Search Results - (Author, Cooperation:K. Rajewsky)
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1Latest Papers from Table of Contents or Articles in PressK. Wilhelm ; K. Happel ; G. Eelen ; S. Schoors ; M. F. Oellerich ; R. Lim ; B. Zimmermann ; I. M. Aspalter ; C. A. Franco ; T. Boettger ; T. Braun ; M. Fruttiger ; K. Rajewsky ; C. Keller ; J. C. Bruning ; H. Gerhardt ; P. Carmeliet ; M. Potente
Nature Publishing Group (NPG)
Published 2016Staff ViewPublication Date: 2016-01-07Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Cell Proliferation ; Cell Respiration ; Endothelium, Vascular/cytology/*growth & development/*metabolism ; Female ; Forkhead Transcription Factors/deficiency/genetics/*metabolism ; Glycolysis ; Human Umbilical Vein Endothelial Cells/cytology/metabolism ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Proto-Oncogene Proteins c-myc/deficiency/genetics/metabolism ; Signal TransductionPublished by: -
2Latest Papers from Table of Contents or Articles in PressKabrani, E., Chu, V. T., Tasouri, E., Sommermann, T., Bassler, K., Ulas, T., Zenz, T., Bullinger, L., Schultze, J. L., Rajewsky, K., Sander, S.
American Society of Hematology (ASH)
Published 2018Staff ViewPublication Date: 2018-12-21Publisher: American Society of Hematology (ASH)Print ISSN: 0006-4971Electronic ISSN: 1528-0020Topics: BiologyMedicineKeywords: Lymphoid NeoplasiaPublished by: -
3Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Colony bred NMRI mice and random bred rabbits were used. Mice were injected intravenously with 108 SRC and subsequently twice weekly with 107 SRC. Antiserum was obtained 7 days after the fifth SRC injection and found by sucrose gradient analysis to contain 7$ antibody only. The serum pool ...Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 0926-6569Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 0014-4827Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesFormation of cross-reacting antigenic determinants on lactate dehydrogenases I and IV by acetylationStaff View
ISSN: 0304-4165Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyMedicinePhysicsType of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesBEYREUTHER, K. ; BOVENS, J. ; BRÜGGEMANN, M. ; DILDROP, R. ; KELSOE, G. ; KRAWINKEL, U. ; MÜLLER, C. ; NISHIKAWA, S. ; RADBRUCH, A. ; RETH, M. ; SIEKEVITZ, M. ; TAKEMORI, T. ; TESCH, H. ; WILDNER, G. ; ZAISS, S. ; RAJEWSKY, K.
Oxford, UK : Blackwell Publishing Ltd
Published 1983Staff ViewISSN: 1749-6632Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Natural Sciences in GeneralType of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 1569-8041Keywords: germinal center ; Hodgkin's disease ; Ig gene rearrangement ; micromanipulation ; Reed–Sternberg cell ; single-cell PCRSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract During their development, B lymphocytes are repeatedly selected for the expression of an appropriate surface receptor: the pre-B-cell receptor at the pre-B-cell stage and surface immunoglobulin (Ig) at the transition from a pre-B cell to a mature B cell. Furthermore, stringent selection for B cells expressing high affinity antibodies operates when antigen-activated B cells proliferate within germinal centers (GC). Here, somatic point mutations are introduced into rearranged V region genes at a high rate, and B cells acquiring favorable mutations are selected to differentiate into memory B cells or plasma cells. In the frame of this developmental scheme, extending a recent analysis, we investigated 10 primary cases of Hodgkin's disease (HD) for B-lineage origin and clonality [1]. Single Hodgkin and Reed–Sternberg (H-RS) cells were micro manipulated from frozen tissue sections and analyzed by PCR for rearranged V genes. Clonal VH and/orV_κ/V_λ gene rearrangements were obtained from 9 of the cases. This shows that H-RS cells represent a clonal, B-lineage-derived population of tumor cells. Somatic mutations were found in all clonal VH gene rearrangements. Interestingly, mutations leading to stop codons in in-frame V gene rearrangements were detected in four cases. Since GC B cells acquiring such crippling mutations are usually efficiently eliminated within the GC, the finding of those mutations indicates that H-RS cells are derived from precursors within the GC that escaped apoptosis by a transforming event.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1569-8041Keywords: germinal center ; Hodgkin's disease ; Ig gene rearrangement ; micromanipulation ; Reed–Sternberg cell ; single-cell PCRSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract During their development, B lymphocytes are repeatedly selected for theexpression of an appropriate surface receptor: the pre-B-cell receptor atthe pre-B-cell stage and surface immunoglobulin (Ig) at the transition froma pre-B cell to a mature B cell. Furthermore, stringent selection for Bcells expressing high affinity antibodies operates when antigen-activated Bcells proliferate within germinal centers (GC). Here, somatic pointmutations are introduced into rearranged V region genes at a high rate, andB cells acquiring favorable mutations are selected to differentiate intomemory B cells or plasma cells. In the frame of this developmental scheme, extending a recent analysis, weinvestigated 10 primary cases of Hodgkin's disease (HD) for B-lineage originand clonality [1]. Single Hodgkin and Reed–Sternberg (H-RS) cells weremicromanipulated from frozen tissue sections and analyzed by PCR forrearranged V genes. Clonal VH and/orV_κ/V_λ gene rearrangements wereobtained from 9 of the cases. This shows that H-RS cells represent a clonal,B-lineage-derived population of tumor cells. Somatic mutations were found inall clonal VH gene rearrangements. Interestingly, mutationsleading to stop codons in in-frame V gene rearrangements were detected in fourcases. Since GC B cells acquiring such crippling mutations are usuallyefficiently eliminated within the GC, the finding of those mutations indicatesthat H-RS cells are derived from precursors within the GC that escapedapoptosis by a transforming event.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesRajewsky, K. ; Ehlich, A. ; Müller, W. ; Taki, S. ; Kitamura, D.
[s.l.] : Nature Publishing Group
Published 1992Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] RAJEWSKY ET AL. REPLY - We1 did not mean to show "another case of allelic inclusion", as Wabl and Steinberg put it, but to test whether expression of the membrane-bound antibody heavy (H) chain of class \n inhibits further H-chain V-region (Vn) gene rearrangement dur-ing B-cell development - a ...Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] We developed previously, by the Kohler-Milstein cell hybridization technique7, a series of monoclonal antibodies of mouse origin each of which recognizes a particular idiotope characteristic for a subset of anti-NP (NP = 4-hydroxy-3-nitrophenyl-acetyl) antibodies of C57BL/6 mice8. When IgG1 ...Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesHoltkamp, B. ; Cramer, M. ; Lemke, H. ; Rajewsky, K.
[s.l.] : Nature Publishing Group
Published 1981Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] Our method for the isolation of structural H-2Kk variants requires a set of monoclonal antibodies, each of which reacts with a single antigenic determinant on the H-2Kk molecule1. The antigenic determinants recognized by these antibodies can be distinguished from each other by genetic analysis in ...Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesClonality and germinal centre B-cell derivation of Hodgkin/Reed-Sternberg cells in Hodgkin's diseaseStaff View
ISSN: 1569-8041Keywords: Hodgkin's disease ; Ig gene rearrangements ; micromanipulation ; Reed-Sternberg cell ; single-cell PCRSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Molecular single-cell studies of Hodgkin and Reed-Sternberg (HRS) cells in Hodgkin's disease (HD) have revealed the clonal nature of these peculiar tumour cells. HRS cells in classical HD as well as lymphocyte predominant (LP) HD originate from germinal center (GC) B cells in most cases, if not all. Whereas HRS cells in LP HD represent transformed antigen-selected GC B cells with evidence of ongoing immunoglobulin (Ig) V gene mutation, HRS cells in classical HD appear to often or always derive from GC B cells that have lost the capacity to express a functional antigen receptor. Using Ig gene rearrangements amplified from HRS cells as clonal markers for the tumour cells, it could be shown that the same HRS cell clone can disseminate in the patient and persist throughout the course of the disease. A common derivation of the tumour cells was recently demonstrated in two cases representing combinations of HD and non-Hodgkin's lymphoma. Finally, V-gene analysis showed that viable cells enriched by magnetic cell sorting from HD patients as HRS cells indeed represent the HRS-cell population of the patient.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesZahn, R. K. ; Rajewsky, K. ; Kiefer, R. ; Kiefer, G. G. ; Eitel, L. ; Zahn, G.
Springer
Published 1959Staff ViewISSN: 1432-1904Source: Springer Online Journal Archives 1860-2000Topics: BiologyChemistry and PharmacologyNatural Sciences in GeneralType of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 0044-8249Keywords: Chemistry ; General ChemistrySource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 0570-0833Keywords: Chemistry ; General ChemistrySource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: