Search Results - (Author, Cooperation:K. M. Shokat)
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1Latest Papers from Table of Contents or Articles in PressD. F. Brennan ; A. C. Dar ; N. T. Hertz ; W. C. Chao ; A. L. Burlingame ; K. M. Shokat ; D. Barford
Nature Publishing Group (NPG)
Published 2011Staff ViewPublication Date: 2011-03-29Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adenosine Triphosphate/metabolism ; Allosteric Regulation/physiology ; Animals ; Biocatalysis ; Catalytic Domain ; Crystallography, X-Ray ; Enzyme Activation ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Humans ; MAP Kinase Kinase 1/*chemistry/*metabolism ; Models, Molecular ; Phosphorylation ; Protein Multimerization ; Protein Structure, Quaternary ; Protein-Serine-Threonine Kinases/*chemistry/*metabolism ; Proto-Oncogene Proteins B-raf/chemistry/genetics/*metabolism ; Rabbits ; Signal TransductionPublished by: -
2Latest Papers from Table of Contents or Articles in PressA. C. Hsieh ; Y. Liu ; M. P. Edlind ; N. T. Ingolia ; M. R. Janes ; A. Sher ; E. Y. Shi ; C. R. Stumpf ; C. Christensen ; M. J. Bonham ; S. Wang ; P. Ren ; M. Martin ; K. Jessen ; M. E. Feldman ; J. S. Weissman ; K. M. Shokat ; C. Rommel ; D. Ruggero
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-03-01Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Benzoxazoles/pharmacology ; Cell Line, Tumor ; Cell Movement/drug effects/genetics ; Eukaryotic Initiation Factor-4E/metabolism ; Eukaryotic Initiation Factors/metabolism ; Gene Expression Regulation, Neoplastic/drug effects/genetics ; Genome/genetics ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Neoplasm Invasiveness/genetics ; *Neoplasm Metastasis/drug therapy/genetics ; Phosphoproteins/metabolism ; Prostatic Neoplasms/drug therapy/genetics/*pathology ; *Protein Biosynthesis ; Pyrimidines/pharmacology ; RNA, Messenger/genetics/metabolism ; Repressor Proteins/metabolism ; *Signal Transduction ; TOR Serine-Threonine Kinases/antagonists & inhibitors/*metabolismPublished by: -
3Latest Papers from Table of Contents or Articles in PressStaff View
Publication Date: 2012-06-09Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Benzenesulfonates/pharmacology ; Cell Transformation, Neoplastic/drug effects/pathology ; Disease Models, Animal ; Drosophila Proteins/antagonists & inhibitors/genetics/metabolism ; Drosophila melanogaster/drug effects/genetics ; Drug Evaluation, Preclinical ; Drug-Related Side Effects and Adverse Reactions ; Extracellular Signal-Regulated MAP Kinases/antagonists & inhibitors/metabolism ; Heterocyclic Compounds with 4 or More Rings/adverse ; effects/chemistry/pharmacology/therapeutic use ; Humans ; Male ; *Molecular Targeted Therapy ; Multiple Endocrine Neoplasia Type 2b/*drug therapy/enzymology/*genetics ; Niacinamide/analogs & derivatives ; Phenylurea Compounds ; *Polypharmacy ; Protein Kinase Inhibitors/adverse effects/chemistry/pharmacology/therapeutic use ; Proto-Oncogene Proteins c-ret/genetics/metabolism ; Pyridines/pharmacology ; Receptor Protein-Tyrosine Kinases/antagonists & inhibitors ; Signal Transduction/drug effects ; Survival Rate ; Xenograft Model Antitumor Assays ; src-Family Kinases/antagonists & inhibitors/metabolismPublished by: -
4Latest Papers from Table of Contents or Articles in PressJ. M. Ostrem ; U. Peters ; M. L. Sos ; J. A. Wells ; K. M. Shokat
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-11-22Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Allosteric Regulation/drug effects ; Allosteric Site/*drug effects ; Apoptosis/drug effects ; Cell Line, Tumor ; Crystallography, X-Ray ; Cysteine/genetics/metabolism ; Drug Discovery ; Genes, ras/genetics ; Guanosine Diphosphate/*metabolism ; Guanosine Triphosphate/*metabolism ; Humans ; Lung Neoplasms/drug therapy/metabolism/pathology ; Models, Molecular ; Mutant Proteins/*antagonists & inhibitors/genetics/*metabolism ; Oncogene Protein p21(ras)/*antagonists & inhibitors/genetics/*metabolism ; Static Electricity ; Substrate Specificity ; raf Kinases/metabolismPublished by: -
5Latest Papers from Table of Contents or Articles in PressJ. E. Burke ; A. J. Inglis ; O. Perisic ; G. R. Masson ; S. H. McLaughlin ; F. Rutaganira ; K. M. Shokat ; R. L. Williams
American Association for the Advancement of Science (AAAS)
Published 2014Staff ViewPublication Date: 2014-05-31Publisher: American Association for the Advancement of Science (AAAS)Print ISSN: 0036-8075Electronic ISSN: 1095-9203Topics: BiologyChemistry and PharmacologyComputer ScienceMedicineNatural Sciences in GeneralPhysicsKeywords: Amino Acid Sequence ; Animals ; Antimalarials/chemistry/pharmacology ; Binding Sites ; Cell Line ; Crystallography, X-Ray ; Drug Design ; Humans ; I-kappa B Kinase/*chemistry ; Molecular Sequence Data ; Mutation ; Phosphotransferases (Alcohol Group Acceptor)/*chemistry/genetics ; Plasmodium/drug effects/growth & development ; Protein Binding ; Protein Structure, Secondary ; Protein Structure, Tertiary ; rab GTP-Binding Proteins/*chemistryPublished by: -
6Articles: DFG German National LicensesShokat, K. M. ; Leumann, C. J. ; Sugasawara, R. ; Schultz, P. G.
[s.l.] : Nature Publishing Group
Published 1989Staff ViewISSN: 1476-4687Source: Nature Archives 1869 - 2009Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsNotes: [Auszug] To expand the scope of antibody catalysis we targeted reac-tions involving proton abstraction from a carbon centre. This class of reactions includes elimination and isomerization reac-tions and aldol and Claisen condensations16'18. Proton abstrac-tion in enzymes is often performed by carboxylate ...Type of Medium: Electronic ResourceURL: