. N. Stilger ; F. Ferraro ; L. Silberstein ; F. K. Wong ; S. S. Farag ; M. Czader ; G. L. Milne ; R. M. Breyer ; C. H. Serezani ; D. T. Scadden ; T. A. Guise ; E. F. Srour ; L. M. Pelus
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-03-15Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Cell Count ; Cell Movement/physiology ; Cells, Cultured ; Dinoprostone/*metabolism ; Hematopoietic Stem Cell Mobilization ; Hematopoietic Stem Cells/*cytology/drug effects ; Heterocyclic Compounds/pharmacology ; Humans ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Osteopontin/genetics ; Papio ; Receptors, Prostaglandin E, EP4 Subtype/genetics/metabolism ; Stem Cells/*cytology/drug effects ; Thiazines/pharmacology ; Thiazoles/pharmacologyPublished by: -
2Staff View
ISSN: 1432-0827Keywords: Key Words: Osteogenesis - amputation - regenerationSource: Springer Online Journal Archives 1860-2000Topics: BiologyMedicinePhysicsNotes: Abstract. Mammals are able to regrow the tips of amputated fingers and toes. However, regrowth is limited to regions covered by, and is dependent upon, the presence of the nail organ. If the nail organ is responsible for bone growth in digit-tips, we reasoned that transplanted nail organ might also be able to induce outgrowth from other levels of the digit. Partial nail organ has been transplanted to amputated proximal phalanges of young rats. To date, six transplants have successfully produced outgrowth of nail. New bone growth, not seen in control amputated digits, was documented by x-ray and by alizarin red and calcein injections to be directed toward implanted nail organ. These results support an inductive role for nail organ epithelium in bone growth after amputation and provide encouragement for attempts to enhance a positive outcome after appendage amputation.Type of Medium: Electronic ResourceURL: