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1Latest Papers from Table of Contents or Articles in PressS. De Rubeis ; X. He ; A. P. Goldberg ; C. S. Poultney ; K. Samocha ; A. E. Cicek ; Y. Kou ; L. Liu ; M. Fromer ; S. Walker ; T. Singh ; L. Klei ; J. Kosmicki ; F. Shih-Chen ; B. Aleksic ; M. Biscaldi ; P. F. Bolton ; J. M. Brownfeld ; J. Cai ; N. G. Campbell ; A. Carracedo ; M. H. Chahrour ; A. G. Chiocchetti ; H. Coon ; E. L. Crawford ; S. R. Curran ; G. Dawson ; E. Duketis ; B. A. Fernandez ; L. Gallagher ; E. Geller ; S. J. Guter ; R. S. Hill ; J. Ionita-Laza ; P. Jimenz Gonzalez ; H. Kilpinen ; S. M. Klauck ; A. Kolevzon ; I. Lee ; I. Lei ; J. Lei ; T. Lehtimaki ; C. F. Lin ; A. Ma'ayan ; C. R. Marshall ; A. L. McInnes ; B. Neale ; M. J. Owen ; N. Ozaki ; M. Parellada ; J. R. Parr ; S. Purcell ; K. Puura ; D. Rajagopalan ; K. Rehnstrom ; A. Reichenberg ; A. Sabo ; M. Sachse ; S. J. Sanders ; C. Schafer ; M. Schulte-Ruther ; D. Skuse ; C. Stevens ; P. Szatmari ; K. Tammimies ; O. Valladares ; A. Voran ; W. Li-San ; L. A. Weiss ; A. J. Willsey ; T. W. Yu ; R. K. Yuen ; E. H. Cook ; C. M. Freitag ; M. Gill ; C. M. Hultman ; T. Lehner ; A. Palotie ; G. D. Schellenberg ; P. Sklar ; M. W. State ; J. S. Sutcliffe ; C. A. Walsh ; S. W. Scherer ; M. E. Zwick ; J. C. Barett ; D. J. Cutler ; K. Roeder ; B. Devlin ; M. J. Daly ; J. D. Buxbaum
Nature Publishing Group (NPG)
Published 2014Staff ViewPublication Date: 2014-11-05Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Amino Acid Sequence ; Child Development Disorders, Pervasive/*genetics/pathology ; Chromatin/*genetics/metabolism ; Chromatin Assembly and Disassembly ; Exome/genetics ; Female ; Genetic Predisposition to Disease/*genetics ; Germ-Line Mutation/genetics ; Humans ; Male ; Molecular Sequence Data ; Mutation/*genetics ; Mutation, Missense/genetics ; Nerve Net/metabolism ; Odds Ratio ; Synapses/*metabolism ; Transcription, Genetic/*geneticsPublished by: -
2Articles: DFG German National LicensesMäntymaa, M. ; Puura, K. ; Luoma, I. ; Salmelin, R. ; Davis, H. ; Tsiantis, J. ; Ispanovic-Radojkovic, V. ; Paradisiotou, A. ; Tamminen, T.
Oxford, UK : Blackwell Science Ltd
Published 2003Staff ViewISSN: 1365-2214Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicinePsychologyNotes: Background Psychological stress is associated with physical illnesses like asthma or infections. For an infant, situations perceived as stressful are highly dependent on the relationship with the caregiver. Constantly poor mother–infant interaction increases the child's vulnerability to stressful conditions and experiences. The aim of the study was to investigate the impact of the quality of early mother–infant interaction on the subsequent physical health of the child. Poor mother–infant interaction was hypothesized to be associated with chronic or recurrent health problems in the child.Participants Fifty-seven mother-infant dyads from families at risk of psychosocial problems and 63 from non-risk families, altogether 120 dyads, participated in the study. Families were drawn from normal population, from well-baby clinics in the city of Tampere, Finland. Infants were full-term and healthy, families with severe risks like psychotic illnesses of the parents or a history of child protection concerns were excluded from the study.Methods After the initial interview with the mother, the mother–infant interaction was videotaped when the infants were 8–11 weeks of age and the interaction was assessed using the Global Rating Scale for Mother–Infant Interaction (Murray et al. 1996a). After the 2-year follow-up mothers were interviewed again and the health problems of the child were elicited.Results Poor dyadic mother–infant interaction and infant's poor interactive behaviour assessed at two months were separately associated with the physical health of the child during the two-year follow-up. After adjusting for other factors in the logistic regression analysis infant's poor interactive behaviour remained as a significant predictor of chronic or recurrent health problems in the child. Infant's health problems at the time of the initial interview and day care centre attendance were also significant predictors.Conclusions The results suggest that interactional issues between a mother and her infant are related to the child's subsequent physical health. Children with recurrent or chronic health problems may have relationship difficulties with which they need help. Also, early avoidant behaviour of the infant should be regarded as an indicator of the infant's distress with possibly adverse outcomes in the child's physical health, among other consequences.Type of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesHeikkinen, A. ; Puura, K. ; Ala-Laurila, E.-L. ; Niskanen, T. ; Mattila, K.
Oxford, UK : Blackwell Science Ltd.
Published 2002Staff ViewISSN: 1365-2214Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicinePsychologyNotes: Objective To study Finnish general practitioners’ (GP’s) perceptions of their child psychiatric skills.Methods The study sample consisted of physicians (n = 755) working in health centres situated in the special response area of the Tampere University Hospital, Finland. They were requested to assess their competence in 16 areas on a four-step Likert scale. The response rate was 66.1% (n = 499).Results Physicians evaluated their child psychiatric skills as inadequate on many issues. The ability to identify depression was poorer the younger the child in question. Only a minority (14%) felt they were well able to identify a depressed infant. Many physicians considered themselves poorly skilled in assessing the relationship between infant and parents (39.8%), in assessing a child’s need for psychiatric treatment (42.7%) and in identifying a child with attention-deficit disorder (40.7%). A majority (75.9%) rated their skills poor in co-operating with daycare personnel or school staff in matters concerning a child with conduct disturbance. Only 26.8% could assess the necessity of taking a child into custody. Women gave higher ratings of their skills in identifying depressed infants and in assessing the infant–parent relationship than men, whereas men assessed their skills as better in cases in which there were problems in co-operation with parents.Conclusions In order to provide good psychiatric services for children, attention should be paid to the GPs’ child psychiatric skills.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesPuura, K. ; Almqvist, F. ; Tamminen, T. ; Piha, J. ; Räsänen, E. ; Kumpulainen, K. ; Moilanen, I. ; Koivisto, A.-M.
Springer
Published 1998Staff ViewISSN: 1433-9285Source: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract The prevalence of psychiatric disorders among prepubertal children in Southern Finland was studied in a two-stage epidemiological survey. In the first stage of the study 3397 children aged 8 or 9 were screened with the Rutter A2 scale for parents, Rutter B2 scale for teachers and Children's Depression Inventory (CDI). In the second stage a random sample of the children screened was drawn for more detailed assessment. Altogether 279 children were interviewed with the Finnish version of the Diagnostic Interview Schedule for Children (DISC), and their parents with the Isle of Wight Interview Schedule. In the parental interview the prevalence of psychiatric disturbance among children was 15.1%. The rate was higher for boys (23.7%) than for girls (5.3%). The prevalence of psychiatric disturbance verified with the child interview was 14.9%. The prevalence of psychiatric disturbance in boys based on the child interview was 20.5%. For girls the prevalence of psychiatric disturbance based on the child interview was 8.7%. The spectrum of psychiatric disturbance differed in the two interviews. Attention deficit disorder, depression and conduct disorder were the most common diagnoses in the parent interview, while anxiety disorder and depression were most common according to the child interview. In only 24% of the cases both the parent and child interview gave the same diagnosis.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesKumpulainen, K. ; Räsänen, E. ; Henttonen, I. ; Moilanen, I. ; Piha, J. ; Puura, K. ; Tamminen, T. ; Almqvist, F.
Springer
Published 1999Staff ViewISSN: 1435-165XKeywords: Key words Behavioural/emotional symptoms – agreement – epidemiologySource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract This study assessed the agreement between parents and teachers concerning behavioural/emotional symptoms of children. 5671 children born in 1981 (mean age 8.5 years at the time of study) were studied using the Rutter Parent Questionnaire (RA2) and the Rutter Teacher Questionnaire (RB2). Boys had more behavioural symptoms on both scales, 3.6% of the boys and 2.3% of the girls were deviant on both scales. Agreement between parents and teachers on single behaviours was better for deviant girls than for deviant boys. The factors constructed from the Rutter scale items (separately of each scale) represented externalising, internalising and hyperactivity behaviours. For all children, moderate correlations between parents' and teachers' ratings were found in externalising behaviour and hyperactivity. Correlations of the factors were clearly higher for deviant girls than for deviant boys. Scoring high on one of the scales increased the probability of scoring high on the second scale. The discussion focuses on factors that may affect agreement between parents and teachers when behavioural symptoms are assessed.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesKumpulainen, K. ; Räsänen, E. ; Henttonen, I. ; Puura, K. ; Moilanen, I. ; Piha, J. ; Tamminen, T. ; Almqvist, F.
Springer
Published 1999Staff ViewISSN: 1435-165XKeywords: Key words Psychiatric disorders – performance level – special educationSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract We assessed the relationship between psychological deviance and performance level at school among 8-year-old children. The use of special education among children with psychiatric disorders was also studied. In Stage 1, 5813 children were studied using the Rutter Parent Questionnaire (RA2), the Rutter Teacher Questionnaire (RB2) and the Children's Depression Inventory (CDI). In Stage 2, a subsample (n = 424) of these children were interviewed, using the Isle of Wight Interview. In Stage 1, more children defined as lower achievers (LAs) came from low SES families than did average (NAs) and high achievers (HAs). They also had more psychiatric symptoms, and they scored above the cutoff (13 points on the RA2, nine points on the RB2 and 17 points on the CDI) more commonly than other children. In Stage 2, two thirds of children who received special education had some psychiatric disorder. The probability of a child with psychiatric disorder obtaining some extra tutoring or special education was 3.1-fold when compared with children without psychiatric disorders. Depressive children and children with attention deficit disorders most commonly had extra tutoring (4.8-fold) when compared with children without psychiatric disorders. The probability of getting special education was highest for attention deficit disorders (6.2-fold), thereafter for anxiety (3.1-fold), and for oppositional/conduct disorders (2.8-fold).Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesAlmqvist, F. ; Puura, K. ; Kumpulainen, K. ; Tuompo-Johansson, E. ; Henttonen, I. ; Huikko, E. ; Linna, S.-L. ; Ikäheimo, K. ; Aronen, E. ; Katainen, S. ; Piha, J. ; Moilanen, I. ; Räsänen, E. ; Tamminen, T.
Springer
Published 1999Staff ViewISSN: 1435-165XKeywords: Key words Childhood – psychiatric disorder – interview – prevalence – care – durationSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Using three questionnaires, the Rutter Parent Questionnaire (RA2), The Rutter Teacher Questionnaire (RB2) and the Children's Depression Inventory (CDI), we screened 8–9-year-old children representing a total annual birth cohort (N = 60007) in Finland. In a second stage we interviewed the parents of 119 screen negative, and 316 screen positive children by using a structured parent interview. At the population level the overall prevalence rate for psychiatric disturbance was 21.8%, higher among boys (29.8%) than among girls (12.8%). Nine percent of the children were in urgent need of treatment and, in addition, 25% were in need of assessment. The prevalence of different levels of disturbance was: reactive 9.5%; neurotic 18.4%; borderline 3.1%; and other severe disorders 2.3%. The prevalence of different diagnostic groups were: anxiety disorder 5.2%; depressive disorder 6.2%; specific fears 2.4%; defiant and conduct disorder 4.7%; and attention-deficit hyperactivity-disorder 7.1%. The prevalence for the most common single first Axis-I DSM-III-R diagnoses were: attention-deficit hyperactivity-disorder 7%; dysthymia 4.6%; adjustment disorder with mixed disturbance of emotion and conduct 3.4%; oppositional defiant disorder 2.7%; specific fear 1.7%; anxiety disorder 1.5%; enuresis nocturnal 1.5%; and depression 1.4%. Only 3.1% of the children had visited health professionals for psychiatric problems during the previous three months. Only a minority of the children with psychiatric disturbances had ever consulted health professionals for their problems. Of all the children, 7.5% had a severe psychiatric disturbance that had lasted for more than 3 years.Type of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesAlmqvist, F. ; Ikäheimo, K. ; Kumpulainen, K. ; Tuompo-Johansson, E. ; Linna, S.-L. ; Puura, K. ; Moilanen, I. ; Räsänen, E. ; Tamminen, T. ; Piha, J.
Springer
Published 1999Staff ViewISSN: 1435-165XKeywords: Key words Child psychiatry – epidemiology – demographic – school – familySource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract In an epidemiological multi-centre study, parents filled in the Rutter Parent Questionnaire (RA2) and teachers filled in the Rutter Teacher Questionnaire (RB2) for almost 6000 children. The children filled in the Children's Depression Inventory (CDI). The subjects well represented the entire population of 8–9-year-old children in Finland. The material and design of the study as well as the basic demographic characteristics are presented.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesAlmqvist, F. ; Kumpulainen, K. ; Ikäheimo, K. ; Linna, S.-L. ; Henttonen, I. ; Huikko, E. ; Tuompo-Johansson, E. ; Aronen, E. ; Puura, K. ; Piha, J. ; Tamminen, T. ; Räsänen, E. ; Moilanen, I.
Springer
Published 1999Staff ViewISSN: 1435-165XKeywords: Key words Childhood psychopathology – epidemiology – emotional symptoms – conduct symptoms – hyperactive symptoms – depressive symptomsSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract We present epidemiological data from a multi-centre study on psychiatric symptoms among 6017 8–9-year-old children representing a total annual birth cohort (N = 60007) in Finland. The results are based on three questionnaires: the Rutter Parent Scale (RA2), the Rutter Teacher Scale (RB2), the Children's Depression Inventory (CDI). The proportion of children that scored above the cutoff points, indicating probable psychiatric disturbance, were 11.2% for the RA2, 13.9% for the RB2 and 6.9% for the CDI. Twenty-four percent of the subjects scored above the cutoff point on at least one of the questionnaires. Low family social status and disrupted family relations correlated strongly with high rates of symptoms in the children.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesLuoma, I. ; Puura, K. ; Tamminen, T. ; Kaukonen, P. ; Piha, J. ; Räsänen, E. ; Kumpulainen, K. ; Moilanen, I. ; Koivisto, A.-M. ; Almqvist, F.
Springer
Published 1999Staff ViewISSN: 1435-165XKeywords: Key words Family structure – child – behavioural symptoms – emotional symptomsSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract The association between family structure and behavioural and emotional symptoms in prepubertal children was studied in an epidemiological survey conducted in Finland. Five thousand eight hundred thirteen children aged 8 and 9 years were screened using the Rutter Parent Questionnaire (RA2) for parents and the Rutter Teacher Questionnaire (RB2) for teachers. Information concerning family type, birth order and sibship size were obtained from the parents. The majority of the children (84%) in the sample lived with both their biological parents, 10% with a single parent, and around 5% with a biological parent and a stepparent. Around 1% of the children lived outside their original home. The prevalence of behavioural and emotional symptoms was lowest in children living with both their biological parents and highest among children living outside their original home according to both parents' and teachers' reports. Children living with a parent a stepparent had problems more often at home, but less often at school than children living with a single parent. Living with a single father was associated with having more externalising, school-related problems, while living with a stepfather was associated with having more internalising, home related problems. Having younger siblings seemed to be associated with fewer problems at school, and being the youngest child with having less problems both at home and at school.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesPuura, K. ; Tamminen, T. ; Almgvist, F. ; Kresanov, K. ; Kumpulainen, K. ; Koivisto, A. M. ; Moilanen, I.
Springer
Published 1997Staff ViewISSN: 1435-165XKeywords: Child ; depression ; epidemiology ; diagnostic criteriaSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract In a two-stage epidemiological study 5686 randomly selected 8 to 9-year-old children were screened using the CDI (Children's Depression Inventory), of whom 418 were questioned with the DISC-C1 (Diagnostic Interview Schedule for Children). According to DSM-III criteria the prevalence of MDD (Major Depressive Disorders) was 0.48% and of DD (Dysthymic Disorder) 0.06%. The prevalence rates did not change when DSM-111-R and DSM-IV criteria were employed. Fifteen children reported suicidal thoughts but according to DSM-III criteria only 1 of these children was depressed. Duration and frequency of depressive symptoms are essential for making a diagnosis of depressive disorder by the DSM-III, but children's reliability in reporting them is questionable. Omitting the duration and frequency of symptoms from the DSM-111 criteria raised the prevalence of MDD to 4.0% and of DD to 2.2%. Eight of the children with suicidal thoughts were depressed. By the adapted DSM-III-R and DSM-IV criteria the prevalence rate of MDD was 4.0% and of DD 9.7%.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesPuura, K. ; Tamminen, T. ; Almqvist, F. ; Kresanov, K. ; Kumpulainen, K. ; Moilanen, I. ; Koivisto, A.-M.
Springer
Published 1997Staff ViewISSN: 1435-165XKeywords: Key words Child ; depression ; epidemiology ; diagnostic criteriaSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract In a two-stage epidemiological study 5686 randomly selected 8 to 9-year-old children were screened using the CDI (Children‘s Depression Inventory), of whom 418 were questioned with the DISC-C1 (Diagnostic Interview Schedule for Children). According to DSM-III criteria the prevalence of MDD (Major Depressive Disorders) was 0.48% and of DD (Dysthymic Disorder) 0.06%. The prevalence rates did not change when DSM-III-R and DSM-IV criteria were employed. Fifteen children reported suicidal thoughts but according to DSM-III criteria only 1 of these children was depressed. Duration and frequency of depressive symptoms are essential for making a diagnosis of depressive disorder by the DSM-III, but children‘s reliability in reporting them is questionable. Omitting the duration and frequency of symptoms from the DSM-III criteria raised the prevalence of MDD to 4.0% and of DD to 2.2%. Eight of the children with suicidal thoughts were depressed. By the adapted DSM-III-R and DSM-IV criteria the prevalence rate of MDD was 4.0% and of DD 9.7%.Type of Medium: Electronic ResourceURL: