Search Results - (Author, Cooperation:K. Nagai)
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1Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2011-04-26Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Binding Sites ; Crystallography, X-Ray ; Humans ; Models, Molecular ; Nucleotides/chemistry/metabolism ; Protein Folding ; Protein Structure, Tertiary ; RNA/chemistry/metabolism ; Ribonucleoprotein, U1 Small Nuclear/chemistry ; Ribonucleoprotein, U4-U6 Small Nuclear/*biosynthesis/*chemistry/metabolism ; Spliceosomes/chemistry/metabolism ; Structure-Activity RelationshipPublished by: -
2Latest Papers from Table of Contents or Articles in PressT. H. Nguyen ; W. P. Galej ; X. C. Bai ; C. G. Savva ; A. J. Newman ; S. H. Scheres ; K. Nagai
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-06-25Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Binding Sites ; Cryoelectron Microscopy ; *Models, Molecular ; Protein Structure, Quaternary ; RNA Helicases/chemistry/metabolism ; Ribonucleoprotein, U4-U6 Small Nuclear/*chemistry/metabolism ; Ribonucleoprotein, U5 Small Nuclear/chemistry/metabolism ; Saccharomyces cerevisiae/*chemistry/metabolism ; Saccharomyces cerevisiae Proteins/chemistry/metabolism ; Spliceosomes/chemistry/*physiologyPublished by: -
3Latest Papers from Table of Contents or Articles in PressT. H. Nguyen ; W. P. Galej ; X. C. Bai ; C. Oubridge ; A. J. Newman ; S. H. Scheres ; K. Nagai
Nature Publishing Group (NPG)
Published 2016Staff ViewPublication Date: 2016-02-02Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Base Pairing ; Catalytic Domain ; *Cryoelectron Microscopy ; DNA Helicases/metabolism ; Exons/genetics ; Guanosine Triphosphate/metabolism ; Hydrogen Bonding ; Models, Molecular ; Nucleic Acid Conformation ; RNA Splice Sites ; RNA, Small Nuclear/chemistry/genetics/metabolism ; Ribonucleoprotein, U4-U6 Small Nuclear/chemistry/metabolism ; Ribonucleoprotein, U5 Small Nuclear/chemistry/metabolism ; Ribonucleoproteins, Small Nuclear/chemistry/genetics/metabolism/*ultrastructure ; Saccharomyces cerevisiae/chemistry/genetics/growth & development/*ultrastructure ; Saccharomyces cerevisiae Proteins/chemistry/genetics/metabolism/*ultrastructure ; Spliceosomes/metabolismPublished by: -
4Latest Papers from Table of Contents or Articles in PressK. Nagai, H. Fujiwara, H. Aratani, S. Fujioka, H. Yomosa, Y. Nakatani, T. Kiss, A. Sekiyama, F. Kuroda, H. Fujii, T. Oguchi, A. Tanaka, J. Miyawaki, Y. Harada, Y. Takeda, Y. Saitoh, S. Suga, and R. Y. Umetsu
American Physical Society (APS)
Published 2018Staff ViewPublication Date: 2018-01-19Publisher: American Physical Society (APS)Print ISSN: 1098-0121Electronic ISSN: 1095-3795Topics: PhysicsKeywords: Electronic structure and strongly correlated systemsPublished by: -
5Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2013-01-29Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Catalytic Domain ; *Models, Molecular ; Nuclear Proteins/chemistry/metabolism ; Protein Structure, Tertiary ; Ribonucleoprotein, U4-U6 Small Nuclear/*chemistry/genetics ; Ribonucleoprotein, U5 Small Nuclear/*chemistry/genetics ; Saccharomyces cerevisiae/*chemistry/genetics ; Saccharomyces cerevisiae Proteins/*chemistry/genetics/metabolism ; Spliceosomes/*chemistryPublished by: -
6Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2018-11-09Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyGeosciencesComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: BiochemistryPublished by: -
7Latest Papers from Table of Contents or Articles in PressKuroha, T., Nagai, K., Gamuyao, R., Wang, D. R., Furuta, T., Nakamori, M., Kitaoka, T., Adachi, K., Minami, A., Mori, Y., Mashiguchi, K., Seto, Y., Yamaguchi, S., Kojima, M., Sakakibara, H., Wu, J., Ebana, K., Mitsuda, N., Ohme-Takagi, M., Yanagisawa, S., Yamasaki, M., Yokoyama, R., Nishitani, K., Mochizuki, T., Tamiya, G., McCouch, S. R., Ashikari, M.
American Association for the Advancement of Science (AAAS)
Published 2018Staff ViewPublication Date: 2018-07-13Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyGeosciencesComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: BotanyPublished by: -
8Articles: DFG German National LicensesOzaki, N. ; Sasatani, Y. ; Kishida, K. ; Nakano, M. ; Miyanaga, M. ; Nagai, K. ; Nishihara, K. ; Norimatsu, T. ; Tanaka, K. A.
[S.l.] : American Institute of Physics (AIP)
Published 2001Staff ViewISSN: 1089-7550Source: AIP Digital ArchiveTopics: PhysicsNotes: Two partially coherent light laser beams, coupled with a random phase plate were focused at an angle of 31.7° with the centers of the beams offset by 250 μm. This produced a relatively uniform (7% root-mean-square) irradiated spot of 400 μm. When this technique was used to produce a shock wave in a copper wedge, a relatively uniform shock of 2 ns duration was produced. In addition, a multilayered flyer plate was accelerated using this method to an average speed of 21 km/s and produced a planar impact on a glass window. It is anticipated that this technique can be used to produce important multi-Mbar equation of state information in future experiments. © 2001 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 1365-2133Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 1471-4159Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineType of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesKido, J. ; Hongawa, K. ; Okuyama, K. ; Nagai, K.
Woodbury, NY : American Institute of Physics (AIP)
Published 1994Staff ViewISSN: 1077-3118Source: AIP Digital ArchiveTopics: PhysicsNotes: White light-emitting electroluminescent devices were fabricated using poly(N-vinylcarbazole) (PVK) as a hole-transporting emitter layer and a double layer of 1,2,4-triazole derivative (TAZ) and tris(8-quinolinolato)aluminum(III) complex (Alq) as an electron transport layer. The PVK layer was doped with fluorescent dyes such as blue-emitting 1,1,4,4-tetraphenyl-1,3-butadiene, green-emitting coumarin 6, and orange-emitting DCM 1. A cell structure of glass substrate/indium-tin-oxide/doped PVK/TAZ/Alq/Mg:Ag was employed. White emission covering a wide range of the visible region and a high luminance of 3400 cd/m2 were obtained at a drive voltage of 14 V.Type of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesKido, J. ; Shionoya, H. ; Nagai, K.
Woodbury, NY : American Institute of Physics (AIP)
Published 1995Staff ViewISSN: 1077-3118Source: AIP Digital ArchiveTopics: PhysicsNotes: Bright single-layer white light-emitting organic electroluminescent devices were developed by using dye-dispersed poly(N-vinylcarbazole) (PVK). The active layer consists only of one polymer layer that is simply sandwiched between two electrodes, indium-tin oxide, and Mg:Ag. In order to achieve bipolarity in the single polymer emitter layer, PVK was molecularly dispersed with electron-transporting additives such as 2-(4-biphenyl)-5-(4-tert-butylphenyl)-1,3,4-oxadiazole. In addition, several fluorescent dyes, having different emission colors, were dispersed as emitting centers. By adjusting the concentration of the fluorescent dyes, white light with a maximum luminescence of 4100 cd/m2 was obtained, which is the brightest white light ever observed for organic electroluminescent devices. © 1995 American Institute of Physics.Type of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesAdachi, K. ; Hirata, T. ; Nagai, K. ; Sakaguchi, M.
Oxford, UK : Blackwell Publishing Ltd
Published 2001Staff ViewISSN: 1750-3841Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, NutritionProcess Engineering, Biotechnology, Nutrition TechnologyNotes: : Hemocyanin (Hc) from plasma of kuruma prawn was characterized as a potent inducer of black spots during storage. An oxygen transporter, hemocyanin was converted into phenoloxidase (PO)-like enzyme (HdPO) with SDS treatment as well as prophenoloxidase isolated from hemocytes. Both enzymes showed similar biochemical properties. The isolated PO, however, was so unstable that its activity was drastically reduced when frozen and thawed at -25°C for less than a week, while HdPO completely retained its activity for more than a month, suggesting that HdPO is a key factor in black spot development in freeze-thawed prawn.Type of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesNAGAI, K. ; NAGAI, T. ; TAKATSUKI, K. ; UCHINO, H.
Oxford, UK : Blackwell Publishing Ltd
Published 1982Staff ViewISSN: 1365-3083Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Immunoglobulin-secreting cells (ISC) in the peripheral blood of healthy individuals and in the bone marrow, peripheral blood, or plasmacytomas of patients with multiple myeloma were enumerated by a protein-A plaque-forming cell assay after treatment with anti-Ia antibody and complement. Rabbit anti-human B-cell antisera and monoclonal anti-Ia antibody (OKIal) were used. By this treatment, the number of ISC in the peripheral blood of healthy individuals decreased to half, and that of M-protein-secreting cells from some patients with multiple myeloma also decreased markedly. In one patient, the number of M-protein-secreting cells in the bone marrow were markedly reduced by this treatment, but this was not the case after 6 months of chemotherapy, suggesting that the chemo therapy reduced chiefly the Ia-positive myeloma cells rather than Ia-negative myeloma cells.Type of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 1365-3083Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Immunoglobulin-secreting cells were enumerated in the peripheral blood of 31 patients with multiple myeloma, nine patients with so-called benign monoclonal gammopathy, and ten patients with polyclonal hypergammaglobulinaemia or idiopathic hypogammaglobulinaemia. Immunoglobulin-secreting cells were detected by a haemolytic plaque assay using protein-A-coated erythrocytes in the presence of class- or type-specific rabbit anti-human immunoglobulin antisera. In about two-thirds of patients with multiple myeloma, cells secreting the same light-chain isotype of their serum M-protein increased in number, whereas this was not the case in the patients with so-called benign monoclonal gammopathy. Follow-up studies of immunoglobulin-secreting cells in multiple myeloma revealed that these cells increased or decreased, correlating with the severity of the disease, and alterations were more rapid than other clinical features. This plaque assay is therefore useful in evaluating the response to chemotherapy in patients with multiple myeloma.Type of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesHamamoto, Y. ; Nagai, K. ; Muto, M. ; Nakamura, K. ; Yasui, H. ; Asagami, C.
Oxford, UK : Blackwell Publishing Ltd
Published 1997Staff ViewISSN: 1600-0625Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Abstract Large amounts of homogeneous cells are not always available for in vitro studies of inflammatory skin disorders. Here we demonstrate that a novel cell line, termed YAA, has been established from peripheral blood mononuclear cells, which were separated by the Ficoll method, of a patient with atopic dermatitis. YAA cells were grown in suspension culture. The cytochemical staining showed a positive reaction for α-naphthyl butyrate esterase, which was completely inhibited by sodium fluoride, but a negative result for periodic acid-Schiff, peroxidase and alkaline phosphatase. A large population of YAA cells exhibited phenotype of CD33 and CD56 but neither of CD2 nor CD3. The phorbol ester-stimulated YAA cells produced a considerable amount of tumor neerosis factor-α. These findings suggest that YAA might be a monocytoid line with an additional phcnolype specific for natural killer cells.Type of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesHamamoto, Y. ; Nagai, K. ; Ichimiya, M. ; Yamamoto, K. ; Kinoshita, E. ; Muto, M.
Oxford, UK : Blackwell Science Ltd
Published 2001Staff ViewISSN: 1365-2230Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Cutaneous metastatic diseases remain nearly incurable and a major medical challenge. It has been shown that interleukin-2 (IL-2) has potential as a therapeutic agent for various neoplastic diseases such as melanoma, renal cell carcinoma and myeloid leukaemia. However, IL-2 therapy for metastatic skin lesions has not been established yet. In the present study, we investigated the effect of recombinant IL-2 in a 79-year-old Japanese man with carcinoma erysipeloides, a rare type of cutaneous metastasis from gastric cancer. He was treated with an intralesional injection of rIL-2 (200 000 JRU) daily. Ten days after treatment, an erythematous plaque was eliminated almost completely leaving light brown pigmentation. A skin biopsy from the pigmented area revealed the absence of obvious tumour cells. These findings suggest that this cytokine should be considered for the clinical treatment of several inoperative metastatic cutaneous diseases, including gastric cancer.Type of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 1365-2044Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: We report a unilateral hypoglossal nerve paralysis following the use of a laryngeal mask airway in a 62 year-old women with rheumatoid arthritis undegoing a shoulder joint replancement,. Cervical epidural anesthesia was vombined with general anaesthesia using nitrous oxide administrered via a larygeal mask airway with a the patient in the right lateral decubitus postion. The next morning, the patient was noted to have a right hypoglossal nerve palsy. compression of the nerve between the laryngeal mask airway cuff. distended with nitrous oxide, and the hyoid bone, was considered to be the cause ot the nerve paralysis.Type of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesStaff View
ISSN: 0304-4165Keywords: (Rat ventral prostate) ; Aging ; Androgen dependence ; Nuclear proteinSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyMedicinePhysicsType of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesStaff View
ISSN: 0005-2736Keywords: Detergent-protein interaction ; Lipid-protein interaction ; Membrane protein ; RhodopsinSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: BiologyChemistry and PharmacologyMedicinePhysicsType of Medium: Electronic ResourceURL: