Search Results - (Author, Cooperation:K. Pittman)

2018-09-29

Nature Publishing Group (NPG)

2041-1723

Biology

Chemistry and Pharmacology

Natural Sciences in General

Physics

2014-11-22

American Association for the Advancement of Science (AAAS)

0036-8075

1095-9203

Biology

Chemistry and Pharmacology

Computer Science

Medicine

Natural Sciences in General

Physics

Alu Elements ; Animals ; Anti-Inflammatory Agents, Non-Steroidal/*pharmacology/therapeutic use ; Apoptosis/drug effects ; Carrier Proteins/metabolism ; Caspase 1/metabolism ; Choroidal Neovascularization/drug therapy ; Disease Models, Animal ; Geographic Atrophy/drug therapy ; Graft vs Host Disease/drug therapy ; Hepatitis/drug therapy ; Inflammasomes/*drug effects ; Liver/drug effects ; Mice ; Receptors, Purinergic P2X7/metabolism ; Retinal Pigment Epithelium/drug effects/metabolism/physiology ; Reverse Transcriptase Inhibitors/*pharmacology/therapeutic use

1365-2109

Blackwell Publishing Journal Backfiles 1879-2005

Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition

Electronic Resource

1365-2109

Blackwell Publishing Journal Backfiles 1879-2005

Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition

The effect of size and acclimation period to full-strength sea water was investigated using the mortality, growth, chloride cell proliferation and plasma Na concentration in four size groups (0.03-1.6 g mean initial weight) of mixed-parentage, sex-reversed, all-male fry and fingerlings of Oreochromis spilurus spilurus Günter obtained from University of Stirling. The fish were transferred from fresh water to sea water (36.6%0) through a continuous salinity increase during a 48, 72 or 120 h acclimation period. Survival was high in all groups, although the smallest fish (0.03 g) showed significantly higher mortality than the larger fish. The acclimation regime had no effect on growth rate, but 120 h acclimation gave highest final weight in the newly released group. Regardless of acclimation period, size and plasma Na concentration during the acclimation period, the plasma Na level stabilized within 12 h after full salinity in the two largest size groups. Ovoid voluminous chloride cells proliferated in all groups during the acclimation period, and numbers stabilized with stable salinity. It is concluded in this study that O. spilurus spilurus can successfully be acclimated to sea water with a gradual continuous acclimation period of 48 h, even as newly released fry (0.03 g). However, an acclimation period of 120 h gave the highest final weight for this size group.

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1365-2109

Blackwell Publishing Journal Backfiles 1879-2005

Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition

The diel feeding pattern, electivity and ration of 4.5-6.9 and 11.5-13.6 cm (total length) silver barb, Puntius gonionotus Bleeker, were investigated along with water quality characteristics in a nursery pond and a ricefield in Bangladesh. Small fish had two peaks (0900-1200 h and 1500-1800 h) in feeding activity in the pond but only one in the ricefield at 1500 h. Feeding at high levels went on throughout the day and on moonlit nights for small fish, and their diet was dominated in both environments by aquatic macrophytes as well as Microcystis, Spirogyra, Oedogonium and Cladophora, rotifers, crustaceans and insects. Large fish fed at low levels, had a single feeding peak during midday in the pond but no clear feeding peak in the ricefield. Large fish consumed macrophytes as well as Microcystis, Anabaena, Spirogyra and Cladophora, and crustaceans (in the pond) or molluscs (in the ricefield). Overall electivity was negative for microalgae. Zooplankton were avoided by large fish in the ricefield. The gastric evacuation time was 1-5 h at 27.5-34.0°C. Daily rations for small and large fish were estimated to be 1.4% and 0.3% of body weight in the pond and 1.1% and 0.6% in the ricefield. Improved fish yields may be achieved by stocking small P. gonionotus where the available food resources include important amounts of zooplankton, and by allowing aquatic macrophytes and weeds to grow in the ricefield or pond after stocking, such that the growing fish can feed increasingly on these.

Electronic Resource

1365-2109

Blackwell Publishing Journal Backfiles 1879-2005

Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition

The effect of thermal history (11°C and 14°C) on growth of juvenile halibut, Hippoglossus hippoglossus (L.) (initial mean weight 140 g, n= 254), was studied. Fish were divided into four groups, two groups remaining at constant temperature (C11, Cl4), and fish in the other groups being transferred from either 11°C to 14°C (F11:14) or from 14°C to 11°C (F14:11). Twenty fish in each tank were tagged (PIT) at the start of the experiment. The final mean weights were significantly higher in F14:11 (384 g) than in F11:14 (308 g) and C14 (317 g). Further, F14:11 had significantly higher length growth rate (SLGR) than both F11:14 and C14. No significant differences between the experimental groups within each temperature (F14.11 vs. C11, and F11:14 vs. C14) were, however, found. Growth rate (SGR) declined rapidly with increasing size (from 1.4–1.8% day−1 to 0.4–0.8% day−1). It is concluded that the optimal temperature for growth of juvenile halibut declines with increasing size. Thus, as halibut grow larger, the temperature should be reduced to take advantage of this change in optimal temperature for growth.

Electronic Resource

1095-8649

Blackwell Publishing Journal Backfiles 1879-2005

Biology

The iodine concentration in wild zooplankton was 700 times higher than in Artemia and threefold higher in Atlantic halibut Hippoglossus hippoglossus larvae fed wild zooplankton than in those fed Artemia. In larvae fed wild zooplankton thyroxine (T4) and triiodothyronine (T3) concentrations were significantly higher than in those fed Artemia at the commencement of metamorphosis, 68–77 days post hatching. There was no difference in the amino acids phenylalanine and tyrosine levels in larvae fed Artemia in comparison with those fed wild zooplankton. The selenium level was significantly higher in larvae fed Artemia than in those fed wild zooplankton, but concentrations in the prey were not different. The results indicate sufficient amounts of phenylalanine, tyrosine and selenium in Artemia, but indicated a lower thyroid status due to an insufficient iodine supply at commencement of metamorphosis in larvae fed Artemia. This may partly explain the higher frequency of juveniles with complete eye migration and asymmetric pigmentation in the group fed wild zooplankton.

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1095-8649

Blackwell Publishing Journal Backfiles 1879-2005

Biology

Live yolk-sac halibut, Hippoglossus hippoglossus (L.) larvae from rearing experiments at Austevoll Aquaculture Station, Norway, were examined from hatching to past first feeding for developmental morphology and behaviour. The findings include development of the respiratory and circulatory organs, eye pigmentation, mouth formation, organs of the digestive system and the process of yolk absorption, as well as swimming speed and activity levels.A stomodeum is not present at hatching although drinking is possible through a pair of branchial pits which gradually develop into the operculum and gill basket. The mouth normally opens slowly, the gape being restricted by a transverse septum until bones are formed. The amount of time spent swimming varies from less than 15% of the observation period during the first 2 weeks after hatching to between 70 and 100% around the seventh week after hatching, when individual differences become more apparent. Larvae generally react with a burst of swimming when two come into contact. Speed and duration of swimming seems to be correlated with development of eye pigment, heart size and fin formation. The yolk-sac period is divided into four stages.

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1095-8649

Blackwell Publishing Journal Backfiles 1879-2005

Biology

Electronic Resource

1095-8649

Blackwell Publishing Journal Backfiles 1879-2005

Biology

The effect of egg vitamin A (VA) status and egg incubation temperature on the development of spinal disorders was investigated in Atlantic salmon Salmo salar fry. Atlantic salmon eggs were sorted into two groups with high VA (3·3 ± 0·1 μg retinol g−1 dry mass) and low VA (2·2 ± 0·3 μg retinol g−1 dry mass) status before fertilization and incubated at high (14° C) or low (8° C) temperature from 133 day degrees until the onset of feeding. High egg incubation temperatures increased the concentration of retinol in the eggs: the high VA and high temperature group displayed a significantly higher retinol concentration than the high VA and low temperature group (P = 0·001). After hatching, all experimental groups increased their retinol concentration. The source of the increased retinol levels was probably retinal, although astaxanthin may also be a VA precursor after hatching. Atlantic salmon fry incubated at high temperatures had increased amounts of notochord tissue. When measuring morphogenic activity in the notochord using the expression of sonic hedgehog (shh, mRNA), however, no significant difference was found between the experimental groups. No clear effect of VA status or incubation temperature could be found on the formation of the early vertebral column although Atlantic salmon fry incubated at low temperatures had less regular constrictions of the prospective vertebral column than fry incubated at high temperatures.

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1365-2095

Blackwell Publishing Journal Backfiles 1879-2005

Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition

Atlantic halibut larvae were fed docosohexanoic acid- (DHA) selco enriched Artemia (RH-cysts) or wild zooplankton in duplicate tanks from first-feeding and 60 days onward. The zooplankton were collected from a fertilized sea water pond and consisted mainly of different stages of Eurytemora affinis and Centropages hamatus. There were no differences in survival, or in growth during the first 45 days of feeding, between larvae fed the two prey items, but the larvae fed Artemia showed much higher incidence of malpigmentation and impaired eye migration than larvae fed zooplankton. The prey organisms contained similar amounts of dry matter and protein, but Artemia was higher in lipid and glycogen than the zooplankton. Larvae fed Artemia were higher in both glycogen and lipid than the zooplankton-fed larvae towards the end of the feeding period. There were large differences between the prey organisms in the concentrations of essential fatty acids (% of total fatty acids) which was reflected in the fatty acid composition of the larval body. It is concluded that the macronutrient composition of Artemia in the present study was probably within the optimal range for promotion of growth and survival in young Atlantic halibut. The concentration of n-3 HUFA, and especially DHA, is however, very much lower in enriched Artemia than in copepods, and may be one of the factors triggering developmental errors in Atlantic halibut.

Electronic Resource

1432-0800

Springer Online Journal Archives 1860-2000

Energy, Environment Protection, Nuclear Power Engineering

Medicine

Electronic Resource

1432-0800

Springer Online Journal Archives 1860-2000

Energy, Environment Protection, Nuclear Power Engineering

Medicine

Electronic Resource

0169-2046

Elsevier Journal Backfiles on ScienceDirect 1907 - 2002

Architecture, Civil Engineering, Surveying

Geography

Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition

Electronic Resource

1432-2072

Lithium ; Haloperidol ; Dopamine ; Amphetamine ; Apomorphine ; DA receptors

Springer Online Journal Archives 1860-2000

Medicine

Abstract The effects of dietary lithium on several indices of dopamine receptor supersensitivity were examined in rats during withdrawal from chronic administration of haloperidol. Chronic haloperidol enhanced the locomotor stimulant action of d-amphetamine, and this effect was attenuated by lithium. In contrast, lithium did not affect the amphetamine response in animals that had not previously received haloperidol. Apomorphine-induced hypothermia was not influenced by the chronic haloperidol treatment. On the other hand, during withdrawal from chronic haloperidol, spontaneous locomotor activity (20 h) and apomorphine-induced stereotypy were increased, but neither of these effects was attenuated by lithium. In addition, lithium did not affect the chronic haloperidol-induced increase in 3H-spiperone binding sites in the striatum. Lithium alone had no effect on any of these measures except for causing a slight prolongation of the hypothermic effect of apomorphine. The results indicate that not all DA-receptor-mediated responses are enhanced by chronic administration of neuroleptics (e. g., apomorphine-induced hypothermia). In addition, while lithium reduces the effects of chronic haloperidol administration on d-amphetamine-induced locomotor activity, this is not because lithium prevents haloperidol-induced supersensitivity of postsynaptic DA receptors because more direct measures of this phenomenon (e.g., 3H-spiperone binding, apomorphine-induced stereotypy) are not affected by lithium.

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1432-1041

Buspirone ; pharmacokinetics ; renal impairment ; hepatic impairment ; healthy volunteers

Springer Online Journal Archives 1860-2000

Chemistry and Pharmacology

Medicine

Abstract The single dose and steady-state pharmacokinetics of buspirone and its metabolite 1-pyrimidinyl piperazine (1-PP) have been evaluated in normal volunteers and patients with renal or hepatic impairment, using a parallel group design, with assignment of patients to study group on the basis of the degree of renal (mild, moderate, severe) or hepatic (compensated or decompensated) impairment. Each healthy volunteer or patient received a single dose of 10 mg buspirone on Day 1 of the study, and starting 36 h after the first dose, healthy volunteers and patients received 10 mg doses of buspirone every 12 hours for 9 days. On the morning of Day 10 they received the last dose. Serial blood samples were collected on Days 1, 5 and 10 and plasma was analysed for buspirone and 1-PP. The plasma concentrations of buspirone and 1-PP were highly variable regardless of the renal or hepatic function. The peak concentrations (Cmax) and area under the curves (AUC) of buspirone and 1-PP on Days D 5 and 10 were higher than on Day D 1. The trough levels (Cmin) and AUCs (D 5 and 10) of buspirone and 1-PP indicated, that, regardless of renal or hepatic function, steady state was reached after 3 to 5 days of dosing. At steady-state, patients with renal or hepatic impairment had significantly higher Cmax and AUC values of buspirone than in normal volunteers. However, the intensity and frequency of adverse experiences in patients with renal or hepatic impairment were not significantly different from those observed in normal volunteers. There was no correlation between the average plasma concentrations of buspirone ( $$\bar C$$ ) and the degree of renal impairment judged by creatinine clearance. An excellent correlation was observed between $$\bar C$$ of buspirone and serum albumin (r=0.862, and P〈0.0001) as well as between $$\bar C$$ and bromsulphalein clearance (r=0.678, P〈0.0003). In view of high intra-and inter-subject variability in buspirone concentrations, definitive dosing recommendations for patients with compromised renal or hepatic function could not be made, but such patients should initially be dosed cautiously with buspirone.

Electronic Resource

1432-1041

Butorphanol ; transdermal ; pharmacokinetics

Springer Online Journal Archives 1860-2000

Chemistry and Pharmacology

Medicine

Abstract We have studied the effects of age and sex on the pharmacokinetics and the systemic availability of transnasal butorphanol in a randomized, two-way, crossover study of 48 subjects: young men and women, and elderly men and women. Each subject took a single 1 mg dose of intravenous and transnasal butorphanol tartrate on separate occasions with a one-week washout period. Blood samples were collected over 16 hours. Plasma butorphanol concentrations were determined using radioimmunoassay. The AUC of plasma butorphanol concentrations after an intravenous injection were higher in the elderly women than in the other groups. However, there were no significant differences in Cmax and AUC between the groups after transnasal administration. The mean systemic availability of transnasal butorphanol was about 70 %, except for the elderly women (48 %). After intravenous and transnasal administration, the half-life and mean residence time were greater in the elderly than the young. Clearance was lower in women than men. Apparent volume of distribution was higher for elderly men than the others. The age- and sex-related changes in the pharmacokinetics of transnasal butorphanol are not large enough to necessitate dosage differences.

Electronic Resource

1432-1041

cimetidine ; etintidine ; duodenal ulcer ; histamine H2 antagonist ; gastric acidity ; pharmacodynamics

Springer Online Journal Archives 1860-2000

Chemistry and Pharmacology

Medicine

Summary The gastric antisecretory activity of etintidine, a new histamine H2-receptor antagonist, was evaluated in 5 patients with quiescent duodenal ulcer disease. Meal-stimulated acid secretion was measured after 100 and 300 mg oral doses of etintidine, 100 and 300 mg oral doses of cimetidine, and placebo. Reductions from placebo in four-hour gastric acid secretion were 49, 65, 80, and 94%, with 100 mg cimetidine, 100 mg etintidine, 300 mg cimetidine, and 300 mg etintidine, respectively. Drug concentrations in plasma were determined by HPLC. The pharmacokinetics of the 2 drugs were similar. We analyzed sigmoid-shaped concentration-response curves to both agents; the concentrations causing 50% inhibition of meal-stimulated gastric acid secretion were 0.44±0.04 and 0.15±0.04 µg/ml for cimetidine and etintidine, respectively. However, characteristics of these curves were such that the potency difference diminished at higher concentrations.

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1432-1041

Butorphanol ; Rhinitis ; transnasal administration ; pharmacokinetic

Springer Online Journal Archives 1860-2000

Chemistry and Pharmacology

Medicine

Summary The absolute bioavailability (f) and pharmacokinetics of transnasal butorphanol were evaluated in patients experiencing rhinitis. In an open three-way crossover study, a single 2-mg dose of butorphanol tartrate was administered by intravenous bolus injection (Treatment A), by the transnasal route (Treatment B), or by the transnasal route with pretreatment of the vasoconstrictor, oxymetazoline (Treatment C). Plasma concentrations of butorphanol were determined using a drug specific radioimmunoassay. The pharmacokinetic parameters were derived using the noncompartmental methods. Butorphanol was rapidly absorbed after transnasal administration. The mean maximum concentrations (Cmax) for the transnasal treatment with and without pretreatment of oxymetazoline were 1.61 and 3.01 ng·ml−1, respectively. The corresponding mean absorption times (MAT) were 1.34 and 0.23 h. The mean half-life values were 5.95, 6.28, and 5.77 h, for treatments A, B, and C, respectively. The resulting mean area under the plasma concentration curve (AUC) values were 11.9, 8.6, and 8.07 ng·h·ml−1 for treatments A, B, and C, respectively. The estimates for absolute bioavailability (f) of transnasal butorphanol were 69% and 72% when administered with and without oxymetazoline, respectively. The mean CLT and Vss were 121 l·h−1 and 791 l, respectively, for the intravenous treatment. The pretreatment of oxymetazoline significantly lowered the Cmax and prolonged the absorption time of butorphanol. Although the rate of absorption of transnasal butorphanol was affected by oxymetazoline, the absolute bioavailability in rhinitis patients (72%) was similar to that found with the pretreatment of oxymetazoline (69%) and those reported in healthy volunteers. Dosage regimen of transnasal butorphanol does not need modification in patients experiencing rhinitis even when they are pretreated with oxymetazoline.

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