Search Results - (Author, Cooperation:K. Okubo)
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1Latest Papers from Table of Contents or Articles in PressYamato, G., Shiba, N., Yoshida, K., Hara, Y., Shiraishi, Y., Ohki, K., Okubo, J., Park, M.-j., Sotomatsu, M., Arakawa, H., Kiyokawa, N., Tomizawa, D., Adachi, S., Taga, T., Horibe, K., Miyano, S., Ogawa, S., Hayashi, Y.
American Society of Hematology (ASH)
Published 2018Staff ViewPublication Date: 2018-05-18Publisher: American Society of Hematology (ASH)Print ISSN: 0006-4971Electronic ISSN: 1528-0020Topics: BiologyMedicineKeywords: Pediatric Hematology, Myeloid NeoplasiaPublished by: -
2Latest Papers from Table of Contents or Articles in PressT. Okuyama ; S. Yokoi ; H. Abe ; Y. Isoe ; Y. Suehiro ; H. Imada ; M. Tanaka ; T. Kawasaki ; S. Yuba ; Y. Taniguchi ; Y. Kamei ; K. Okubo ; A. Shimada ; K. Naruse ; H. Takeda ; Y. Oka ; T. Kubo ; H. Takeuchi
American Association for the Advancement of Science (AAAS)
Published 2014Staff ViewPublication Date: 2014-01-05Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Female ; Gonadotropin-Releasing Hormone/*physiology ; Male ; *Mating Preference, Animal ; Mutation ; Neurons/*physiology ; Oryzias/genetics/*physiology ; Pyrrolidonecarboxylic Acid/*analogs & derivatives ; *Recognition (Psychology) ; Sex Factors ; *Visual PerceptionPublished by: -
3Articles: DFG German National LicensesItoh, K. ; Kawasaki, S. ; Kawamoto, S. ; Seishima, M. ; Chiba, H. ; Michibata, H. ; Wakimoto, K. ; Imai, Y. ; Minesaki, Y. ; Otsuji, M. ; Okubo, K.
Oxford, UK; Malden, USA : Munksgaard International Publishers
Published 2005Staff ViewISSN: 1600-0625Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Abstract: To identify differentially expressed genes which play causal roles in pathogenesis and maintenance for psoriasis, we used BodyMapping and introduced amplified fragment length polymorphism approaches. From the BodyMap database, we selected 2007 genes which specifically expressed in epithelial tissues. Among 2007 genes, we surveyed genes which differentially expressed in involved or uninvolved psoriatic lesional skin samples compared with atopic dermatitis, mycosis fungoides, and normal skin samples. As a result of surveying 2007 genes, 241 genes were differentially expressed only in involved psoriatic skin but not in the other samples. Hierarchical cluster analysis of gene expression profiles showed that 13 independent psoriatic-involved skin samples clustered tightly together, reflecting highly similar expression profiles. Using the same 2007 gene set, we examined gene expression levels in five serial lesions from distal uninvolved psoriatic skin to involved psoriatic plaque. We identified seven genes such as alpha-1-microglobulin/bikunin precursor, calnexin, claudin 1, leucine zipper down-regulated in cancer 1, tyrosinase-related protein 1, Yes-associated protein 1, and unc-13-like protein (Coleonyx elegans) which show high-expression levels only in uninvolved psoriatic lesions. These seven genes, which were reported to be related to apoptosis or antiproliferation, might have causal roles in pathophysiology in psoriasis.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesOTSUKA, H. ; MEZAWA, A. ; OHNISHI, M. ; OKUBO, K. ; SEKI, H. ; OKUDA, M.
Oxford, UK : Blackwell Publishing Ltd
Published 1991Staff ViewISSN: 1365-2222Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: We have investigated changes of nasal metachromatic cell number, nasal symptoms and nasal provocation at the third and sixth month during allergen immunotherapy. Twenty-five subjects with perennial allergic rhinitis (house dust (23), Alternaria (2)) were divided into two groups: an immunotherapy-treated group (n= 14) and a control group (n=11). At the first visit nasal symptom scores, nasal provocation reactions and the number of metachromatic cells in nasal mucosal epithelial scrapings were not significantly different between groups. At the third and sixth month after immunotherapy nasal symptom scores, nasal provocation and the metachromatic cells in epithelial scrapings were significantly reduced (P 〈 0.05) compared with the pretreatment values in the immunotherapy group, but unchanged in the control group. These results suggest that the reduction in metachromatic cell number at the nasal mucosal surface may be one of the mechanisms which could explain the improvement of nasal allergic symptoms by immunotherapy.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesMOSS, R. B. ; NAGATA, H. ; GOFF, J. ; OKUBO, K. ; HAUSEFELD, J. ; KALINER, MICHAEL A.
Oxford, UK : Blackwell Publishing Ltd
Published 1997Staff ViewISSN: 1365-2222Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Background The nasal mucosa is the initial site in the upper airway of host defence against antigenic challenge in the form of airborne allergens, irritants, toxins and infectious agents, and yet little is known about nasal mucosal cytokine expression and function. We hypothesized that IL-2 might play a role in immunocompetence of the upper airway.Methods IL-2 immunoreactivity was measured by ELISA in nasal secretions and by Western blot. Immunohistochemistry and electron microscopy were performed on turbinated tissue. mRNA for IL-2 was evaluated by RTPCR and Southern hybridization.Results IL-2 immunoreactivity was demonstrated by Western blot and quantitated by an enzyme immunoassay. Immunohistochemical and electron microscopy analysis of turbinate tissue revealed interstitial staining for IL-2. By RTPCR, IL-2 message was evident in 5/5 atopies and 5/5 non-atopics. IL-2 message was expressed in all subjects by Southern hybridization to an internal probe after PCR.Conclusion This study has demonstrated constitutive expression of IL-2 protein and mRNA in the upper airway of heallhy individuals. The further characterization of cytokines in the upper airway could provide useful insights into immune regulation at the mucosal level.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesOkubo, K. ; Kobayashi, M. ; Takiguchi, T. ; Takada, T. ; Ohazama, A. ; Okamatsu, Y. ; Hasegawa, K.
Oxford, UK : Munksgaard International Publishers
Published 2003Staff ViewISSN: 1600-0765Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Previous studies have provided the biological basis for the therapeutic use of enamel matrix derivative (EMD) at sites of periodontal regeneration. A purpose of this study is to determine effects of EMD on cell growth, osteoblastic differentiation and insulin-like growth factor-I (IGF-I) and transforming growth factor-β1 (TGF-β1) production in human periodontal ligament cells (HPLC). We also examined participation of endogenous IGF-I and TGF-β1 with EMD-stimulated cell growth in these cells. HPLCs used in this study were treated with EMD alone or in combination with antihuman IGF-I antibody (anti-hIGF-I) or anti-hTGF-β1, recombinant human bone morphogenetic protein-2 (rhBMP-2), 1,25-dihydroxyvitamin D3[1,25(OH)2D3], rhTGF-β1 or rhIGF-I. After each treatment, cell growth, the production of IGF-I and TGF-β1 and the expression of osteoblastic phenotypes were evaluated. EMD stimulated cell growth in dose-dependent and time-dependent manners. EMD was also stimulated to express IGF-I and TGF-β1 at protein and mRNA levels. The EMD-stimulated cell growth was partially suppressed by cotreatment with anti-hIGF-I or anti-hTGF-β1, and cell growth was also stimulated by treatment with rhIGF-I or rhTGF-β1. rhBMP-2 stimulated alkaline phosphatase (ALPase) activity and ALPase mRNA expression, and 1,25(OH)2D3 stimulated ALPase and osteocalcin mRNA expression. However, EMD showed no effect on the osteoblastic phenotypes expression. These results demonstrated that EMD has no appreciable effect on osteoblastic differentiation, however it stimulates cell growth and IGF-I and TGF-β1 production in HPLC, and that these endogenous growth factors partially relate to the EMD-stimulated cell growth in HPLC.Type of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 0003-2670Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 0378-1119Keywords: 3'-directed cDNAs ; Gene signature ; HepG2 ; aortic cells ; core ; genomic PCR ; template-dependent primer dimerSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 0378-1119Keywords: GenBank ; body map ; cDNA project ; expression profile ; gene signatureSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyType of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesFukushima, A. ; Okubo, K. ; Sugino, H. ; Hori, N. ; Matoba, R. ; Niiyama, T. ; Murakawa, K. ; Yoshii, J. ; Matsubara, K. ; Yokoyama, M.
Amsterdam : ElsevierStaff ViewISSN: 0888-7543Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 0922-338XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Process Engineering, Biotechnology, Nutrition TechnologyType of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 0031-9422Keywords: Legume species ; Leguminosae ; basic 7S globulin. ; heat treatment ; released seed proteins ; seedsSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyType of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesTsukamoto, C. ; Kikuchi, A. ; Kudou, S. ; Harada, K. ; Kitamura, K. ; Okubo, K.
Amsterdam : ElsevierStaff ViewISSN: 0031-9422Keywords: Glycine max ; Glycine soja ; Leguminosae ; deficiency ; mutant ; protein ; saponin ; soybean ; triterpenoid ; β-conglycinin.Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyType of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 0031-9422Keywords: G. soja ; Glycine max ; Leguminosae ; chemical structure. ; gene expression ; inheritance ; sugar chain composition ; triterpenoidsSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyType of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 0031-9422Keywords: Legume species ; Leguminosae ; basic 7S globulin. ; heat treatment ; released seed proteins ; seedsSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyType of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 0031-9422Keywords: DDMP-saponin ; Leguminosae ; Phaseolus coccineus ; scarlet runner bean ; soyasaponin α a. ; triterpenoidsSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyType of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 0888-7543Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyMedicineType of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 1010-6030Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesStaff View
ISSN: 0958-1669Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: MedicineProcess Engineering, Biotechnology, Nutrition TechnologyType of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesMiyasaka, K. ; Matsumoto, M. ; Tomita, H. ; Sazaki, N. ; Okubo, K. ; Shikado, F. ; Funakoshi, A.
Amsterdam : ElsevierStaff ViewISSN: 0167-4943Keywords: Aging ; Brain ; Cholecystokinin ; Intestine ; RatSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: MedicineType of Medium: Electronic ResourceURL: