Search Results - (Author, Cooperation:K. Ohishi)
-
1Latest Papers from Table of Contents or Articles in PressD. R. McIlwain ; P. A. Lang ; T. Maretzky ; K. Hamada ; K. Ohishi ; S. K. Maney ; T. Berger ; A. Murthy ; G. Duncan ; H. C. Xu ; K. S. Lang ; D. Haussinger ; A. Wakeham ; A. Itie-Youten ; R. Khokha ; P. S. Ohashi ; C. P. Blobel ; T. W. Mak
American Association for the Advancement of Science (AAAS)
Published 2012Staff ViewPublication Date: 2012-01-17Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: ADAM Proteins/genetics/*metabolism ; Amino Acid Sequence ; Animals ; B-Lymphocytes/immunology/metabolism ; Base Sequence ; Carrier Proteins/chemistry/genetics/*metabolism ; Cell Line ; Cell Membrane/metabolism ; Gene Deletion ; *Immunity, Innate ; Lipopolysaccharides/*immunology ; Listeria monocytogenes/immunology/physiology ; Listeriosis/*immunology/metabolism/microbiology/pathology ; Macrophages/immunology/metabolism ; Macrophages, Peritoneal/immunology/metabolism/microbiology ; Mice ; Molecular Sequence Data ; Protein Transport ; Shock, Septic/*immunology/metabolism ; Spleen/cytology ; Tumor Necrosis Factor-alpha/blood/genetics/*metabolismPublished by: -
2Articles: DFG German National LicensesTakatsu, Y. ; Ohishi, K. ; Tomita, Y. ; Hayashi, M. ; Nakajima, M. ; Akutsu, K.
Oxford, UK : Blackwell Publishing Ltd
Published 2000Staff ViewISSN: 1439-0523Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionNotes: An efficient incubation and inoculation system for white rust was established using plantlets of chrysanthemum growing in vitro. The internal conditions of a culture vessel (plant box) were maintained at a humidity of 90-100% and an optimum temperature of 20-25°C, which are suitable conditions to germinate teliospores and basidiospores of the pathogen. Telia were maintained continuously on plants in the plant box and were used as an inoculum for infection experiments throughout the year, allowing differences in susceptibility to white rust among chrysanthemum cultivars to be detected. Susceptibility to white rust in the plant-box evaluation showed a good correlation with the rating of sporulation on plants grown in a greenhouse. The method described here is a simple, space-saving inoculation system to evaluate the susceptibility of chrysanthemums to white rust.Type of Medium: Electronic ResourceURL: -
3Articles: DFG German National LicensesSUMIGAWA, T. ; KITAMURA, T. ; OHISHI, K.
PO Box 1354, 9600 Garsington Road, Oxford OX4 2XG, UK. : Blackwell Science Ltd
Published 2004Staff ViewISSN: 1460-2695Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision MechanicsNotes: In order to investigate the characteristic slip behaviour near a grain boundary in high-cycle fatigue, a high-cycle fatigue test is carried out using a copper poly-crystal specimen, which consists of several tens of grains. Seventeen persistent slip bands (PSBs) are observed along the grain boundaries. Their location and the activated slip system are different from those expected by the Schmid factor. After the fatigue test, the crystalline orientation and the three-dimensional shape of each grain are specified by the repetition of polishing and observation by means of an orientation-imaging microscope (OIM). A finite-element method (FEM) analysis is also conducted for the specimen with the same orientation and shape of grains taking into account the anisotropy. This analysis reveals that the shear stress concentrates near the grain boundaries where the PSBs are formed. The activated slip systems predicted by the maximum resolved shear stress agree well with those observed in the fatigue experiment. Thus, the characteristic slip near the grain boundary in the poly-crystal is governed by the concentrated resolved shear stress on the specific slip system due to the deformation constraint by neighbouring crystals.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 0021-9673Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 0378-4347Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesKasahara, S. ; Nishikawa, S. ; Ishida, H. ; Nagata, T. ; Yamauchi, N. ; Ohishi, K. ; Wakano, Y. ; Inoue, H.
Amsterdam : ElsevierStaff ViewISSN: 0006-291XSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyPhysicsType of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 0040-4039Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 0169-4332Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesOhishi, K. ; Morinaga, Yoshihiro ; Ohsumi, Koji ; Nakagawa, Ryusuke ; Suga, Yasuyo ; Tsuji, Takashi ; Akiyama, Yukio ; Tsuruo, Takashi
Springer
Published 1996Staff ViewISSN: 1432-0843Keywords: Key words AC394 ; Multidrug resistance ; Colon cancerSource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Purpose: We have previously shown that a series of N-alkylated 1,4-dihydropyridines potentiate the therapeutic efficacy of vincristine in vincristine-resistant P388 leukemia. The purpose of this study was to investigate the ability of one of the compounds, AC394, and its enantiomers to potentiate the antitumor activity of adriamycin against colon cancer cells in vitro and in vivo. Methods: The effects of AC394 on potentiation of adriamycin cytotoxicity and enhancement of its accumulation were evaluated using colon 26, HCT-15 and MCF-7 cells. Furthermore, the activities of AC394 and its enantiomers were compared. We also studied the combined effects of (+)-AC394 and adriamycin on subcutaneously (s.c.)-implanted and liver metastasis tumor models. Results: AC394 potentiated the cytotoxicity of adriamycin and enhanced its accumulation in colon cancer cells (colon 26 and HCT-15), which are known to express P-GP (P-glycoprotein) intrinsically. Enhancement of adriamycin accumulation by AC394 was found in s.c.-implanted colon 26 cells in vivo. Although both enantiomers of AC394 showed equal activity in vitro, (+)-AC394 was more effective than (−)-AC394 given orally. (−)-AC394 was found to be cleared more rapidly from the plasma than (+)-AC394. Thus, (+)-AC394 was evaluated for further study. Administration of (+)-AC394 significantly potentiated the antitumor activities of adriamycin in human colon cancer HCT-15 cells implanted s.c. Furthermore, in the liver metastasis model using colon 26 cells, a model completely resistant to adriamycin, the combination therapy of adriamycin with (+)-AC394 produced superior antitumor effects over adriamycin alone. Conclusions: A newly synthesized N-alkylated 1,4-dihydropyridine derivative, (+)-AC394, showed superior effects on the potentiation of adriamycin antitumor and antimetastatic activities in vivo. These results suggest that this combination may have therapeutic efficacy not only against primary colon cancers but also against metastatic liver cancer.Type of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 1573-7357Source: Springer Online Journal Archives 1860-2000Topics: PhysicsNotes: Abstract We measured the interfacial tension of 3 He-4 He mixtures under pressure of 21 atm down to about 0.2K by using the resonance of the interfacial wave and found that the decrease from absolute zero is proportional to T2 up to about 0.4 K. From the simple extrapolation of this T2-dependence the interfacial tension at absolute zero is obtained as σ i (0) = 19.3 ± 1.3 mdyne/cm. Compared with saturated vapor pressure, the interfacial tension at absolute zero decreases by about 20%, and the coefficient of the T2-dependence does not depend strongly on pressure. The large T2-dependence both at saturated vapor pressure and at 21 atm may be attributable to the change in density difference between the two phases.Type of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 1573-7357Source: Springer Online Journal Archives 1860-2000Topics: PhysicsNotes: Abstract We measured the interfacial tension of 3 He- 4 He mixtures at several pressures up to 21 atm down to 0.18 K as well as the number densities of the 4 He-rich and 3 He-rich liquids at the phase-separation line. The interfacial tension was proportional to T2 up to about 0.4 K without respect to pressure, and the coefficient of this T2 -dependence did not depend strongly on pressure. The extrapolated values of the interfacial tension at absolute zero decreased drastically up to 3 atm, and at this level the decrease about 15% of the value at the saturated vapor pressure σi = 23.9 ± 1.0 μN/m. However, this tension was unchanged above 7 atm. From the pressure dependence of the absolute value the adsorption of 3 He relative to the Gibbs dividing surface of 4 He component was calculated.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 1573-7357Source: Springer Online Journal Archives 1860-2000Topics: PhysicsNotes: Abstract The interfacial tension of3He−4He mixtures at saturated vapor pressure has been measured precisely down to 0.15 K by means of the resonance of the interfacial wave. We found that the decrease of the interfacial tension from the value at absolute zero can be described as 56.8T 2 mdyne/cm up to about 0.4 K and that the extrapolated value at absolute zero is 23.9±1.0 mdyne/cm. The large temperature dependence in the low temperature region may be explained by the effect of the change in density difference between the two phases.Type of Medium: Electronic ResourceURL: