Search Results - (Author, Cooperation:K. Ley)
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1Latest Papers from Table of Contents or Articles in PressP. Sundd ; E. Gutierrez ; E. K. Koltsova ; Y. Kuwano ; S. Fukuda ; M. K. Pospieszalska ; A. Groisman ; K. Ley
Nature Publishing Group (NPG)
Published 2012Staff ViewPublication Date: 2012-07-06Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Adhesiveness ; Animals ; Antigens, CD/metabolism ; Cell Adhesion ; Cell Adhesion Molecules/metabolism ; E-Selectin/metabolism ; Inflammation/immunology/metabolism/pathology ; Intercellular Adhesion Molecule-1/metabolism ; *Leukocyte Rolling ; Lymphocyte Function-Associated Antigen-1/metabolism ; Membrane Glycoproteins/metabolism ; Mice ; Mice, Inbred C57BL ; Microvessels/metabolism ; Neutrophils/*cytology/immunology/*metabolism ; P-Selectin/metabolism ; *Shear Strength ; Th1 Cells/cytology/immunology ; Venules/metabolismPublished by: -
2Latest Papers from Table of Contents or Articles in PressS. M. Lee ; G. P. Donaldson ; Z. Mikulski ; S. Boyajian ; K. Ley ; S. K. Mazmanian
Nature Publishing Group (NPG)
Published 2013Staff ViewPublication Date: 2013-08-21Publisher: Nature Publishing Group (NPG)Print ISSN: 0028-0836Electronic ISSN: 1476-4687Topics: BiologyChemistry and PharmacologyMedicineNatural Sciences in GeneralPhysicsKeywords: Animals ; Bacterial Proteins/genetics/metabolism ; Bacteroides/*classification/genetics/growth & development/*physiology ; Bacteroides fragilis/genetics/growth & development/metabolism ; Colon/microbiology ; Conserved Sequence/genetics ; Evolution, Molecular ; Female ; Gastrointestinal Tract/*microbiology ; Gene Deletion ; Genes, Bacterial/genetics ; Germ-Free Life ; Intestinal Mucosa/microbiology ; Male ; Metagenome/*physiology ; Mice ; Polysaccharides/metabolism ; Species Specificity ; Symbiosis/geneticsPublished by: -
3Articles: DFG German National LicensesP238 Collaboration ; Ellett, J. ; Erhan, S. ; Kreuzer, P. ; Lynn, D. ; Medinnis, M. ; Schlein, P. ; Zweizig, J. ; Czermak, A. ; Rudge, A. ; Wilkens, B. ; Biino, C. ; Borreani, G. ; Engelmann, G. ; Wahl, H. ; Ley, K. ; Pesando, L. ; Calvetti, M. ; Price, M. ; Punturo, M. ; Klingsheim, O. ; Karchin, P. ; Weilhammer, P. ; Harr, R. ; Palestini, S.
Amsterdam : ElsevierStaff ViewISSN: 0168-9002Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002Topics: PhysicsType of Medium: Electronic ResourceURL: -
4Articles: DFG German National LicensesStaff View
ISSN: 1420-9071Source: Springer Online Journal Archives 1860-2000Topics: BiologyMedicineNotes: Zusammenfassung Andauernde ACTH-Behandlung beeinflusst sowohl Vermeidungs- als auch Fehlerkomponenten im Zweiwahl-Y-Labyrinthtest. Die Einwirkungen waren von der Intensität des Elektroschocks wie auch von der Reaktionsfähigkeit der Tiere abhängig.Type of Medium: Electronic ResourceURL: -
5Articles: DFG German National LicensesStaff View
ISSN: 1432-2013Keywords: Microcirculation ; Blood rheology ; Leukocytes ; Capillary ; Bifurcation ; Network ; Topology ; Intravital microscopySource: Springer Online Journal Archives 1860-2000Topics: MedicineNotes: Abstract Distribution of leukocytes in rat mesenteric microvessel networks was studied using intravital fluorescence video microscopy. A digital image analysis system was used to measure vessel diameters, flow velocities and leukocyte fluxes in 306 capillaries of 8 networks. Capillaries were defined as vessel segments connecting divergent to convergent branch points. Their topological position within the network was quantified by a generation number defined as the number of bifurcations between the capillary and the arteriole feeding the network. Proximal capillaries (generation numbers 4 and 5) were slightly but significantly smaller in diameter (8.9±0.4) μm, mean ± SEM) than distal ones (generation numbers 20 and 21, 10.1±0.4 μm). Average capillary flow velocity decreased markedly from 2.0±1.0 mm·s−1 in proximal to 0.41 ±0.06 mm·s−1 in distal capillaries. Average leukocyte concentration was 3.4±0.5·109 l−1 and thus significantly below systemic values (6.0·109 l−1) in proximal capillaries, and above in distal ones (11.7±2.6·109l−1). The analysis of flow and leukocyte flux partition at 138 bifurcations showed preferential distribution of leukocytes to the daughter capillary with higher flow rate. This suggests a tentative explanation for the observed leukocyte accumulation along the microvascular tree: due to their low fractional flow, proximal capillaries draw relatively leukocytepoor blood from the arteriole feeding the network; this leads to an increased leukocyte concentration in distal capillaries. As a consequence of the concomitant increase of capillary diameter with increasing generation number, leukocytes are preferentially flowing through larger capillaries and are excluded from small ones.Type of Medium: Electronic ResourceURL: -
6Articles: DFG German National LicensesPopel, A. S. ; Greene, A. S. ; Ellis, C. G. ; Ley, K. F. ; Skalak, T. C. ; Tonellato, P. J.
Springer
Published 1998Staff ViewISSN: 1573-9686Keywords: Physiological database ; Mathematical model ; Physiome: microcirculationSource: Springer Online Journal Archives 1860-2000Topics: MedicineTechnologyNotes: Abstract Presented is a discussion of steps towards the creation of a database of the microcirculation encompassing anatomical and functional experimental data, and conceptual and computational models. The discussion includes issues of database utility, organization, data deposition, and linkage to other databases. The database will span levels from gene to tissue and will serve both research and educational purposes. © 1998 Biomedical Engineering Society. PAC98: 8745Ft, 8710+e, 0130CcType of Medium: Electronic ResourceURL: -
7Articles: DFG German National LicensesStaff View
ISSN: 0044-8249Keywords: Chemistry ; General ChemistrySource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
8Articles: DFG German National LicensesStaff View
ISSN: 0044-8249Keywords: Chemistry ; General ChemistrySource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
9Articles: DFG German National LicensesStaff View
ISSN: 0044-8249Keywords: Chemistry ; General ChemistrySource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
10Articles: DFG German National LicensesStaff View
ISSN: 0044-8249Keywords: Chemistry ; General ChemistrySource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
11Articles: DFG German National LicensesStaff View
ISSN: 0044-8249Keywords: Chemistry ; General ChemistrySource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
12Articles: DFG German National LicensesStaff View
ISSN: 0044-8249Keywords: Chemistry ; General ChemistrySource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
13Articles: DFG German National LicensesStaff View
ISSN: 0044-8249Keywords: Chemistry ; General ChemistrySource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
14Articles: DFG German National LicensesStaff View
ISSN: 0044-8249Keywords: Chemistry ; General ChemistrySource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
15Articles: DFG German National LicensesStaff View
ISSN: 0044-8249Keywords: Chemistry ; General ChemistrySource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
16Articles: DFG German National LicensesStaff View
ISSN: 0044-8249Keywords: Chemistry ; General ChemistrySource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
17Articles: DFG German National LicensesStaff View
ISSN: 0044-8249Keywords: Chemistry ; General ChemistrySource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
18Articles: DFG German National LicensesStaff View
ISSN: 0021-9541Keywords: Life and Medical Sciences ; Cell & Developmental BiologySource: Wiley InterScience Backfile Collection 1832-2000Topics: BiologyMedicineNotes: Mitochondrial protein synthesis was measured in line CHO cells after phases of the cell cycle were synchronized by isoleucine deprivation or mitotic selection. Maximum incorporation of [3H] leucine into mitochondrial polypeptides occurred within 2 hours after isoleucine was added to initiate G1 traverse. In cells synchronized in G1 by mitotic selection, the rate of mitochondrial protein synthesis was fairly constant throughout the cell cycle. SDS-polyacrylamide gel electrophoretic profiles of labeled mitochondrial polypeptides were similar in cells synchronized by either isoleucine deprivation or mitotic selection. Obvious changes in the distribution of polypeptides were not detected during various phases of the cell cycle. The increased rate of incorporation of [3H] leucine into mitochondrial polypeptides after reversal of G1-arrest may indicate that mitochondrial protein synthesis and possibly mitochondrial biogenesis are synchronized in CHO cells deprived of isoleucine.Additional Material: 5 Ill.Type of Medium: Electronic ResourceURL: -
19Articles: DFG German National LicensesLey, K. ; Seng, F. ; Eholzer, U. ; Nast, R. ; Schubart, R.
Weinheim : Wiley-Blackwell
Published 1969Staff ViewISSN: 0570-0833Keywords: Chemistry ; General ChemistrySource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: -
20Articles: DFG German National LicensesStaff View
ISSN: 0570-0833Keywords: Chemistry ; General ChemistrySource: Wiley InterScience Backfile Collection 1832-2000Topics: Chemistry and PharmacologyType of Medium: Electronic ResourceURL: