Search Results - (Author, Cooperation:K. Michelsen)
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1Latest Papers from Table of Contents or Articles in PressX. Huang ; H. Chen ; K. Michelsen ; S. Schneider ; P. L. Shaffer
Nature Publishing Group (NPG)
Published 2015Staff ViewPublication Date: 2015-09-30Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsPublished by: -
2Latest Papers from Table of Contents or Articles in PressD. J. Lloyd ; D. J. St Jean, Jr. ; R. J. Kurzeja ; R. C. Wahl ; K. Michelsen ; R. Cupples ; M. Chen ; J. Wu ; G. Sivits ; J. Helmering ; R. Komorowski ; K. S. Ashton ; L. D. Pennington ; C. Fotsch ; M. Vazir ; K. Chen ; S. Chmait ; J. Zhang ; L. Liu ; M. H. Norman ; K. L. Andrews ; M. D. Bartberger ; G. Van ; E. J. Galbreath ; S. L. Vonderfecht ; M. Wang ; S. R. Jordan ; M. M. Veniant ; C. Hale
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-11-15Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adaptor Proteins, Signal Transducing ; Animals ; Blood Glucose/metabolism ; Carrier Proteins/*antagonists & inhibitors/metabolism ; Cell Nucleus/enzymology ; Crystallography, X-Ray ; Diabetes Mellitus, Type 2/blood/*drug therapy/enzymology ; Disease Models, Animal ; Hepatocytes ; Humans ; Hyperglycemia/blood/drug therapy/enzymology ; Hypoglycemic Agents/chemistry/*pharmacology/*therapeutic use ; Liver/cytology/enzymology/metabolism ; Male ; Models, Molecular ; Organ Specificity ; Phosphorylation/drug effects ; Piperazines/chemistry/metabolism/pharmacology/therapeutic use ; Protein Binding/drug effects ; Protein Transport/drug effects ; Rats ; Rats, Wistar ; Sulfonamides/chemistry/metabolism/pharmacology/therapeutic usePublished by: -
3Articles: DFG German National LicensesFogel, W. A. ; Michelsen, K. A. ; Granerus, G. ; Sasiak, K. ; Andrzejewski, W. ; Panula, P. ; Maslinski, C.
Oxford, UK : Blackwell Science, Ltd
Published 2002Staff ViewISSN: 1471-4159Source: Blackwell Publishing Journal Backfiles 1879-2005Topics: MedicineNotes: Rats with portocaval anastomosis (PCA), an animal model of hepatic encephalopathy (HE), have very high brain histamine concentrations. Our previous studies based on a biochemical approach indicated histamine accumulation in the neuronal compartment. In this study, immunohistochemical evidence is presented which further supports the amine localization in histaminergic neurons. These neurons become pathological in appearance with cisternae frequently seen along histaminergic fibres in many brain areas, including the hypothalamus, amygdala, substantia nigra and cerebral cortex. Such formations were not observed in sham-operated animals. The neuronal deposition is predominant, and unique for histamine. It serves as a mechanism to counterbalance excessive brain neurotransmitter formation evoked by PCA. However, there are other mechanisms. The data provided here show that there is also a significant increase in histamine catabolism in the shunted rats, as reflected by both the higher brain N-tele-methylhistamine (t-MeHA) concentration and urinary excretion of N-tele-methylimidazoleacetic acid (t-MeImAA), a major brain histamine end product. The stomach, in addition to the brain, is a site of enhanced histamine synthesis in portocavally shunted subjects. After gastrectomy or food deprivation to eliminate the contribution of the stomach, shunted rats excrete significantly more t-MeImAA, implying the role of the CNS. This last finding suggests that under strictly defined conditions, namely in parenterally fed HE patients with abnormal plasma l-histidine, the measurement of urinary t-MeImAA might provide valuable information concerning putative brain histaminergic activity.Type of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 0020-1693Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesCorbin, K.M. ; Hodgson, D.J. ; Lynn, M.H. ; Michelsen, K. ; Margrethe Nielsen, K. ; Pedersen, E.
Amsterdam : ElsevierStaff ViewISSN: 0020-1693Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesStaff View
ISSN: 0020-1693Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 0020-1693Keywords: Amine complexes ; Crystal structures ; Iron complexes ; Oxo complexes ; Polydentate ligand complexesSource: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 0020-1693Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 0020-1693Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: