Search Results - (Author, Cooperation:K. Quek)

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  1. 1
    A. M. Patch ; E. L. Christie ; D. Etemadmoghadam ; D. W. Garsed ; J. George ; S. Fereday ; K. Nones ; P. Cowin ; K. Alsop ; P. J. Bailey ; K. S. Kassahn ; F. Newell ; M. C. Quinn ; S. Kazakoff ; K. Quek ; C. Wilhelm-Benartzi ; E. Curry ; H. S. Leong ; A. Hamilton ; L. Mileshkin ; G. Au-Yeung ; C. Kennedy ; J. Hung ; Y. E. Chiew ; P. Harnett ; M. Friedlander ; M. Quinn ; J. Pyman ; S. Cordner ; P. O'Brien ; J. Leditschke ; G. Young ; K. Strachan ; P. Waring ; W. Azar ; C. Mitchell ; N. Traficante ; J. Hendley ; H. Thorne ; M. Shackleton ; D. K. Miller ; G. M. Arnau ; R. W. Tothill ; T. P. Holloway ; T. Semple ; I. Harliwong ; C. Nourse ; E. Nourbakhsh ; S. Manning ; S. Idrisoglu ; T. J. Bruxner ; A. N. Christ ; B. Poudel ; O. Holmes ; M. Anderson ; C. Leonard ; A. Lonie ; N. Hall ; S. Wood ; D. F. Taylor ; Q. Xu ; J. L. Fink ; N. Waddell ; R. Drapkin ; E. Stronach ; H. Gabra ; R. Brown ; A. Jewell ; S. H. Nagaraj ; E. Markham ; P. J. Wilson ; J. Ellul ; O. McNally ; M. A. Doyle ; R. Vedururu ; C. Stewart ; E. Lengyel ; J. V. Pearson ; A. deFazio ; S. M. Grimmond ; D. D. Bowtell
    Nature Publishing Group (NPG)
    Published 2015
    Staff View
    Publication Date:
    2015-10-28
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    N. Waddell ; M. Pajic ; A. M. Patch ; D. K. Chang ; K. S. Kassahn ; P. Bailey ; A. L. Johns ; D. Miller ; K. Nones ; K. Quek ; M. C. Quinn ; A. J. Robertson ; M. Z. Fadlullah ; T. J. Bruxner ; A. N. Christ ; I. Harliwong ; S. Idrisoglu ; S. Manning ; C. Nourse ; E. Nourbakhsh ; S. Wani ; P. J. Wilson ; E. Markham ; N. Cloonan ; M. J. Anderson ; J. L. Fink ; O. Holmes ; S. H. Kazakoff ; C. Leonard ; F. Newell ; B. Poudel ; S. Song ; D. Taylor ; S. Wood ; Q. Xu ; J. Wu ; M. Pinese ; M. J. Cowley ; H. C. Lee ; M. D. Jones ; A. M. Nagrial ; J. Humphris ; L. A. Chantrill ; V. Chin ; A. M. Steinmann ; A. Mawson ; E. S. Humphrey ; E. K. Colvin ; A. Chou ; C. J. Scarlett ; A. V. Pinho ; M. Giry-Laterriere ; I. Rooman ; J. S. Samra ; J. G. Kench ; J. A. Pettitt ; N. D. Merrett ; C. Toon ; K. Epari ; N. Q. Nguyen ; A. Barbour ; N. Zeps ; N. B. Jamieson ; J. S. Graham ; S. P. Niclou ; R. Bjerkvig ; R. Grutzmann ; D. Aust ; R. H. Hruban ; A. Maitra ; C. A. Iacobuzio-Donahue ; C. L. Wolfgang ; R. A. Morgan ; R. T. Lawlor ; V. Corbo ; C. Bassi ; M. Falconi ; G. Zamboni ; G. Tortora ; M. A. Tempero ; A. J. Gill ; J. R. Eshleman ; C. Pilarsky ; A. Scarpa ; E. A. Musgrove ; J. V. Pearson ; A. V. Biankin ; S. M. Grimmond
    Nature Publishing Group (NPG)
    Published 2015
    Staff View
    Publication Date:
    2015-02-27
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Adenocarcinoma/drug therapy/genetics ; Animals ; Carcinoma, Pancreatic Ductal/drug therapy/genetics ; *DNA Mutational Analysis ; DNA Repair/genetics ; Female ; Genes, BRCA1 ; Genes, BRCA2 ; Genetic Markers/genetics ; Genome, Human/*genetics ; Genomic Instability/genetics ; *Genomics ; Genotype ; Humans ; Mice ; Mutation/*genetics ; Pancreatic Neoplasms/classification/drug therapy/*genetics ; Platinum/pharmacology ; Point Mutation/genetics ; Poly(ADP-ribose) Polymerase Inhibitors ; Xenograft Model Antitumor Assays
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    P. Bailey ; D. K. Chang ; K. Nones ; A. L. Johns ; A. M. Patch ; M. C. Gingras ; D. K. Miller ; A. N. Christ ; T. J. Bruxner ; M. C. Quinn ; C. Nourse ; L. C. Murtaugh ; I. Harliwong ; S. Idrisoglu ; S. Manning ; E. Nourbakhsh ; S. Wani ; L. Fink ; O. Holmes ; V. Chin ; M. J. Anderson ; S. Kazakoff ; C. Leonard ; F. Newell ; N. Waddell ; S. Wood ; Q. Xu ; P. J. Wilson ; N. Cloonan ; K. S. Kassahn ; D. Taylor ; K. Quek ; A. Robertson ; L. Pantano ; L. Mincarelli ; L. N. Sanchez ; L. Evers ; J. Wu ; M. Pinese ; M. J. Cowley ; M. D. Jones ; E. K. Colvin ; A. M. Nagrial ; E. S. Humphrey ; L. A. Chantrill ; A. Mawson ; J. Humphris ; A. Chou ; M. Pajic ; C. J. Scarlett ; A. V. Pinho ; M. Giry-Laterriere ; I. Rooman ; J. S. Samra ; J. G. Kench ; J. A. Lovell ; N. D. Merrett ; C. W. Toon ; K. Epari ; N. Q. Nguyen ; A. Barbour ; N. Zeps ; K. Moran-Jones ; N. B. Jamieson ; J. S. Graham ; F. Duthie ; K. Oien ; J. Hair ; R. Grutzmann ; A. Maitra ; C. A. Iacobuzio-Donahue ; C. L. Wolfgang ; R. A. Morgan ; R. T. Lawlor ; V. Corbo ; C. Bassi ; B. Rusev ; P. Capelli ; R. Salvia ; G. Tortora ; D. Mukhopadhyay ; G. M. Petersen ; D. M. Munzy ; W. E. Fisher ; S. A. Karim ; J. R. Eshleman ; R. H. Hruban ; C. Pilarsky ; J. P. Morton ; O. J. Sansom ; A. Scarpa ; E. A. Musgrove ; U. M. Bailey ; O. Hofmann ; R. L. Sutherland ; D. A. Wheeler ; A. J. Gill ; R. A. Gibbs ; J. V. Pearson ; A. V. Biankin ; S. M. Grimmond
    Nature Publishing Group (NPG)
    Published 2016
    Staff View
    Publication Date:
    2016-02-26
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Animals ; Basic Helix-Loop-Helix Transcription Factors/genetics ; Carcinoma, Pancreatic ; Ductal/classification/genetics/immunology/metabolism/pathology ; Cell Line, Tumor ; DNA Methylation ; DNA-Binding Proteins/genetics ; Gene Expression Regulation, Neoplastic ; Gene Regulatory Networks ; Genes, Neoplasm/*genetics ; Genome, Human/*genetics ; *Genomics ; Hepatocyte Nuclear Factor 3-beta/genetics ; Hepatocyte Nuclear Factor 3-gamma/genetics ; Histone Demethylases/genetics ; Homeodomain Proteins/genetics ; Humans ; Mice ; Mutation/*genetics ; Nuclear Proteins/genetics ; Pancreatic Neoplasms/*classification/*genetics/immunology/metabolism/pathology ; Prognosis ; Receptors, Cytoplasmic and Nuclear/genetics ; Survival Analysis ; Trans-Activators/genetics ; Transcription Factors/genetics ; Transcription, Genetic ; Transcriptome ; Tumor Suppressor Protein p53/genetics ; Tumor Suppressor Proteins/genetics
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  4. 4
    A. M. Patch ; E. L. Christie ; D. Etemadmoghadam ; D. W. Garsed ; J. George ; S. Fereday ; K. Nones ; P. Cowin ; K. Alsop ; P. J. Bailey ; K. S. Kassahn ; F. Newell ; M. C. Quinn ; S. Kazakoff ; K. Quek ; C. Wilhelm-Benartzi ; E. Curry ; H. S. Leong ; A. Hamilton ; L. Mileshkin ; G. Au-Yeung ; C. Kennedy ; J. Hung ; Y. E. Chiew ; P. Harnett ; M. Friedlander ; M. Quinn ; J. Pyman ; S. Cordner ; P. O'Brien ; J. Leditschke ; G. Young ; K. Strachan ; P. Waring ; W. Azar ; C. Mitchell ; N. Traficante ; J. Hendley ; H. Thorne ; M. Shackleton ; D. K. Miller ; G. M. Arnau ; R. W. Tothill ; T. P. Holloway ; T. Semple ; I. Harliwong ; C. Nourse ; E. Nourbakhsh ; S. Manning ; S. Idrisoglu ; T. J. Bruxner ; A. N. Christ ; B. Poudel ; O. Holmes ; M. Anderson ; C. Leonard ; A. Lonie ; N. Hall ; S. Wood ; D. F. Taylor ; Q. Xu ; J. L. Fink ; N. Waddell ; R. Drapkin ; E. Stronach ; H. Gabra ; R. Brown ; A. Jewell ; S. H. Nagaraj ; E. Markham ; P. J. Wilson ; J. Ellul ; O. McNally ; M. A. Doyle ; R. Vedururu ; C. Stewart ; E. Lengyel ; J. V. Pearson ; A. deFazio ; S. M. Grimmond ; D. D. Bowtell
    Nature Publishing Group (NPG)
    Published 2015
    Staff View
    Publication Date:
    2015-05-29
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Cohort Studies ; Cyclin E/genetics ; Cystadenocarcinoma, Serous/drug therapy/genetics ; DNA Methylation ; DNA Mutational Analysis ; DNA-Binding Proteins/genetics ; Drug Resistance, Neoplasm/*drug effects/*genetics ; Female ; Genes, BRCA1 ; Genes, BRCA2 ; Genes, Neurofibromatosis 1 ; Genome, Human/*genetics ; Germ-Line Mutation/genetics ; Humans ; Mutagenesis/genetics ; Oncogene Proteins/genetics ; Ovarian Neoplasms/drug therapy/*genetics ; P-Glycoprotein/genetics ; PTEN Phosphohydrolase/genetics ; Promoter Regions, Genetic/genetics ; Retinoblastoma Protein/genetics
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  5. 5
    GOH, K.-L. ; QUEK, K.-F. ; YEO, G. T. S. ; HILMI, I. N. ; LEE, C.-K. ; HASNIDA, N. ; AZNAN, M. ; KWAN, K.-L. ; ONG, K.-T.

    Oxford, UK : Blackwell Science Ltd
    Published 2005
    Staff View
    ISSN:
    1365-2036
    Source:
    Blackwell Publishing Journal Backfiles 1879-2005
    Topics:
    Medicine
    Notes:
    Background : Colorectal cancer is one of the most common forms of gastrointestinal cancer in the world today. In the Asia–Pacific area, it is the fastest emerging gastrointestinal cancer.Aim : To determine the basic demographic features of patients with colorectal cancer and the anatomic distribution and characteristics of the tumour in a local Asian population.Methods : We conducted a review of consecutive patients who had undergone colonoscopy from 1999 to 2003 at the University of Malaya Medical Center, Kuala Lumpur, Malaysia.Results : Analysis was carried out on 3404 patients who underwent colonoscopy. A total of 228 patients (7%) were diagnosed with carcinoma. The mean age of diagnosis (±s.d.) was 64.4 ± 13.1 years. The male to female ratio was 1.15. Polyps were noted in 470 patients (14%). Polyps detected concomitantly with a colorectal cancer were noted in 55 patients (2%). Four patients (0.1%) were diagnosed to have familial adenomatous polyposis coli. Of the 228 patients 209 (92%) had tumours at only one site whereas 19 (8%) had synchronous lesions. Tumours were mainly left sided [198 of 248 patients (80%)] with the majority located in the recto-sigmoid region. Detailed records of treatment were available only in 176 patients. A total of 147 of 176 patients (84%) underwent surgery and 50 (28%) also received adjuvant or palliative chemotherapy (28%). Seven of 154 patients (5%) were diagnosed to have stage A cancers, 64 (42%), stage B, 23 (15%), stage C and 60 (39%), stage D. Multivariate analysis using multiple logistic regression analysis showed that age ≥65 years (OR = 1.78; 95% CI: 1.35– 2.36) and Malay (OR = 2.09; 95% CI: 1.30–3.35) and Chinese (OR = 1.77; 95% CI: 1.77–2.69) race were significant independent predictive factors for colorectal cancer.Conclusions : The demography of colorectal cancer is different from western patients. Tumours were mainly left sided in our patients. However, no differences in anatomic location were found between races, men and women and younger and older age groups. Colorectal cancer presented in an advanced stage in the majority of patients.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1111/j.1365-2036.2005.02646.x

    Articles: DFG German National Licenses