Search Results - (Author, Cooperation:K. O'Rourke)

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  1. 1
    Staff View
    Publication Date:
    2011-05-17
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Keywords:
    Amino Acid Motifs ; Animals ; Carrier Proteins/metabolism ; Cell Line ; Cell Line, Tumor ; Cell Proliferation ; Cell Transformation, Neoplastic ; DNA-Binding Proteins/genetics/metabolism ; Humans ; Male ; Mice ; Nuclear Proteins/deficiency/*metabolism ; PTEN Phosphohydrolase/deficiency ; Prostatic Neoplasms/metabolism/pathology ; Protein Binding ; Proto-Oncogene Proteins c-ets/*metabolism ; Transcription Factors/genetics/metabolism ; Tumor Suppressor Proteins/*metabolism ; Ubiquitin-Protein Ligases/deficiency/genetics/*metabolism ; Ubiquitination
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  2. 2
    Staff View
    Publication Date:
    2015-09-17
    Publisher:
    Nature Publishing Group (NPG)
    Print ISSN:
    0028-0836
    Electronic ISSN:
    1476-4687
    Topics:
    Biology
    Chemistry and Pharmacology
    Medicine
    Natural Sciences in General
    Physics
    Published by:
    http://www.nature.com/

    Latest Papers from Table of Contents or Articles in Press
  3. 3
    Riser, B.L. ; Varani, J. ; O'Rourke, K. ; Dixit, V.M.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0014-4827
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Biology
    Medicine
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0014-4827(88)90303-5

    Articles: DFG German National Licenses
  4. 4
    O'Rourke, K.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0014-4983
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    History
    Economics
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1006/exeh.1994.1005

    Articles: DFG German National Licenses
  5. 5
    O'Rourke, K.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0014-4983
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    History
    Economics
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1016/0014-4983(91)90002-Z

    Articles: DFG German National Licenses
  6. 6
    O'Rourke, K.

    Amsterdam : Elsevier
    Staff View
    ISSN:
    0165-1765
    Source:
    Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics:
    Economics
    Type of Medium:
    Electronic Resource
    URL:
    http://linkinghub.elsevier.com/retrieve/pii/0165-1765(89)90158-4

    Articles: DFG German National Licenses
  7. 7
    Delbono, O. ; O'Rourke, K. S. ; Ettinger, W. H.
    Springer
    Published 1995
    Staff View
    ISSN:
    1432-1424
    Keywords:
    Dihydropyridine receptor ; Muscle contraction ; Calcium release ; Voltage-clamp ; Calcium channels ; Muscle weakness
    Source:
    Springer Online Journal Archives 1860-2000
    Topics:
    Biology
    Chemistry and Pharmacology
    Notes:
    Abstract The biological mechanisms underlying decline in muscle power and fatigue with age are not completely understood. The contribution of alterations in the excitation-calcium release coupling in single muscle fibers was explored in this work. Single muscle fibers were voltage-clamped using the double Vaseline gap technique. The samples were obtained by needle biopsy of the vastus lateralis (quadriceps) from 9 young (25–35 years; 25.9 ± 9.1; 5 female and 4 male) and 11 old subjects (65–75 years; 70.5 ± 2.3; 6 f, 5 m). Data were obtained from 36 and 39 fibers from young and old subjects, respectively. Subjects included in this study had similar physical activity. Denervated and slow-twitch muscle fibers were excluded from this study. A significant reduction of maximum charge movement (Qmax) and DHP-sensitive Ca current were recorded in muscle fibers from the 65–75 group. Qmax values were 7.6 ± 0.9 and 3.2 ± 0.3 nC/μF for young and old muscle fibers, respectively (P 〈 0.01). No evidences of charge inactivation or interconversion (charge 1 to charge 2) were found. The peak Ca current was (−)4.7 ± 0.08 and (−)2.15 ± 0.11 μA/μF for young and old fibers, respectively (P 〈 0.01). The peak calcium transient studied with mag-fura-2 (400 μm) was 6.3 ± 0.4 μm and 4.2 ± 0.3 μm for young and old muscle fibers, respectively. Caffeine (0.5 mm) induced potentiation of the peak calcium transient in both groups. The decrease in the voltage-/ Ca-dependent Ca release ratio in old fibers (0.18 ± 0.02) compared to young fibers (0.47 ± 0.03) (P 〈 0.01), was recorded in the absence of sarcoplasmic reticulum calcium depletion. These data support a significant reduction of the amount of Ca available for triggering mechanical responses in aged skeletal muscle and, the reduction of Ca release is due to DHPR-ryanodine receptor uncoupling in fast-twitch fibers. These alterations can account, at least partially for the skeletal muscle function impairment associated with aging.
    Type of Medium:
    Electronic Resource
    URL:
    http://dx.doi.org/10.1007/BF00235039

    Articles: DFG German National Licenses